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1. 发明申请

US20110251150A2 Targeting MicroRNAs For The Treatment Of Liver Cancer 有权
标题翻译：靶向微小RNA治疗肝癌
公开(公告)号：US20110251150A2
公开(公告)日：2011-10-13
申请号：US12740211
申请日：2008-10-29
申请人： C. Bennett , Ayelet Chajut , Christine Esau , Eric Marcusson , Noga Yerushalmi
发明人： C. Bennett , Ayelet Chajut , Christine Esau , Eric Marcusson , Noga Yerushalmi
IPC分类号： A61K31/7125 , A61P35/00 , A61K31/7115 , A61K31/7088 , A61K31/712
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译：本文提供了用于治疗肝癌的方法。这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。

2. 发明授权

US08680067B2 Targeting microRNAs for the treatment of liver cancer 有权
标题翻译：靶向microRNAs用于治疗肝癌
公开(公告)号：US08680067B2
公开(公告)日：2014-03-25
申请号：US13481105
申请日：2012-05-25
申请人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric Marcusson , Noga Yerushalmi
发明人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric Marcusson , Noga Yerushalmi
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译：本文提供了用于治疗肝癌的方法。这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。

3. 发明申请

US20120295962A1 TARGETING MICRORNAS FOR THE TREATMENT OF LIVER CANCER 有权
标题翻译：靶向治疗肝癌的微阵列
公开(公告)号：US20120295962A1
公开(公告)日：2012-11-22
申请号：US13481105
申请日：2012-05-25
申请人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
发明人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
IPC分类号： A61K31/7088 , A61P35/00 , A61K31/7115 , A61K31/7125 , A61K31/712
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译：本文提供了用于治疗肝癌的方法。这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。

4. 发明授权

US08211867B2 Targeting microRNAs for the treatment of liver cancer 有权
标题翻译：靶向microRNAs用于治疗肝癌
公开(公告)号：US08211867B2
公开(公告)日：2012-07-03
申请号：US12740211
申请日：2008-10-29
申请人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
发明人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译：本文提供了用于治疗肝癌的方法。这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。

5. 发明申请

US20100267814A1 Targeting MicroRNAs for the Treatment of Liver Cancer 有权
标题翻译：靶向微小RNA治疗肝癌
公开(公告)号：US20100267814A1
公开(公告)日：2010-10-21
申请号：US12740211
申请日：2008-10-29
申请人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
发明人： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric G. Marcusson , Noga Yerushalmi
IPC分类号： A61K31/7125 , A61K31/7088 , A61K31/712 , A61K31/7115 , A61P35/00
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译：本文提供了用于治疗肝癌的方法。这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。

6. 发明申请

US20050261218A1 Oligomeric compounds and compositions for use in modulation small non-coding RNAs 失效
标题翻译：用于调制小非编码RNA的低聚化合物和组合物
公开(公告)号：US20050261218A1
公开(公告)日：2005-11-24
申请号：US10909125
申请日：2004-07-30
申请人： Christine Esau , Bridget Lollo , C. Bennett , Susan Freier , Richard Griffey , Brenda Baker , Timothy Vickers , Eric Marcusson , Erich Koller , Eric Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Bennett , Susan Freier , Richard Griffey , Brenda Baker , Timothy Vickers , Eric Marcusson , Erich Koller , Eric Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K20060101 , A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译：提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。组合物包含靶向小的非编码RNA的寡聚化合物。还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。

7. 发明授权

US07998677B2 MicroRNA detection 有权
标题翻译：微RNA检测
公开(公告)号：US07998677B2
公开(公告)日：2011-08-16
申请号：US12393523
申请日：2009-02-26
申请人： Christine Esau , Scott E. Davis , Frank C. Bennett
发明人： Christine Esau , Scott E. Davis , Frank C. Bennett
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , G01N27/44717 , C12Q2537/1373 , C12Q2525/207 , C12Q2525/107
摘要： Provided herein are methods for detection of miRNA in a sample. In certain embodiments, the sample comprises RNA and is derived from a cell or tissue. The methods of detection employ a competitor molecule to allow for detection of an miRNA in the presence of an anti-miRNA oligonucleotide.
摘要翻译：本文提供了检测样品中miRNA的方法。在某些实施方案中，样品包含RNA并衍生自细胞或组织。检测方法使用竞争剂分子来在抗miRNA寡核苷酸存在下允许检测miRNA。

