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1. 发明申请

US20090136999A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES 有权
标题翻译：癌症和感染性疾病免疫组合物和方法
公开(公告)号：US20090136999A1
公开(公告)日：2009-05-28
申请号：US12102292
申请日：2008-04-14
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
IPC分类号： C12P21/00 , A61K38/16 , A61K31/7088 , A61K35/12 , A61P35/00 , C07K16/18 , C12N5/10 , C07H21/00 , A61K38/21 , A61K38/20 , A61K39/395 , A61K38/19
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

2. 发明授权

US08257714B2 Compositions and methods for immunotherapy of cancer and infectious diseases 有权
标题翻译：癌症和传染病免疫治疗的组成和方法
公开(公告)号：US08257714B2
公开(公告)日：2012-09-04
申请号：US12102292
申请日：2008-04-14
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
IPC分类号： A61K39/00 , A61K39/002 , A61K35/68 , A61P31/16
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

3. 发明申请

US20050169935A1 Compositions and methods for immunotherapy of cancer and infectious diseases 有权
标题翻译：癌症和传染病免疫治疗的组成和方法
公开(公告)号：US20050169935A1
公开(公告)日：2005-08-04
申请号：US10892659
申请日：2004-07-15
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John Judge , Barnett Rosenberg , Igor Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John Judge , Barnett Rosenberg , Igor Zlatkin , Tatiana Zlatkin
IPC分类号： A61K38/16 , A61K39/00 , A61K39/012 , A61K39/39 , C07K14/455 , A61K38/17
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

4. 发明授权

US07550150B2 Methods of treating or preventing a disease, disorder or condition associated with a viral infection 失效
标题翻译：治疗或预防与病毒感染相关的疾病，病症或病症的方法
公开(公告)号：US07550150B2
公开(公告)日：2009-06-23
申请号：US11376656
申请日：2006-03-14
申请人： Barnett Rosenberg , John W. Judge
发明人： Barnett Rosenberg , John W. Judge
IPC分类号： A61K39/00 , A61K39/002 , A61K39/012 , A61K49/00
CPC分类号： A61K38/16 , A61K38/193 , A61K38/2013 , A61K38/217 , Y02A50/397 , A61K2300/00
摘要： The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.
摘要翻译：本发明涉及使用给药和静息方案治疗或预防与病毒感染相关的疾病，病症或病症的方法，用于施用提供ARP的药物组合物。

5. 发明授权

US4665069A Analgesic composition and method of relieving pain 失效
标题翻译：止痛组合物和缓解疼痛的方法
公开(公告)号：US4665069A
公开(公告)日：1987-05-12
申请号：US719239
申请日：1985-04-02
申请人： Barnett Rosenberg
发明人： Barnett Rosenberg
IPC分类号： A61K31/165 , A61K31/22 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/455 , A61K31/465 , A61K31/55 , A61K31/505 , A61K31/54
CPC分类号： A61K31/55 , A61K31/165 , A61K31/22 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/455 , A61K31/465 , Y10S514/817 , Y10S514/969 , Y10S514/97
摘要： An analgesia composition comprising an aqueous solution of a neurologically active agent in a concentration of from about 10.sup.-3 to about 10.sup.-13 grams/ml and a method of relieving pain comprising topically applying the composition to the genitalia of a human or non-human animal.
摘要翻译：一种镇痛组合物，其包含浓度为约10-3至约10-13克/毫升的神经活性剂的水溶液，以及减轻疼痛的方法，包括将组合物局部施用于人或非人的生殖器动物。

6. 发明授权

US4440782A Method of treating viral infections 失效
标题翻译：治疗病毒感染的方法
公开(公告)号：US4440782A
公开(公告)日：1984-04-03
申请号：US188343
申请日：1980-09-18
申请人： James P. Davidson , Barnett Rosenberg , Ronald W. Hinz
发明人： James P. Davidson , Barnett Rosenberg , Ronald W. Hinz
IPC分类号： A61K31/28 , A61K31/395 , A61K31/44 , A61K31/555
CPC分类号： A61K31/44 , A61K31/28 , A61K31/395
摘要： A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.
摘要翻译：用于治疗患有病毒感染的动物的方法，包括向动物施用铂配位化合物。

7. 发明申请

US20050058658A1 Compositions and methods for immunotherapy of human immunodeficiency virus (HIV) 审中-公开
标题翻译：人类免疫缺陷病毒（HIV）免疫治疗的组成和方法
公开(公告)号：US20050058658A1
公开(公告)日：2005-03-17
申请号：US10893581
申请日：2004-07-15
申请人： Barnett Rosenberg
发明人： Barnett Rosenberg
IPC分类号： A61K39/002 , A61K39/21 , C07K14/455 , C12N20060101
CPC分类号： A61K39/002 , A01K2267/0337 , A61K2039/53 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of an infectious disease caused by infection with HIV and for stimulating an immune response in a subject. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of an infectious disease caused by infection with HIV and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of an infectious disease caused with infection with HIV, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供了用于预防和治疗由HIV感染引起的感染性疾病和刺激受试者的免疫应答的组合物和方法。特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防由HIV感染和免疫调节引起的感染性疾病的用途。提供了包含ARP的组合。还提供了使用ARP来预防和/或治疗由HIV感染引起的感染性疾病和用于在受试者中引发免疫应答的方法。

