专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120045830A1 STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS OF DIFFERENTIATION THEREOF 有权
标题翻译：干细胞聚集悬浮剂组合物及其分离方法
公开(公告)号：US20120045830A1
公开(公告)日：2012-02-23
申请号：US13220590
申请日：2011-08-29
申请人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
发明人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
IPC分类号： C12M3/00 , C12N5/0735 , C12N5/071
CPC分类号： C12N5/0606 , C12N5/0676 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/195 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
摘要翻译：本发明涉及从未分化或分化的胚胎干细胞单细胞悬液及其分化方法生产未分化或分化的胚胎干细胞聚集悬浮培养物的方法。

2. 发明授权

US08008075B2 Stem cell aggregate suspension compositions and methods of differentiation thereof 有权
标题翻译：干细胞骨料悬浮液组合物及其分化方法
公开(公告)号：US08008075B2
公开(公告)日：2011-08-30
申请号：US12264760
申请日：2008-11-04
申请人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
发明人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C12N5/0606 , C12N5/0676 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/195 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
摘要翻译：本发明涉及从未分化或分化的胚胎干细胞单细胞悬液及其分化方法生产未分化或分化的胚胎干细胞聚集悬浮培养物的方法。

3. 发明申请

US20100112691A1 Stem Cell Aggregate Suspension Compositions and Methods of Differentiation Thereof 有权
标题翻译：干细胞聚集体悬浮组合物及其分化方法
公开(公告)号：US20100112691A1
公开(公告)日：2010-05-06
申请号：US12264760
申请日：2008-11-04
申请人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
发明人： Chad Green , Xiaojie Yu , Anne Bang , Eugene Brandon , Olivia Kelly , Alan D. Agulnick , E. Edward Baetge , Kevin A. D'Amour , Thomas C. Schulz , Allan J. Robins
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , C12N5/0676 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/195 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
摘要翻译：本发明涉及从未分化或分化的胚胎干细胞单细胞悬液及其分化方法生产未分化或分化的胚胎干细胞聚集悬浮培养物的方法。

4. 发明授权

US08211699B2 Methods for culturing pluripotent stem cells in suspension using ERBB3 ligands 有权
标题翻译：使用ERBB3配体在悬浮液中培养多能干细胞的方法
公开(公告)号：US08211699B2
公开(公告)日：2012-07-03
申请号：US11838054
申请日：2007-08-13
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0606 , C12N2500/90 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/195 , C12N2501/235 , C12N2502/13 , C12N2509/00 , G01N33/5008 , G01N33/5073
摘要： The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
摘要翻译：本发明涉及基本上不含血清并包含基础盐营养液和ErbB3配体的细胞培养方法和组合物。

5. 发明授权

US07737253B2 Human cancer stem cell culture compositions comprising Erbb2 variants and methods of use thereof 失效
标题翻译：包含Erbb2变体的人类癌症干细胞培养组合物及其使用方法
公开(公告)号：US07737253B2
公开(公告)日：2010-06-15
申请号：US11764752
申请日：2007-06-18
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C07K14/00 , C12N15/85
CPC分类号： C12N5/0606 , C07K16/32 , C12N2501/195 , G01N33/5748 , G01N2333/71
摘要： The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2Δ16 homodimer, an Erbb2Δ16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs. In addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin. The invention further relates to the use of an Erbb2 variant isoform to generate robust cell cultures that are independent of heregulin.
摘要翻译：本发明提供了用于培养和维持癌症干细胞的组合物和方法。更具体地，本发明提供癌症干细胞特异性标志物的鉴定和识别癌症干细胞特异性标记物的方法以及用于检测肿瘤，促进肿瘤患者的预后和用于治疗各种癌症的方法。本发明还提供了特异性识别二硫键连接的Erbb2和Dgr; 16同二聚体，Erbb2和Dgr; 16 / Erbb3异二聚体或Erbb2的翻译后修饰的抗体，其对变体hESC的Erbb2是特异性的。此外，本发明提供了一种修饰的限定培养基，其在不存在饲养层且不存在血清或血清替代物的情况下可用，其包含基础盐营养溶液bFGF，IGF-I和活化素A，并且其中组合物不包括蛋白质。本发明还涉及使用Erbb2变体同种型来产生独立于调节蛋白的鲁棒细胞培养物。

