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1. 发明申请

US20140287045A1 METHOD OF PREPARING MICROSPHERES BY USING POLYMER HAVING SOL-GEL TRANSITION PROPERTY AND MICROSPHERES PREPARED THEREBY 有权
标题翻译：通过使用具有溶胶凝胶转移性能的聚合物制备微球的方法和制备的微球
公开(公告)号：US20140287045A1
公开(公告)日：2014-09-25
申请号：US14220875
申请日：2014-03-20
申请人： CJ CHEILJEDANG CORPORATION
发明人： Yi Mi Kim , Young Joon Park , Seung Hee Baek , Sun Kyung Lim
IPC分类号： A61K9/16 , A61K38/09
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K38/09
摘要： The present invention relates to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby, and more particularly, to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby capable of preventing a solvent in a polymer solution for a carrier from being rapidly diffused to the aqueous medium before formation of the microspheres to reduce porosity of the microspheres and reduce surface roughness of the microspheres in order to obtain microspheres having a sphere shape, and increasing an encapsulation ratio of a bioactive substance, by using a polymer having a sol-gel transition property as a surfactant included in an aqueous medium into which a primary emulsion is injected and gelating a secondary emulsion formed after injecting the primary emulsion using the sol-gel transition property of the polymer used as the surfactant.
摘要翻译：本发明涉及通过使用具有溶胶 - 凝胶转变特性的聚合物和由其制备的微球制备微球的方法，更具体地说，涉及一种通过使用具有溶胶 - 凝胶转变特性的聚合物和制备微球而制备微球的方法从而能够防止载体的聚合物溶液中的溶剂在形成微球之前迅速扩散到水性介质中，以降低微球的孔隙率，并降低微球的表面粗糙度，以获得具有球形的微球，以及通过使用具有溶胶 - 凝胶转移特性的聚合物作为包含在其中注入初级乳液的水性介质中的表面活性剂增加生物活性物质的包封率，并且使用溶胶 - 凝胶转移特性注射初级乳液之后形成的二次乳液凝胶化，用作表面活性剂的聚合物的凝胶过渡性质。

2. 发明授权

US09539213B2 Method of preparing microspheres by using polymer having sol-gel transition property and microspheres prepared thereby 有权
标题翻译：通过使用具有溶胶 - 凝胶转变特性的聚合物制备微球的方法和由此制备的微球
公开(公告)号：US09539213B2
公开(公告)日：2017-01-10
申请号：US14220875
申请日：2014-03-20
申请人： CJ CHEILJEDANG CORPORATION
发明人： Yi Mi Kim , Young Joon Park , Seung Hee Baek , Sun Kyung Lim
IPC分类号： A61K9/16 , A61K38/09
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K38/09
摘要： The present invention relates to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby, and more particularly, to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby capable of preventing a solvent in a polymer solution for a carrier from being rapidly diffused to the aqueous medium before formation of the microspheres to reduce porosity of the microspheres and reduce surface roughness of the microspheres in order to obtain microspheres having a sphere shape, and increasing an encapsulation ratio of a bioactive substance, by using a polymer having a sol-gel transition property as a surfactant included in an aqueous medium into which a primary emulsion is injected and gelating a secondary emulsion formed after injecting the primary emulsion using the sol-gel transition property of the polymer used as the surfactant.
摘要翻译：本发明涉及通过使用具有溶胶 - 凝胶转变特性的聚合物和由其制备的微球制备微球的方法，更具体地说，涉及一种通过使用具有溶胶 - 凝胶转变特性的聚合物和制备微球而制备微球的方法从而能够防止载体的聚合物溶液中的溶剂在形成微球之前迅速扩散到水性介质中，以降低微球的孔隙率，并降低微球的表面粗糙度，以获得具有球形的微球，以及通过使用具有溶胶 - 凝胶转移特性的聚合物作为包含在其中注入初级乳液的水性介质中的表面活性剂增加生物活性物质的包封率，并且使用溶胶 - 凝胶转移特性注射初级乳液之后形成的二次乳液凝胶化，用作表面活性剂的聚合物的凝胶过渡性质。

3. 发明申请

US20140341997A1 CONTINUOUS PROCESS FOR PREPARING MICROSPHERES AND MICROSPHERES PREPARED THEREBY 审中-公开
标题翻译：制备微生物和微生物的连续制备方法
公开(公告)号：US20140341997A1
公开(公告)日：2014-11-20
申请号：US14278035
申请日：2014-05-15
申请人： CJ CHEILJEDANG CORPORATION
发明人： Yi Mi Kim , Sun Kyung Lim , Mi Ran Park , Young Joon Park , Seung Hee Baek , Hyun Woo Shin
IPC分类号： A61K9/16 , B01F15/02 , B01F3/08 , A61K38/22 , B01F5/04
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/1694 , A61K38/22 , B01F3/0807 , B01F5/04 , B01F15/0222 , B01F2215/0032
摘要： The present invention relates to a continuous process for preparing microspheres and microspheres prepared thereby, and in particular, a process for preparing microspheres comprising steps of injecting a first emulsion and a second emulsion at the same time to form microspheres instantaneously, applying high pressure to the microspheres formed, and injecting the microspheres into an agitator, wherein the steps can be carried out continuously, and microspheres prepared thereby.When microspheres are prepared using the method of the present invention, scale variables, which have been the biggest disadvantage in existing preparation methods of microspheres, can be significantly reduced, drug encapsulation efficiency can be improved, and small and uniform particles can be obtained.
摘要翻译：本发明涉及一种用于制备由此制备的微球和微球的连续方法，特别是一种制备微球的方法，包括同时注射第一乳液和第二乳液的步骤，以立即形成微球，向形成微球，并将微球注入搅拌器中，其中步骤可以连续进行，由此制备微球。当使用本发明的方法制备微球时，可以显着降低已经成为现有微球制备方法中最大缺点的尺度变量，可以提高药物包封效率，并且可以获得小而均匀的颗粒。

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