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1. 发明申请

US20100300433A1 Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol 审中-公开
标题翻译：用于提高形成冷凝气溶胶的化合物的纯度或产率的底物
公开(公告)号：US20100300433A1
公开(公告)日：2010-12-02
申请号：US12789044
申请日：2010-05-27
申请人： C.V. Krishnamohan Sharma , Mingzu Lei , Peter D. Noymer , Daniel J. Myers
发明人： C.V. Krishnamohan Sharma , Mingzu Lei , Peter D. Noymer , Daniel J. Myers
IPC分类号： A61M15/00 , A61K9/12 , A61P11/00 , B05D3/00 , A61M11/00
CPC分类号： A61K9/007 , A61K31/553 , A61M11/001 , A61M11/041 , A61M11/042 , A61M11/047 , B05B7/0012 , B05B7/1686 , B05D1/60 , C23C4/123 , C23C24/04
摘要： A device for vaporizing a composition. The device comprises a thermally conductive substrate having a surface, the surface comprising a thermally conductive surface structure. A dry composition capable of a solid to liquid phase change upon being heated to at least a select temperature is disposed on the surface structure. The surface structure is configured to form liquid droplets of the composition upon heating of the surface structure to at least the select temperature. The liquid droplets have a median diameter less than a median diameter of liquid droplets formed on a planar substrate surface heated to at least the select temperature.
摘要翻译：用于蒸发组合物的装置。该装置包括具有表面的导热基底，该表面包括导热表面结构。在表面结构上设置能够在被加热至至少一个选择温度时固体和液相变化的干燥组合物。表面结构构造成在将表面结构加热至至少选择温度时形成组合物的液滴。液滴的中值直径小于形成在加热到至少选择温度的平面基板表面上的液滴的中值直径。

2. 发明申请

US20110253135A1 METAL COORDINATION COMPLEXES OF VOLATILE DRUGS 审中-公开
标题翻译：挥发性药物的金属协调复合物
公开(公告)号：US20110253135A1
公开(公告)日：2011-10-20
申请号：US13078519
申请日：2011-04-01
申请人： Ron L. HALE , C.V Krishnamohan Sharma , Mingzu Lei
发明人： Ron L. HALE , C.V Krishnamohan Sharma , Mingzu Lei
IPC分类号： A61M15/06 , A61K31/555 , A61K31/58 , A61K31/428 , A61K31/551 , A61P11/00 , A61P25/34 , A61P25/24 , A61P25/16 , A61P21/02 , A61P25/08 , A61K9/70 , A61K31/465
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/7007 , A61K31/428 , A61K31/465 , A61K31/57 , A61K31/573 , A61K31/58 , A61M11/042 , A61M11/047 , A61M15/0031 , A61M15/0045 , A61M15/06 , A61M2202/064 , A61M2205/8268
摘要： The present disclosure provides a drug delivery device comprising a housing defining an airway, wherein the airway comprises at least one air inlet and a mouthpiece having at least one air outlet, at least one heated metal substrate disposed within the airway, at least one drug disposed on the at least one heated metal substrate. Drugs that can be complexed with metals or metal salts and could be deposited as thin films on heated metal substrate for generating thermal condensation aerosols are particularly suited. The metal substrate could be electrically or chemically heated. Further, the chemically heated metal source could be activated by an igniter that generates heat or spark.
摘要翻译：本公开提供了一种药物递送装置，其包括限定气道的壳体，其中所述气道包括至少一个空气入口和具有至少一个空气出口的口器，设置在所述气道内的至少一个加热的金属基底，设置有至少一种药物在所述至少一个加热的金属基底上。可以与金属或金属盐络合的药物，并且可以作为薄膜沉积在加热的金属基底上以产生热凝结气溶胶是特别合适的。金属基底可以电或化学加热。此外，化学加热的金属源可以由产生热量或火花的点火器激活。

