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1. 发明授权

US4497062A Digitally controlled X-ray beam attenuation method and apparatus 失效
标题翻译：数字控制X射线束衰减方法和装置
公开(公告)号：US4497062A
公开(公告)日：1985-01-29
申请号：US501607
申请日：1983-06-06
申请人： Charles A. Mistretta , Walter W. Peppler , Balakrishna V. Kudva , Bruce H. Hasegawa , James T. Dobbins, III
发明人： Charles A. Mistretta , Walter W. Peppler , Balakrishna V. Kudva , Bruce H. Hasegawa , James T. Dobbins, III
IPC分类号： G21K3/00 , A61B6/00 , G21K1/10 , G21K5/02 , H05G1/26 , H05G1/60 , G03B41/16 , H05G3/00
CPC分类号： G21K1/10 , H05G1/26 , H05G1/60
摘要： X-ray compensation masks (51) are prepared by exposing an X-ray target object (43), such as a patient, to a first beam of X-rays. The X-ray fluence from the patient is received by an electronic image receptor (44) which provides an output signal indicating the intensity of the X-rays at all positions in the image field. The image information is converted by an image processor (47) to transformed X-ray intensity values for a plurality of pixels which cover the image field. A mask generating controller (48) determines the minimum transformed intensity value for any pixel, assigns to each pixel an attenuation number which is proportional to the difference between the transformed intensity value for the pixel and the minimum transformed intensity value, and issues control signals to a mask former (49) which deposits on a non-attenuating substrate (50) attenuating masses in a two dimensional array of pixels with the mass thickness in each pixel proportional to the attenuation number. When the mask (51) is inserted into the beam from the X-ray source (41), and a second exposure taken, the X-ray fluence passing through both the attenuating mask (51) and the patient (43) will be substantially equalized across the image field.
摘要翻译：通过将诸如患者的X射线目标物体（43）暴露于第一X射线束来制备X射线补偿掩模（51）。来自患者的X射线能量密度由电子图像接收器（44）接收，电子图像接收器（44）提供指示图像场中所有位置的X射线强度的输出信号。图像信息由图像处理器（47）转换为覆盖图像场的多个像素的变换的X射线强度值。掩模生成控制器（48）确定任何像素的最小变换强度值，向每个像素分配与像素的变换强度值和最小变换强度值之间的差成比例的衰减数，并将控制信号发送到沉积在非衰减衬底（50）上的掩模形成器（49），其衰减像素的二维阵列中的质量，每个像素中的质量厚度与衰减数量成正比。当掩模（51）从X射线源（41）插入光束中并进行第二次曝光时，穿过衰减掩模（51）和患者（43）的X射线能量密度将基本上在整个图像场均衡。

2. 发明授权

US4364392A Detachable balloon catheter 失效
标题翻译：可拆卸球囊导管
公开(公告)号：US4364392A
公开(公告)日：1982-12-21
申请号：US212759
申请日：1980-12-04
申请人： Charles M. Strother , Balakrishna V. Kudva
发明人： Charles M. Strother , Balakrishna V. Kudva
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61M25/00
CPC分类号： A61B17/0057 , A61B17/12109 , A61B17/12136 , A61B17/12195 , A61B2017/00557 , A61F2250/0067 , A61M2025/1052 , A61M2025/1054 , A61M2025/1072
摘要： A method and apparatus is disclosed for providing therapeutic occlusions of blood vessels and other body tubular structures using an inflatable balloon (11) mounted at the end of a catheter (15). The balloon (11) and catheter (15) are passed through a blood vessel (12) until the balloon (15) reaches the desired location of the occlusion; a suspension of solid filler particles (27) in a carrier liquid is then pumped through the catheter tube (15) and inflates the blloon (11) until it blocks off the blood vessel. The carrier liquid is forced out through the porous walls of the balloon, leaving a compacted mass of filler particles which will not allow the balloon to shrink. Ridges (20) on the end of the catheter tube (15) engage mating grooves (21) in the neck portion (14) of the balloon structure during insertion and filling of the balloon; the size, shape, and number of these ridges and grooves can be selected to provide a desired force required to detach the catheter tube from the balloon. A valve (18) in the neck portion (14) of the balloon structure allows the particle suspension to pass into the balloon but blocks flow of particles out of the balloon while preferably allowing the carrier liquid to pass therethrough. Medication may be impregnated in either the particles in the balloon or the porous balloon walls to allow controlled release of the medication into the bloodstream.
摘要翻译：公开了一种使用安装在导管（15）的端部处的可充气气囊（11）来提供血管和其他身体管状结构的治疗性闭塞的方法和装置。气球（11）和导管（15）穿过血管（12）直到球囊（15）到达闭塞的期望位置; 然后将固体填料颗粒（27）在载体液体中的悬浮液泵送通过导管（15）并使气泡（11）膨胀，直到其堵塞血管。载体液体被挤出通过球囊的多孔壁，留下一个压实的填料颗粒物质，这将不允许球囊收缩。在插入和填充球囊期间，导管管（15）端部上的脊（20）与球囊结构的颈部（14）中的配合凹槽（21）接合; 可以选择这些脊和槽的尺寸，形状和数量以提供将导管从气囊分离所需的力。球囊结构的颈部（14）中的阀（18）允许颗粒悬浮液进入球囊，但阻止颗粒流出球囊，同时优选允许载液通过。药物可以浸渍在球囊或多孔气囊壁中的颗粒中，以允许将药物控制释放到血流中。

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