专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090123516A1 DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS 审中-公开
标题翻译：使用自组装单机治疗药物从植入物输送药物
公开(公告)号：US20090123516A1
公开(公告)日：2009-05-14
申请号：US11997092
申请日：2006-08-08
申请人： C. Mauli Agrawal , David Johnson , Gopinath Mani , Anil Mahapatro , Marc Feldman , Devang Patel , Arturo Ayon
发明人： C. Mauli Agrawal , David Johnson , Gopinath Mani , Anil Mahapatro , Marc Feldman , Devang Patel , Arturo Ayon
IPC分类号： A61F2/82 , A61F2/02 , A61K38/43 , A61K39/395 , A61K31/7088 , A61K38/02 , A61K31/485 , A61P35/00 , A61P9/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P19/02
CPC分类号： B82Y40/00 , A61K47/543 , A61K47/60 , B82Y30/00
摘要： Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
摘要翻译：公开了包括一个或多个表面的医疗装置，附接到医疗装置的一个或多个表面的一个或多个SAM分子和连接到一个或多个自组装单层分子的一种或多种治疗剂。还公开了包括一个或多个表面的医疗装置，附接到医疗装置的一个或多个表面的一个或多个自组装单层分子，一个或多个包含第一官能团和第二官能团的接头，第一官能团附着于自组装单层分子和连接到第二官能团的治疗剂。治疗剂可以通过接头连接到SAM分子。本发明还涉及向受试者施用治疗剂的方法，包括使受试者与本文所述的医疗装置之一接触。

2. 发明申请

US20050171595A1 Method and apparatus for stent deployment with enhanced delivery of bioactive agents 有权
标题翻译：用于具有增强的生物活性剂递送的支架展开的方法和装置
公开(公告)号：US20050171595A1
公开(公告)日：2005-08-04
申请号：US10469632
申请日：2002-02-27
申请人： Marc Feldman , Steven Bailey , C. Mauli Agrawal , Kyriacos Athansiou
发明人： Marc Feldman , Steven Bailey , C. Mauli Agrawal , Kyriacos Athansiou
IPC分类号： A61F2/00 , A61F2/82 , A61F2/06
CPC分类号： A61F2/82 , A61F2250/0067
摘要： A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein where the protected regions are protected by the unprotected regions when the stent is in its undeployed state which has a smaller cross-sectional dimension than the stent in its deployed state. And when the stent is in its deployed state the bioactive or biopenetrating agent(s) are brought into direct and intimate contact with a tissue or interior of a blood vessel of an animal including a human.
摘要翻译：公开了一种用于包括人类在内的动物的支架，其包括未受保护和保护的区域，每个保护区域包括其中包含生物活性或生物穿透剂，其中当支架处于其未被部署状态时受保护区域被未保护区域保护，横截面尺寸比其展开状态下的支架。并且当支架处于其展开状态时，使生物活性或生物穿透剂与包括人的动物的血管的组织或内部直接且紧密接触。

