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1. 发明授权

US5897577A Pacing lead impedance monitoring circuit and method 失效
标题翻译：起搏线阻抗监测电路及方法
公开(公告)号：US5897577A
公开(公告)日：1999-04-27
申请号：US965801
申请日：1997-11-07
申请人： Can Cinbis , James D. Reinke , Todd M. Tanji
发明人： Can Cinbis , James D. Reinke , Todd M. Tanji
IPC分类号： A61N1/37
CPC分类号： A61N1/3706
摘要： A circuit for determining lead impedance during the time a pacing or other stimulating electrical pulse is being delivered measures current and voltage simultaneously to check for open circuits or short circuits based on different thresholds. The detection of a bad lead can force a double pulse to be delivered in real time in a unipolar configuration. Switching from unipolar to bipolar configuration based on detecting a bad bipolar circuit can be supported.
摘要翻译：用于在起搏或其它刺激电脉冲输送期间确定引线阻抗的电路同时测量电流和电压，以根据不同的阈值检查开路或短路。不良引线的检测可以强制双脉冲在单极配置下实时传输。可以支持基于检测不良双极电路从单极性转换为双极配置。

2. 发明授权

US5910156A Non-physiologic sense detection for implantable medical devices 失效
标题翻译：用于可植入医疗器械的非生理检测
公开(公告)号：US5910156A
公开(公告)日：1999-06-08
申请号：US966107
申请日：1997-11-07
申请人： Can Cinbis , James D. Reinke , Todd M. Tanji
发明人： Can Cinbis , James D. Reinke , Todd M. Tanji
IPC分类号： A61N1/37
CPC分类号： A61N1/3704
摘要： Method and apparatus for detection of non-physiologic senses checks the output of the sense amplifier of an implanted medical device where the inputs of the sense amplifier are adapted to connect to a living body for sensing electrical signals representative of physiologic events, and especially heart beats, and if that sense output senses a physiologic event within a predetermined time after a non-physiologic event is sensed by another circuit also connected to receive electrical signals from said living body, then there is reported out a signal indicating that the event sensed by the sense amplifier is of a non-physiologic nature. Various uses are accomplished with the information in these output signals.
摘要翻译：用于检测非生理感觉的方法和装置检查植入医疗装置的感测放大器的输出，其中感测放大器的输入适于连接到活体，用于感测代表生理事件的电信号，特别是心跳并且如果该感测输出在非连接事件之后的预定时间内感测到生理事件，该另一电路也被连接以接收来自所述活体的电信号，则报告出一个信号，该信号指示由感觉放大器具有非生理性质。这些输出信号中的信息可以实现各种用途。

3. 发明申请

US20100185262A1 CO-LOCATION OF EMITTERS AND DETECTORS AND METHOD OF OPERATION 有权
标题翻译：发射器和探测器的合作位置及其操作方法
公开(公告)号：US20100185262A1
公开(公告)日：2010-07-22
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61N1/08 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少另一个作为光检测组件进行操作

4. 发明申请

US20090270953A1 Optical Device 有权
标题翻译：光学设备
公开(公告)号：US20090270953A1
公开(公告)日：2009-10-29
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
IPC分类号： A61N5/06 , H01L31/12
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

5. 发明授权

US08452402B2 Optical sensing device for use in a medical device 有权
标题翻译：用于医疗设备的光学感测装置
公开(公告)号：US08452402B2
公开(公告)日：2013-05-28
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
IPC分类号： A61B5/1455
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

6. 发明授权

US08275435B2 Co-location of emitters and detectors and method of operation 有权
标题翻译：发射器和探测器的共同定位和操作方法
公开(公告)号：US08275435B2
公开(公告)日：2012-09-25
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test.
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少一个以作为光检测组件进行操作。