3. 发明申请

US20120048963A1 Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter 审中-公开
标题翻译：使用能够进行放热金属氧化还原反应的固体燃料的加热装置，无需点火器传播
公开(公告)号：US20120048963A1
公开(公告)日：2012-03-01
申请号：US13217385
申请日：2011-08-25
申请人： C.V. Krishnamohan Sharma , Mingzu Lei
发明人： C.V. Krishnamohan Sharma , Mingzu Lei
IPC分类号： A61L9/00 , H01R43/00
CPC分类号： A61M11/041 , A61M5/44 , A61M11/047 , A61M15/0051 , A61M15/06 , A61M2205/364 , A61M2205/8268 , F24V30/00 , Y10T29/49117
摘要： A heating unit comprising an electrically conductive substrate. A solid fuel layer comprising a metal reducing agent, a metal containing oxidizing agent and a binder is coated on a surface of the substrate, the solid fuel layer having a solid fuel surface spaced from the substrate. A first electrode coupled to the substrate. A second electrode coupled to the solid fuel surface. A power supply is configured to be selectively coupled to the first and second electrodes to provide a voltage between the metallic substrate and the solid fuel surface. The voltage acts to propagate an exothermic metal oxidation-reduction reaction without the use of an igniter.
摘要翻译：一种加热单元，包括导电基底。包含金属还原剂，含金属的氧化剂和粘合剂的固体燃料层涂覆在基材的表面上，固体燃料层具有与基材间隔开的固体燃料表面。耦合到衬底的第一电极。耦合到固体燃料表面的第二电极。电源被配置为选择性地耦合到第一和第二电极以在金属基板和固体燃料表面之间提供电压。该电压用于在不使用点火器的情况下传播放热金属氧化还原反应。

4. 发明申请

US20090180968A1 Metal Coordination Complexes Of Volatile Drugs 审中-公开
标题翻译：挥发性药物的金属配位络合物
公开(公告)号：US20090180968A1
公开(公告)日：2009-07-16
申请号：US12352582
申请日：2009-01-12
申请人： Ron L. Hale , C.V. Krishnamohan Sharma , Mingzu Lei
发明人： Ron L. Hale , C.V. Krishnamohan Sharma , Mingzu Lei
IPC分类号： A61K9/72
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/7007 , A61K31/428 , A61K31/465 , A61K31/57 , A61K31/573 , A61K31/58 , A61M11/042 , A61M11/047 , A61M15/0031 , A61M15/0045 , A61M15/06 , A61M2202/064 , A61M2205/8268
摘要： The present disclosure provides a drug delivery device comprising a housing defining an airway, wherein the airway comprises at least one air inlet and a mouthpiece having at least one air outlet, at least one heated metal substrate disposed within the airway, at least one drug disposed on the at least one heated metal substrate. Drugs that can be complexed with metals or metal salts and could be deposited as thin films on heated metal substrate for generating thermal condensation aerosols are particularly suited. The metal substrate could be electrically or chemically heated. Further, the chemically heated metal source could be activated by an igniter that generates heat or spark.
摘要翻译：本公开提供了一种药物递送装置，其包括限定气道的壳体，其中所述气道包括至少一个空气入口和具有至少一个空气出口的口器，设置在所述气道内的至少一个加热的金属基底，设置有至少一种药物在所述至少一个加热的金属基底上。可以与金属或金属盐络合的药物，并且可以作为薄膜沉积在加热的金属基底上以产生热凝结气溶胶是特别合适的。金属基底可以电或化学加热。此外，化学加热的金属源可以由产生热量或火花的点火器激活。

5. 发明申请

US20100068155A1 Reactant Formulations and Methods for Controlled Heating 审中-公开
标题翻译：控制加热的反应物配方和方法
公开(公告)号：US20100068155A1
公开(公告)日：2010-03-18
申请号：US12211628
申请日：2008-09-16
申请人： Mingzu Lei , C.V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang
发明人： Mingzu Lei , C.V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang
IPC分类号： A61K9/72
CPC分类号： A61K9/007
摘要： Disclosed herein are reactant formulations capable of undergoing an exothermic chemical reaction. The reactant formulations comprise a metal reducing agent, a metal-containing oxidizing agent, and manganese oxide in an amount effective to control a temperature profile of the reactant formulation. The manganese oxide may be, for example and without limitation, MnO, MnO2, or Mn3O4. The manganese oxide may be present at a concentration within the range of 2 to 60 percent, and in other embodiments, 8 to 40 percent, by weight of the reactant formulation. Also disclosed are an article for vaporization of a vaporizable compound and a heating unit.
摘要翻译：本文公开了能够经历放热化学反应的反应物制剂。反应物制剂包含有效控制反应物制剂的温度分布的量的金属还原剂，含金属的氧化剂和氧化锰。锰氧化物可以是例如但不限于MnO，MnO 2或Mn 3 O 4。氧化锰的浓度可以为反应物制剂的2至60重量％，在其它实施方案中为8至40重量％。还公开了可蒸发化合物和加热单元的蒸发的物品。

