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1. 发明授权

US08895744B2 Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl 有权
标题翻译： NPM-ALK，RET和Bcr-Abl的α-咔啉抑制剂
公开(公告)号：US08895744B2
公开(公告)日：2014-11-25
申请号：US13062665
申请日：2009-08-27
申请人： Carlo Gambacorti Passerini , Luca Mologni , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Benoit Joseph , Cedric Schneider , Pierre Garcia
发明人： Carlo Gambacorti Passerini , Luca Mologni , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Benoit Joseph , Cedric Schneider , Pierre Garcia
IPC分类号： A61K31/44 , C07D221/22 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumors (IMT) and non-small cell lung cancer (NSCLC).
摘要翻译：本发明涉及其中R1，R2和R3如说明书中所定义的式（I）化合物及其药物组合物及其用于治疗表达致癌性ALK蛋白，特别是间变型大细胞淋巴瘤（ALCL）的癌症的用途，弥漫性大B细胞淋巴瘤（DLBCL），炎性肌成纤维细胞瘤（IMT）和非小细胞肺癌（NSCLC）。

2. 发明申请

US20110281862A1 ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL 有权
标题翻译： NPM-ALK，RET和BCR-ABL的ALFA- CARBOLINE抑制剂
公开(公告)号：US20110281862A1
公开(公告)日：2011-11-17
申请号：US13062665
申请日：2009-08-27
申请人： Carlo Gambacorti Passerini , Luca Mologni , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Benoit Joseph , Cedric Schneider , Pierre Garcia
发明人： Carlo Gambacorti Passerini , Luca Mologni , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Benoit Joseph , Cedric Schneider , Pierre Garcia
IPC分类号： A61K31/437 , A61P35/00 , A61K31/5377 , C07D471/04 , A61K31/496
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumours (IMT) and non-small cell lung cancer (NSCLC).
摘要翻译：本发明涉及其中R1，R2和R3如说明书中所定义的式（I）化合物及其药物组合物及其用于治疗表达致癌性ALK蛋白，特别是间变型大细胞淋巴瘤（ALCL）的癌症的用途，弥漫性大B细胞淋巴瘤（DLBCL），炎性肌成纤维细胞瘤（IMT）和非小细胞肺癌（NSCLC）。

3. 发明申请

US20110112110A1 ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：抗生素化合物及其治疗用途
公开(公告)号：US20110112110A1
公开(公告)日：2011-05-12
申请号：US12935795
申请日：2009-03-30
申请人： Carlo Gambacorti Passerini , Rosalind Helen Gunby , Alfonso Zambon , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Cerric Schneider
发明人： Carlo Gambacorti Passerini , Rosalind Helen Gunby , Alfonso Zambon , Leonardo Scapozza , Shaheen Ahmed , Peter G. Goekjian , David Gueyrard , Florence Popowycz , Cerric Schneider
IPC分类号： A61K31/496 , C07D403/10 , A61K31/4178 , C07D417/14 , C07D405/14 , A61K31/444 , A61K31/4439 , C07D417/10 , A61K31/433 , A61P35/00
CPC分类号： C07D233/88 , C07D277/40 , C07D277/46 , C07D307/68
摘要： Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.
摘要翻译：致癌性酪氨酸激酶ALK和Bcr-Abl突变体T315I Bcr-Abl的抑制剂，含有它们的药物组合物及其用于治疗高增殖性疾病的用途。

