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1. 发明申请

US20090053782A1 YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL 审中-公开
标题翻译：具有从二羟基乙酸酯磷酸盐到甘油的破坏途径的YEAST细胞
公开(公告)号：US20090053782A1
公开(公告)日：2009-02-26
申请号：US12281286
申请日：2007-03-13
申请人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
发明人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
IPC分类号： C12P7/56 , C12N1/19
CPC分类号： B65G15/12 , B65G17/12 , C12N15/52 , C12P7/06 , C12P7/40 , C12P7/56 , E01B29/32 , Y02E50/17 , Y10T137/85986
摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
摘要翻译：酵母细胞被遗传修饰以破坏从二羟基丙酮到甘油的天然代谢途径。在某些方面，酵母细胞是克鲁维酵母属，假丝酵母属或发chen类。在其它方面，酵母细胞能够产生至少一种有机酸，如乳酸盐。酵母细胞比野生型菌株产生明显较少的甘油，并且通常产生更高产量的所需发酵产物。本发明的酵母细胞在培养时经常生长良好，尽管它们的甘油产量减少。

2. 发明申请

US20090253189A1 Lactic Acid-Producing Yeast Cells Having Nonfunctional L- or D-Lactate:Ferricytochrome C Oxidoreductase Cells 有权
标题翻译：具有非功能性L-或D-乳酸的乳酸生产酵母细胞：铁染色质C氧化还原酶细胞
公开(公告)号：US20090253189A1
公开(公告)日：2009-10-08
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
IPC分类号： C12P7/56 , C12N1/19 , C12N15/74
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译：酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。具有降低的I或D-乳酸：铁染色质c氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。

3. 发明授权

US08137953B2 Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells 有权
标题翻译：具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞
公开(公告)号：US08137953B2
公开(公告)日：2012-03-20
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
IPC分类号： C12N1/19 , C12N1/00 , C12N15/70 , C12Q1/68
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译：酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。具有降低的L-乳酸或D-乳酸：细胞色素C氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。

4. 发明申请

US20090226989A1 Genetically modified yeast of the species issatchenkia orientalis and closely relates species, and fermentation processes using same 有权
标题翻译：物种的转基因酵母和密切相关的物种，以及使用它们的发酵过程
公开(公告)号：US20090226989A1
公开(公告)日：2009-09-10
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
IPC分类号： C12P7/56 , C12N1/19 , C12N15/63
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译：用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。

5. 发明申请

US20120129230A1 Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same 审中-公开
标题翻译：东方药物和密切相关物种的转基因酵母和使用相同的发酵过程
公开(公告)号：US20120129230A1
公开(公告)日：2012-05-24
申请号：US13316044
申请日：2011-12-09
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
IPC分类号： C12P7/56 , C12P17/06 , C12P7/62 , C12N1/19
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译：用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。

6. 发明授权

US08097448B2 Genetically modified yeast of the species Issatchenkia orientalis and closely relates species, and fermentation processes using same 有权
标题翻译：发酵物种的转基因酵母，与物种密切相关，发酵过程使用相同
公开(公告)号：US08097448B2
公开(公告)日：2012-01-17
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
IPC分类号： C12N1/00 , C12N15/00 , C12N15/09
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译：用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。

7. 发明申请

US20100159546A1 METABOLIC ENGINEERING OF YEASTS FOR THE PRODUCTION OF 1-BUTANOL 审中-公开
标题翻译：用于生产1-丁醇的代谢工程
公开(公告)号：US20100159546A1
公开(公告)日：2010-06-24
申请号：US12593842
申请日：2008-03-27
申请人： Aristos Aristidou , Arlene M. Fosmer , Catherine Asleson Dundon , Brian J. Rush
发明人： Aristos Aristidou , Arlene M. Fosmer , Catherine Asleson Dundon , Brian J. Rush
IPC分类号： C12P7/16 , C12N1/19
CPC分类号： C12N15/52 , C12P7/16 , Y02E50/10
摘要： The present invention provides genetically modified yeast cells, and methods of using those yeast cells, to produce 1-butanol. The yeast cell can be selected from the genera Saccharomyces, Candida, Pichia, Kluyveromyces, Issatchenkia, Yarrowia, Rhodotorula, Hansenula, Schizochytrium, or Thraustochytrium. The yeast cell of the invention overexpresses at least one enzyme that catalyzes one or more butanoate pathways selected from the group consisting of pyruvate to acetyl-CoA, acetyl-CoA to acetoacetyl-CoA, acetoacetyl-CoA to 3-hydroxybutanoyl-CoA, 3-hydroxybutanoyl-CoA to crotonoyl-CoA, crotonoyl-CoA to butyryl-CoA to butyraldehyde, and butyraldehyde to 1-butanol. Some embodiments overexpress enzymes that are endogenous to the bacterium Clostridium acetobutylicum. The genetically modified yeast cell can further be subjected to other desired genetic changes, such as deletion or disruption of one or more native PDC genes.
摘要翻译：本发明提供遗传修饰的酵母细胞，以及使用这些酵母细胞的方法来生产1-丁醇。酵母细胞可以选自酵母属，假丝酵母属，毕赤酵母属，克鲁维酵母属，发chen ia属，耶氏酵母属，红酵母属，汉逊酵母属，裂殖酵菌属或破囊壶菌属。本发明的酵母细胞过表达至少一种催化一种或多种选自丙酮酸至乙酰辅酶A，乙酰辅酶A，乙酰乙酰辅酶A，乙酰乙酰辅酶A至3-羟基丁酰辅酶A，羟基丁酰辅酶A，巴豆酰基-CoA，巴豆酰基-CoA至丁酰-CoA至丁醛，丁醛至丁醇。一些实施方案过表达对细菌丙酮丁醇梭菌是内源的酶。遗传修饰的酵母细胞可进一步经受其它所需的遗传变化，例如一个或多个天然PDC基因的缺失或破坏。

8. 发明授权

US08440451B2 Genetically modified yeast species, and fermentation processes using genetically modified yeast 有权
标题翻译：转基因酵母和使用转基因酵母的发酵过程
公开(公告)号：US08440451B2
公开(公告)日：2013-05-14
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12N1/19 , C12P21/00
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译：酵母细胞用外源木糖异构酶基因转化。另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。

9. 发明授权

US07943366B2 Genetically modified yeast species and fermentation processes using genetically modified yeast 有权
标题翻译：使用转基因酵母的转基因酵母和发酵过程
公开(公告)号：US07943366B2
公开(公告)日：2011-05-17
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12N1/00 , C12N1/19
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译：酵母细胞用外源木糖异构酶基因转化。另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。

10. 发明申请

US20110287506A1 GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权
标题翻译：遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程
公开(公告)号：US20110287506A1
公开(公告)日：2011-11-24
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12P1/02 , C12N1/19
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译：酵母细胞用外源木糖异构酶基因转化。另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。

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