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1. 发明授权

US07883541B2 Muscle-based grafts/implants 有权
标题翻译：基于肌肉的移植物/植入物
公开(公告)号：US07883541B2
公开(公告)日：2011-02-08
申请号：US11949687
申请日：2007-12-03
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
IPC分类号： A61F2/08 , A61K35/34 , A61K38/17 , A61K38/18
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。

2. 发明申请

US20110091516A1 Muscle-based grafts/implants 有权
标题翻译：基于肌肉的移植物/植入物
公开(公告)号：US20110091516A1
公开(公告)日：2011-04-21
申请号：US12807599
申请日：2010-09-09
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, JR.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, JR.
IPC分类号： A61K9/00 , A61K38/18
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可以与接种的细胞，组织生长因子和/或趋化性配偶组合以吸引所需细胞。

3. 发明授权

US07131994B2 Muscle-based grafts/implants 有权
公开(公告)号：US07131994B2
公开(公告)日：2006-11-07
申请号：US10793976
申请日：2004-03-05
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
IPC分类号： A61F2/08 , A61K35/34 , A61K38/17
CPC分类号： A61L27/48 , A61L27/3604 , A61L27/3608 , A61L27/3683
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.

4. 发明授权

US07001430B2 Matrix composition for human grafts/implants 有权
标题翻译：用于人类移植物/植入物的基质组合物
公开(公告)号：US07001430B2
公开(公告)日：2006-02-21
申请号：US10754310
申请日：2004-01-09
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell, Jr.
IPC分类号： A61F2/08 , A61F2/02 , A61K38/17 , A61K35/34
CPC分类号： A61L27/3683 , A61L27/3604 , A61L27/3608 , A61L27/48
摘要： The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes measured at 25° C. In another aspect, the present invention is directed to a tissue implant comprising a human muscle tissue matrix.
摘要翻译：本发明涉及一种用于生产适合于植入人体的肌肉组织基质的中间组合物，其包含与含水载体（优选生物相容性酸溶液）组合的切碎的同种异体人肌肉组织，以形成具有在25℃下测量的粘度范围为1厘沲至20,000厘沲。另一方面，本发明涉及包含人肌肉组织基质的组织植入物。

5. 发明申请

US20130149356A1 Muscle-based grafts/implants 有权
标题翻译：基于肌肉的移植物/植入物
公开(公告)号：US20130149356A1
公开(公告)日：2013-06-13
申请号：US13815184
申请日：2013-02-07
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
IPC分类号： A61L27/36 , A61L27/56
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。

6. 发明授权

US08747467B2 Muscle-based grafts/implants 有权
标题翻译：基于肌肉的移植物/植入物
公开(公告)号：US08747467B2
公开(公告)日：2014-06-10
申请号：US13815184
申请日：2013-02-07
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
IPC分类号： A61F2/02 , A61F2/08 , A61F2/10 , A61K38/18
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可与接种的细胞，组织生长因子和/或趋化剂组合以吸引期望的细胞。

7. 发明授权

US08394141B2 Connective-tissue-based or dermal-tissue-based grafts/implants 有权
标题翻译：基于结缔组织或基于皮肤组织的移植物/植入物
公开(公告)号：US08394141B2
公开(公告)日：2013-03-12
申请号：US12807599
申请日：2010-09-09
申请人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
发明人： C. Randal Mills , John R. Bianchi , Michael R. Roberts , David T. Cheung , Chandrasekaran Nataraj , John W. Howell
IPC分类号： A61F2/08 , A61F2/10 , A61K38/18
CPC分类号： A61L27/3608 , A61F2/08 , A61F2/105 , A61F2002/0894 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/38 , A61L27/3826 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/10 , A61L2430/30 , B33Y80/00
摘要： The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
摘要翻译：本发明涉及一种包含适合于植入人体的基质的组合物，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人肌肉组织。还公开了一种组织移植物或植入物，其包含适合于植入人体的基质，其包含已经与水性载体组合并且以预定形状干燥的脱脂，切碎的同种异体人类肌肉组织。本发明的组合物和/或组织移植物或植入物可以与接种的细胞，组织生长因子和/或趋化性配偶组合以吸引所需细胞。

8. 发明授权

US07736845B2 Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 有权
标题翻译：治疗由宿主细胞重建为生物体组织的植入物的胶原结缔组织的方法
公开(公告)号：US07736845B2
公开(公告)日：2010-06-15
申请号：US11345768
申请日：2006-01-19
申请人： David T. Cheung
发明人： David T. Cheung
IPC分类号： A61F2/04 , A61F2/08
CPC分类号： A01N1/02 , A01N1/0226 , A61K38/39 , A61L27/3604 , A61L27/3687
摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.
摘要翻译：本发明涉及一种治疗从供体移出的胶原结缔组织的方法，用于植入到受体中，其被宿主细胞重新吸收或重新定植而没有免疫排斥和炎症反应。从供体移除后，将组织修整，然后在温度范围为4至10摄氏度的冷稳定溶液中浸泡。然后将组织在预定温度下浸入预定量和浓度的聚二醇，盐，过氧化氢和磷酸盐缓冲液第一溶液中并具有足够的离子强度，以使研磨物质解离，使得胶原纤维保持稳定。然后将组织在预定温度下在醇和水溶液中浸泡足够的时间以除去第一溶液的残余物。除去残留物后，将组织在预定温度下在抗炎剂，抗血栓剂，酒精和水的第三溶液中浸泡，或依次在抗炎剂，酒精和水溶液中浸泡，然后在抗血栓剂，酒精和水溶液中储存。

9. 发明授权

US07687230B2 Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 有权
标题翻译：治疗由宿主细胞重建为生物体组织的植入物的胶原结缔组织的方法
公开(公告)号：US07687230B2
公开(公告)日：2010-03-30
申请号：US11345769
申请日：2006-01-19
申请人： David T. Cheung
发明人： David T. Cheung
IPC分类号： A61F2/04 , A61F2/08
CPC分类号： A01N1/02 , A01N1/0226 , A61K38/39 , A61L27/3604 , A61L27/3687
摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.
摘要翻译：本发明涉及一种治疗从供体移出的胶原结缔组织的方法，用于植入到受体中，其被宿主细胞重新吸收或重新定植而没有免疫排斥和炎症反应。从供体中取出后，对组织进行修整，然后将其浸泡在温度范围为4至10摄氏度的冷稳定溶液中。然后将组织在预定温度下浸入预定量和浓度的聚二醇，盐，过氧化氢和磷酸盐缓冲液第一溶液中并具有足够的离子强度，以使研磨物质解离，使得胶原纤维保持稳定。然后将组织在预定温度下在醇和水溶液中浸泡足够的时间以除去第一溶液的残余物。除去残留物后，将组织在预定温度下在抗炎剂，抗血栓剂，酒精和水的第三溶液中浸泡，或依次在抗炎剂，酒精和水溶液中浸泡，然后在抗血栓剂，酒精和水溶液中储存。

10. 发明授权

US07008763B2 Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 失效
公开(公告)号：US07008763B2
公开(公告)日：2006-03-07
申请号：US10253017
申请日：2002-09-23
申请人： David T. Cheung
发明人： David T. Cheung
IPC分类号： A61F2/04 , A61F2/08
CPC分类号： A01N1/02 , A01N1/0226 , A61K38/39 , A61L27/3604 , A61L27/3687
摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.

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