6. 发明申请

US20100279399A1 Human Cancer Stem Cell Culture Compositions Comprising ErbB2 Variants and Methods of Use 审中-公开
标题翻译：人类癌症干细胞培养组合物包含ErbB2变体和使用方法
公开(公告)号：US20100279399A1
公开(公告)日：2010-11-04
申请号：US12604942
申请日：2009-10-23
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C07K16/28 , C12N5/12
CPC分类号： C12N5/0606 , C07K16/32 , C12N2501/195 , G01N33/5748 , G01N2333/71
摘要： The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2Δ16 homodimer, an Erbb2Δ16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs, in addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin. The invention further relates to the use of an Erbb2 variant isoform to generate robust cell cultures that are independent of heregulin.
摘要翻译：本发明提供了用于培养和维持癌症干细胞的组合物和方法。更具体地，本发明提供癌症干细胞特异性标志物的鉴定和识别癌症干细胞特异性标记物的方法以及用于检测肿瘤，促进肿瘤患者的预后和用于治疗各种癌症的方法。本发明还提供了特异性识别二硫键连接的Erbb2和Dgr; 16同二聚体，Erbb2和Dgr; 16 / Erbb3异源二聚体的抗体或对变体hESC的Erbb2特异性的Erbb2的翻译后修饰，此外，本发明提供了修饰的定义的介质在不存在饲养层的情况下和在不存在血清或血清替代物的情况下有用，其包含基础盐营养液，bFGF，IGF-1和活化素A，并且其中所述组合物不包含调味蛋白。本发明还涉及使用Erbb2变体同种型来产生独立于调节蛋白的鲁棒细胞培养物。

7. 发明申请

US20080268534A1 COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS 有权
公开(公告)号：US20080268534A1
公开(公告)日：2008-10-30
申请号：US11678487
申请日：2007-02-23
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2500/90 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/195 , C12N2501/235 , C12N2502/13 , C12N2509/00 , G01N33/5008 , G01N33/5073
摘要： The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.

8. 发明申请

US20080113433A1 COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS 有权
标题翻译：用于培养不同细胞的组合物和方法
公开(公告)号：US20080113433A1
公开(公告)日：2008-05-15
申请号：US11838054
申请日：2007-08-13
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2500/90 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/195 , C12N2501/235 , C12N2502/13 , C12N2509/00 , G01N33/5008 , G01N33/5073
摘要： The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
摘要翻译：本发明涉及基本上不含血清并包含基础盐营养液和ErbB3配体的细胞培养方法和组合物。

9. 发明授权

US08623650B2 Methods and compositions for feeder-free pluripotent stem cell media containing human serum 有权
标题翻译：含有人血清的无饲养多能干细胞培养基的方法和组成
公开(公告)号：US08623650B2
公开(公告)日：2014-01-07
申请号：US11875057
申请日：2007-10-19
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C12N5/00 , C12N5/02 , C12N5/10 , C12N5/071
CPC分类号： C12N5/0606 , C12N5/068 , C12N2500/84 , C12N2500/98 , C12N2501/15 , C12N2506/02
摘要： The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
摘要翻译：本发明提供了用于培养和维持多能干细胞的组合物和方法。更具体地说，本发明提供了用于培养，保持，生长和稳定灵长类多能干细胞的组合物和方法，所述组合物和方法还包含进料器的限定的培养基，其还包含人血清或人血清的可溶性附着组分，用于促进细胞附着。

10. 发明申请

US20100311164A1 METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM 有权
标题翻译：含有人血清的无饲料细胞干细胞培养基的方法和组合物
公开(公告)号：US20100311164A1
公开(公告)日：2010-12-09
申请号：US12856662
申请日：2010-08-15
申请人： Allan J. Robins , Thomas C. Schulz
发明人： Allan J. Robins , Thomas C. Schulz
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N5/068 , C12N2500/84 , C12N2500/98 , C12N2501/15 , C12N2506/02
摘要： The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
摘要翻译：本发明提供了用于培养和维持多能干细胞的组合物和方法。更具体地说，本发明提供了用于培养，保持，生长和稳定灵长类多能干细胞的组合物和方法，所述组合物和方法还包含进料器的限定的培养基，其还包含人血清或人血清的可溶性附着组分，用于促进细胞附着。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式