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1. 发明授权

US06605074B2 Method for containing and removing occlusions in the carotid arteries 失效
公开(公告)号：US06605074B2
公开(公告)日：2003-08-12
申请号：US10246077
申请日：2002-09-16
申请人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
发明人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
IPC分类号： A61M3100
CPC分类号： A61M25/008 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0071 , A61M25/1011 , A61M2025/0081 , A61M2025/0183 , A61M2025/1052 , A61M2210/0693
摘要： A method for the treatment of a stenosis or an occlusion in a blood vessel is disclosed in which a main catheter is first delivered to a site proximal to the occlusion. The main catheter may include an occlusive device at its distal end. An inner catheter or elongate member (e.g., a guidewire) having an occlusive device at its distal end is delivered to the site of the occlusion, and the occlusive device is activated at a site distal to the occlusion. A therapy catheter is then introduced to treat the occlusion. Next, a catheter is delivered just proximal to the occlusive device, and this catheter is used to aspirate and/or irrigate the area removing particles and debris. The aspiration and irrigation steps are preferably repeated until the particles and debris are removed. Perfusion may be performed by using a perfusion-filter distal of the lesion to be treated or a hypotube which extends beyond the occlusive device attached to the guidewire. The present invention provides for a minimally invasive procedure which can be performed quickly and efficiently, with reduced risks to the patient.

2. 发明授权

US6022336A Catheter system for emboli containment 失效
公开(公告)号：US6022336A
公开(公告)日：2000-02-08
申请号：US812570
申请日：1997-03-06
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Ketan P. Muni
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Ketan P. Muni
IPC分类号： A61B17/22 , A61F2/958 , A61M1/00 , A61M25/00 , A61M29/02 , B29C55/04 , A61M29/00
CPC分类号： A61M25/10184 , A61B17/22 , A61M25/0009 , A61M25/0053 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1011 , A61M25/1018 , A61M25/104 , B29C55/04 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M2025/0018 , A61M2025/0037 , A61M2025/0081 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1031 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , A61M25/0026 , A61M25/0029 , A61M25/005 , A61M25/0068 , A61M25/007 , A61M25/008 , A61M25/10 , A61M25/1027
摘要： A multi-catheter emboli containment system is disclosed which is adapted to provide at least one pair of optimized paths for irrigation and aspiration fluid flow. Through careful design of the cross-sectional area of these paths, the present system is able to be compactly utilized in even the smaller size blood vessels. The catheter system itself is provided with occlusive devices to form an emboli containment chamber in which irrigation and aspiration occur. The catheter system of the present invention provides an improved emboli containment and removal system which can be utilized in a wide range of vessel diameters. The system is easy to use and can quickly and efficiently evacuate the containment chamber.

3. 发明授权

US5868705A Pre-stretched catheter balloon 失效
标题翻译：预先拉伸的导管球囊
公开(公告)号：US5868705A
公开(公告)日：1999-02-09
申请号：US812140
申请日：1997-03-06
申请人： Celso J. Bagaoisan , Ketan P. Muni , Hung V. Ha , Sivette Lam , Gholan-Reza Zadno-Azizi
发明人： Celso J. Bagaoisan , Ketan P. Muni , Hung V. Ha , Sivette Lam , Gholan-Reza Zadno-Azizi
IPC分类号： A61B17/22 , A61F2/958 , A61M1/00 , A61M25/00 , A61M29/02 , B29C55/04 , A61M29/00
CPC分类号： B29C55/04 , A61B17/22 , A61L29/00 , A61M25/0009 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1011 , A61M25/1018 , A61M25/104 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M2025/0018 , A61M2025/0081 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1031 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , A61M25/0026 , A61M25/0068 , A61M25/007 , A61M25/10 , A61M25/1027
摘要： Disclosed herein is a compliant catheter balloon with an improved elastic response and reduced longitudinal expansion, and a method of forming the same. The balloon comprises a SEBS block copolymer, which is longitudinally prestretched during the balloon manufacture process.
摘要翻译：本文公开了一种具有改进的弹性响应和减小的纵向膨胀的柔顺导管气囊及其形成方法。气球包含SEBS嵌段共聚物，其在球囊制造过程中被纵向预拉伸。

4. 发明授权

US5569196A Trackable intravascular catheter 失效
标题翻译：可追踪的血管内导管
公开(公告)号：US5569196A
公开(公告)日：1996-10-29
申请号：US272103
申请日：1994-07-07
申请人： Ketan P. Muni , Celso J. Bagaoisan , Troy L. Thornton
发明人： Ketan P. Muni , Celso J. Bagaoisan , Troy L. Thornton
IPC分类号： A61L29/04 , A61L29/14 , A61M25/00 , A61M29/00
CPC分类号： A61L29/14 , A61L29/041 , A61M25/0045
摘要： A trackable intravascular catheter having a distal section having a laminated tubular structure with the outer lamina of the tubular structure having a Shore hardness of about 30 to about 80 D and an inner lamina which is diametrically more rigid than the outer lamina. The catheter construction is particularly suitable for over-the-wire coronary angioplasty catheters.
摘要翻译：可跟踪的血管内导管，其具有具有层压管状结构的远端部分，其中管状结构的外层具有约30至约80D的肖氏硬度，以及比外层更直径更刚性的内层。导管结构特别适用于线上冠状动脉血管成形术导管。