8. 发明授权

US4344440A Microprobe for monitoring biophysical phenomena associated with cardiac and neural activity 失效
标题翻译：用于监测与心脏和神经活动相关的生物物理现象的微探针
公开(公告)号：US4344440A
公开(公告)日：1982-08-17
申请号：US136317
申请日：1980-04-01
申请人： Trygve Aaby , Barnett Rosenberg
发明人： Trygve Aaby , Barnett Rosenberg
IPC分类号： A61B5/05 , A61B5/04
CPC分类号： A61B5/0507 , A61B5/05 , A61B5/407
摘要： A portable microprobe uses 10 gigahertz CW microwave radiation at a power level of less than 10 milliwatts for recording of a number of biophysical phenomena associated with the cardiac and neural activity of the life system. The microprobe consists of a Gunn diode feeding power into a short, insulated dielectric waveguide, the free end of which houses a point contact semiconductor diode isolated by a metal shield from the incident beam. The wave guide concentrates and delivers a pencil shaped beam into the tissue of interest and the back-scattered radiation is modulated and detected by the diode. The detected signal is filtered, amplified and recorded to reflect on-going biological activity. The receiver electronics is housed in a small self-contained package and has its output connected through a flexible attachment to two ear tubes which enable continuous monitoring of the audio response through an electrical and audio converter indicative of the on-going biological activity. By scanning step wise across the chest, the microprobe allows localization of many details of cardiac activity. The microprobe can also be used to monitor activities of the brain and the spinal cord.
摘要翻译：便携式微探针使用10千兆赫CW微波辐射，功率水平低于10毫瓦，用于记录与生命系统的心脏和神经活动相关的许多生物物理现象。微探针由一个耿氏二极管组成，将一个绝缘的绝缘介质波导输入一个短路绝缘介质波导，其自由端容纳一个由金属屏蔽与入射光束隔离的点接触半导体二极管。波导集中并将铅笔形光束传送到感兴趣的组织中，并且反向散射的辐射被二极管调制和检测。检测到的信号被过滤，扩增和记录以反映正在进行的生物活性。接收器电子器件容纳在小的独立包装中，并且其输出通过柔性附件连接到两个耳管，其能够通过指示正在进行的生物活性的电和音频转换器连续监视音频响应。通过逐步扫描胸部，微探针允许定位心脏活动的许多细节。微探针还可用于监测大脑和脊髓的活动。

9. 发明授权

US4053587A Method of treating viral infections 失效
标题翻译：治疗病毒感染的方法
公开(公告)号：US4053587A
公开(公告)日：1977-10-11
申请号：US540109
申请日：1975-01-10
申请人： James P. Davidson , Barnett Rosenberg , Ronald W. Hinz
发明人： James P. Davidson , Barnett Rosenberg , Ronald W. Hinz
IPC分类号： A61K31/28 , A61K31/395 , A61K31/44 , A61K33/24
CPC分类号： A61K31/395 , A61K31/28 , A61K31/44
摘要： A method for treating animals afflicted with a viral infection comprising the administration to the animal of a platinum coordination compound.This is a Continuation, of application Ser. No. 350,924, filed Apr. 13, 1973, now abandoned.

10. 发明授权

US5522974A Method of preparing gel containing capillaries 失效
标题翻译：制备凝胶含毛细血管的方法
公开(公告)号：US5522974A
公开(公告)日：1996-06-04
申请号：US140680
申请日：1993-10-21
申请人： Laurence A. Fishel , Barnett Rosenberg , David A. Juckett
发明人： Laurence A. Fishel , Barnett Rosenberg , David A. Juckett
IPC分类号： C08J3/075 , G01N27/447 , C08L5/00
CPC分类号： C08J3/075 , G01N27/44704 , G01N27/44747 , C08J2333/26
摘要： Described is a method of preparing polyacrylamide gel containing capillary tube wherein acrylamide is polymerized from a liquid to a gel within the tube, the improvement comprising the steps of: a) after the polymerization, annealing the gel inside the tube by cycling the gel/tube at least once in a temperature range from 20.degree. C. to a temperature not to exceed about 75.degree. C. and back to ambient; and b) recovering the stress released gel-filled tube. Preferably, the polymerization commences at the middle of the tube and commences toward the extremities of the tube.
摘要翻译：描述了一种制备含有毛细管的聚丙烯酰胺凝胶的方法，其中丙烯酰胺从管内的液体聚合成凝胶，改进包括以下步骤：a）聚合后，通过循环凝胶/管使管内的凝胶退火至少在20℃的温度范围内至不超过约75℃的温度回到环境温度; 和b）回收释放凝胶填充管的应力。优选地，聚合在管的中间开始并且朝向管的末端开始。

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