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1. 发明申请

US20150259710A1 DECARBOXYLASE PROTEINS WITH HIGH KETO-ISOVALERATE DECARBOXYLASE ACTIVITY 审中-公开
标题翻译：具有高KETO-ISOVALERATE脱羧酶活性的脱羧蛋白
公开(公告)号：US20150259710A1
公开(公告)日：2015-09-17
申请号：US13561560
申请日：2012-07-30
申请人： Catherine Asleson Dundon , Kevin Roberg-Perez , Christopher Snow , Peter Meinhold
发明人： Catherine Asleson Dundon , Kevin Roberg-Perez , Christopher Snow , Peter Meinhold
IPC分类号： C12P7/16 , C12N9/04 , C12N9/88
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/88 , C12Y101/01001 , C12Y101/01086 , C12Y401/01 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise at least one nucleic acid molecule encoding a polypeptide with keto-isovalerate decarboxylase (KIVD) activity, wherein said polypeptide is at least about 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a polypeptide selected from SEQ ID NOs: 1-214. Also provided are modified decarboxylases exhibiting an improved ability to utilize α-ketoisovalerate as a substrate in various beneficial enzymatic conversions.
摘要翻译：本发明涉及包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。在本发明的各个方面，重组微生物可包含编码具有酮 - 异戊酸脱羧酶（KIVD）活性的多肽的至少一种核酸分子，其中所述多肽至少约65％，70％，75％，80％与选自SEQ ID NO：1-214的多肽的85％，90％，91％，92％，93％，94％，95％，96％，97％，98％或99％相同。还提供了改进的脱羧酶，其表现出在各种有益的酶转化中利用α-酮异戊酸作为底物的改进能力。

2. 发明申请

US20140295513A1 High-Performance Ketol-Acid Reductoisomerases 审中-公开
标题翻译：高效Ketol-Acid Reductoisomerases
公开(公告)号：US20140295513A1
公开(公告)日：2014-10-02
申请号：US14131984
申请日：2012-07-11
申请人： Peter Meinhold , Doug Lies , Stephanie Porter-Scheinman , Christopher Smith , Christopher Snow , Sabine Bastian , Sebastian Schoof
发明人： Peter Meinhold , Doug Lies , Stephanie Porter-Scheinman , Christopher Smith , Christopher Snow , Sabine Bastian , Sebastian Schoof
IPC分类号： C12P7/16 , C12N9/04
CPC分类号： C12P7/16 , C12N9/0006 , C12Y101/01086 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 80% identical to SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 28, SEQ ID NO: 40, or SEQ ID NO: 58. The present invention also relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 99% identical to SEQ ID NO: 64. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
摘要翻译：本发明涉及包含编码酮酸酸还原异构酶（KARI）或修饰的NADH依赖性变体的至少一种核酸分子的重组微生物，其中所述KARI与SEQ ID NO：2，SEQ ID NO：2至少约80％ SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8，SEQ ID NO：10，SEQ ID NO：28，SEQ ID NO：40或SEQ ID NO：58.本发明还涉及重组微生物其包含至少一个编码酮酸酸还原异构酶（KARI）或其修饰的NADH依赖性变体的核酸分子，其中所述KARI与SEQ ID NO：64至少约99％相同。在本发明的各个方面，重组微生物可以包含产生异丁醇的代谢途径，并可用于制备异丁醇的方法。

3. 发明申请

US20140295512A1 Ketol-Acid Reductoisomerases With Improved Performance Properties 审中-公开
标题翻译：具有改善性能特性的酮酸酸性还原异构酶
公开(公告)号：US20140295512A1
公开(公告)日：2014-10-02
申请号：US14126606
申请日：2012-06-15
申请人： Thomas Buelter , Doug Lies , Stephanie Porter-Scheinman , Christopher Smith , Peter Meinhold , Ruth Berry , Christopher Snow , Sabine Bastian
发明人： Thomas Buelter , Doug Lies , Stephanie Porter-Scheinman , Christopher Smith , Peter Meinhold , Ruth Berry , Christopher Snow , Sabine Bastian
IPC分类号： C12P7/16 , C12N9/04
CPC分类号： C12P7/16 , C12N9/0006 , C12N15/52 , C12Y101/01086 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
摘要翻译：本发明涉及包含编码酮酸酸还原异构酶（KARI）或其修饰的NADH依赖性变体的至少一种核酸分子的重组微生物，其中所述KARI与SEQ ID NO：2至少约60％相同。本发明的方面，重组微生物可包含产生异丁醇的代谢途径，可用于制备异丁醇的方法。

