专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130060049A1 METHOD FOR PREPARING (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE 审中-公开
标题翻译：制备（S）-4-羟基-2-氧代-1-吡咯烷酮乙酰胺的方法
公开(公告)号：US20130060049A1
公开(公告)日：2013-03-07
申请号：US13581832
申请日：2010-09-09
申请人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
发明人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
IPC分类号： C07D207/12
CPC分类号： C07D207/273
摘要： A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide is provided, which includes the steps of preparing the crude product and crystallizing, wherein acetone and water are used as solvents in the step of crystallizing. The (S)-oxiracetam prepared by the method of the present invention has high purity of more than 99.3% and low impurity of 0-0.5%, based on the percentages of the mass. According to the method of the present invention, with regard to the way of charging materials, adding inorganic base only just a few times is easier to handle and more convenient to the industrial manufacturing and application.
摘要翻译：提供（S）-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法，其包括制备粗产物并结晶的步骤，其中在结晶步骤中使用丙酮和水作为溶剂。通过本发明方法制备的（S） - 氧乙酰胺基于质量百分比具有大于99.3％的高纯度和0-0.5％的低杂质。根据本发明的方法，对于充电材料的方式，只加几次无机碱容易处理，更方便工业制造和应用。

2. 发明授权

US09238622B2 Crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, preparing method and use thereof 有权
标题翻译：（S）-4-羟基-2-氧代-1-吡咯烷乙酰胺的晶型I的制备方法和用途
公开(公告)号：US09238622B2
公开(公告)日：2016-01-19
申请号：US13581821
申请日：2010-09-08
申请人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
发明人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
IPC分类号： C07D207/273
CPC分类号： C07D207/273
摘要： A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction. Concerning the way of charging materials, adding inorganic base only a few times is simpler and more beneficial to industrial manufacturing and application.
摘要翻译：提供（S）-4-羟基-2-氧代-1-吡咯烷乙酰胺的结晶形式I，或称为（S） - 氧西拉坦，其特征在于粉末x射线衍射图，其显示d- 值相对于7.075（M），5.355（S），5.092（S），4.590（M），4.325（M），4.259（S），4.041（VS），3.808（M）），3.445（M），3.393（M），2.972（M），2.914（S）。还提供了制备（S） - 氧西拉坦的晶形I的方法，其包括制备粗产物并结晶A（S） - 氧西拉坦的晶型I的用途在制备用于预防和治疗记忆的药物中还提供功能障碍。因此，通过该方法制备的（S） - 氧乙酰胺的晶型I基于质量百分比具有高于99.3％的高纯度，与用于预防或治疗记忆功能障碍的（S） - 奥昔西坦相比，具有更好的功效。关于充电材料的方法，仅添加无机碱几次更简单，更有利于工业制造和应用。

3. 发明申请

US20130059900A1 CRYSTAL FORM I OF (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE, PREPARING METHOD AND USE THEREOF 有权
标题翻译：（S）-4-羟基-2-氧代-1-吡咯烷基乙酰胺的晶体形式，其制备方法和用途
公开(公告)号：US20130059900A1
公开(公告)日：2013-03-07
申请号：US13581821
申请日：2010-09-08
申请人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
发明人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
IPC分类号： C07D207/273 , A61P25/28 , A61K31/4015
CPC分类号： C07D207/273
摘要： A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction. Concerning the way of charging materials, adding inorganic base only a few times is simpler and more beneficial to industrial manufacturing and application.
摘要翻译：提供（S）-4-羟基-2-氧代-1-吡咯烷乙酰胺的结晶形式I，或称为（S） - 氧西拉坦，其特征在于粉末x射线衍射图，其显示d- 值相对于7.075（M），5.355（S），5.092（S），4.590（M），4.325（M），4.259（S），4.041（VS），3.808（M）），3.445（M），3.393（M），2.972（M），2.914（S）。还提供了制备（S） - 氧西拉坦的晶形I的方法，其包括制备粗产物并结晶A（S） - 氧西拉坦的晶型I的用途在制备用于预防和治疗记忆的药物中还提供功能障碍。因此，通过该方法制备的（S） - 氧乙酰胺的晶型I基于质量百分比具有高于99.3％的高纯度，与用于预防或治疗记忆功能障碍的（S） - 奥昔西坦相比，具有更好的功效。关于充电材料的方法，仅添加无机碱几次更简单，更有利于工业制造和应用。

