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1. 发明申请

US20070197660A1 Compounds for modulating cell proliferation 审中-公开
标题翻译：用于调节细胞增殖的化合物
公开(公告)号：US20070197660A1
公开(公告)日：2007-08-23
申请号：US10566815
申请日：2004-07-30
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Thomas Grunberger , Octavian Cimpean
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Thomas Grunberger , Octavian Cimpean
IPC分类号： A61K31/135
CPC分类号： A61K31/4402 , C07C255/41 , C07C323/46 , C07D213/71
摘要： Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—(C1-6alkyl), N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n=1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.
摘要翻译：具有式（I）或（III）的化合物，其中R 1，R 2和R 3各自独立地选自H，OH， C 1-6烷基，C 1-6烷氧基，NH 2，NH-（C 1-6）烷基，烷基），N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6烷基， CH 2，CF 3，OCF 3 N和卤素; R 4是未取代的Ar或Ar，其被1-4个独立地选自C 1-6 - 烷基，C 1-6 - 烷氧基和卤代 ; X选自（CH 2 CH 2 CH 2）n和（CH）n N，且n = 1 -4，其盐，溶剂化物和水合物，可用于调节或抑制细胞增殖。

2. 发明申请

US20050085538A1 Compounds for modulating cell proliferation 有权
标题翻译：用于调节细胞增殖的化合物
公开(公告)号：US20050085538A1
公开(公告)日：2005-04-21
申请号：US10501699
申请日：2003-01-17
申请人： Chaim Roifman , Peter Demin , Thomas Grunberger , Olga Rounova , Octavian Cimpean
发明人： Chaim Roifman , Peter Demin , Thomas Grunberger , Olga Rounova , Octavian Cimpean
IPC分类号： C07D213/70 , A61K31/165 , A61K31/216 , A61K31/222 , A61K31/265 , A61K31/277 , A61K31/4402 , A61P35/00 , A61P35/02 , C07C255/23 , C07C255/38 , C07C255/41 , C07C309/67 , C07C309/73 , C07C317/44 , C07C317/46
CPC分类号： C07C255/41 , C07C317/46 , C07D213/71
摘要： The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Formula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6 alkyl), SH, S—C1-6 alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.
摘要翻译：可以公开以下可用于治疗多种细胞增殖性疾病的式（I）和（III）化合物：式（I），（II），其中R 1，R 2 > 2和R 3各自独立地选自H，OH，C 1-6烷基，C 1-6 - 烷氧基，NH 2，NH-C 1-6烷基，N（C 1-6烷基），SH，SC 1〜 C 1 -C 6烷基，NO 2，CF 3，OCF 3和卤素; R 4是未取代的Ar或被1-4个取代基取代的Ar，其独立地选自C 1-6 - 烷基，C 1-6 - 烷氧基和光环; X选自（CH 2 CH 2 CH 2）n和（CH 2）n） / SUB>，n = 1-4。

3. 发明申请

US20070243612A1 Novel Compounds for Modulating Cell Proliferation 有权
标题翻译：用于调节细胞增殖的新型化合物
公开(公告)号：US20070243612A1
公开(公告)日：2007-10-18
申请号：US10593851
申请日：2005-03-22
申请人： Chaim Roifman , Peter Demin , Andrew Freywald , Thomas Grunberger , Olga Rounova , Nigel Sharfe
发明人： Chaim Roifman , Peter Demin , Andrew Freywald , Thomas Grunberger , Olga Rounova , Nigel Sharfe
IPC分类号： A61K31/277 , A61K31/341 , A61K31/36 , A61K31/44 , A61K31/662 , A61K31/695 , A61P35/00 , A61P35/02 , C07C255/10 , C07C255/13 , C07C255/14 , C07C255/29 , C07C255/34 , C07C317/32 , C07D213/40 , C07D307/54 , C07D317/60 , C07F7/02 , C07F9/40
CPC分类号： C07C255/41 , C07C255/42 , C07C317/46 , C07C327/44 , C07D213/40 , C07D307/52 , C07D317/58 , C07D317/60 , C07F7/1804 , C07F9/3826 , C07F9/4015
摘要： Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
摘要翻译：公开了可用于治疗各种细胞增殖性疾病如癌症的新型苯乙烯基丙烯腈化合物。

4. 发明授权

US07202383B2 Compounds useful for modulating abnormal cell proliferation 有权
标题翻译：可用于调节异常细胞增殖的化合物
公开(公告)号：US07202383B2
公开(公告)日：2007-04-10
申请号：US10940010
申请日：2004-09-14
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
IPC分类号： C07C233/09 , A61K31/165
CPC分类号： C07C235/34
摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1–4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
摘要翻译：描述了式I的化合物及其盐，溶剂化物和水合物：

5. 发明申请

US20060241084A1 Inhibition of vascular endothelial growth factor 审中-公开
标题翻译：抑制血管内皮生长因子
公开(公告)号：US20060241084A1
公开(公告)日：2006-10-26
申请号：US10530800
申请日：2003-10-10
申请人： Chaim Roifman , Amos Simon , Peter Demin , Olga Rounova
发明人： Chaim Roifman , Amos Simon , Peter Demin , Olga Rounova
IPC分类号： A61K31/537 , A61K31/675 , A61K31/40 , A61K31/277
CPC分类号： A61K31/40 , A61K31/137 , A61K31/165 , A61K31/216 , A61K31/277 , A61K31/537 , A61K31/662 , A61K31/675
摘要： This invention relates to therapeutic organic compounds and inhibition of secretion of vascular endothelial growth factor (VEGF) and its effects, including angiogenesis.
摘要翻译：本发明涉及治疗性有机化合物和抑制血管内皮生长因子（VEGF）的分泌及其作用，包括血管生成。

