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1. 发明申请

US20130253426A1 ELUTING MEDICAL DEVICES 有权
标题翻译：医用器械
公开(公告)号：US20130253426A1
公开(公告)日：2013-09-26
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Krazler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

2. 发明授权

US09415193B2 Eluting medical devices 有权
标题翻译：洗脱医疗器械
公开(公告)号：US09415193B2
公开(公告)日：2016-08-16
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
IPC分类号： A61M25/10 , A61L29/08 , A61L29/16
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译：本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

3. 发明授权

US5029960A Fiber optic canister with compliant baselayer 失效
标题翻译：光纤罐具有兼容的基底层
公开(公告)号：US5029960A
公开(公告)日：1991-07-09
申请号：US574577
申请日：1990-08-27
申请人： George H. Hulderman , Gary R. Redford , Gregory LoStracco
发明人： George H. Hulderman , Gary R. Redford , Gregory LoStracco
IPC分类号： G02B6/00 , B65H55/00 , B65H75/10 , G02B6/44
CPC分类号： B65H55/00 , G02B6/4457
摘要： A fiber optic cannister includes a compliant baselayer underlying layers of an optical fiber wound onto a bobbin. The compliant material is useful to form a base layer over which the layers of optical fiber are wound. The use of such a compliant baselayer eliminates the need to fabricate and stock expensive baselayer wire material.
摘要翻译：纤维光纤插座包括缠绕在线轴上的光纤的层之下的柔性基底层。顺应性材料可用于形成其上缠绕有光纤层的基底层。使用这种符合标准的底层消除了制造和储存昂贵的基底线材料的需要。

4. 发明授权

US5594829A Optical fiber dispenser with thermal expansion accommodation layer 失效
标题翻译：具有热膨胀调节层的光纤分配器
公开(公告)号：US5594829A
公开(公告)日：1997-01-14
申请号：US478297
申请日：1995-06-07
申请人： Gregory LoStracco , Ronald B. Chesler , Hui-Pin Hsu
发明人： Gregory LoStracco , Ronald B. Chesler , Hui-Pin Hsu
IPC分类号： G02B6/00 , G02B6/44 , G02B6/36
CPC分类号： G02B6/4457
摘要： An optical fiber dispenser (40) includes a bobbin (42), an optical fiber pack (52) overlying the bobbin (42), and a thermal expansion accommodation layer (50) positioned between the bobbin (42) and the optical fiber pack (52 ). The thermal expansion accommodation layer (50) is made of a material, such as a silicone elastomer, that is readily deformable to accommodate the different longitudinal coefficients of thermal expansion of the bobbin (42) and the optical fiber pack (52). The thermal expansion accommodation layer (50) has a thickness, typically more than about 1/8 inch for a conventional bobbin size, sufficient to reduce any thermal stresses produced by the different longitudinal coefficients of thermal expansion to less than the failure strength of the optical fiber pack (52).
摘要翻译：光纤分配器（40）包括线轴（42），覆盖线轴（42）的光纤组件（52）和位于线轴（42）和光纤组件（42）之间的热膨胀容纳层（50） 52）。热膨胀容纳层（50）由诸如硅氧烷弹性体的材料制成，其容易变形以适应线轴（42）和光纤组件（52）的不同纵向热膨胀系数。对于传统的筒管尺寸，热膨胀容纳层（50）具有通常大于约+ E，fra 1/8 + EE英寸的厚度，足以将由不同纵向热膨胀系数产生的任何热应力减小到小于光纤组件（52）的故障强度。

5. 发明授权

US5067665A Base layer for an optical fiber wound pack 失效
标题翻译：用于光纤缠绕包的基层
公开(公告)号：US5067665A
公开(公告)日：1991-11-26
申请号：US611811
申请日：1990-11-13
申请人： Gregory LoStracco , George W. LeCompte
发明人： Gregory LoStracco , George W. LeCompte
IPC分类号： B65H75/10 , B65H55/04 , B65H75/26 , F41A35/00 , F41F3/055 , G02B6/00
CPC分类号： B65H75/265 , B65H55/04
摘要： A winding form baselayer (20) has a flexible insulative substrate (22) on which a plurality of parallel spaced apart filament cable guides (24) are located. Optionally, the guides (24) can be formed by depositing a metal layer and etching out spaces (W) between the guides or plating the individual guides. A wound pack (28) is produced by winding a first filament layer (26) into the spaces (W) with subsequent layers wound over the first layer in conventional manner. In an alternate version, the filament cable guides (52) are etched into the top side of a metal sheet and the opposite side is etched into a diagonally arranged set of struts (56) which provide lateral resiliency for the entire baselayer (46).

