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1. 发明授权

US07894652B2 Prompt gamma correction for non-standard isotopes in a PET scanner 有权
标题翻译： PET扫描仪中非标准同位素的伽马校正
公开(公告)号：US07894652B2
公开(公告)日：2011-02-22
申请号：US12110474
申请日：2008-04-28
申请人： Charles H. Hayden, Jr. , Michael E. Casey , Charles C. Watson
发明人： Charles H. Hayden, Jr. , Michael E. Casey , Charles C. Watson
IPC分类号： G06K9/00 , G01R23/02 , G01N23/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method for correcting PET emission data for prompt gamma emission background components present in non-pure positron-emitting isotopes uses a two component fit of modeled scatter and modeled prompt gamma emission in the area of scatter tails in a normalized emission sinogram. The method allows a PET scan using non-standard PET isotopes to be quantitative and thus more clinically useful.
摘要翻译：用于校正存在于非纯正电子发射同位素中的迅速γ发射背景分量的PET发射数据的方法使用归一化发射正弦图中散射尾部区域中的建模散射和建模的提示γ发射的双分量拟合。该方法允许使用非标准PET同位素的PET扫描是定量的，因此在临床上更有用。

2. 发明申请

US20080283758A1 PROMPT GAMMA CORRECTION FOR NON-STANDARD ISOTOPES IN A PET SCANNER 有权
标题翻译： PET扫描仪中非标准同位素的准确伽马校正
公开(公告)号：US20080283758A1
公开(公告)日：2008-11-20
申请号：US12110474
申请日：2008-04-28
申请人： Charles H. Hayden, JR. , Michael E. Casey , Charles C. Watson
发明人： Charles H. Hayden, JR. , Michael E. Casey , Charles C. Watson
IPC分类号： G01T1/15
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method for correcting PET emission data for prompt gamma emission background components present in non-pure positron-emitting isotopes uses a two component fit of modeled scatter and modeled prompt gamma emission in the area of scatter tails in a normalized emission sinogram. The method allows a PET scan using non-standard PET isotopes to be quantitative and thus more clinically useful.
摘要翻译：用于校正存在于非纯正电子发射同位素中的迅速γ发射背景分量的PET发射数据的方法使用归一化发射正弦图中散射尾部区域中的建模散射和建模的提示γ发射的双分量拟合。该方法允许使用非标准PET同位素的PET扫描是定量的，因此在临床上更有用。

3. 发明申请

US20110127413A1 Systems and Methods for Calibrating Time Alignment For A Positron Emission Tomography (PET) System 有权
标题翻译：用于校正正电子发射断层扫描（PET）系统的时间对准的系统和方法
公开(公告)号：US20110127413A1
公开(公告)日：2011-06-02
申请号：US12628259
申请日：2009-12-01
申请人： Michael E. Casey , Mu Chen , Timothy G. Gremillion , Charles H. Hayden, JR. , Mark W. Lenox , Vladimir Y. Panin
发明人： Michael E. Casey , Mu Chen , Timothy G. Gremillion , Charles H. Hayden, JR. , Mark W. Lenox , Vladimir Y. Panin
IPC分类号： G12B13/00
CPC分类号： G12B13/00 , G01T1/2985
摘要： A representative positron emission tomography (PET) calibration system includes a PET scanner having a ring detector, a phantom that is placed at approximately the center of the ring detector, and a time alignment calibration manager that is coupled to the PET scanner. The time alignment calibration manager detects coincidence events from the phantom, calculates position of time of flight events from the ring detector based on the detected coincidence events, and calculates time offsets for the ring detector using a mean value calculation based on the calculated position of the time of flight events.
摘要翻译：代表性的正电子发射断层摄影（PET）校准系统包括具有环检测器的PET扫描器，放置在环检测器的大约中心处的体模，以及耦合到PET扫描器的时间对准校准管理器。时间校准管理器检测来自幻影的重合事件，基于检测到的重合事件来计算来自环形探测器的飞行时间的位置，并使用基于计算出的位置的计算的平均值计算环形探测器的时间偏移量飞行时间事件