3. 发明授权

US06187329B1 Variable permeability bone implants, methods for their preparation and use 失效
标题翻译：可变渗透性骨植入物，其制备和使用方法
公开(公告)号：US06187329B1
公开(公告)日：2001-02-13
申请号：US08996708
申请日：1997-12-23
申请人： C. Mauli Agrawal , Kyriacos A. Athanasiou
发明人： C. Mauli Agrawal , Kyriacos A. Athanasiou
IPC分类号： A61F202
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/30011 , A61F2002/30062 , A61F2210/0004 , A61F2250/0023 , A61L27/56 , A61L27/58 , Y10S623/901
摘要： The present invention involves filler for treating injured tissue sites made from compositions having variable permeability to bodily fluid to reduce the flow to these fluids (bleeding) from the site of injury into the surrounding tissue. The fillers are prepared by dispersing a pore-forming agent in a polymer with agitation. Density developing a variable concentration of pore-forming agent throughout the polymer through application of an external force acting on the mixture so that a portion of the filler has a variable impermeability to bodily fluids. After agitation and/or density development, the pore-forming agent is leached from the mixture to form a polymer matrix having variable permeability. Alternatively, the compositions can be made by fixedly combining a permeable material with an impermeable material to form a filler with reduced permeability to bodily fluid flow.
摘要翻译：本发明涉及用于治疗由对体液具有可变渗透性的组合物制成的损伤组织部位的填料，以减少从损伤部位到周围组织的这些流体的流动（渗血）。通过在搅拌下将成孔剂分散在聚合物中来制备填料。密度通过施加作用在混合物上的外力而在整个聚合物中产生可变浓度的成孔剂，使得一部分填料对体液具有可变的不渗透性。在搅拌和/或密度显影之后，从混合物中浸出成孔剂以形成具有可变渗透性的聚合物基质。或者，可以通过将可渗透材料与不渗透材料固定地组合以形成具有降低的对体液流动的渗透性的填料来制备组合物。

4. 发明申请

US20130150947A1 SCAFFOLD SYSTEM TO REPAIR CARDIOVASCULAR CONDITIONS 审中-公开
标题翻译： SCAFFOLD系统修复心脏病
公开(公告)号：US20130150947A1
公开(公告)日：2013-06-13
申请号：US13634206
申请日：2011-03-11
申请人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
发明人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61L27/18 , A61L27/54 , A61L27/56 , A61L31/00 , C08L67/04
摘要： A device for treating a cardiovascular condition includes an expandable scaffold positionable in a portion of a vasculature of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The biodegradable compound serves as a temporary template that allows the cardiovascular tissue to be rebuilt about the scaffold.
摘要翻译：用于治疗心血管病症的装置包括可定位在哺乳动物脉管系统的一部分中的可扩展支架; 并通过支架技术维持，其中支架由由可生物降解的化合物组成的电纺纤维组成。可生物降解的化合物用作临时模板，允许围绕支架重建心血管组织。

5. 发明授权

US07238199B2 Method and apparatus for stent deployment with enhanced delivery of bioactive agents 有权
标题翻译：用于具有增强的生物活性剂递送的支架部署的方法和装置
公开(公告)号：US07238199B2
公开(公告)日：2007-07-03
申请号：US10469632
申请日：2002-02-27
申请人： Marc D. Feldman , Stephen R. Bailey , C. Mauli Agrawal , Kyriacos A. Athanasiou
发明人： Marc D. Feldman , Stephen R. Bailey , C. Mauli Agrawal , Kyriacos A. Athanasiou
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2250/0067
摘要： A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein where the protected regions are protected by the unprotected regions when the stent is in its undeployed state which has a smaller cross-sectional dimension than the stent in its deployed state. And when the stent is in its deployed state the bioactive or biopenetrating agent(s) are brought into direct and intimate contact with a tissue or interior of a blood vessel of an animal including a human.
摘要翻译：公开了一种用于包括人类在内的动物的支架，其包括未受保护和保护的区域，每个保护区域包括其中包含生物活性或生物穿透剂，其中当支架处于其未被部署状态时受保护区域被未保护区域保护，横截面尺寸比其展开状态下的支架。并且当支架处于其展开状态时，使生物活性或生物穿透剂与包括人的动物的血管的组织或内部直接且紧密接触。

