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1. 发明授权

US07301041B2 Bi-functional metallocenes, preparation process and use in the labeling or biological molecules 失效
公开(公告)号：US07301041B2
公开(公告)日：2007-11-27
申请号：US10501347
申请日：2003-02-14
申请人： Carole Chaix-Bauvais , Corinne Moustrou , Aude-Emmanuelle Navarro , Hugues Brisset , Francis Garnier , Bernard Mandrand , Nicolas Spinelli
发明人： Carole Chaix-Bauvais , Corinne Moustrou , Aude-Emmanuelle Navarro , Hugues Brisset , Francis Garnier , Bernard Mandrand , Nicolas Spinelli
IPC分类号： C07F17/02 , C07K1/00
CPC分类号： C07F17/02 , Y02P20/55
摘要： The invention relates to bi-functionalised metallocenes of general formula (I) where Me=a transition metal, preferably chosen from Fe, Ru and Os, Y and Z, when identical are selected from —(CH2)n—O—, (CH2)—O—[(CH2)2—O]P— and —(CH2)q—CONH—(CH2)r—O—, or Y=—(CH2)S—NH— and Z=—(CH2)t—COO—, n=a whole number from 3 to 6 inclusive, p=a whole number from 1 to 4 inclusive, q=a whole number from 0 to 2 inclusive, r=a whole number from 0 to 2 inclusive, s=a whole number from 2 to 5 inclusive, t=a whole number from 3 to 6 inclusive, R and R′=H atoms or are protective groups used in oligonucleotide and peptide synthesis, where at least one of R or R′ is protective group used in oligonucleotide and peptide synthesis and R and R′ are as defined below: (i) when Z and Y are selected from (CH2)n—O—, —(CH2)—O—[(CH2)2—O]p— and —(CH2)q—CONH—(CH2)r—O—, then R and R′ are protective groups used in oligonucleotide synthesis and R is a group which can leave a free OH group after deprotection, preferably a photolabile group such as monomethroxythoxytrityl, dimethoxytrityl, t-butyldimethylsilyl, acetyl or trifluroacetyl, and R′ is a phosphorylated group which can react with a free OH, preferably a phosphodiester, phosphoramidite or H-phosphonate and (ii) when Y=—(CH2)s—NH— and Z=—(CH2)t—COO—, then R is a protective group used in the synthesis of peptides and is an amino-protecting group, preferably 9-fluorenyloxycarbonyl, t-butoxycarbonyl or benzyloxycarbonyl and R′=H. The above is applied in marking.

2. 发明申请

US20050038234A1 Bi-functionalised metallocenes use for marking biological molecules 失效
标题翻译：双功能金属茂用于标记生物分子
公开(公告)号：US20050038234A1
公开(公告)日：2005-02-17
申请号：US10501347
申请日：2003-02-14
申请人： Carole Chaix-Bauvais , Corinne Moustrou , Aude-Emmanuelle Navarro , Hugues Brisset , Francis Garnier , Bernard Mandrand , Nicolas Spinelli
发明人： Carole Chaix-Bauvais , Corinne Moustrou , Aude-Emmanuelle Navarro , Hugues Brisset , Francis Garnier , Bernard Mandrand , Nicolas Spinelli
IPC分类号： C12N15/00 , A61K49/00 , C07F17/00 , C07F17/02 , C07H21/04 , C07K5/00 , C07K7/00 , C07K14/00 , C07K1/00
CPC分类号： C07F17/02 , Y02P20/55
摘要： The invention relates to bi-functionalised metallocenes of general formula (I) where Me=a transition metal, preferably chosen from Fe, Ru and Os, Y and Z, when identical are selected from —(CH2)n—O—, (CH2)—O—[(CH2)2—O]P— and —(CH2)q—CONH—(CH2)r—O—, or Y=—(CH2)S—NH— and Z=—(CH2)t—COO—, n=a whole number from 3 to 6 inclusive, p=a whole number from 1 to 4 inclusive, q=a whole number from 0 to 2 inclusive, r=a whole number from 0 to 2 inclusive, s=a whole number from 2 to 5 inclusive, t=a whole number from 3 to 6 inclusive, R and R′=H atoms or are protective groups used in oligonucleotide and peptide synthesis, where at least one of R or R′ is protective group used in oligonucleotide and peptide synthesis and R and R′ are as defined below: (i) when Z and Y are selected from (CH2)n—O—, —(CH2)—O—[(CH2)2—O]p— and —(CH2)q—CONH—(CH2)r—O—, then R and R′ are protective groups used in oligonucleotide synthesis and R is a group which can leave a free OH group after deprotection, preferably a photolabile group such as monomethroxythoxytrityl, dimethoxytrityl, t-butyldimethylsilyl, acetyl or trifluroacetyl, and R′ is a phosphorylated group which can react with a free OH, preferably a phosphodiester, phosphoramidite or H-phosphonate and (ii) when Y=—(CH2)n—NH— and Z=—(CH2)t—COO—, then R is a protective group used in the synthesis of peptides and is an amino-protecting group, preferably 9-fluorenyloxycarbonyl, t-butoxycarbonyl or benzyloxycarbonyl and R′=H. The above is applied in marking.
摘要翻译：本发明涉及通式（I）的双官能化金属茂，其中Me =过渡金属，优选选自Fe，Ru和Os，Y和Z，当相同时，选自 - （CH 2）n O-，（CH 2） O - [（CH 2）2 -O] P - 和 - （CH 2）q -CONH-（CH 2）r O-或Y = - （CH 2）S -NH-和Z = - （CH 2）t -COO-， n =从3到6的整数，p =从1到4的整数，q =从0到2的整数，包括0和2，r =从0到2的整数，s =从 2〜5，t = 3〜6的整数，R和R'= H原子，或者是寡核苷酸和肽合成中使用的保护基，其中R或R'中的至少一个为寡核苷酸中使用的保护基，肽合成和R和R'定义如下：（i）当Z和Y选自（CH 2）n O-， - （CH 2）-O - [（CH 2）2 -O] p - 和 - （CH 2） q-CONH-（CH 2）r O - ，则R和R'是寡核苷酸合成中使用的保护基，R是在去保护后可以留下游离OH基团的基团，顺式基团如单甲氧基三苯甲基，二甲氧基三苯甲基，叔丁基二甲基甲硅烷基，乙酰基或三氟乙酰基，R'是可以与游离OH，优选磷酸二酯，亚磷酰胺或H-膦酸酯反应的磷酸化基团，和（ii）当Y = - （CH2 ）n-NH-和Z = - （CH2）t-COO-，则R是用于合成肽的保护基，并且是氨基保护基，优选9-氟芳氧基羰基，叔丁氧基羰基或苄氧基羰基和R' = H。上述适用于标记。

