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1. 发明授权

US08936940B2 Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium 有权
标题翻译：通过处理培养基中的糖混合物，在植物细胞培养中大量生产次生代谢物
公开(公告)号：US08936940B2
公开(公告)日：2015-01-20
申请号：US11915869
申请日：2006-06-02
申请人： Jin-Ah Kim , Chang-Heon Kim , Jai-Young Song , Ho-Joon Choi
发明人： Jin-Ah Kim , Chang-Heon Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C12N5/00 , C12N5/02 , C12N1/38 , C12P17/02
CPC分类号： C12N5/0025 , C12N1/38 , C12P17/02
摘要： The present invention relates to a method of producing secondary metabolites with a high yield using plant cell culture, and a medium for the production of secondary metabolites. More specifically, the method of the present invention is characterized in that the plant cell culture is conducted by adding a saccharide mixture to the culture medium as a carbon source, to increase the productivity of the secondary metabolites. For example, the present invention establishes the method of increasing the productivity of secondary metabolites and shortening the culture time by the use of the mixture of glucose and fructose in the plant cell culture, thereby contributing in producing useful secondary metabolites on an industrial scale using plant cell culture.
摘要翻译：本发明涉及使用植物细胞培养物产生高产率的次级代谢产物的方法和用于生产次级代谢产物的培养基。更具体地说，本发明的方法的特征在于，通过向作为碳源的培养基中添加糖混合物来进行植物细胞培养，以提高次级代谢物的生产率。例如，本发明建立了通过在植物细胞培养物中使用葡萄糖和果糖的混合物来提高次级代谢产物的生产率并缩短培养时间的方法，从而有助于在工业规模上使用植物生产有用的次级代谢物细胞培养。

2. 发明申请

US20090317877A1 MASS PRODUCTION OF SECONDARY METABOLITE IN PLANT CELL CULTURE BY TREATMENT OF SACCHARIDE MIXTURE IN MEDIUM 有权
标题翻译：通过处理中等浓度的混合物在植物细胞培养中大量生产次生代谢物
公开(公告)号：US20090317877A1
公开(公告)日：2009-12-24
申请号：US11915869
申请日：2006-06-02
申请人： Jin-Ah Kim , Chang-Heon Kim , Jai-Young Song , Ho-Joon Choi
发明人： Jin-Ah Kim , Chang-Heon Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C12P17/02
CPC分类号： C12N5/0025 , C12N1/38 , C12P17/02
摘要： The present invention relates to a method of producing secondary metabolites with a high yield using plant cell culture, and a medium for the production of secondary metabolites. More specifically, the method of the present invention is characterized in that the plant cell culture is conducted by adding a saccharide mixture to the culture medium as a carbon source, to increase the productivity of the secondary metabolites. For example, the present invention establishes the method of increasing the productivity of secondary metabolites and shortening the culture time by the use of the mixture of glucose and fructose in the plant cell culture, thereby contributing in producing useful secondary metabolites on an industrial scale using plant cell culture.
摘要翻译：本发明涉及使用植物细胞培养物产生高产率的次级代谢产物的方法和用于生产次级代谢产物的培养基。更具体地说，本发明的方法的特征在于，通过向作为碳源的培养基中添加糖混合物来进行植物细胞培养，以提高次级代谢物的生产率。例如，本发明建立了通过在植物细胞培养物中使用葡萄糖和果糖的混合物来提高次级代谢产物的生产率并缩短培养时间的方法，从而有助于在工业规模上使用植物生产有用的次级代谢物细胞培养。

3. 发明授权

US08101411B2 Method for production of corosolic acid in suspension culture of plant cells 有权
标题翻译：在植物细胞悬浮培养中生产科罗索酸的方法
公开(公告)号：US08101411B2
公开(公告)日：2012-01-24
申请号：US11993316
申请日：2006-06-30
申请人： Chang-Heon Kim , Jin-Ah Kim , Jai-Young Song , Ho-Joon Choi
发明人： Chang-Heon Kim , Jin-Ah Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/04 , A01H4/00 , A01H4/005 , C12P7/42
摘要： The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a plant producing corosolic acid; preparing a cell line capable of being cultured in liquid culture medium from the induced callus; culturing the cell line in a suspension culture; and isolating corosolic acid from the culture solution. The present invention has advantage of maximizing productivity by utilizing two-stage culture, treatment with inducing agent, and high cell-density culture in the suspension culture of plant cells producing corosolic acid.
摘要翻译：本发明涉及通过使用产生科罗索酸的植物细胞来生产科罗索酸的方法。更具体地，本发明涉及通过使用植物细胞悬浮培养物生产科罗索酸的方法，包括以下步骤：从产生科罗索酸的植物的组织诱导愈伤组织; 制备能够从诱导愈伤组织在液体培养基中培养的细胞系; 在悬浮培养中培养细胞系; 并从培养液中分离出科罗索酸。本发明具有通过利用两阶段培养，诱导剂处理以及在产生科罗索酸的植物细胞的悬浮培养中的高细胞密度培养来最大化生产率的优点。