6. 发明授权

US5211789A Optical cable composite-material bobbin with grooved base layer 失效
标题翻译：光缆复合材料BOBBIN带有基底层
公开(公告)号：US5211789A
公开(公告)日：1993-05-18
申请号：US551220
申请日：1990-07-11
申请人： John F. Christian , Daniel Schotter , Gregory LoStracco
发明人： John F. Christian , Daniel Schotter , Gregory LoStracco
IPC分类号： B65H75/10 , B65H75/26 , B65H75/50 , G02B6/00 , G02B6/44
CPC分类号： B65H75/265 , B65H75/50 , G02B6/4457 , B65H2701/32
摘要： A composite bobbin (10) for use in an optical fiber canister has a surface with a spirally groove base layer (38) in which the first layer of an optical cable (42) is wound. The base layer (38) is prepared by coating the external surface of a central portion (12) of the bobbin (10) with an adhesive layer (16) of a curable two-stage epoxy, winding a tensioned wire (22) in a spiral pattern along the length of the central portion (12), and heating the bobbin (10) to cure the epoxy. The proper combination of tension and curing cycle permits the grooves of the base layer (38) to be formed to a depth of about 1/3 of the diameter of the optical cable (42).

7. 发明授权

US5607532A Use of ultraviolet-curable adhesive in preparation of optical fiber dispensers 失效
标题翻译：使用紫外线固化胶粘剂制备光纤分配器
公开(公告)号：US5607532A
公开(公告)日：1997-03-04
申请号：US478304
申请日：1995-06-07
申请人： Gregory LoStracco
发明人： Gregory LoStracco
IPC分类号： G02B6/00 , C09J5/00 , C09J5/06 , G02B6/44 , G02B6/04
CPC分类号： G02B6/4457
摘要： An optical fiber pack (42) having layers (52) of optical fiber (22) is formed on a bobbin (32) using an ultravlolet-curable adhesive. A layer (50) of a UV-curable adhesive is deposited, and a length of the optical fiber (52) is wound over the layer (50) of ultraviolet-curable adhesive. Ultraviolet radiation is directed at the layer (50) of ultraviolet-curable adhesive through the layer (52) of optical fiber wound over the layer (50) of adhesive, to cure the adhesive. The approach can be used, for example, to apply adhesive to entire layers of the optical fiber, or to tack the ends of the optical fiber layers into place.
摘要翻译：具有光纤（22）的层（52）的光纤组件（42）使用超弹性固化型粘合剂形成在线轴（32）上。沉积紫外线固化型粘合剂层（50），将光纤（52）的长度卷绕在紫外线固化型粘合剂层（50）上。紫外线辐射通过缠绕在粘合剂层（50）上的光纤层（52）指向紫外线固化粘合剂层（50），以固化粘合剂。该方法可以用于例如将粘合剂施加到光纤的整个层，或者将光纤层的端部固定到位。

8. 发明授权

US5220632A Preparation of an optical fiber canister 失效
标题翻译：光纤罐的制备
公开(公告)号：US5220632A
公开(公告)日：1993-06-15
申请号：US903394
申请日：1992-06-24
申请人： Gregory LoStracco
发明人： Gregory LoStracco
IPC分类号： B65H75/26 , G02B6/44
CPC分类号： B65H75/265 , G02B6/4457
摘要： A method for preparing an optical fiber canister includes providing a length of a wire (44) having a diameter of about that of the optical fiber (60), and winding the wire (44) onto a mandrel (40) in a preselected winding pattern to form a base layer (46). A replicating strip (48) having a flexible substrate (50) with a patterning layer (52) of b-staged epoxy on one side thereof is provided, and the patterning layer (52) is pressed against the base layer (46) to form a groove pattern (62) in the patterning layer (52). The b-staged epoxy layer (52) is cured to harden it to preserve the groove pattern, and then the flexible substrate (50) is applied to an optical fiber bobbin (56) with the grooved patterning layer (52) facing outwardly. An optical fiber (60) is wound into the groove (62) of the patterning layer (52) to form an optical fiber pack (66).
摘要翻译：一种制备光纤罐的方法，包括提供直径大约为光导纤维（60）直径的线（44）的长度，并以预选的卷绕图案将线（44）缠绕在心轴（40）上以形成基底层（46）。提供了具有柔性基板（50）的复制带（48），其上具有一侧上具有b阶环氧树脂的图案化层（52），并且图案化层（52）被压靠在基层（46）上以形成图形层（52）中的凹槽图案（62）。固化b阶环氧树脂层（52）以使其硬化以保持凹槽图案，然后将柔性基底（50）施加到具有面向外的凹槽图案层（52）的光纤线轴（56）上。光纤（60）被卷绕到图形层（52）的凹槽（62）中以形成光纤组件（66）。

9. 发明授权

US5022602A Fiber dispenser 失效
标题翻译：光纤分配器
公开(公告)号：US5022602A
公开(公告)日：1991-06-11
申请号：US425768
申请日：1989-10-23
申请人： Gregory LoStracco
发明人： Gregory LoStracco
IPC分类号： F42B15/04 , B65H55/00 , B65H63/00 , F41G7/32 , G02B6/00 , G02B6/44
CPC分类号： G02B6/4457 , B65H55/00 , F41G7/32 , Y10S242/909
摘要： A fiber dispenser 10 which provides a bobbin 12 with an expansion ring 30 mounted on an end thereof. The expansion ring 30 is coaxial with the bobbin 12 and permits the use of a nontapered bobbin for high speed dispensation applications. In a specific embodiment, the invention includes a mechanism for adjusting the diameter of the expansion ring as the fiber is dispensed. A further, more specific embodiment includes a mechanism 42, 44 for adjusting the longitudinal position of the expansion ring 30 as the fiber 21 is wound thereon.

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