4. 发明申请

US20130011691A1 POROUS TANTALUM USED FOR MEDICAL IMPLANTATION AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于医疗植入物的多孔剂及其制备方法
公开(公告)号：US20130011691A1
公开(公告)日：2013-01-10
申请号：US13581799
申请日：2010-09-08
申请人： Jianming Ruan , Jianquan Xie , Yunfeng Jie , Zhiqiang Wang , Hua Feng , Chao You , Qi Pang , Jian Zhou , Lei Ye , Bin Liu , Yazhuo Zhang
发明人： Jianming Ruan , Jianquan Xie , Yunfeng Jie , Zhiqiang Wang , Hua Feng , Chao You , Qi Pang , Jian Zhou , Lei Ye , Bin Liu , Yazhuo Zhang
IPC分类号： B22F3/11 , B32B3/26
CPC分类号： A61L27/56 , A61L27/047 , A61L2400/08 , B22F3/1137 , B22F3/1146 , B22F2003/248 , B22F2998/10 , B22F2999/00 , Y10T428/12153 , B22F1/0074 , B22F3/1021 , B22F2201/20
摘要： A porous tantalum used for medical implantation is provided, which includes a foam structure with three-dimensional interconnecting pores and produced by: mixing a solution made by organic binder and dispersant and tantalum powder to form tantalum slurry, casting the tantalum slurry into a organic foam body through impregnation until the pores of the organic foam body are filled, drying the impregnated organic foam body with the tantalum slurry to remove the dispersant, degreasing the dried organic foam body to separate the organic binder and the organic foam body from the dried tantalum slurry in a protective environment of inert gas, vacuum sintering the dried tantalum slurry to obtain a porous sintered body, and vacuum annealing then treating the porous sintered body with normal post-treatments to obtain the porous tantalum. Accordingly, the porous tantalum has well-distributed interconnecting pores and sintering neck structures resulting in good mechanical properties, and especially good ductility.
摘要翻译：提供用于医学植入的多孔钽，其包括具有三维互连孔的泡沫结构，其通过以下方式制备：将由有机粘合剂制成的溶液和分散剂和钽粉末混合以形成钽浆料，将钽浆料浇铸成有机泡沫通过浸渍直到有机泡沫体的孔被填充，用钽浆料干燥浸渍的有机泡沫体以除去分散剂，将干燥的有机泡沫体脱脂以将有机粘合剂和有机泡沫体与干燥的钽浆料分离在惰性气体的保护环境中，真空烧结干燥的钽浆料，得到多孔烧结体，真空退火，然后用正常后处理处理多孔烧结体，得到多孔钽。因此，多孔钽具有良好分布的互连孔和烧结颈结构，导致良好的机械性能，特别是良好的延展性。

5. 发明授权

US09254136B2 Drill head locking apparatus and drill head 有权
标题翻译：钻头锁定装置和钻头
公开(公告)号：US09254136B2
公开(公告)日：2016-02-09
申请号：US13823087
申请日：2011-08-24
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： B23B31/107 , A61B17/16 , B23B31/10
CPC分类号： A61B17/162 , A61B17/1695 , B23B31/10 , B23B31/1071 , Y10S279/905 , Y10T279/17 , Y10T279/17145 , Y10T279/17196 , Y10T279/17743 , Y10T279/17752
摘要： A drill head locking apparatus and a drill head are provided. The locking apparatus includes a protruding platform having a through hole, a bearing on the inner wall of a small cylinder on the protruding platform, a locking sleeve fitted on the protruding platform, and a protrusion arranged on the upper part of the inner wall of the locking sleeve. The lower part of the inner wall of the locking sleeve is a conical face. A spring is arranged between the bottom face of the conical face and an upper bottom face of the protruding platform. A press plate is connected with a screw thread on the outer wall of the top part of the small cylinder on the protruding platform and presses down on the protrusion. A conical hole is arranged on the wall of the small cylinder and communicates with the through hole of the protruding platform.
摘要翻译：提供了钻头锁定装置和钻头。锁定装置包括具有通孔的突出平台，突出平台上的小圆筒的内壁上的轴承，安装在突出平台上的锁定套，以及布置在该突出平台的内壁的上部上的突起锁紧套。锁定套筒内壁的下部是圆锥面。在锥面的底面和突出平台的上底面之间设有弹簧。压板与突出平台上的小圆筒顶部的外壁上的螺纹连接，并且向下按压突出部。在小圆筒的壁上设置有锥形孔，并与突出平台的通孔连通。

