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1. 发明授权

US10137135B2 Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith 有权
公开(公告)号：US10137135B2
公开(公告)日：2018-11-27
申请号：US11205297
申请日：2005-08-15
申请人： Charles Ebert , Gary Hoel , Angela Anigbogu , Samir Roy
发明人： Charles Ebert , Gary Hoel , Angela Anigbogu , Samir Roy
IPC分类号： A61K31/57 , A61K9/70 , A61K31/565
摘要： Formulations and methods for providing progestin-only contraception to a woman while minimizing various side effects, such as breakthrough bleeding, that are normally associated with progestin-only contraception are disclosed and described. In one aspect, the method can include transdermally administering a formulation having a contraceptively effective amount of a single progestin as the sole active hormonal agent to the woman as part of a contraceptive regimen.

2. 发明申请

US20070037780A1 Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith 审中-公开
标题翻译：提供仅孕激素避孕的制剂和方法，同时最小化与之相关的不良副作用
公开(公告)号：US20070037780A1
公开(公告)日：2007-02-15
申请号：US11205297
申请日：2005-08-15
申请人： Charles Ebert , Gary Hoel , Angela Anigbogu , Samir Roy
发明人： Charles Ebert , Gary Hoel , Angela Anigbogu , Samir Roy
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K9/7061 , A61K31/565
摘要： Formulations and methods for providing progestin-only contraception to a woman while minimizing various side effects, such as breakthrough bleeding, that are normally associated with progestin-only contraception are disclosed and described. In one aspect, the method can include transdermally administering a formulation having a contraceptively effective amount of a single progestin as the sole active hormonal agent to the woman as part of a contraceptive regimen.
摘要翻译：公开和描述了通常仅与孕激素避孕相关的各种副作用，例如突破性出血，同时为女性提供仅孕激素避孕的制剂和方法。在一个方面，该方法可以包括经皮给药具有避孕有效量的单一孕激素作为唯一活性荷尔蒙剂的制剂作为避孕方案的一部分。

3. 发明申请

US20070148195A1 Compositions and methods for transdermal oxybutynin therapy 有权
公开(公告)号：US20070148195A1
公开(公告)日：2007-06-28
申请号：US11645076
申请日：2006-12-21
申请人： Charles Ebert , Steven Sanders
发明人： Charles Ebert , Steven Sanders
IPC分类号： A61K31/24 , A61K9/00
CPC分类号： A61K31/216 , A61F2013/00646 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1647 , A61K9/7061 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
摘要： The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.

4. 发明授权

US4576409A Sun visor with molded stiffening frame 失效
标题翻译：遮阳板带模制加强框架
公开(公告)号：US4576409A
公开(公告)日：1986-03-18
申请号：US561051
申请日：1983-12-13
申请人： Charles Ebert
发明人： Charles Ebert
IPC分类号： B60J3/02 , B60J3/00
CPC分类号： B60J3/0282
摘要： A sun visor for an automotive vehicle includes a visor body which is reinforced by an insert in the form of a wire bent into an approximately rectangular frame. A brace for stiffening the rectangular frame is disposed in the area surrounded by the frame. The brace is an injection molding including a longitudinal brace extending to and molded on the short arms of the rectangular insert and a plurality of transverse braces extending to and molded on the long arms of the rectangular insert. One surface of the brace carries a frame for receiving a mirror. Various additional frames are provided on the mirror-receiving frame for holding the mirror in place. A visor body support shaft mounting housing is also molded as part of the brace and is injection molded onto the reinforcing insert. The mounting housing has an opening therein for receiving the support shaft for supporting the visor body. An outer mounting shaft is also molded on the brace for being received in a supporting receiver on the vehicle body.
摘要翻译：一种用于机动车辆的遮阳板包括一面罩体，该遮阳板体由插入件以一弯曲成大致矩形框架的线材形式加固。用于加强矩形框架的支架设置在由框架包围的区域中。支架是一种注射成型件，其包括延伸到矩形插入件的短臂上并模制在矩形插入件的短臂上的纵向支架以及延伸到矩形插入件的长臂上并在其上模制的多个横向支架。支架的一个表面带有用于接收反射镜的框架。在镜子接收框架上设有各种附加的镜架，用于将镜子保持在适当位置。护罩体支撑轴安装壳体也被模制为支架的一部分，并且被注射到加强插入件上。安装壳体具有用于接收用于支撑遮阳板体的支撑轴的开口。外装安装轴也被模制在支架上，用于容纳在车身上的支撑接收器中。

