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1. 发明申请

US20170312520A9 INTRACARDIAC IMPEDANCE AND ITS APPLICATIONS 审中-公开
公开(公告)号：US20170312520A9
公开(公告)日：2017-11-02
申请号：US13888835
申请日：2013-05-07
申请人： CARDIAC PACEMAKERS, INC.
发明人： Yunlong Zhang , James O. Gilkerson , Yongxing Zhang , Loell Boyce Moon
IPC分类号： A61N1/362 , A61B5/053 , A61B5/00 , A61B5/0464 , A61B5/02 , A61B5/046 , A61B5/024 , A61B5/0402 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/02028 , A61B5/02444 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61B5/0538 , A61B5/686 , A61B5/6869 , A61B5/7239 , A61B5/7242 , A61B5/7282 , A61N1/36521 , A61N1/3962
摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

2. 发明授权

US09364154B2 Differentiating decompensation detection based on co-morbidities in heart failure 有权
公开(公告)号：US09364154B2
公开(公告)日：2016-06-14
申请号：US14714402
申请日：2015-05-18
申请人： Cardiac Pacemakers, Inc.
发明人： Haresh G. Sachanandani , Yunlong Zhang
IPC分类号： A61B5/0205 , A61B5/042 , A61B5/08 , A61B5/00 , A61N1/39 , A61B5/02 , A61B5/021 , A61B5/029 , A61B5/11 , A61B7/02 , A61B5/087 , A61B7/04 , A61B5/0245 , A61B5/145 , A61N1/362 , A61B5/053
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/02 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/02455 , A61B5/029 , A61B5/0408 , A61B5/042 , A61B5/0538 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/1118 , A61B5/145 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B7/02 , A61B7/04 , A61N1/3627 , A61N1/3704 , A61N1/3956 , G06F19/00
摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

3. 发明授权

US08644916B2 Differentiating decompensation detection based on co-morbidities in heart failure 有权
标题翻译：基于心力衰竭合并症的差异代偿失调检测
公开(公告)号：US08644916B2
公开(公告)日：2014-02-04
申请号：US13848869
申请日：2013-03-22
申请人： Cardiac Pacemakers, Inc.
发明人： Haresh G. Sachanandani , Yunlong Zhang
IPC分类号： A61B5/04
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/02 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/02455 , A61B5/029 , A61B5/0408 , A61B5/042 , A61B5/0538 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/1118 , A61B5/145 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B7/02 , A61B7/04 , A61N1/3627 , A61N1/3704 , A61N1/3956 , G06F19/00
摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.
摘要翻译：该文件尤其涉及一种包括传感器信号处理器的系统，该传感器信号处理器被配置为接收由多个传感器产生的多个电传感器信号和由可植入传感器产生的至少一个传感器信号，存储器包括指示co 根据所指示的并发症，从所述多个传感器信号中选择要监视的传感器信号的传感器信号选择电路，根据所述传感器信号选择电路调整所选择的传感器信号的检测阈值的阈值调整电路，指示的并发症，以及决定电路，其将所调整的检测阈值应用于所选择的传感器信号，以确定与受试者中是否发生与恶化的心力衰竭（HF）有关的事件，并且输出与恶化HF相关的事件的指示发生在用户或进程。

4. 发明申请

US20130211266A1 DIFFERENTIATING DECOMPENSATION DETECTION BASED ON CO-MORBIDITIES IN HEART FAILURE 有权
公开(公告)号：US20130211266A1
公开(公告)日：2013-08-15
申请号：US13848869
申请日：2013-03-22
申请人： Cardiac Pacemakers, Inc.
发明人： Haresh G. Sachanandani , Yunlong Zhang
IPC分类号： A61B5/0205
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/02 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/02455 , A61B5/029 , A61B5/0408 , A61B5/042 , A61B5/0538 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/1118 , A61B5/145 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B7/02 , A61B7/04 , A61N1/3627 , A61N1/3704 , A61N1/3956 , G06F19/00
摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

