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1. 发明申请

US20190000432A1 VASCULAR CLOSURE WITH MULTIPLE CONNECTIONS 审中-公开
公开(公告)号：US20190000432A1
公开(公告)日：2019-01-03
申请号：US16126262
申请日：2018-09-10
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Ram H. Paul, JR. , Dennis Griffin
IPC分类号： A61B17/00
摘要： Among other things, methods and apparatus for inserting devices for closing a tissue opening are disclosed. An anchoring or sealing member has one or more stems and/or filaments that are offset from the center of the member, so that lateral adjustments or movements of the anchoring or sealing member do not uncover the opening, cause the anchoring or sealing member to stick through or pull through the opening. Embodiments including a valve adapted to accommodate a guide wire for addressing emergencies are also disclosed.

2. 发明申请

US20170189001A1 VASCULAR CLOSURE DEVICE SUTURE TENSION LIMITING AND INDICATION MECHANISM 审中-公开
公开(公告)号：US20170189001A1
公开(公告)日：2017-07-06
申请号：US15468875
申请日：2017-03-24
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Ram H. Paul, JR.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00623 , A61B2017/00654 , A61B2017/00659 , A61B2017/00862 , A61B2090/064 , A61B2090/0807
摘要： Disclosed is an apparatus and system that includes an elongated body, a vascular closure device that can occlude a hole in a vessel wall coupled to a distal end of the elongated body, a sleeve assembly and a biasing member arranged to elastically deform coupled between the elongated body and the sleeve assembly, wherein the vascular closure device is pliant and is deformable to fit with the sleeve assembly but is too large to fit within the sleeve assembly without deforming it and where application of tension to the elongated body by retracting the sleeve assembly away from the deployed vascular closure device elastically deforms the biasing member and exerts a force on the vascular closure device.

3. 发明申请

US20210154031A1 DETACHABLE AND RETRIEVABLE STENTS FOR THERAPEUTIC AGENT DELIVERY 有权
公开(公告)号：US20210154031A1
公开(公告)日：2021-05-27
申请号：US17096056
申请日：2020-11-12
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Alec E. Cerchiari , Brian Feng , Timothy Foley , Christopher Mobley , Gary Neff , Ram H. Paul, JR.
IPC分类号： A61F2/88 , A61F2/95
摘要： The present embodiments provide systems and methods for treating a medical condition. In one embodiment, the system comprises a stent having proximal and distal regions, and further having a delivery state and an expanded state. A therapeutic agent is disposed on a segment of the stent. The stent is disposed around an exterior surface of a core assembly in the delivery state. A coupling assembly releasably secures the proximal region of the stent to the exterior surface of the core assembly. The coupling assembly secures the stent to the core assembly for a predetermined period while the stent is in the expanded state and during release of the therapeutic agent at a target site. The coupling assembly further enables the stent to be disengaged from the core assembly and deployed in a bodily passageway.

4. 发明申请

US20170340434A1 DEVICE USEFUL FOR LOCALIZED THERAPEUTIC DELIVERY WITHOUT FLOW OBSTRUCTION 审中-公开
公开(公告)号：US20170340434A1
公开(公告)日：2017-11-30
申请号：US15603122
申请日：2017-05-23
申请人： Cook Medical Technologies LLC
发明人： Alec E. Cerchiari , Gary L. Neff , Brent A. Mayle , James C. Merk , Sean D. Chambers , Ram H. Paul, JR. , Seoggwan Kim , Richard A. Swift
IPC分类号： A61F2/07 , A61M31/00 , A61B17/12 , A61M25/00 , A61F2/966
CPC分类号： A61F2/07 , A61B17/12036 , A61B17/12109 , A61B17/12118 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61F2/966 , A61F2002/068 , A61F2002/077 , A61F2002/825 , A61F2002/91575 , A61F2230/001 , A61F2230/0067 , A61F2250/0039 , A61F2250/0059 , A61F2250/0067 , A61M25/002 , A61M25/0026 , A61M25/1002 , A61M31/00 , A61M31/005 , A61M2025/0037 , A61M2025/1052
摘要： Medical devices and methods are provided. In some aspects, devices useful for applying therapy locally within a body vessel are disclosed, the devices having a stent graft with flared end regions with a catheter providing fluid communication to the outer side of the narrower, intermediate region of the stent graft. Kits and systems including the same devices and methods are also disclosed.

5. 发明申请

US20160262737A1 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：US20160262737A1
公开(公告)日：2016-09-15
申请号：US15062749
申请日：2016-03-07
申请人： Cook Medical Technologies LLC , Cook Biotech Incorporated
发明人： Ram H. Paul, JR. , Cleon Stanley , Brian L. Bates , F. Joseph Obermiller , Thomas A. Osborne , Sean D. Chambers
IPC分类号： A61B17/00
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

6. 发明申请

US20140277116A1 DELIVERY SYSTEM FOR TISSUE OPENING CLOSURES 有权
标题翻译：用于组织开放闭合的递送系统
公开(公告)号：US20140277116A1
公开(公告)日：2014-09-18
申请号：US14211513
申请日：2014-03-14
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Tyler J. Bunch , Jonathan Lee Bennett , Ram H. Paul, JR. , Brian L. Bates
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/0483 , A61B2017/00575 , A61B2017/0061 , A61B2017/00623 , A61B2017/0496 , A61B2090/037
摘要： Among other things, methods and apparatus for inserting devices for closing tissue openings are disclosed. Examples may include a handle, sheath and/or sleeve for insertion into a patient and through or adjacent a tissue defect, fistula, or other tissue opening to be closed. Winding mechanisms for operation in or with such inserting devices are also described.
摘要翻译：其中包括用于插入用于封闭组织开口的装置的方法和装置。实例可以包括用于插入患者体内并通过或邻近组织缺损，瘘管或其他要关闭的组织开口的手柄，护套和/或套筒。还描述了用于在这种插入装置中进行操作的绕线机构。