6. 发明申请

US20100068154A1 Printable Igniters 失效
标题翻译：可打印点火器
公开(公告)号：US20100068154A1
公开(公告)日：2010-03-18
申请号：US12211554
申请日：2008-09-16
申请人： C.V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang , Mingzu Lei , Vladimir Rappoport
发明人： C.V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang , Mingzu Lei , Vladimir Rappoport
IPC分类号： A61K9/12 , F42C11/00 , H01T1/16 , H01T1/22 , H01T1/24 , H01R43/00 , A61M15/00
CPC分类号： F42B3/124 , A61M11/041 , A61M11/047 , A61M15/0003 , A61M15/025 , A61M2016/0015 , H05K1/16 , Y10T29/53204
摘要： An igniter comprises at least two conductors in the spaced-apart configuration and an electrically conductive layer bridging the at least two conductors, wherein the conductive layer has an electrical resistance greater than an electrical resistance of the at least two conductors. In one embodiment, the at least two conductors and the electrically conductive layer comprise a conductive ink, which may be the same conductive ink having different dimensions. A supplementary initiator composition may be deposited on or incorporated into the conductive layer. In a process for producing the igniter, the electrically conductive layer and the at least two conductors are printed on a non-electrically conducting substrate. Also disclosed are a method for igniting a combustible composition using the igniter, a method for producing an aerosol drug using the igniter, a method for providing a dose of a drug to a human patient using the igniter, a drug delivery device comprising the igniter and a drug supply unit comprising the igniter.
摘要翻译：点火器包括间隔开的构造中的至少两个导体和桥接至少两个导体的导电层，其中导电层的电阻大于至少两个导体的电阻。在一个实施例中，所述至少两个导体和导电层包括导电油墨，其可以是具有不同尺寸的相同的导电油墨。补充的引发剂组合物可以沉积在导电层上或结合到导电层中。在制造点火器的过程中，导电层和至少两个导体印刷在非导电基底上。还公开了使用点火器点燃可燃组合物的方法，使用该点火器生产气溶胶药物的方法，使用点火器向人类患者提供药物剂量的方法，包括点火器的药物递送装置和包括点火器的药物供应单元。

7. 发明申请

US20100065052A1 Heating Units 审中-公开
标题翻译：加热单元
公开(公告)号：US20100065052A1
公开(公告)日：2010-03-18
申请号：US12211247
申请日：2008-09-16
申请人： C.V. Krishnamohan Sharma , Mingzu Lei , Karen Wang , Hoi Sze Lau , Ron L. Hale , Reynaldo Quintana , Pravin Soni
发明人： C.V. Krishnamohan Sharma , Mingzu Lei , Karen Wang , Hoi Sze Lau , Ron L. Hale , Reynaldo Quintana , Pravin Soni
IPC分类号： A61M15/00 , B32B37/06 , B32B37/12
CPC分类号： A61M11/041 , A61M11/047 , A61M11/048 , A61M15/0003 , A61M31/00 , A61M35/00
摘要： A heating unit comprises a substrate having a first surface and a second surface. A chemical reactant material capable of undergoing an exothermic reaction is disposed on at least a portion of the first surface of the substrate. An igniter is in proximity with the chemical reactant material. A layer of adhesive material overlays at least a portion of at least one of the chemical reactant material and the first surface of the substrate. Other embodiments of the heating unit include a first and a second substrate, each having first and second surfaces positioned with the first surfaces opposing each other in a sandwich construction. A chemical reactant material is disposed on at least a portion of the first surface of at least one of the substrates. The first and the second substrates are sealed together to define a cavity containing the chemical reactant material and an igniter is provided in proximity with the chemical reactant material.
摘要翻译：加热单元包括具有第一表面和第二表面的基底。能够经受放热反应的化学反应物质被设置在基板的第一表面的至少一部分上。点火器靠近化学反应物料。一层粘合剂材料覆盖至少一部分化学反应物质和基材的第一表面的至少一部分。加热单元的其它实施例包括第一和第二基板，每个基板具有第一和第二表面，其中第一表面和第二表面以夹层结构彼此相对。化学反应物料设置在至少一个基底的第一表面的至少一部分上。将第一和第二基板密封在一起以限定包含化学反应物料的空腔，并且靠近化学反应物料提供点火器。