3. 发明授权

US06312811B1 Photochromic naphtho [2,1-b]pyran compounds containing bithienyl or terthienyl substituents, process for their manufacture, and photochromic materials and articles obtained 失效
标题翻译：含有二噻吩基或三噻吩基取代基的光致变色萘并[2,1-b]吡喃化合物，其制备方法和光致变色材料和制品
公开(公告)号：US06312811B1
公开(公告)日：2001-11-06
申请号：US09349686
申请日：1999-07-08
申请人： Michel Frigoli , Nicole Rebiere-Galy , Corinne Moustrou , Andre Samat , Robert Guglielmetti
发明人： Michel Frigoli , Nicole Rebiere-Galy , Corinne Moustrou , Andre Samat , Robert Guglielmetti
IPC分类号： C03C406
CPC分类号： C07D409/14 , B32B17/10486 , C09K9/02 , G02B5/23 , Y10T428/31504
摘要： The photochromic compounds of the invention correspond to the formula: in which Th2 represents a bithienyl group in one of the positions 5 to 10 of the naphthenic ring system system, R1 denotes a bithienyl or trithienyl group and R2 denotes a bithienyl, trithienyl, aryl, naphthyl, thienyl, furyl, pyrrolyl or N-alkylpyrrolyl group.
摘要翻译：本发明的光致变色化合物对应于下列通式：其中Th2表示环烷系体系的5至10位中的二噻吩基，R1表示双噻吩基或三噻吩基，R2表示双噻吩基，三噻吩基，芳基，萘基，噻吩基，呋喃基，吡咯基或N-烷基吡咯基。

4. 发明授权

US06281366B1 Photochromic [3H]naphtho[2,1-b]pyran compounds containing an acetylenic substituent, process for their manufacture, and photochromic materials and articles obtained 失效
标题翻译：含有炔取代基的光致变色[3 H]萘并[2,1-b]吡喃化合物，其制造方法和光致变色材料及制品
公开(公告)号：US06281366B1
公开(公告)日：2001-08-28
申请号：US09515142
申请日：2000-02-29
申请人： Michel Frigoli , Corinne Moustrou , André Samat , Robert Guglielmetti
发明人： Michel Frigoli , Corinne Moustrou , André Samat , Robert Guglielmetti
IPC分类号： C07D40906
CPC分类号： C07D409/14 , C07D311/92 , C07D409/06 , C09K9/02
摘要： The present invention relates to photochromic [3H]naphtho[2,1-b]pyran compounds containing an acetylenic substituent, process for their manufacture, and photochromic materials and articles obtained therefrom. The invention, in some specific aspects, relates to photochromic compounds having a [3H]naphtho-[2,1-b]pyran structure and bearing an acetylenic group in one of the positions 7 to 10 of the naphthopyran ring structure.
摘要翻译：本发明涉及含有炔属取代基的光致变色[3 H]萘并[2,1-b]吡喃化合物及其制备方法，以及由此得到的光致变色材料及制品。在一些具体方面，本发明涉及具有[3H]萘并[2,1-b]吡喃结构并在萘并吡喃环结构的7至10位中具有炔基的光致变色化合物。

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