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1. 发明申请

US20210389315A1 POINT OF CARE DEVICE FOR EARLY AND RAPID DISEASE DIAGNOSIS 有权
公开(公告)号：US20210389315A1
公开(公告)日：2021-12-16
申请号：US17347892
申请日：2021-06-15
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay , Robert Deissler , Robert Brown
IPC分类号： G01N33/543 , G01N33/569
摘要： Early stage, rapid, low-cost, and accurate detection of disease components in a biological fluid is critically important. A point of care device can use functionalized magnetic beads to facilitate this detection. The device can include a sample holder with a collection region. A magnet can be used to draw the functionalized nanoparticles bound to the disease component into the collection region, where the disease component is captured. A light source can shine a light beam through the collection region; and a detector can detect the light beam after traversing the collection region to determine whether the disease component is present in the sample.

2. 发明申请

US20210100920A1 METHODS AND AGENTS FOR THE DETECTION AND TREATMENT OF CANCER 有权
公开(公告)号：US20210100920A1
公开(公告)日：2021-04-08
申请号：US16608021
申请日：2017-05-24
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Susann Brady-Kalnay , Mette L. Johansen
IPC分类号： A61K49/10 , A61K49/00 , A61K49/08 , A61K49/14
摘要： An agent for use in detecting, monitoring, and/or imaging cancer cells and/or cancer cell metastasis, migration, dispersal, and/or invasion, and/or for treating cancer in a subject includes a targeting peptide and at least one of a detectable moiety, therapeutic agent, or a theranostic agent that is directly or indirectly linked to the targeting peptide. The targeting peptide specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule that is expressed by a cancer cell or another cell in the cancer cell microenvironment.

3. 发明申请

US20160083734A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US20160083734A1
公开(公告)日：2016-03-24
申请号：US14873528
申请日：2015-10-02
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Susann Brady-Kalnay
IPC分类号： C12N15/113 , A61K47/48 , A61K31/7088
摘要： A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell includes administering to the cell an amount of an agent effective to inhibit one or more of the catalytic activity and function of the proteolytically cleaved intracellular domain-containing fragments of the RPTP.
摘要翻译：一种或多种抑制表达RPTP的细胞的运动，迁移，分散和转移的方法，所述细胞在蛋白水解切割以形成细胞内的细胞内片段，包括给予细胞一定量的有效抑制一种或更多的RPTP的蛋白水解裂解的细胞内结构域的片段的催化活性和功能。

4. 发明申请

US20220308048A1 POINT OF CARE DEVICE FOR EARLY AND RAPID DISEASE DIAGNOSIS 有权
公开(公告)号：US20220308048A1
公开(公告)日：2022-09-29
申请号：US17839831
申请日：2022-06-14
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay , Robert Deissler , Robert Brown
IPC分类号： G01N33/543 , G01N33/58 , G01N33/569 , G01N21/64 , G01N21/11
摘要： Early stage, rapid, low-cost detection of disease components in a biological sample is critically important. A point of care device can include a collection region and can be used to hold a sample that is combined with a fluorescent dye and a plurality of magnetic particles such that disease components in the sample are tagged with the fluorescent dye and the plurality of magnetic particles. At least one magnet can be located next to the collection region to establish a magnetic field gradient to draw the tagged disease components into the collection region from the device. A fluorescence microscope can image the small collection region based on the fluorescent dye to detect the disease components. The fluorescence microscope uses light to excite the fluorescent dye and a filter to transmit light emitted by the fluorescent dye to the fluorescence microscope, while restricting light used to excite the fluorescent dye.

5. 发明申请

US20200041595A1 SYSTEM AND METHOD FOR DYNAMIC MULTIPLE CONTRAST ENHANCED, MAGNETIC RESONANCE FINGERPRINTING (DMCE-MRF) 审中-公开
公开(公告)号：US20200041595A1
公开(公告)日：2020-02-06
申请号：US16603335
申请日：2018-04-06
申请人： Case Western Reserve University
发明人： Chris Flask , Christian Anderson , Xin Yu , Nicole Steinmetz , Mark A. Griswold , Susann Brady-Kalnay
IPC分类号： G01R33/50 , A61B5/055 , G01R33/56 , G06T7/00 , G01R33/48
摘要： The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

6. 发明申请

US20140178299A1 METHODS AND COMPOSITIONS FOR DETECTION OF CANCER 审中-公开
标题翻译：用于检测癌症的方法和组合物
公开(公告)号：US20140178299A1
公开(公告)日：2014-06-26
申请号：US14188404
申请日：2014-02-24
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay
IPC分类号： A61K49/00 , C07K16/18
CPC分类号： A61K49/0058 , A61K49/0032 , A61K51/088 , C07K16/18 , G01N33/57407 , G01N2333/70503
摘要： A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
摘要翻译：用于检测表达在受试者中以亲和方式结合的Ig超家族细胞粘附分子的癌细胞的分子探针包括与Ig超家族细胞粘附的蛋白水解切割的细胞外片段特异性结合和/或复合的靶向剂分子。

7. 发明授权

US10745703B2 Compositions and methods for treating cancer 有权
公开(公告)号：US10745703B2
公开(公告)日：2020-08-18
申请号：US14873528
申请日：2015-10-02
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Susann Brady-Kalnay
IPC分类号： C12N15/113 , A61K38/17 , A61K47/64 , A61K31/7105 , A61K31/7088 , A61K49/00
摘要： A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell includes administering to the cell an amount of an agent effective to inhibit one or more of the catalytic activity and function of the proteolytically cleaved intracellular domain-containing fragments of the RPTP.