4. 发明授权

US08691982B2 Pyrazolo[1,5-a]-1,3,5-triazine derivatives, preparation thereof, and therapeutic use thereof 有权
标题翻译：吡唑并[1,5-a] -1,3,5-三嗪衍生物及其治疗用途
公开(公告)号：US08691982B2
公开(公告)日：2014-04-08
申请号：US13203427
申请日：2010-03-11
申请人： Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
发明人： Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 is a (C1-C6)alkyl or (C3-C6)cycloalkyl group; R2 is a (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkenyl, (C1-C6)fluoroalkyl, (C1-C3)fluoroalkoxy, or (C1-C6)alkoxy(C1-C6)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRaRb group, where Ra and Rb are independently a hydrogen atom or a (C1-C3)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; R9 is the same as R2 or hydrogen; the R2 and R9 groups independently being substitutable with an —OCOR3 group, where R3 is a natural or unnatural amino acid derivative or a piperidyl group; alternatively, R2 and R9 together form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and R6 is a hydrogen or a (C1-C3)alkyl group.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中R 1是（C 1 -C 6）烷基或（C 3 -C 6）环烷基; R2是（C1-C6）烷基，（C3-C6）环烷基，（C1-C6）烯基，（C1-C6）氟烷基，（C1-C3）氟烷氧基或（C1-C6）烷氧基（C1-C6）烷基，取代：（i）具有一至三个羟基，或（ii）与NR a R b基团，其中R a和R b独立地是氢原子或（C 1 -C 3）烷基; 或被一至三个羟基取代的吡咯烷基甲基; R9与R2或氢相同; R 2和R 9独立地可以被-OCOR 3基团取代，其中R 3是天然或非天然氨基酸衍生物或哌啶基; 或者，R2和R9一起形成杂环化合物; X和Y独立地是可取代的苯基或杂芳基，杂芳基是噻吩基，吡啶基，嘧啶基，噻唑基，吡咯基或呋喃基; R6为氢或（C1-C3）烷基。

5. 发明申请

US20120184557A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 有权
标题翻译：吡咯并[1,5-A] -1,3,5-三嗪衍生物，其制备方法及其治疗方法
公开(公告)号：US20120184557A1
公开(公告)日：2012-07-19
申请号：US13203427
申请日：2010-03-11
申请人： Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
发明人： Laurent Meijer , Hervé Galons , Benoit Joseph , Florence Popowycz , Nassima Oumata
IPC分类号： A61K31/53 , A61P35/00 , A61P25/28 , A61P25/08 , A61P29/00 , A61P33/00 , A61P31/12 , A61P31/14 , A61P3/10 , A61P25/00 , A61P13/12 , C07D487/04 , A61P19/02
CPC分类号： C07D487/04
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 is a (C1-C6)alkyl or (C3-C6)cycloalkyl group; R2 is a (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkenyl, (C1-C6)fluoroalkyl, (C1-C3)fluoroalkoxy, or (C1-C6)alkoxy(C1-C6)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRaRb group, where Ra and Rb are independently a hydrogen atom or a (C1-C3)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; R9 is the same as R2 or hydrogen; the R2 and R9 groups independently being substitutable with an —OCOR3 group, where R3 is a natural or unnatural amino acid derivative or a piperidyl group; alternatively, R2 and R9 together form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and R6 is a hydrogen or a (C1-C3)alkyl group.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中R 1是（C 1 -C 6）烷基或（C 3 -C 6）环烷基; R2是（C1-C6）烷基，（C3-C6）环烷基，（C1-C6）烯基，（C1-C6）氟烷基，（C1-C3）氟烷氧基或（C1-C6）烷氧基（C1-C6）烷基，取代：（i）具有一至三个羟基，或（ii）与NR a R b基团，其中R a和R b独立地是氢原子或（C 1 -C 3）烷基; 或被一至三个羟基取代的吡咯烷基甲基; R9与R2或氢相同; R 2和R 9独立地可以被-OCOR 3基团取代，其中R 3是天然或非天然氨基酸衍生物或哌啶基; 或者，R2和R9一起形成杂环化合物; X和Y独立地是可取代的苯基或杂芳基，杂芳基是噻吩基，吡啶基，嘧啶基，噻唑基，吡咯基或呋喃基; R6为氢或（C1-C3）烷基。