6. 发明申请

US20070185123A1 Novel compounds useful for modulating abnormal cell proliferation 失效
标题翻译：用于调节异常细胞增殖的新型化合物
公开(公告)号：US20070185123A1
公开(公告)日：2007-08-09
申请号：US11723261
申请日：2007-03-19
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
IPC分类号： A61K31/4965 , A61K31/505 , A61K31/44 , A61K31/165 , A61K31/405 , A61K31/4172 , A61K31/381 , A61K31/34
CPC分类号： C07C235/34
摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
摘要翻译：描述式I化合物及其盐，溶剂合物和水合物：其中：R 1，R 2和R 3各自独立地为选自OH，C 1-6烷基，OC 1-6烷基，OC（O）C 1-6烷基，C（O ）C 1-6烷基，NH 2，NH-C 1-6烷基，N（C 1-6）烷基， C（O）NHC 1-6烷基，C（O）N（C 1-6）烷基）（C 1-6烷基）烷基）（C 1-6烷基），SH，SC 1-6烷基，NO 2，CF 3 OCF 3和卤素; 并且Ar是选自苯，萘，喹啉，异喹啉，吲哚，吡啶，吡嗪，嘧啶，咪唑，呋喃和噻吩的芳族或杂芳族基团，未取代或被1-4个独立地选自OH，C 1 C 1-6烷基，C 1-6烷氧基，C 1-3亚烷基二氧基，NH 2 N，NH- 1-6烷基，N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6，烷基，NO 2，CF 3，OCF 3和卤素。式I的化合物可用于治疗方法和用于调节细胞增殖的组合物，在诊断测定和研究工具中。

7. 发明申请

US20060058297A1 Novel compounds useful for modulating abnormal cell proliferation 有权
标题翻译：用于调节异常细胞增殖的新型化合物
公开(公告)号：US20060058297A1
公开(公告)日：2006-03-16
申请号：US10940009
申请日：2004-09-14
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
IPC分类号： A61K31/537 , A61K31/40 , A61K31/277
CPC分类号： C07C255/41 , C07D213/40 , C07D213/57 , C07D307/54 , C07D333/24
摘要： There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
摘要翻译：描述式I，II，III，IV和V的化合物。式I，II，III，IV和/或V的化合物可用于在诊断测定和研究中用于调节细胞增殖的治疗方法和组合物工具

8. 发明申请

US20050014690A1 Styryl acrylonitrile compounds and their use to promote myelopoiesis 审中-公开
标题翻译：苯乙烯基丙烯腈化合物及其用于促进骨髓细胞生成的用途
公开(公告)号：US20050014690A1
公开(公告)日：2005-01-20
申请号：US10492251
申请日：2002-10-11
申请人： Chaim Roifman , Thomas Grunberger , Nigel Sharfe , Olga Rounova , Demin Peter , Andrew Freywald
发明人： Chaim Roifman , Thomas Grunberger , Nigel Sharfe , Olga Rounova , Demin Peter , Andrew Freywald
IPC分类号： A61K31/277 , A61K38/17 , A61P15/06
CPC分类号： A61K31/277
摘要： The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.
摘要翻译：本发明涉及有机化合物，苯乙烯基丙烯腈化合物促进骨髓生成的用途。这些化合物以前可用于治疗患有中性粒细胞减少症的受试者和可从增加的骨髓细胞中获益的其它病症。此外，该化合物可用于离体治疗造血细胞以促进骨髓生成，因此可有利地用于骨髓或外周血干细胞移植。

9. 发明申请

US20100331549A1 Novel compounds useful for modulating abnormal cell proliferation 审中-公开
标题翻译：用于调节异常细胞增殖的新型化合物
公开(公告)号：US20100331549A1
公开(公告)日：2010-12-30
申请号：US12805954
申请日：2010-08-26
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
IPC分类号： C07D401/12 , C07D213/57 , C07D333/24 , C07D307/54 , C07C255/44
CPC分类号： C07C255/41 , C07D213/40 , C07D213/57 , C07D307/54 , C07D333/24
摘要： There is described compounds of Formulæ I, II, III, IV and V. The compounds of Formulæ I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
摘要翻译：描述了FormulæI，II，III，IV和V的化合物。FormulæI，II，III，IV和/或V的化合物可用于：用于调节细胞增殖的治疗方法和组合物，在诊断测定和研究中工具

10. 发明授权

US07807719B2 Compounds useful for modulating abnormal cell proliferation 有权
标题翻译：可用于调节异常细胞增殖的化合物
公开(公告)号：US07807719B2
公开(公告)日：2010-10-05
申请号：US10940009
申请日：2004-09-14
申请人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
发明人： Chaim Roifman , Peter Demin , Olga Rounova , Tom Grunberger
IPC分类号： A61K31/275 , A61P35/02 , C07C47/11
CPC分类号： C07C255/41 , C07D213/40 , C07D213/57 , C07D307/54 , C07D333/24
摘要： There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.
摘要翻译：描述式I，II，III，IV和V的化合物。式I，II，III，IV和/或V的化合物可用于在诊断测定和研究中用于调节细胞增殖的治疗方法和组合物工具

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