4. 发明申请

US20100159545A1 METHOD FOR PRODUCTION OF COROSOLIC ACID IN SUSPENSION CULTURE OF PLANT CELLS 有权
标题翻译：用于在植物细胞悬浮培养物中生产赤霉酸的方法
公开(公告)号：US20100159545A1
公开(公告)日：2010-06-24
申请号：US11993316
申请日：2006-06-30
申请人： Chang-Heon Kim , Jin-An Kim , Jai-Young Song , Ho-Joon Choi
发明人： Chang-Heon Kim , Jin-An Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C12P7/42 , C12N5/04
CPC分类号： C12N5/04 , A01H4/00 , A01H4/005 , C12P7/42
摘要： The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a plant producing corosolic acid; preparing a cell line capable of being cultured in liquid culture medium from the induced callus; culturing the cell line in a suspension culture; and isolating corosolic acid from the culture solution. The present invention has advantage of maximizing productivity by utilizing two-stage culture, treatment with inducing agent, and high cell-density culture in the suspension culture of plant cells producing corosolic acid.
摘要翻译：本发明涉及通过使用产生科罗索酸的植物细胞来生产科罗索酸的方法。更具体地，本发明涉及通过使用植物细胞悬浮培养物生产科罗索酸的方法，包括以下步骤：从产生科罗索酸的植物的组织诱导愈伤组织; 制备能够从诱导愈伤组织在液体培养基中培养的细胞系; 在悬浮培养中培养细胞系; 并从培养液中分离出科罗索酸。本发明具有通过利用两阶段培养，诱导剂处理以及在产生科罗索酸的植物细胞的悬浮培养中的高细胞密度培养来最大化生产率的优点。

5. 发明授权

US08410294B2 Method for preparing highly pure anhydrous crystalline docetaxel 有权
标题翻译：制备高纯度无水结晶多西紫杉醇的方法
公开(公告)号：US08410294B2
公开(公告)日：2013-04-02
申请号：US13518630
申请日：2010-12-27
申请人： Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Jeong-Hwan Yun , Jong-Won Yoon , Ho-Joon Choi
发明人： Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Jeong-Hwan Yun , Jong-Won Yoon , Ho-Joon Choi
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： A method for preparing highly pure anhydrous crystalline docetaxel is provided. The method for preparing highly pure anhydrous crystalline docetaxel enables preparation of anhydrous crystalline docetaxel that has purity of 99.5% or more, and is useful as an anticancer agent due to remarkably low residual solvent content compared to the standard of residual solvents in drugs.
摘要翻译：提供了制备高纯度无水结晶多西紫杉醇的方法。制备高纯度无水结晶多西紫杉醇的方法能够制备纯度为99.5％以上的无水结晶多西紫杉醇，与药物中残留溶剂的标准相比，残留溶剂含量显着降低，可用作抗癌剂。

6. 发明授权

US08633326B2 Method for preparing taxane derivatives 有权
标题翻译：紫杉烷衍生物的制备方法
公开(公告)号：US08633326B2
公开(公告)日：2014-01-21
申请号：US13262936
申请日：2009-12-03
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C07D407/00 , C07D493/00
CPC分类号： C07D305/14 , Y02P20/55
摘要： Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
摘要翻译：提供了一种紫杉烷衍生物的制备方法，其包括：使作为侧链的保护基的苯基异丝氨酸衍生物或其异构体的混合物与浆果赤霉素III衍生物或10-脱乙酰基浆果赤霉素III衍生物得到异构体的混合物; 通过色谱分离异构体; 并进行选择性分离的异构体的立体化学结构的回归，其适用于以高产率大规模生产紫杉烷衍生物。

7. 发明申请

US20130046104A1 METHOD FOR PREPARING HIGHLY PURE ANHYDROUS CRYSTALLINE DOCETAXEL 有权
标题翻译：制备高纯度无定形晶体的方法
公开(公告)号：US20130046104A1
公开(公告)日：2013-02-21
申请号：US13518630
申请日：2010-12-27
申请人： Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Jeong-Hwan Yun , Jong-Won Yoon , Ho-Joon Choi
发明人： Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Jeong-Hwan Yun , Jong-Won Yoon , Ho-Joon Choi
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： A method for preparing highly pure anhydrous crystalline docetaxel is provided. The method for preparing highly pure anhydrous crystalline docetaxel enables preparation of anhydrous crystalline docetaxel that has purity of 99.5% or more, and is useful as an anticancer agent due to remarkably low residual solvent content compared to the standard of residual solvents in drugs.
摘要翻译：提供了制备高纯度无水结晶多西紫杉醇的方法。制备高纯度无水结晶多西紫杉醇的方法能够制备纯度为99.5％以上的无水结晶多西紫杉醇，与药物中残留溶剂的标准相比，残留溶剂含量显着降低，可用作抗癌剂。

8. 发明申请

US20120035379A1 METHOD FOR PREPARING TAXANE DERIVATIVES 有权
标题翻译：制备TAXANE衍生物的方法
公开(公告)号：US20120035379A1
公开(公告)日：2012-02-09
申请号：US13262936
申请日：2009-12-03
申请人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
发明人： Sang-Hyun Pyo , Jin-Suk Cho , Moon-Suk Kim , Jai-Young Song , Ho-Joon Choi
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
摘要翻译：提供了一种紫杉烷衍生物的制备方法，其包括：使作为侧链的保护基的苯基异丝氨酸衍生物或其异构体的混合物与浆果赤霉素III衍生物或10-脱乙酰基浆果赤霉素III衍生物得到异构体的混合物; 通过色谱分离异构体; 并进行选择性分离的异构体的立体化学结构的回归，其适用于以高产率大规模生产紫杉烷衍生物。

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