5. 发明授权

US06569148B2 Methods for emboli containment 失效
公开(公告)号：US06569148B2
公开(公告)日：2003-05-27
申请号：US09769775
申请日：2001-01-25
申请人： Celso J. Bagaoisan , Jefferey C. Bleam , Ketan P. Muni , Gholam RezaZadno Azizi
发明人： Celso J. Bagaoisan , Jefferey C. Bleam , Ketan P. Muni , Gholam RezaZadno Azizi
IPC分类号： A61M3100
CPC分类号： A61M25/10184 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0009 , A61M25/0026 , A61M25/0029 , A61M25/005 , A61M25/0053 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/0075 , A61M25/008 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/1027 , A61M25/104 , A61M2025/0018 , A61M2025/0037 , A61M2025/0081 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/1015 , A61M2025/1031 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , B29C55/04
摘要： A multi-catheter emboli containment system is disclosed which is adapted to provide at least one pair of optimized paths for irrigation and aspiration fluid flow. Through careful design of the cross-sectional area of these paths, the present system is able to be compactly utilized in even the smaller size blood vessels. The catheter system itself is provided with occlusive devices to form an emboli containment chamber in which irrigation and aspiration occur. The catheter system of the present invention provides an improved emboli containment and removal system which can be utilized in a wide range of vessel diameters. The system is easy to use and can quickly and efficiently evacuate the containment chamber.

6. 发明授权

US06375629B1 Core wire with shapeable tip 有权
标题翻译：具有可塑尖端的芯线
公开(公告)号：US06375629B1
公开(公告)日：2002-04-23
申请号：US09690588
申请日：2000-10-17
申请人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
发明人： Ketan P. Muni , Sivette Lam , Juan T. Domingo , Gholam-Reza Zadno-Azizi , Samuel Omaleki , Isaac J. Kim , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： C22F1/006 , A61M25/09 , A61M2025/09175 , A61M2025/1093
摘要： The present invention provides an improved core wire for use in a medical catheter. In one aspect, the invention provides a core wire with a shapeable tip and method of manufacturing the same. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本发明提供一种用于医疗导管的改进的芯线。一方面，本发明提供一种具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

7. 发明授权

US06355016B1 Catheter core wire 有权
标题翻译：导管芯线
公开(公告)号：US06355016B1
公开(公告)日：2002-03-12
申请号：US09253971
申请日：1999-02-22
申请人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
发明人： Celso J. Bagaoisan , Ketan P. Muni , Gholam-Reza Zadno-Azizi , Sivette Lam , Juan T. Domingo , Isaac J. Kim , Samuel L. Omaleki , Jefferey C. Bleam
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/09 , A61M25/09033 , A61M2025/09175 , A61M2025/1093 , C22F1/006
摘要： Disclosed herein is an improved core wire for use in a medical catheter. In one aspect, a tapering core wire is incorporated into the distal end of a catheter. The catheter has a tubular body. Both ends of an inflatable balloon are mounted to the tubular body. The core wire extends from the distal end of the tubular body. In one embodiment, substantially all of the taper of the core wire occurs in the extending portion of the core wire over a length of at least 15 mm but no more than 60 mm. In another aspect, a core wire with a shapeable tip and method of manufacturing the same are provided. A core wire previously made superelastic is subject to additional processing to remove its superelasticity thereby allowing the material to be shapeable to aid in advancing the core wire through a blood vessel or other body cavities. In another aspect of the present invention, a method is provided for securing the core wire to the distal end of an elongated catheter tubular body. The tubular body is mechanically crimped onto the core wire to secure the core wire in place. This crimping method has been found to increase the strength of the bond between the core wire and the catheter tube so that greater pull force is required to break the core wire off from the catheter.
摘要翻译：本文公开了一种用于医疗导管的改进的芯线。在一个方面，锥形芯线被并入导管的远端。导管具有管状体。可充气气囊的两端安装在管状体上。芯线从管状体的远端延伸。在一个实施例中，芯线的基本上所有的锥形在芯线的延伸部分中发生长度至少为15mm但不大于60mm。另一方面，提供了具有可成形尖端的芯线及其制造方法。预先制成超弹性的芯线经受额外的处理以去除其超弹性，从而允许材料可成型以帮助将芯线推进通过血管或其它体腔。在本发明的另一方面，提供了一种用于将芯线固定到细长导管管体的远端的方法。将管状体机械地压接在芯线上以将芯线固定到位。已经发现这种卷曲方法增加了芯线和导管之间的结合强度，使得需要更大的拉力来将芯线从导管断开。