6. 发明授权

US08900260B2 Surgical milling cutter 有权
标题翻译：手术铣刀
公开(公告)号：US08900260B2
公开(公告)日：2014-12-02
申请号：US13822937
申请日：2011-08-24
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： A61B17/32 , A61B17/00 , B23B31/16 , A61C3/02 , A61B17/16 , A61B19/00
CPC分类号： A61B17/32 , A61B17/162 , A61B17/32002 , A61B2090/08021 , Y10T279/17752
摘要： A surgical milling cutter includes a milling cutter bracket, a locking device and a bottom electric motor connected successively. The milling cutter bracket includes a fixing seat with a through hole. A finger guide apparatus with an L-type first bracket at the top end thereof is provided on the upper part of the fixing seat. The end of the L-type first bracket's short side is provided with a downward projection. The lowest point of the projection is lower than that of the milling cutter's cylindrical head when the milling cutter is working normally. The surgical milling cutter utilizes the projection to prevent the possibility of an object contacting with the cylindrical head, thus avoiding an object being cut unevenly. Meanwhile, the L-type bracket can be driven by the finger guide apparatus to rotate so as to change the running direction of the milling cutter, thus facilitating surgical procedures.
摘要翻译：外科铣刀包括铣刀支架，锁定装置和连续连接的底部电动马达。铣刀支架包括具有通孔的固定座。在固定座的上部设置有在其顶端具有L型第一支架的手指引导装置。 L型第一支架的短边的端部设置有向下的突出部。当铣刀正常工作时，投影的最低点低于铣刀的圆柱头。外科铣刀利用突起来防止物体与圆柱形头部接触的可能性，从而避免物体被不均匀地切割。同时，L型托架可以由手指引导装置驱动旋转，从而改变铣刀的行进方向，从而便于外科手术。

7. 发明申请

US20130178861A1 SURGICAL MILLING CUTTER BRACKET 有权
标题翻译：手术切割支架
公开(公告)号：US20130178861A1
公开(公告)日：2013-07-11
申请号：US13823021
申请日：2011-08-24
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： A61B17/17
CPC分类号： A61B17/17 , A61B17/1613 , A61B17/1633 , A61B17/32002
摘要： A surgical milling cutter bracket includes a retaining base having a through hole. The upper part of the retaining base is provided with a finger guide having an L-shaped support frame on the top of the finger guide. A downward protrusion is provided at the end of the short side of the L-shaped support frame. The lowest point of the protrusion is lower than the lowest point of the cylindrical head of the milling cutter during normal operation of the milling cutter. A bolt having a through hole at the center is fixed within the cavity of the finger guide. A depressor is provided on the upper part of the retaining base. The bolt passes through a hole of the depressor and is connected to a nut. The protrusion is able to prevent an object from contacting the cylindrical head, thus avoiding cutting the object unevenly.
摘要翻译：外科铣刀支架包括具有通孔的保持基座。保持基座的上部设置有在手指引导件的顶部具有L形支撑框架的手指引导件。在L形支撑框架的短边的端部处设置向下突出部。在铣刀的正常操作期间，突起的最低点低于铣刀的圆柱形头部的最低点。在中心具有通孔的螺栓固定在手指引导件的空腔内。在保持基座的上部设有抑制器。螺栓通过压力机的孔并连接到螺母。突起能够防止物体接触圆柱形头部，从而避免不均匀地切割物体。