4. 发明申请

US20130139777A1 Intake Manifold with Overmolded Structural Enhancement 有权
标题翻译：进气歧管与包覆结构增强
公开(公告)号：US20130139777A1
公开(公告)日：2013-06-06
申请号：US13753383
申请日：2013-01-29
申请人： Christopher William Newman , Mohammad Ali Moetakef , Christopher Snow
发明人： Christopher William Newman , Mohammad Ali Moetakef , Christopher Snow
IPC分类号： F02M35/104
CPC分类号： F02M35/104 , F02M35/10321 , F02M35/10327 , F02M35/116
摘要： A composite intake manifold coupled to a V-engine is provided. The composite intake manifold includes a supporting member overmolded in an unsupported region of the composite intake manifold.
摘要翻译：提供了耦合到V发动机的复合进气歧管。复合进气歧管包括在复合进气歧管的非支撑区域中包覆模制的支撑构件。

5. 发明申请

US20110253080A1 Intake Manifold with Overmolded Structural Enhancement 有权
标题翻译：进气歧管与包覆结构增强
公开(公告)号：US20110253080A1
公开(公告)日：2011-10-20
申请号：US12759989
申请日：2010-04-14
申请人： Chris William Newman , Mohammad Ali Moetakef , Christopher Snow
发明人： Chris William Newman , Mohammad Ali Moetakef , Christopher Snow
IPC分类号： F02B75/22 , F02M35/10
CPC分类号： F02M35/104 , F02M35/10321 , F02M35/10327 , F02M35/116
摘要： A composite intake manifold coupled to a V-engine is provided. The composite intake manifold includes a supporting member overmolded in an unsupported region of the composite intake manifold.
摘要翻译：提供了耦合到V发动机的复合进气歧管。复合进气歧管包括在复合进气歧管的非支撑区域中包覆模制的支撑构件。

6. 发明申请

US20050227362A1 Multiple sorter monitor and control subsystem for flow cytometer 有权
标题翻译：流式细胞仪多重分拣机监控和控制子系统
公开(公告)号：US20050227362A1
公开(公告)日：2005-10-13
申请号：US10819745
申请日：2004-04-07
申请人： Todd Lary , Robert Burr , Christopher Snow
发明人： Todd Lary , Robert Burr , Christopher Snow
IPC分类号： G01N15/14 , G01N33/48
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/1481 , G01N2015/149 , Y10S209/906
摘要： An optical illumination and monitoring subsystem controls the operation of a flow cytometer having a carrier fluid that flows along a channel coupled to a droplet generator, which controls a point at which droplets break off from the carrier fluid, and a droplet sorter that is operative to cause selected droplets to be sorted along one or more droplet travel paths. The subsystem is operative to illuminate a respective droplet monitoring location along each of one or more droplet travel paths with a respective beam of light, such as that sourced from a common laser. In response to backscatter reflection from a droplet passing through the respective beam of light at a respective droplet monitoring location, the amplitude of the beam of light is increased. Then the droplet is monitored for the presence of a particle therein exhibiting detectable fluorescence as a result of the increase in the amplitude of the respective beam of light.
摘要翻译：光学照明和监测子系统控制流式细胞仪的操作，所述流式细胞仪具有沿耦合到液滴发生器的通道流动的载体流体，该液滴发生器控制液滴从载体流体脱落的点，以及液滴分选器，使选定的液滴沿着一个或多个液滴行进路径排序。该子系统可操作以沿着一个或多个液滴行进路径中的每一个以相应的光束照射相应的液滴监测位置，例如来自普通激光的光束。响应于在相应的液滴监测位置处通过相应光束的液滴的反向散射反射，光束的振幅增加。然后，由于各个光束的幅度增加，液滴被监测其中呈现出可检测的荧光的颗粒的存在。

7. 发明授权

US08360025B2 Intake manifold with overmolded structural enhancement 有权
标题翻译：进气歧管包覆成型结构增强
公开(公告)号：US08360025B2
公开(公告)日：2013-01-29
申请号：US12759989
申请日：2010-04-14
申请人： Chris William Newman , Mohammad Ali Moetakef , Christopher Snow
发明人： Chris William Newman , Mohammad Ali Moetakef , Christopher Snow
IPC分类号： F02M35/10
CPC分类号： F02M35/104 , F02M35/10321 , F02M35/10327 , F02M35/116
摘要： A composite intake manifold coupled to a V-engine is provided. The composite intake manifold includes a supporting member overmolded in an unsupported region of the composite intake manifold.
摘要翻译：提供了耦合到V发动机的复合进气歧管。复合进气歧管包括在复合进气歧管的非支撑区域中包覆模制的支撑构件。

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