6. 发明申请

US20150148455A1 DISPERSING POLYMERS WITH IMPROVED THERMAL STABILITY 有权
标题翻译：具有改进的热稳定性的分散聚合物
公开(公告)号：US20150148455A1
公开(公告)日：2015-05-28
申请号：US14238190
申请日：2012-08-09
申请人： Alexandre Desseroir , Philippe Maitrasse , Marc Lemaire , Florence Popowycz , PIERRE Labourt-Ibarre
发明人： Alexandre Desseroir , Philippe Maitrasse , Marc Lemaire , Florence Popowycz , PIERRE Labourt-Ibarre
IPC分类号： C04B24/26 , C08J3/12 , C08F120/06
CPC分类号： C04B24/2647 , C04B24/2658 , C04B2103/006 , C04B2103/408 , C04B2103/52 , C08F8/14 , C08F8/30 , C08F8/32 , C08F120/06 , C08F2220/285 , C08G81/025 , C08J3/12 , C08J3/21 , C08J2333/02 , C08J2333/04 , C08J2333/06 , C08K5/005 , C08K5/18
摘要： The invention relates mainly to a polymer comprising a hydrocarbon-based main chain bearing carboxylic groups and polyalkoxylated chains and up to 4% by weight of anti-oxidant groups, relative to the weight of the final polymer, grafted to the main chain. It also relates to a method for preparing such a polymer and to an admixture which is of use as a plasticizer of suspensions of mineral particles comprising same. Finally, it is related to the use of such a polymer for fluidifying suspensions of mineral particles and reducing the water demand of hydraulic compositions.
摘要翻译：本发明主要涉及一种聚合物，其包含相对于接枝到主链上的最终聚合物重量的含有羧基和聚烷氧基化链的烃基主链和最多达4重量％的抗氧化剂基团的聚合物。它还涉及一种制备这种聚合物的方法和一种混合物，其可用作包含其的矿物颗粒的悬浮液的增塑剂。最后，它涉及使用这种聚合物来流化矿物颗粒的悬浮液并降低水硬性组合物的用水需求。

7. 发明授权

US09546111B2 Dispersing polymers with improved thermal stability 有权
标题翻译：具有改善的热稳定性的分散聚合物
公开(公告)号：US09546111B2
公开(公告)日：2017-01-17
申请号：US14238190
申请日：2012-08-09
申请人： Alexandre Desseroir , Philippe Maitrasse , Marc Lemaire , Florence Popowycz , Pierre Labourt-Ibarre
发明人： Alexandre Desseroir , Philippe Maitrasse , Marc Lemaire , Florence Popowycz , Pierre Labourt-Ibarre
IPC分类号： C08F120/06 , C04B24/26 , C08G81/02 , C08J3/21 , C08F8/14 , C08F8/30 , C08F8/32 , C08J3/12 , C08K5/00 , C04B103/00 , C04B103/40 , C04B103/52 , C08F220/28 , C08K5/18
CPC分类号： C04B24/2647 , C04B24/2658 , C04B2103/006 , C04B2103/408 , C04B2103/52 , C08F8/14 , C08F8/30 , C08F8/32 , C08F120/06 , C08F2220/285 , C08G81/025 , C08J3/12 , C08J3/21 , C08J2333/02 , C08J2333/04 , C08J2333/06 , C08K5/005 , C08K5/18
摘要： The invention relates mainly to a polymer comprising a hydrocarbon-based main chain bearing carboxylic groups and polyalkoxylated chains and up to 4% by weight of anti-oxidant groups, relative to the weight of the final polymer, grafted to the main chain. It also relates to a method for preparing such a polymer and to an admixture which is of use as a plasticizer of suspensions of mineral particles comprising same. Finally, it is related to the use of such a polymer for fluidifying suspensions of mineral particles and reducing the water demand of hydraulic compositions.
摘要翻译：本发明主要涉及一种聚合物，其包含相对于接枝到主链上的最终聚合物重量的含有羧基和聚烷氧基化链的基于烃的主链和高达4重量％的抗氧化剂基团的聚合物。它还涉及一种制备这种聚合物的方法和一种混合物，其可用作包含其的矿物颗粒的悬浮液的增塑剂。最后，它涉及使用这种聚合物来流化矿物颗粒的悬浮液并降低水硬性组合物的用水需求。

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