5. 发明申请

US20050226898A1 Compositions and methods for transdermal oxybutynin therapy 有权
标题翻译：用于透皮奥昔布宁治疗的组合物和方法
公开(公告)号：US20050226898A1
公开(公告)日：2005-10-13
申请号：US10913019
申请日：2004-08-06
申请人： Charles Ebert , Steven Sanders
发明人： Charles Ebert , Steven Sanders
IPC分类号： A61K9/00 , A61K9/16 , A61K9/70 , A61K31/216 , A61K47/10 , A61K47/14 , A61K47/38
CPC分类号： A61K31/216 , A61F2013/00646 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1647 , A61K9/7061 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
摘要： The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.
摘要翻译：本发明提供了用于奥昔布宁的组合物和方法，同时最小化与奥昔布宁治疗相关的不良药物经历的发生率和/或严重程度。在一个方面，这些组合物和方法提供了较低的奥昔布宁代谢物的血浆浓度，例如N-去乙氧基丁啶，其被推定为至少部分地促成一些不良药物经历，同时保持足够的奥昔布宁血浆浓度以有益于奥昔布宁治疗。本发明还提供了符合以下特征的奥昔布宁及其代谢物的异构体，这些特征使不良药物经历的发生率和/或严重程度最小化，以及维持膀胱过度活动症的有益和有效治疗。在一些方面，组合物可以呈局部施用凝胶的未被包裹或游离形式存在。

6. 发明授权

US4917676A User-activated transdermal therapeutic system 失效
标题翻译：用户激活的透皮治疗系统
公开(公告)号：US4917676A
公开(公告)日：1990-04-17
申请号：US251016
申请日：1988-09-27
申请人： Werner Heiber , Robert Andriola , Paul Williams , Charles Ebert
发明人： Werner Heiber , Robert Andriola , Paul Williams , Charles Ebert
IPC分类号： A61K9/70
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092
摘要： A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just prior to or immediately after applying the system to the patient's skin is disclosed.
摘要翻译：一种透皮药物递送系统，其以预激活状态制造，用于储存稳定性，制造安全性，用户安全性或释放特性考虑的控制中的至少一种，并且由患者（或其他人将该系统应用于公开了在将系统应用于患者皮肤之前或之后的患者皮肤上。

7. 发明授权

US4720132A Electrically conductive stiffening wire for a sun visor for vehicles 失效
标题翻译：用于车辆遮阳板的导电加强丝
公开(公告)号：US4720132A
公开(公告)日：1988-01-19
申请号：US004329
申请日：1987-01-15
申请人： Charles Ebert , Hermann Krehl , Lothar Viertel , Bernard Hilbert , Rudiger Walter
发明人： Charles Ebert , Hermann Krehl , Lothar Viertel , Bernard Hilbert , Rudiger Walter
IPC分类号： B60J3/02
CPC分类号： B60J3/023 , B60J3/0265
摘要： A sun visor for vehicles is formed of a sun visor body constructed of plastic foam which is stiffened by a two section stiffening wire. The sun visor is supported by a mounting housing, located at one corner of the sun visor body. The mounting housing receives a sun visor support shaft. An outer support pin which can be detachably connected to a support member of the vehicle is located longitudinally opposite of the mounting housing. The mounting housing defines a first insertion opening into which is plugged one end of one of the stiffening wires and a second insertion opening which accommodates a leaf spring which bears on the sun visor support shaft. The outer support pin and the mounting housing have additional insertion holes which enable rapid connection of the stiffening wire sections to the outer support pin and to the mounting housing by plugging of the components into one another. The two stiffening wire sections are further utilized to conduct electrical power to a sun visor lamp.
摘要翻译：用于车辆的遮阳板由塑料泡沫构成的遮阳板构成，塑料泡沫由两段加强线加固。遮阳板由安装的外壳支撑，位于遮阳板的一个角落。安装壳体接收遮阳板支撑轴。可拆卸地连接到车辆的支撑构件的外部支撑销位于与安装壳体纵向相对的位置。所述安装壳体限定第一插入孔，所述第一插入口插入所述第一插入孔中，所述第一插入口插入所述加强线中的一个的一端，以及第二插入开口，所述第二插入开口容纳支撑在所述遮阳板支撑轴上的板簧。外部支撑销和安装壳体具有附加的插入孔，其能够通过将部件彼此插入而将加强的线部分快速连接到外部支撑销和安装壳体。两个加强线段进一步用于将电力传导到遮阳板灯。