4. 发明授权

US08089043B2 Systems and methods for calibrating time alignment for a positron emission tomography (PET) system 有权
标题翻译：用于校正正电子发射断层摄影（PET）系统的时间对准的系统和方法
公开(公告)号：US08089043B2
公开(公告)日：2012-01-03
申请号：US12628259
申请日：2009-12-01
申请人： Michael E. Casey , Mu Chen , Timothy G. Gremillion , Charles H. Hayden, Jr. , Mark W. Lenox , Vladimir Y. Panin
发明人： Michael E. Casey , Mu Chen , Timothy G. Gremillion , Charles H. Hayden, Jr. , Mark W. Lenox , Vladimir Y. Panin
IPC分类号： G01D18/00
CPC分类号： G12B13/00 , G01T1/2985
摘要： A representative positron emission tomography (PET) calibration system includes a PET scanner having a ring detector, a phantom that is placed at approximately the center of the ring detector, and a time alignment calibration manager that is coupled to the PET scanner. The time alignment calibration manager detects coincidence events from the phantom, calculates position of time of flight events from the ring detector based on the detected coincidence events, and calculates time offsets for the ring detector using a mean value calculation based on the calculated position of the time of flight events.
摘要翻译：代表性的正电子发射断层摄影（PET）校准系统包括具有环检测器的PET扫描器，放置在环检测器的大约中心处的体模，以及耦合到PET扫描器的时间对准校准管理器。时间校准管理器检测来自幻影的重合事件，基于检测到的重合事件来计算来自环形探测器的飞行时间的位置，并使用基于计算出的位置的计算的平均值计算环形探测器的时间偏移量飞行时间事件

5. 发明授权

US07851763B2 Method for improving clinical data quality in positron emission tomography 失效
标题翻译：正电子发射断层扫描技术提高临床资料质量的方法
公开(公告)号：US07851763B2
公开(公告)日：2010-12-14
申请号：US12622623
申请日：2009-11-20
申请人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
发明人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj),and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.
摘要翻译：一种改善正电子发射断层扫描（PET）临床数据质量的方法。该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。对患者剂量进行分级，最初给予较小的校准剂量。经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。

6. 发明授权

US06329657B1 Coincidence transmission source 失效
标题翻译：一致传输源
公开(公告)号：US06329657B1
公开(公告)日：2001-12-11
申请号：US09070951
申请日：1998-05-01
申请人： Charles C. Watson , Ronald Nutt , J. Clifton Moyers , Michael E. Casey , William F. Jones
发明人： Charles C. Watson , Ronald Nutt , J. Clifton Moyers , Michael E. Casey , William F. Jones
IPC分类号： G01T1163
CPC分类号： G01T1/2985 , A61B6/037
摘要： A coincidence transmission source serves to detect coincident activity from a radiation source. The coincidence transmission source includes a detector dedicated to collecting attenuation data. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The coincidence transmission source includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. The attenuation detector and collimator are designed to illuminate only a strip of the imaging detector, thereby eliminating events not of interest in the attenuation measurement. In a dual head tomograph device, one coincidence transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera.
摘要翻译：符合传输源用于检测来自辐射源的重合活动。重合传输源包括专用于收集衰减数据的检测器。准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。重合传输源包括其中设置有辐射源的准直仪。由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。相对于成像检测器定位在辐射源之后，是专用的衰减检测器。衰减检测器和准直器被设计为仅照射成像检测器的条带，从而消除衰减测量中不感兴趣的事件。在双头断层摄影装置中，本发明的一个重合传播源与每一组成像检测器相对设置。源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。源和检测器相对于成像头是固定的。为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。

7. 发明申请

US20100148047A1 Method for Improving Clinical Data Quality In Positron Emission Tomography 失效
标题翻译：在正电子发射断层扫描中改善临床数据质量的方法
公开(公告)号：US20100148047A1
公开(公告)日：2010-06-17
申请号：US12622623
申请日：2009-11-20
申请人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
发明人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
IPC分类号： G01T1/161 , G12B13/00
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data single-to-noise ratio (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of a quantity proportional to SNR, similar in function to the SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal does is then determined and the remainder injected.
摘要翻译：一种改善正电子发射断层扫描（PET）临床数据质量的方法。该方法提供PET数据的处理，以准确且有效地确定与每个单独的临床患者扫描相对应的数据单一噪声比（SNR），作为PET扫描仪中单打率的函数。该方法将注射剂量与单次速率相关联以确定SNR（Dinj），并且提供与SNR成比例的量的精确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。对患者剂量进行分级，最初给予较小的校准剂量。经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳确定并且剩余部分注射。

