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1. 发明申请

US20190024188A1 METHOD OF DIAGNOSING NEOPLASMS - II 审中-公开
公开(公告)号：US20190024188A1
公开(公告)日：2019-01-24
申请号：US16149653
申请日：2018-10-02
申请人： CLINICAL GENOMICS PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： Lawrence C. LAPOINTE , Robert DUNNE , Graeme P. YOUNG , Trevor John LOCKETT , William J. WILSON , Peter Laurence MOLLOY
IPC分类号： C12Q1/6886
摘要： The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as a adenoma or an adeocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinoma. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in thin DNA or the RNA or protein expression profile of one or more nucleic acid molecule markers.

2. 发明申请

US20170211152A1 METHOD OF DIAGNOSING NEOPLASMS 审中-公开
公开(公告)号：US20170211152A1
公开(公告)日：2017-07-27
申请号：US15381895
申请日：2016-12-16
申请人： CLINICAL GENOMICS PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： Lawrence Charles LAPOINTE , Robert DUNNE , Graeme P. YOUNG , Trevor John LOCKETT , William J. WILSON
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446 , G01N2800/06
摘要： The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.

3. 发明申请

US20150159223A1 METHOD OF DIAGNOSING NEOPLASMS 审中-公开
标题翻译：诊断NEOPLASMS的方法
公开(公告)号：US20150159223A1
公开(公告)日：2015-06-11
申请号：US14540583
申请日：2014-11-13
申请人： CLINICAL GENOMICS PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： Lawrence Charles LAPOINTE , Robert DUNNE , Graeme P. YOUNG , Trevor John LOCKETT , William J. WILSON
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446 , G01N2800/06
摘要： The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.
摘要翻译：本发明一般涉及核酸分子，其RNA和蛋白质表达谱表示肿瘤发病和/或进展的发病倾向。更具体地，本发明涉及核酸分子，其表达谱表示大肠肿瘤如腺瘤或腺癌的发作和/或进展。本发明的表达谱可用于一系列应用，包括但不限于与结肠直肠肿瘤如结肠直肠腺癌的诊断和/或监测有关的应用。因此，在相关方面，本发明涉及通过筛选一种或多种核酸分子标记物的表达谱中的调节来筛选受试者对于肿瘤发病和/或进展的易感性的方法。

4. 发明申请

US20180100200A1 METHOD OF DIAGNOSING NEOPLASMS 审中-公开
公开(公告)号：US20180100200A1
公开(公告)日：2018-04-12
申请号：US15809162
申请日：2017-11-10
申请人： CLINICAL GENOMICS PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： Lawrence Charles LAPOINTE , Robert DUNNE , Graeme P. YOUNG , Trevor John LOCKETT , William J. WILSON
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446 , G01N2800/06
摘要： The present invention relates generally to nucleic acid molecules, the RNA and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the expression profile of one or more nucleic acid molecule markers.

5. 发明申请

US20140287940A1 METHOD OF DIAGNOSING NEOPLASMS - II 审中-公开
标题翻译：诊断NEOPLASMS的方法 - II
公开(公告)号：US20140287940A1
公开(公告)日：2014-09-25
申请号：US14057812
申请日：2013-10-18
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , CLINICAL GENOMICS PTY. LTD.
发明人： Lawrence C. LAPOINTE , Robert DUNNE , Graeme P. YOUNG , Trevor John LOCKETT , William J. WILSON , Peter Laurence MOLLOY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the DNA or the RNA or protein expression profile of one or more nucleic acid molecule markers.
摘要翻译：本发明一般涉及核酸分子，其中DNA或RNA或蛋白质表达谱的变化指示肿瘤发病和/或进展的发病，倾向。更具体地，本发明涉及关于DNA或RNA或蛋白质表达谱的改变指示大肠肿瘤如腺瘤或腺癌的发作和/或进展的核酸分子。本发明的DNA或表达谱可用于一系列应用，包括但不限于与结肠直肠肿瘤如结肠直肠腺癌的诊断和/或监测有关的应用。因此，在相关方面，本发明涉及通过筛选DNA或RNA中的调节或RNA或蛋白质表达谱中发现和/或进展肿瘤的发病和/或进展的筛选受试者的方法更多的核酸分子标记。

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