8. 发明申请

US20090236225A1 MICRORNA DETECTION 有权
标题翻译： MICRORNA检测
公开(公告)号：US20090236225A1
公开(公告)日：2009-09-24
申请号：US12393523
申请日：2009-02-26
申请人： Christine Esau , Scott E. Davis , Frank C. Bennett
发明人： Christine Esau , Scott E. Davis , Frank C. Bennett
IPC分类号： G01N27/447 , C12Q1/68
CPC分类号： C12Q1/6809 , G01N27/44717 , C12Q2537/1373 , C12Q2525/207 , C12Q2525/107
摘要： Provided herein are methods for detection of miRNA in a sample. In certain embodiments, the sample comprises RNA and is derived from a cell or tissue. The methods of detection employ a competitor molecule to allow for detection of an miRNA in the presence of an anti-miRNA oligonucleotide.
摘要翻译：本文提供了检测样品中miRNA的方法。在某些实施方案中，样品包含RNA并衍生自细胞或组织。检测方法使用竞争剂分子来在抗miRNA寡核苷酸存在下允许检测miRNA。

9. 发明授权

US08969314B2 Methods for use in modulating miR-122a 有权
标题翻译：用于调节miR-122a的方法
公开(公告)号：US08969314B2
公开(公告)日：2015-03-03
申请号：US11513102
申请日：2006-08-29
申请人： Christine Esau , Sanjay Bhanot
发明人： Christine Esau , Sanjay Bhanot
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Methods are provided for the treatment of cardiovascular or metabolic diseases characterized by elevated serum total cholesterol, elevated serum LDL-cholesterol, or elevated serum triglycerides, through the administration of an oligomeric compound which modulates the levels or activity of miR-122a. Further provided are methods for reducing hepatic steatosis or liver tissue triglyceride accumulation through the administration of an oligomeric compound which modulates the levels or activity of miR-122a. Such methods employ oligomeric compounds which hybridize with or sterically interfere with nucleic acid molecules comprising or encoding miR-122a. Such oligomeric compounds may include one or more modifications thereon, which may improve the activity, stability, or nuclease resistance of the oligomeric compound. These modified oligomeric compounds are used as single compounds or in compositions, including pharmaceutical compositions, to modulate or mimic the targeted nucleic acid comprising or encoding miR-122a.
摘要翻译：提供了通过施用调节miR-122a的水平或活性的寡聚化合物来治疗以血清总胆固醇升高，血清LDL-胆固醇升高或血清甘油三酯升高为特征的心血管或代谢疾病的方法。还提供了通过施用调节miR-122a的水平或活性的寡聚化合物来减少肝脂肪变性或肝组织甘油三酯积聚的方法。这样的方法使用与包含miR-122a或编码miR-122a的核酸分子杂交或空间干扰的寡聚化合物。这样的低聚化合物可以包括其上的一个或多个修饰，其可以改善低聚化合物的活性，稳定性或核酸酶抗性。这些改性的寡聚化合物用作单一化合物或组合物，包括药物组合物，以调节或模拟包含或编码miR-122a的靶向核酸。

10. 发明申请

US20120115228A1 OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS 有权
标题翻译：用于微波调制的低分子化合物和组合物
公开(公告)号：US20120115228A1
公开(公告)日：2012-05-10
申请号：US13353114
申请日：2012-01-18
申请人： Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
发明人： Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
IPC分类号： C12N5/071 , C07H21/04
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2320/51 , C12N2310/3527 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activing in a cell.
摘要翻译：提供化合物，组合物和方法用于调节miRNA的水平表达，加工和功能。组合物包含靶向小的非编码RNA和miRNA的寡聚化合物。寡聚化合物具有有效的miRNA抑制活性，并进一步表现出改善的治疗指数。还提供了选择性调节细胞中miRNA活化的方法。

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