8. 发明申请

US20090075961A1 Testosterone Oral Dosage Formulations And Associated Methods 审中-公开
标题翻译：睾酮口服配方及相关方法
公开(公告)号：US20090075961A1
公开(公告)日：2009-03-19
申请号：US12240006
申请日：2008-09-29
申请人： Charles Ebert
发明人： Charles Ebert
IPC分类号： A61K31/568 , A61P15/00
CPC分类号： A61K9/2031 , A61K31/568
摘要： Solid oral dosage forms of testosterone and methods for the preparation thereof are disclosed and described. The solid oral dosage form may include a therapeutically effective amount of testosterone in a substantially solid polyethylene glycol carrier. Such a form has been found to alleviate many of the undesirable consequences of undergoing testosterone therapy, such as the pain of injections and problems with patient noncompliance.
摘要翻译：公开和描述了固体口服剂型睾酮及其制备方法。固体口服剂型可包括在基本上固体的聚乙二醇载体中治疗有效量的睾丸激素。已经发现这种形式减轻了经历睾丸激素治疗的许多不期望的后果，例如注射疼痛和患者不合规的问题。

9. 发明授权

US07018970B2 Process of making fatty alcohol based gel detergent compositions 有权
标题翻译：制备基于脂肪醇的凝胶洗涤剂组合物的方法
公开(公告)号：US07018970B2
公开(公告)日：2006-03-28
申请号：US10694980
申请日：2003-10-28
申请人： Feng-Lung Gordon Hsu , Yun-Peng Zhu , Charles Ebert , Agnes Boudou , Ronald Frederick Vogel , John David Hines
发明人： Feng-Lung Gordon Hsu , Yun-Peng Zhu , Charles Ebert , Agnes Boudou , Ronald Frederick Vogel , John David Hines
IPC分类号： C11D17/00
CPC分类号： C11D3/2006 , C11D11/0094 , C11D17/003
摘要： According to the inventive method of making gels, the main mixture comprising most of the ingredients with the exception of a fatty alcohol is mixed, using at least one in-line mixer, with the gelling post-mix comprising the fatty alcohol. The preferred process includes the mixing of the main mixture and the gelling post-mix just prior to either filling or storing the composition.
摘要翻译：根据本发明的制备凝胶的方法，使用至少一个在线混合器将包含除脂肪醇以外的大部分成分的主要混合物与包含脂肪醇的胶凝后混合物混合。优选的方法包括在填充或储存组合物之前混合主混合物和胶凝后混合物。

10. 发明授权

US06815409B2 Gel laundry detergent and/or pretreater which piles up after dispensing 失效
标题翻译：凝胶衣物洗涤剂和/或预处理剂，在分配后堆积
公开(公告)号：US06815409B2
公开(公告)日：2004-11-09
申请号：US10251458
申请日：2002-09-20
申请人： Feng-Lung Gordon Hsu , Yun-Peng Zhu , Ronald Frederick Vogel , Agnes Boudou , Charles Ebert , Kwang H Lee
发明人： Feng-Lung Gordon Hsu , Yun-Peng Zhu , Ronald Frederick Vogel , Agnes Boudou , Charles Ebert , Kwang H Lee
IPC分类号： C11D1700
CPC分类号： C11D17/003 , C11D1/04 , C11D1/146 , C11D1/22 , C11D3/2079
摘要： Gel detergent compositions which pile-up on a surface, upon dispensing, to minimize the spreading of the gel to a substantially larger area. The gels that can pile up are less messy to use and provide better stain removal, since more detergent is concentrated on the desired area of fabric (e.g., the spot). The composition comprises from about 10% to about 35% of a surfactant, from about 0.1 to about 5% of a non-neutralized fatty acid; from about 50 to about 85% of water; with the total of anionic surfactants selected from soap, linear alkyl benzene sulfonic acid, primary and secondary alkyl sulfates being more than 50% of total surfactant level.

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