7. 发明授权

US08515559B2 Communication dipole for implantable medical device 有权
标题翻译：用于可植入医疗器械的通信偶极子
公开(公告)号：US08515559B2
公开(公告)日：2013-08-20
申请号：US13359886
申请日：2012-01-27
申请人： Jonathan P. Roberts , Can Cinbis , David J. Peichel , James C. Allan , James D. Reinke , Kamal Deep Mothilal , Erik Griswold , George Patras
发明人： Jonathan P. Roberts , Can Cinbis , David J. Peichel , James C. Allan , James D. Reinke , Kamal Deep Mothilal , Erik Griswold , George Patras
IPC分类号： A61N1/00
CPC分类号： A61N1/37205 , A61B5/0028 , A61B5/0031 , A61B5/0215 , A61B5/6876 , A61B5/6882 , A61B2562/0247 , A61N1/37217 , H04B13/005
摘要： This disclosure is directed to an implantable medical device having a communication dipole configured in accordance with the techniques described herein. In one example, the disclosure is directed to an implantable medical device comprising a housing that encloses at least a communication module, a first electrode of a communication dipole electrically coupled to the communication module and an electrically conductive fixation mechanism that is electrically coupled to a portion of the housing and wherein a portion of the fixation mechanism is configured to function as at least part of a second electrode of the communication dipole. The electrically conductive fixation mechanism includes a dielectric material that covers at least part of a surface of the fixation mechanism. The communication module is configured to transmit or receive a modulated signal between the first electrode and second electrode of the communication dipole.
摘要翻译：本公开涉及具有根据本文所描述的技术配置的通信偶极子的可植入医疗装置。在一个示例中，本公开涉及可植入医疗装置，其包括壳体，该壳体至少包围通信模块，电耦合到通信模块的通信偶极子的第一电极和电连接到通信模块的部分的导电固定机构并且其中所述固定机构的一部分被配置为用作所述通信偶极子的第二电极的至少一部分。导电固定机构包括覆盖固定机构的表面的至少一部分的电介质材料。通信模块被配置为在通信偶极子的第一电极和第二电极之间发送或接收调制信号。

8. 发明申请

US20120197350A1 COMMUNICATION DIPOLE FOR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于可植入医疗器械的通信用DIPOLE
公开(公告)号：US20120197350A1
公开(公告)日：2012-08-02
申请号：US13359886
申请日：2012-01-27
申请人： Jonathan P. Roberts , Can Cinbis , David J. Peichel , James C. Allan , James D. Reinke , Kamal Deep Mothilal , Erik Griswold , George Patras
发明人： Jonathan P. Roberts , Can Cinbis , David J. Peichel , James C. Allan , James D. Reinke , Kamal Deep Mothilal , Erik Griswold , George Patras
IPC分类号： A61N1/08
CPC分类号： A61N1/37205 , A61B5/0028 , A61B5/0031 , A61B5/0215 , A61B5/6876 , A61B5/6882 , A61B2562/0247 , A61N1/37217 , H04B13/005
摘要： This disclosure is directed to an implantable medical device having a communication dipole configured in accordance with the techniques described herein. In one example, the disclosure is directed to an implantable medical device comprising a housing that encloses at least a communication module, a first electrode of a communication dipole electrically coupled to the communication module and an electrically conductive fixation mechanism that is electrically coupled to a portion of the housing and wherein a portion of the fixation mechanism is configured to function as at least part of a second electrode of the communication dipole. The electrically conductive fixation mechanism includes a dielectric material that covers at least part of a surface of the fixation mechanism. The communication module is configured to transmit or receive a modulated signal between the first electrode and second electrode of the communication dipole.
摘要翻译：本公开涉及具有根据本文所描述的技术配置的通信偶极子的可植入医疗装置。在一个示例中，本公开涉及可植入医疗装置，其包括壳体，该壳体至少包围通信模块，电耦合到通信模块的通信偶极子的第一电极和电连接到通信模块的部分的导电固定机构并且其中所述固定机构的一部分被配置为用作所述通信偶极子的第二电极的至少一部分。导电固定机构包括覆盖固定机构的表面的至少一部分的电介质材料。通信模块被配置为在通信偶极子的第一电极和第二电极之间发送或接收调制信号。

9. 发明授权

US10179242B2 Tissue oxygenation monitoring in heart failure 有权
公开(公告)号：US10179242B2
公开(公告)日：2019-01-15
申请号：US12797815
申请日：2010-06-10
申请人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
发明人： Can Cinbis , James K. Carney , Jonathan L. Kuhn , David A. Anderson
IPC分类号： A61N1/36 , A61B5/145 , A61N1/365
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.

10. 发明授权

US09636059B2 Implantable tissue perfusion sensing system and method 有权
公开(公告)号：US09636059B2
公开(公告)日：2017-05-02
申请号：US13612967
申请日：2012-09-13
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： G01N33/46 , G01N31/00 , C12M1/00 , A61B5/1459 , A61B5/00 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/145 , A61N1/39
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

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