8. 发明申请

US20110042572A1 Method for Improving Clinical Data Quality In Positron Emission Tomography 失效
标题翻译：在正电子发射断层扫描中改善临床数据质量的方法
公开(公告)号：US20110042572A1
公开(公告)日：2011-02-24
申请号：US12917701
申请日：2010-11-02
申请人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
发明人： Bernard Bendriem , Michael E. Casey , Charles C. Watson
IPC分类号： G01T1/20
CPC分类号： G01T1/2985 , G01T7/005
摘要： A method for improving clinical data quality in Positron Emission Tomography (PET). The method provides for the processing of PET data to accurately and efficiently determine a data signal-to-noise (SNR) corresponding to each individual clinical patient scan, as a function of a singles rate in a PET scanner. The method relates an injected dose to the singles rate to determine SNR(Dinj), and provides an accurate estimate of quantity proportional to SNR, similar in function to SNR(Dinj). Knowledge of SNR(Dinj) permits determination of peak SNR, optimal dose, SNR deficit, dose deficit, and differential dose benefit. The patient dose is fractionated, with a small calibration dose given initially. After a short uptake, the patient is pre-scanned to determine T, S, and R. An optimal dose is then determined and the remainder is injected.
摘要翻译：一种改善正电子发射断层扫描（PET）临床数据质量的方法。该方法提供PET数据的处理，以便根据PET扫描仪中的单打率来准确有效地确定与每个单独的临床患者扫描相对应的数据信噪比（SNR）。该方法将注射剂量与单打率相关联以确定SNR（Dinj），并提供与SNR成比例的量的准确估计，其功能类似于SNR（Dinj）。 SNR（Dinj）的知识允许确定峰值SNR，最佳剂量，SNR赤字，剂量缺陷和差异剂量效益。对患者剂量进行分级，最初给予较小的校准剂量。经过短暂摄取后，患者被预先扫描以确定T，S和R.然后确定最佳剂量，并注射剩余部分。

9. 发明授权

US07737405B2 Time-of-flight (TOF) positron emission tomography (PET) reconstruction from time-truncated projection data 有权
标题翻译：从时间截断的投影数据重建飞行时间（TOF）正电子发射断层扫描（PET）重建
公开(公告)号：US07737405B2
公开(公告)日：2010-06-15
申请号：US12212130
申请日：2008-09-17
申请人： Charles C. Watson , Vladimir Panin , Bernard Bendriem , Michael E. Casey
发明人： Charles C. Watson , Vladimir Panin , Bernard Bendriem , Michael E. Casey
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method of TOF-PET image reconstruction using time-truncated TOF-PET projection data. The time-truncated TOF-PET data is obtained by narrowing the scanner time window to a smaller “time window field of view,” which reduces the field of view of a TOF-PET scanner. This results in a lower list mode stream transfer rate, which can be useful in high count rate data acquisitions, in particular 82Rb cardiac studies.
摘要翻译：使用时间截断的TOF-PET投影数据的TOF-PET图像重建方法。通过将扫描仪时间窗缩小到更小的“时间窗视野”来获得时间截断的TOF-PET数据，这减少了TOF-PET扫描仪的视场。这导致较低的列表模式流传输速率，其可用于高计数率数据采集，特别是82Rb心脏研究。

10. 发明授权

US06429434B1 Transmission attenuation correction method for PET and SPECT 失效
标题翻译： PET和SPECT传输衰减校正方法
公开(公告)号：US06429434B1
公开(公告)日：2002-08-06
申请号：US09398497
申请日：1999-09-17
申请人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
发明人： Charles C. Watson , Stephen D. Miller , Ronald Nutt , Michael E. Casey , James J. Hamill
IPC分类号： G01T1166
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1648 , G21K1/02
摘要： A transmission source serves to detect activity from a radiation source for correcting attenuation in either PET mode or SPECT mode. The transmission source includes a detector dedicated to collecting attenuation data in PET mode. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The transmission source can either be a coincidence transmission source or a singles transmission source and includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. In a dual head tomograph device, one transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera. In SPECT mode, the point source is selected to have sufficiently high energy to shine through the patient and the collimators associated with the imaging detector.
摘要翻译：传输源用于检测来自辐射源的活动以校正PET模式或SPECT模式中的衰减。传输源包括专用于在PET模式下收集衰减数据的检测器。准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。传输源可以是重合传输源或单个传输源，并且包括准直仪，其中设置有辐射源。由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。相对于成像检测器定位在辐射源之后，是专用的衰减检测器。在双头断层摄影装置中，本发明的一个发射源与每一组成像检测器相对设置。源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。源和检测器相对于成像头是固定的。为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。在SPECT模式中，点源被选择为具有足够高的能量以照射通过患者和与成像检测器相关联的准直仪。

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