8. 发明申请

US20100006092A1 Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages 审中-公开
标题翻译：气溶胶药物输送装置包含冲击式活化热包装
公开(公告)号：US20100006092A1
公开(公告)日：2010-01-14
申请号：US12550209
申请日：2009-08-28
申请人： Ron L. Hale , Mingzu Lei , Peter M. Lloyd , Patrik Munzar , C.V. Krishnamohan Sharma , Dennis W. Solas , Matthew D. Stracker
发明人： Ron L. Hale , Mingzu Lei , Peter M. Lloyd , Patrik Munzar , C.V. Krishnamohan Sharma , Dennis W. Solas , Matthew D. Stracker
IPC分类号： A61M15/06 , F23Q1/06
CPC分类号： A61M11/041 , A61M11/047 , A61M15/0031 , A61M15/0045
摘要： Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.
摘要翻译：公开了包含冲击活化热包装的气溶胶药物递送装置。热包装包括打击式点火器和能够在被打击式点火器点燃时经历放热氧化还原反应的燃料。所公开的药物输送装置可以由致动机构激活，以蒸发包括设置在帽子包装的外部上的药物的薄的固体膜。还公开了挥发性药物的金属配位络合物，特别是加热时药物可以从其中选择性蒸发的尼古丁。还公开了包括尼古丁金属盐络合物的薄膜用于治疗尼古丁渴望和用于戒烟的气溶胶药物递送装置的使用。

9. 发明授权

US07923662B2 Stable initiator compositions and igniters 有权
标题翻译：稳定的引发剂组合物和点火器
公开(公告)号：US07923662B2
公开(公告)日：2011-04-12
申请号：US12015893
申请日：2008-01-17
申请人： Ron L. Hale , Mingzu Lei , Hilary N. Pettit , Dennis W. Solas , Soonho Song , Curtis Tom
发明人： Ron L. Hale , Mingzu Lei , Hilary N. Pettit , Dennis W. Solas , Soonho Song , Curtis Tom
IPC分类号： F23Q7/22 , F23Q3/00
CPC分类号： F23Q3/006
摘要： High sparking initiator compositions with a controlled amount of power are disclosed. The initiator compositions comprise a metal containing oxidizing agent, at least one metal reducing agent, and a non-explosive binder. Low voltage igniters that provide bidirectional plumes upon ignition are also disclosed. These igniters have a electrically resistive element positioned across a hole in a support which directs the plume. These igniters and compositions are useful in the actuation of solid fuel heating unit, in particular, sealed heating units.
摘要翻译：公开了具有受控量功率的高火花引发剂组合物。引发剂组合物包含含金属的氧化剂，至少一种金属还原剂和非爆炸性粘合剂。还公开了在点火时提供双向羽流的低电压点火器。这些点火器具有定位在引导羽流的支撑件中的孔的电阻元件。这些点火器和组合物在固体燃料加热单元，特别是密封加热单元的致动中是有用的。

10. 发明授权

US07834295B2 Printable igniters 失效
标题翻译：可打印点火器
公开(公告)号：US07834295B2
公开(公告)日：2010-11-16
申请号：US12211554
申请日：2008-09-16
申请人： C. V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang , Mingzu Lei , Vladimir Rappoport
发明人： C. V. Krishnamohan Sharma , Hoi Sze Lau , Karen Wang , Mingzu Lei , Vladimir Rappoport
IPC分类号： F23Q7/00 , F02B1/12
CPC分类号： F42B3/124 , A61M11/041 , A61M11/047 , A61M15/0003 , A61M15/025 , A61M2016/0015 , H05K1/16 , Y10T29/53204
摘要： An igniter comprises at least two conductors in the spaced-apart configuration and an electrically conductive layer bridging the at least two conductors, wherein the conductive layer has an electrical resistance greater than an electrical resistance of the at least two conductors. In one embodiment, the at least two conductors and the electrically conductive layer comprise a conductive ink, which may be the same conductive ink having different dimensions. A supplementary initiator composition may be deposited on or incorporated into the conductive layer. In a process for producing the igniter, the electrically conductive layer and the at least two conductors are printed on a non-electrically conducting substrate. Also disclosed are a method for igniting a combustible composition using the igniter, a method for producing an aerosol drug using the igniter, a method for providing a dose of a drug to a human patient using the igniter, a drug delivery device comprising the igniter and a drug supply unit comprising the igniter.
摘要翻译：点火器包括间隔开的构造中的至少两个导体和桥接至少两个导体的导电层，其中导电层的电阻大于至少两个导体的电阻。在一个实施例中，所述至少两个导体和导电层包括导电油墨，其可以是具有不同尺寸的相同的导电油墨。补充的引发剂组合物可以沉积在导电层上或结合到导电层中。在制造点火器的过程中，导电层和至少两个导体印刷在非导电基底上。还公开了使用点火器点燃可燃组合物的方法，使用该点火器生产气溶胶药物的方法，使用点火器向人类患者提供药物剂量的方法，包括点火器的药物递送装置和包括点火器的药物供应单元。

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