8. 发明申请

US20130178858A1 DRILL BIT LOCKING DEVICE AND DRILL BIT 有权
标题翻译：钻头锁定装置和钻头
公开(公告)号：US20130178858A1
公开(公告)日：2013-07-11
申请号：US13823095
申请日：2011-08-26
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： A61B17/16
CPC分类号： A61B17/162 , A61B17/1615 , A61B17/1695 , B23B31/005 , B23B31/1071 , Y10T279/17
摘要： A drill bit locking device and a drill bit are provided. The locking device includes a boss with a through hole, a bearing and a support member are arranged an inner wall of a small cylinder above the boss; a locking sleeve is sleeved over the boss, a first bulge is on an inner wall of an upper part of the locking sleeve, and a second bulge is on an inner wall of a lower part; a spring is between the second bulge and an upper bottom surface of the boss; a press plate is threadedly connected with an outer wall of a top part of the small cylinder and presses against the first bulge; holes of different sizes are on the inner wall of the small cylinder and the support member to form a stepped hole, and a steel ball is arranged in the stepped hole.
摘要翻译：提供钻头锁定装置和钻头。锁定装置包括具有通孔的凸台，轴承和支撑构件，其布置在凸台上方的小圆筒的内壁上; 锁定套筒套在凸台上，第一凸起位于锁定套筒的上部的内壁上，第二凸起位于下部的内壁上; 弹簧在第二凸起和凸起的上底表面之间; 压板与小圆筒的顶部的外壁螺纹连接并压靠第一凸起; 在小圆筒的内壁和支撑构件上形成不同尺寸的孔以形成台阶孔，并且在阶梯孔中布置钢球。

9. 发明授权

US09017332B2 Surgical milling cutter 有权
标题翻译：手术铣刀
公开(公告)号：US09017332B2
公开(公告)日：2015-04-28
申请号：US13823065
申请日：2011-09-15
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： A61B17/00 , A61B17/16 , A61B17/32
CPC分类号： A61B17/16 , A61B17/162 , A61B17/1622 , A61B17/1624 , A61B17/32002 , A61B2017/1602
摘要： A surgical milling cutter includes a milling cutter holder, a locking device, a locking seat, and a main machine. The milling cutter holder includes a fixing seat with a through hole. A finger guider with an L-type holder on a top end thereof is arranged at an upper part of the fixing seat. A distal end of a short side of the L-type holder is disposed with a downward projection, and a lowest point of the projection is lower than that of a cylindrical head when the milling cutter works normally. A bolt with a central through hole is fixed in a cavity of the finger guider. A pressing disk is arranged at the upper part of the fixing seat, and a nut is connected to the bolt through a hole in the pressing disk.
摘要翻译：外科铣刀包括铣刀保持器，锁定装置，锁定座和主机。铣刀架包括具有通孔的固定座。在固定座的上部设置有在其顶端具有L型保持器的手指导杆。 L型保持器的短边的远端设置有向下的突起，并且当铣刀正常工作时，突起的最低点低于圆柱形头的最低点。具有中心通孔的螺栓固定在手指导板的空腔中。按压盘设置在固定座的上部，螺母通过按压盘上的孔连接到螺栓上。

10. 发明申请

US20130184731A1 SURGICAL MILLING CUTTER 有权
标题翻译：手术切割机
公开(公告)号：US20130184731A1
公开(公告)日：2013-07-18
申请号：US13822937
申请日：2011-08-24
申请人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
发明人： Lei Ye , Jian Zhou , Hua Feng , Fei Li , Hengyang Zhu , Congxiao Li
IPC分类号： A61B17/32
CPC分类号： A61B17/32 , A61B17/162 , A61B17/32002 , A61B2090/08021 , Y10T279/17752
摘要： A surgical milling cutter includes a milling cutter bracket, a locking device and a bottom electric motor connected successively. The milling cutter bracket includes a fixing seat with a through hole. A finger guide apparatus with an L-type first bracket at the top end thereof is provided on the upper part of the fixing seat. The end of the L-type first bracket's short side is provided with a downward projection. The lowest point of the projection is lower than that of the milling cutter's cylindrical head when the milling cutter is working normally. The surgical milling cutter utilizes the projection to prevent the possibility of an object contacting with the cylindrical head, thus avoiding an object being cut unevenly. Meanwhile, the L-type bracket can be driven by the finger guide apparatus to rotate so as to change the running direction of the milling cutter, thus facilitating surgical procedures.
摘要翻译：外科铣刀包括铣刀支架，锁定装置和连续连接的底部电动马达。铣刀支架包括具有通孔的固定座。在固定座的上部设置有在其顶端具有L型第一支架的手指引导装置。 L型第一支架的短边的端部设置有向下的突出部。当铣刀正常工作时，投影的最低点低于铣刀的圆柱头。外科铣刀利用突起来防止物体与圆柱形头部接触的可能性，从而避免物体被不均匀地切割。同时，L型托架可以由手指引导装置驱动旋转，从而改变铣刀的行进方向，从而便于外科手术。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式