5. 发明授权

US09026201B2 Methods and apparatuses for detection of myocardial ischemia upon exertion 有权
标题翻译：用于检测心肌缺血的方法和装置
公开(公告)号：US09026201B2
公开(公告)日：2015-05-05
申请号：US13686305
申请日：2012-11-27
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
IPC分类号： A61B5/0468 , A61B5/083 , A61B5/0205 , A61B5/0215 , A61B5/03 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/4519
摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.
摘要翻译：本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较，以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

6. 发明申请

US20130331919A1 SYSTEM FOR STIMULATING AUTONOMIC TARGETS FROM PULMONARY ARTERY 审中-公开
公开(公告)号：US20130331919A1
公开(公告)日：2013-12-12
申请号：US13964807
申请日：2013-08-12
申请人： Cardiac Pacemakers, Inc.
发明人： Yunlong Zhang , Haresh G. Sachanandani , Dan Li , Bin Mi
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61B5/4035 , A61B5/6862 , A61B5/6876 , A61N1/057 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/37211 , A61N1/37288
摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

7. 发明申请

US20130085401A1 METHODS AND APPARATUSES FOR DETECTION OF MYOCARDIAL ISCHEMIA UPON EXERTION 审中-公开
标题翻译：用于检测心肌梗塞的方法和装置
公开(公告)号：US20130085401A1
公开(公告)日：2013-04-04
申请号：US13686305
申请日：2012-11-27
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/4519
摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.
摘要翻译：本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较，以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

8. 发明申请

US20140336521A1 INTRACARDIAC IMPEDANCE AND ITS APPLICATIONS 审中-公开
标题翻译：肠梗阻及其应用
公开(公告)号：US20140336521A1
公开(公告)日：2014-11-13
申请号：US13888835
申请日：2013-05-07
申请人： CARDIAC PACEMAKERS, INC.
发明人： Yunlong Zhang , James O. Gilkerson , Yongxing Zhang , Loell Boyce Moon
IPC分类号： A61N1/362 , A61B5/046 , A61B5/024 , A61N1/365 , A61B5/0464
CPC分类号： A61N1/3627 , A61B5/02028 , A61B5/02444 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61B5/0538 , A61B5/686 , A61B5/6869 , A61B5/7239 , A61B5/7242 , A61B5/7282 , A61N1/36521 , A61N1/3962
摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.
摘要翻译：测量心内阻抗的系统包括可植入电极和医疗装置。电极感测受试者心脏的电信号。医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。心脏信号感测电路提供感测的心脏信号。阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

9. 发明授权

US09839781B2 Intracardiac impedance and its applications 有权
公开(公告)号：US09839781B2
公开(公告)日：2017-12-12
申请号：US13888835
申请日：2013-05-07
申请人： Cardiac Pacemakers, Inc.
发明人： Yunlong Zhang , James O. Gilkerson , Yongxing Zhang , Loell Boyce Moon
IPC分类号： A61N1/00 , A61N1/362 , A61B5/0464 , A61B5/024 , A61B5/046 , A61B5/00 , A61B5/02 , A61B5/053 , A61N1/365 , A61B5/0402 , A61N1/39
CPC分类号： A61N1/3627 , A61B5/02028 , A61B5/02444 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61B5/0538 , A61B5/686 , A61B5/6869 , A61B5/7239 , A61B5/7242 , A61B5/7282 , A61N1/36521 , A61N1/3962
摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

10. 发明申请

US20170100080A1 DIFFERENTIATING DECOMPENSATION DETECTION BASED ON CO-MORBIDITIES IN HEART FAILURE 审中-公开
公开(公告)号：US20170100080A1
公开(公告)日：2017-04-13
申请号：US15384535
申请日：2016-12-20
申请人： Cardiac Pacemakers, Inc.
发明人： Haresh G. Sachanandani , Yunlong Zhang
IPC分类号： A61B5/00 , A61N1/362 , A61N1/39 , A61B5/0205 , A61B7/04 , A61N1/37 , A61B5/02
CPC分类号： A61B5/7275 , A61B5/0002 , A61B5/02 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/02455 , A61B5/029 , A61B5/0408 , A61B5/042 , A61B5/0538 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/1118 , A61B5/145 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B7/00 , A61B7/02 , A61B7/04 , A61N1/3627 , A61N1/3704 , A61N1/3956 , G16H40/63 , G16H50/30
摘要： This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

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