7. 发明申请

US20140277113A1 VASCULAR CLOSURE DEVICE SUTURE TENSION LIMITING AND INDICATION MECHANISM 有权
标题翻译：液压闭合装置的张力限制和指示机制
公开(公告)号：US20140277113A1
公开(公告)日：2014-09-18
申请号：US14180625
申请日：2014-02-14
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Ram H. Paul, JR.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00623 , A61B2017/00654 , A61B2017/00659 , A61B2017/00862 , A61B2090/064 , A61B2090/0807
摘要： Disclosed is an apparatus and system that includes an elongated body, a vascular closure device that can occlude a hole in a vessel wall coupled to a distal end of the elongated body, a sleeve assembly and a biasing member arranged to elastically deform coupled between the elongated body and the sleeve assembly, where the elongated body is longitudinally displaceable with respect to the sleeve assembly, wherein the biasing member exerts a force on the elongated body approximately proportional to a longitudinal displacement between the elongated body and the sleeve assembly and where the biasing member is arranged deform a discernible amount when a conforming force sufficient to occlude the hole is applied to the elongated body through the biasing member and the sleeve assembly.
摘要翻译：公开了一种装置和系统，其包括细长主体，血管闭合装置，其可闭塞耦合到细长主体的远端的容器壁中的孔，套筒组件和偏置构件，其布置成弹性变形，主体和套筒组件，其中细长主体相对于套筒组件可纵向移位，其中偏压构件在细长体上施加大致与细长主体和套筒组件之间的纵向位移成比例的力，并且偏置构件当通过偏压构件和套筒组件将足够闭塞孔的适形力施加到细长体时，排列变形为可辨别的量。

8. 发明申请

US20140172012A1 VASCULAR CLOSURE DEVICE SUTURE TENSION MECHANISM 审中-公开
标题翻译：血管闭合装置紧张张力机制
公开(公告)号：US20140172012A1
公开(公告)日：2014-06-19
申请号：US14039237
申请日：2013-09-27
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Ram H. Paul, JR.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00623 , A61B2017/00628 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Systems and methods for sealing an opening in a wall within the body of a patient are disclosed. In one embodiment, the system has an elongated body coupled to a vascular closure device and a resisting member, the elongated body having a high resistance portion and a low resistance portion and being constructed and arranged to interface with a resisting member to apply a conforming force to a vascular closure device. In some exemplary embodiments, the elongated body comprises a large diameter portion positioned in a proximal end region of the elongated body. Methods and other embodiments are disclosed.
摘要翻译：公开了用于密封患者体内的壁中的开口的系统和方法。在一个实施例中，系统具有连接到血管闭合装置和阻力构件的细长体，细长体具有高电阻部分和低阻力部分，并且构造和布置成与抵抗构件相接触以施加适形力到血管闭合装置。在一些示例性实施例中，细长主体包括位于细长主体的近端区域中的大直径部分。公开了方法和其它实施例。

9. 发明申请

US20140114348A1 VASCULAR CLOSURE WITH SHAPE MEMORY CHARACTERISTIC 有权
标题翻译：具有形状记忆特性的血管闭合
公开(公告)号：US20140114348A1
公开(公告)日：2014-04-24
申请号：US14056470
申请日：2013-10-17
申请人： Cook Medical Technologies LLC
发明人： Cleon Stanley , Ram H. Paul, JR.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00628
摘要： Among other things, there is disclosed devices for closing an internal opening, e.g. a hole in a blood vessel, that includes a shape memory function. Particular substances have been found to provide advantages in use, and in particular forms of closure structures.
摘要翻译：除其他之外，公开了用于封闭内部开口的装置，例如，血管中的孔，其包括形状记忆功能。已经发现特定的物质在使用中具有优点，特别是封闭结构的形式。

10. 发明申请

US20220218389A1 Medical Devices and Kits Useful for Performing Treatment under Magnetic Resonance Imaging and Related Methods 有权
公开(公告)号：US20220218389A1
公开(公告)日：2022-07-14
申请号：US17573087
申请日：2022-01-11
申请人： Cook Medical Technologies LLC
发明人： Neal Fearnot , Sean D. Chambers , Gary L. Neff , Ram H. Paul, JR. , Eric Brandner
IPC分类号： A61B17/34 , A61B90/00 , A61B17/00 , A61B10/02
摘要： Example medical devices for performing treatment under magnetic resonance imaging and related methods are described. An example medical device includes a cannula and a plug. The cannula has a proximal end, a distal end, a first portion, a second portion, and a main body that defines a lumen and a passageway. The first portion extends from the distal end toward the proximal end. The second portion extends from the first portion toward the proximal end. The first portion is formed of first material. The second portion is formed of a second material that is different than the first material. The plug is disposed within the passageway and has a main body that defines a passageway in fluid communication with the lumen defined by the cannula. The plug is formed of a third material that is different than the second material.

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