8. 发明授权

US06375628B1 Hollow medical wires and methods of constructing same 有权
标题翻译：空心医疗电线及其构造方法
公开(公告)号：US06375628B1
公开(公告)日：2002-04-23
申请号：US09505380
申请日：2000-02-16
申请人： Gholam-Reza Zadno-Azizi , Ketan P. Muni , Celso J. Bagaoisan
发明人： Gholam-Reza Zadno-Azizi , Ketan P. Muni , Celso J. Bagaoisan
IPC分类号： A61B500
CPC分类号： A61M25/10 , A61M25/09 , A61M2025/09008 , A61M2025/09141 , A61M2025/09175 , A61M2025/09183 , A61M2025/1052
摘要： The present invention provides an apparatus for performing angioplasty or vascular intervention procedures. The apparatus of the present invention comprises a catheter apparatus comprised of a superelastic hollow guidewire, a balloon member and a flexible tip. The superelastic hollow guidewire of the invention is preferably a hypotube of nitinol alloy. The use of nitinol alloy as hollow guidewire provides a catheter apparatus having high flexibility and torqueability as well as small cross sectional diameter.
摘要翻译：本发明提供一种用于进行血管成形术或血管介入手术的装置。本发明的装置包括由超弹性中空导丝，球囊构件和柔性尖端构成的导管装置。本发明的超弹性中空导丝优选为镍钛合金的海波管。使用镍钛诺合金作为中空导线提供了具有高柔性和可逆性以及小截面直径的导管装置。

9. 发明授权

US06312407B1 Occlusion of a vessel 失效
标题翻译：阻塞血管
公开(公告)号：US06312407B1
公开(公告)日：2001-11-06
申请号：US09026106
申请日：1998-02-19
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12168 , A61B17/12172 , A61B17/22 , A61B2017/1205 , A61B2017/22067 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0065 , A61F2230/0069 , A61F2230/0076 , A61F2230/008 , A61F2230/0091 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/1011 , A61M25/10182 , A61M29/02 , A61M2025/0018 , A61M2025/0079 , A61M2025/09008 , A61M2025/09116 , A61M2025/09125 , A61M2025/09175 , A61M2025/1015 , A61M2025/1045 , A61M2025/1052 , A61M2025/1079 , A61M2025/1081 , A61M2025/1093
摘要： A device for occluding a vessel employs one of a number of different expansion members joined to one or more elongate members. The expansion member may include a braid, one or more coils, ribs, a ribbon-like structure, a slotted tube, or a filter-like mesh. If the expansion member is enclosed by a suitable membrane, the device seals with the vessel wall to partially or completely occlude the vessel. A perforated membrane may be used to permit the perfusion of blood. The expansion member may be self-expanding, or it may be expanded by engaging it with one of the elongate members. Alternatively, the expansion member may be expanded by heating it.
摘要翻译：用于封闭容器的装置采用与一个或多个细长构件连接的多个不同的膨胀构件中的一个。膨胀构件可以包括编织物，一个或多个线圈，肋，带状结构，开槽管或过滤器状网。如果膨胀构件被合适的膜封闭，则装置与容器壁密封以部分地或完全地封闭容器。穿孔膜可用于允许血液灌注。膨胀构件可以是自膨胀的，或者可以通过使其与细长构件之一接合而膨胀。或者，可以通过加热来膨胀膨胀构件。

10. 发明授权

US06994689B1 Occlusion of a vessel 失效
标题翻译：阻塞血管
公开(公告)号：US06994689B1
公开(公告)日：2006-02-07
申请号：US09636278
申请日：2000-08-10
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
IPC分类号： A61M29/00 , A61M31/00 , A61M5/00
CPC分类号： A61B17/12109 , A61B17/12022 , A61B17/1204 , A61B17/12172 , A61B2017/1205 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2002/30095 , A61F2210/0023 , A61F2230/0065 , A61F2230/0069 , A61F2230/0076 , A61F2230/008 , A61F2230/0091
摘要： A device for occluding a vessel employs one of a number of different expansion members joined to one or more elongate members. The expansion member may include a braid, one or more coils, ribs, a ribbon-like structure, a slotted tube, or a filter-like mesh. If the expansion member is enclosed by a suitable membrane, the device seals with the vessel wall to partially or completely occlude the vessel. A perforated membrane may be used to permit the perfusion of blood. The expansion member may be self-expanding, or it may be expanded by engaging it with one of the elongate members. Alternatively, the expansion member may be expanded by heating it.
摘要翻译：用于封闭容器的装置采用与一个或多个细长构件连接的多个不同的膨胀构件中的一个。膨胀构件可以包括编织物，一个或多个线圈，肋，带状结构，开槽管或过滤器状网。如果膨胀构件被合适的膜封闭，则装置与容器壁密封以部分地或完全地封闭容器。穿孔膜可用于允许血液灌注。膨胀构件可以是自膨胀的，或者可以通过使其与细长构件之一接合而膨胀。或者，可以通过加热来膨胀膨胀构件。

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