6. 发明授权

US6065476A Method of enhancing surface porosity of biodegradable implants 失效
标题翻译：提高生物可降解植入物表面孔隙度的方法
公开(公告)号：US6065476A
公开(公告)日：2000-05-23
申请号：US457661
申请日：1995-06-01
申请人： C. Mauli Agrawal , Kyriacos A. Athanasiou
发明人： C. Mauli Agrawal , Kyriacos A. Athanasiou
IPC分类号： A61L27/50 , A61L27/58 , A61L31/14 , A61B19/00 , A61F2/02
CPC分类号： A61L31/14 , A61L27/50 , A61L27/58 , A61L31/148 , Y10S623/901
摘要： The invention discloses pH-controlling devices that comprise a biodegradable polymer and a pH-controlling substance, particularly an alkaline, acidic or buffering agents. By way of example, such alkaline agents include calcium carbonate and sodium bicarbonate. Methods of preparing such devices are also described. Methods for enhancing biocompatibility of an implantable device are also provided, as neutralizing alkaline materials are released at a rate that offsets changes in pH typically observed as polymers degrade to various acidic or alkaline by-products. By way of example, biodegradable polymers include PLA, PGA, polycaprolactone, copolymers thereof, or mixtures thereof. A new technique is disclosed to increase the surface porosity of porous implants which have a tendency to form relatively impermeable coverings. This technique entails the use of mechanical means to remove at least part of said covering, thus increasing the implant's surface porosity and permeability.
摘要翻译：本发明公开了包含可生物降解聚合物和pH控制物质，特别是碱性，酸性或缓冲剂的pH控制装置。举例来说，这种碱性试剂包括碳酸钙和碳酸氢钠。还描述了制备这种装置的方法。还提供了用于增强可植入装置的生物相容性的方法，因为中和碱性材料以抵消随着聚合物降解为各种酸性或碱性副产物而观察到的pH变化的速率被释放。举例来说，可生物降解的聚合物包括PLA，PGA，聚己酸内酯，其共聚物或其混合物。公开了一种新技术来增加具有形成相对不渗透覆盖层的倾向的多孔植入物的表面孔隙度。该技术需要使用机械装置去除至少部分所述覆盖物，从而增加植入物的表面孔隙率和渗透性。

7. 发明申请

US20130218253A1 SCAFFOLD SYSTEM FOR TISSUE REPAIR 有权
标题翻译：用于组织修复的SCAFFOLD系统
公开(公告)号：US20130218253A1
公开(公告)日：2013-08-22
申请号：US13766530
申请日：2013-02-13
申请人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
发明人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61L27/18 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/148 , A61L2300/21 , A61L2300/412 , A61L2430/22 , D04H1/4391 , D04H1/728 , C08L67/04 , C08L89/06 , C08L5/04
摘要： A device for treating a damaged tissue includes an expandable scaffold positionable in a portion of a luminal tissue structure of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The scaffold serves as a temporary template that allows the tissue to be rebuilt.
摘要翻译：用于治疗受损组织的装置包括可定位在哺乳动物的腔内组织结构的一部分中的可扩展支架; 并通过支架技术维持，其中支架由由可生物降解的化合物组成的电纺纤维组成。支架用作允许组织重建的临时模板。

8. 发明授权

US5876446A Porous prosthesis with biodegradable material impregnated intersticial spaces 失效
标题翻译：多孔假体与可生物降解材料浸渍间隙
公开(公告)号：US5876446A
公开(公告)日：1999-03-02
申请号：US772276
申请日：1996-12-20
申请人： C. Mauli Agrawal , Robert C. Schenck
发明人： C. Mauli Agrawal , Robert C. Schenck
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61L27/04 , A61L27/18 , A61L27/56 , A61F2/02
CPC分类号： A61F2/30767 , A61L27/04 , A61L27/18 , A61L27/56 , A61F2/3094 , A61F2/36 , A61F2/3662 , A61F2002/30064 , A61F2002/30677 , A61F2002/3611 , A61F2002/3631 , A61F2310/0097 , A61F2310/00976
摘要： Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a biodegradable carrier, such as a biodegradable polymer. The pores or intersticial spaces of the tissue-mating surface of the device are impregnated with the biodegradable polymer. The prosthesis of the present invention provides for enhanced rigid fixation, as pores at the surface of said device provide for bony ingrowth as the biodegradable carrier, i.e., polymer, degrades. Methods for preparing said prosthesis are described. Methods for delivering a pharmacologically active substance by including a pharmacologically active substance in the biodegradable carrier (e.g., polymer) are also disclosed.
摘要翻译：被定义为具有至少一个多孔组织配合表面的医疗装置，特别是假体。该装置的组织配合表面包括可生物降解的载体，例如可生物降解的聚合物。装置的组织配合表面的孔或间隙被可生物降解的聚合物浸渍。本发明的假体提供了增强的刚性固定，因为当生物降解的载体即聚合物降解时，在所述装置的表面处的孔提供骨向内生长。描述了制备所述假体的方法。还公开了通过将药理活性物质包括在可生物降解的载体（例如聚合物）中递送药理活性物质的方法。