8. 发明授权

US10076264B2 System and method for quantitative magnetic resonance (MR) analysis using T1 mapping 有权
公开(公告)号：US10076264B2
公开(公告)日：2018-09-18
申请号：US15169208
申请日：2016-05-31
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay , Vikas Gulani , Mark Griswold
IPC分类号： A61B5/055 , G01R33/56 , A61B5/00 , A61K49/10 , G08C23/06 , G01R33/50
CPC分类号： A61B5/055 , A61B5/0073 , A61B5/4244 , A61B5/742 , A61B2576/00 , A61B2576/026 , A61K49/108 , G01R33/50 , G01R33/5601 , G01R33/5602 , G08C23/06
摘要： Example apparatus and methods concern determining whether a target material appears in a region experiencing nuclear magnetic resonance (NMR). One method acquires a baseline value for a magnetic resonance parameter (MRP) while the region is not exposed to a molecular imaging agent that affects the MRP and acquires a series of quantitative values for the MRP while the sample is influenced by a molecular imaging agent. Quantitative values may be acquired during a clinically relevant time period (e.g., 60 minutes) during which the change in the MRP (e.g., T1) caused by the molecular imaging agent is at least 90% of the peak change caused by the molecular imaging agent. The molecular imaging agent may be SBK2 and may produce a desired change in T1 for at least thirty minutes in glioblastoma.

9. 发明申请

US20140292328A1 Magnetic Resonance Imaging (MRI) With Dual Agent Characterization 有权
标题翻译：具有双重特征的磁共振成像（MRI）
公开(公告)号：US20140292328A1
公开(公告)日：2014-10-02
申请号：US14068537
申请日：2013-10-31
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay , Vikas Gulani , Mark Griswold
IPC分类号： G01R33/56
CPC分类号： G08C23/06 , A61B5/0017 , A61B5/0073 , A61B5/055 , A61B5/4244 , A61K49/06 , G01R33/3614 , G01R33/3692 , G01R33/4822 , G01R33/56 , G01R33/5608 , G01R33/56366 , G01R33/58
摘要： Example apparatus and methods concern determining whether a target material appears in a region experiencing nuclear magnetic resonance. One method acquires a baseline value for a magnetic resonance parameter (MRP) while the region is not exposed to a molecular imaging agent that affects the MRP, acquiring a non-specific uptake value for the MRP while the sample is influenced by a non-specific molecular imaging agent and acquiring a specific uptake value for the MRP while the sample is influenced by a specific molecular imaging agent. The non-specific masking problem is solved by characterizing the region as a function of the baseline value, the non-specific uptake value, and the specific uptake value. The function relies on the similarities and differences between non-specific uptake of the non-specific molecular imaging agent, non-specific uptake of the specific molecular imaging agent, and specific uptake of the specific molecular imaging agent.
摘要翻译：确定目标材料是否出现在经历核磁共振的区域中的示例性设备和方法。一种方法获得磁共振参数（MRP）的基线值，而该区域不暴露于影响MRP的分子成像剂，获得MRP的非特异性吸收值，而样品受非特异性分子显像剂，并且在样品受特定分子显像剂影响时获得MRP的特异摄取值。通过将该区域表征为基准值，非特异性摄取值和特异摄取值的函数来解决非特异性掩蔽问题。该功能依赖于非特异性分子显像剂的非特异性摄取，特异性分子显像剂的非特异性摄取和特异性分子成像剂的特异性吸收之间的相似性和差异性。

10. 发明申请

US20130287702A1 METHODS AND COMPOSITIONS FOR THE DETECTION OF CANCER CELLS 有权
标题翻译：用于检测癌细胞的方法和组合物
公开(公告)号：US20130287702A1
公开(公告)日：2013-10-31
申请号：US13938968
申请日：2013-07-10
申请人： Case Western Reserve University
发明人： Susann Brady-Kalnay
IPC分类号： A61K49/00
CPC分类号： A61K49/0058 , A61K49/0032 , A61K49/0056
摘要： A molecular probe for use in detecting, monitoring, and/or imaging cancer cells and/or cancer cell metastasis, migration, dispersal, and/or invasion includes a targeting agent and a detectable moiety. The targeting agent specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule that is expressed by a cancer cell or another cell in the cancer cell microenvironment.
摘要翻译：用于检测，监测和/或成像癌细胞和/或癌细胞转移，迁移，分散和/或侵袭的分子探针包括靶向剂和可检测部分。靶向剂与由癌细胞或癌细胞微环境中的另一细胞表达的免疫球蛋白（Ig）超家族细胞粘附分子的蛋白水解切割的细胞外片段特异性结合和/或复合。

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