9. 发明授权

US09259334B2 Scaffold system for tissue repair 有权
标题翻译：支架系统用于组织修复
公开(公告)号：US09259334B2
公开(公告)日：2016-02-16
申请号：US13766530
申请日：2013-02-13
申请人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
发明人： J. Jordan Massey Kaufmann , C. Mauli Agrawal , Steven R. Bailey
IPC分类号： A61F2/82 , A61L27/56 , D04H1/4391 , D04H1/728 , A61L27/50 , A61L27/58 , A61L27/34 , A61L31/10 , A61L31/14 , A61F2/07
CPC分类号： A61F2/82 , A61F2/07 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61L27/18 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/507 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/148 , A61L2300/21 , A61L2300/412 , A61L2430/22 , D04H1/4391 , D04H1/728 , C08L67/04 , C08L89/06 , C08L5/04
摘要： A device for treating a damaged tissue includes an expandable scaffold positionable in a portion of a luminal tissue structure of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The scaffold serves as a temporary template that allows the tissue to be rebuilt.
摘要翻译：用于治疗受损组织的装置包括可定位在哺乳动物的腔内组织结构的一部分中的可扩展支架; 并通过支架技术维持，其中支架由由可生物降解的化合物组成的电纺纤维组成。支架用作允许组织重建的临时模板。

10. 发明授权

US06767330B2 Foot temperature and health monitoring system 失效
标题翻译：脚温度和健康监测系统
公开(公告)号：US06767330B2
公开(公告)日：2004-07-27
申请号：US10029043
申请日：2001-12-20
申请人： Lawrence A. Lavery , C. Mauli Agrawal , Kyriacos A. Athanasiou , George P. Constantinides , Dan R. Lanctot , Ruben G. Zamorano
发明人： Lawrence A. Lavery , C. Mauli Agrawal , Kyriacos A. Athanasiou , George P. Constantinides , Dan R. Lanctot , Ruben G. Zamorano
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/015 , A61B5/022 , A61B5/024 , A61B5/145 , A61B5/14532 , Y10S128/92
摘要： The present invention provides an apparatus and method for monitoring skin temperatures at predetermined locations on the body of a human or an animal. One embodiment includes a platform with a grid including holes on which the user stands. Under the grid is a movable array of light sensors and temperature sensors. The foot position is determined from the output of the light sensors. The temperatures at predetermined locations on the skin surface are determined by the signals obtained from the temperature sensors. Additional vital health information may be obtained by other sensors on the apparatus. The data may be stored for future retrieval, or transmitted to a remote location for off-site monitoring. Alternative embodiments include sensor blankets or wraps whereby temperature sensors monitor skin temperature for areas of pressure on the blanket or areas covered by the wrap.
摘要翻译：本发明提供了一种监测人或动物身体上预定位置的皮肤温度的装置和方法。一个实施例包括具有网格的平台，包括用户所在的孔。电网下是一个可移动的光传感器和温度传感器阵列。脚位置由光传感器的输出确定。通过从温度传感器获得的信号来确定皮肤表面上预定位置处的温度。另外的重要健康信息可以由设备上的其它传感器获得。可以存储数据以供将来检索，或者将其发送到远程位置进行异地监视。替代实施例包括传感器毯或包裹物，由此温度传感器监测毯子上的压力区域的皮肤温度或由包裹覆盖的区域。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式