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1. 发明申请

US20060257913A1 Genetic polymorphisms associated with myocardial infarction and uses thereof 审中-公开
标题翻译：与心肌梗塞相关的遗传多态性及其用途
公开(公告)号：US20060257913A1
公开(公告)日：2006-11-16
申请号：US11430939
申请日：2006-05-10
申请人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
发明人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including one of the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction.
摘要翻译：提供与心肌梗死相关的遗传多态性。更具体地，提供了包括与心肌梗死相关的单核苷酸多态性（SNP），与多核苷酸杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体，微阵列和包含一个的多核苷酸，心肌梗死诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。

2. 发明申请

US20060252059A1 Method and apparatus for analyzing genotype data 有权
公开(公告)号：US20060252059A1
公开(公告)日：2006-11-09
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.

3. 发明授权

US08554487B2 Method and apparatus for analyzing genotype data 有权
标题翻译：分析基因型数据的方法和装置
公开(公告)号：US08554487B2
公开(公告)日：2013-10-08
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： G01N33/50
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.
摘要翻译：提供了用于分析绘制在二维空间中的基因型数据的方法和装置。该方法包括：将表示基因型数据的点连接到预定点以形成直线并获得相邻直线之间的角度; 从所获得的角度提取两个最大角度; 并使用由两个提取的最大角度分离的三组基因型数据分析绘制的基因型数据。根据本发明，当分析基因型分类的实验结果时，通过连接表示各基因型数据的点和在二维空间中绘制的预定点之间的直线连接获得的角度的两个最大角度为检测到的三个数据区域被检测到的两个最大角度分开，以分析基因型数据。因此，可以快速方便地分析大量用于分类基因型的实验数据。

4. 发明申请

US20060263817A1 Genetic polymorphism associated with myocardial infarction and uses thereof 审中-公开
标题翻译：与心肌梗死相关的遗传多态性及其用途
公开(公告)号：US20060263817A1
公开(公告)日：2006-11-23
申请号：US11438614
申请日：2006-05-22
申请人： Kyu-sang Lee , Ki-eun Kim , Byung-chul Kim , Kyung-Hee Park
发明人： Kyu-sang Lee , Ki-eun Kim , Byung-chul Kim , Kyung-Hee Park
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C07K16/40
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N2500/00 , G01N2800/32
摘要： A genetic polymorphism associated with myocardial infarction is provided. More particularly, a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a complementary polynucleotide of the nucleotide sequences, a polynucleotide hybridized with one of the polynucleotides, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction are provided.
摘要翻译：提供与心肌梗死相关的遗传多态性。更具体地，涉及包含与心肌梗塞相关的单核苷酸多态性（SNP），核苷酸序列的互补多核苷酸的多核苷酸，与多核苷酸之一杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体提供了包括多核苷酸的微阵列和试剂盒，心肌梗死诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。

5. 发明授权

US07981634B2 Method for positively detecting toxic material 有权
标题翻译：积极检测有毒物质的方法
公开(公告)号：US07981634B2
公开(公告)日：2011-07-19
申请号：US11609979
申请日：2006-12-13
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： Disclosed herein is a method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles with an electron donor. The electron donor is reacted with an electron transfer system of the sub-mitochondrial particles to produce a reactant. A pH indicator has its pH adjusted to be in a range of 9 to 11. The pH indicator is added to each reactant. Color changes in the pH indicator permit the detection of toxins present in the sample.
摘要翻译：本文公开了一种积极检测样品内有毒物质的方法，该方法包括使亚线粒体颗粒与电子给体接触。电子给体与亚线粒体颗粒的电子转移体系反应以产生反应物。 pH指示剂的pH调节在9至11的范围内。将pH指示剂加入每种反应物中。 pH指示剂中的颜色变化允许检测样品中存在的毒素。

6. 发明授权

US08367367B2 Kit for positively detecting toxic material 有权
标题翻译：用于积极检测有毒物质的试剂盒
公开(公告)号：US08367367B2
公开(公告)日：2013-02-05
申请号：US13155944
申请日：2011-06-08
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a pH of a pH indicator which change color according to a change in pH, adding the pH indicators to each reaction resultant and identifying color changes of the pH indicator. Also provided is a kit for positively detecting toxic materials within a sample.
摘要翻译：一种积极检测样品内的有毒物质的方法，该方法包括使具有由线粒体内膜形成的感受态线粒体酶的亚线粒体颗粒，将电子传递到亚线粒体颗粒的电子转移系统的电子给体和样品，并形成反应产物，调节pH指示剂的pH值，根据pH的变化改变颜色，向每个反应产物添加pH指示剂并鉴定pH指示剂的颜色变化。还提供了用于积极检测样品中有毒物质的试剂盒。

7. 发明授权

US07856322B2 Method and apparatus for determining specificity of a candidate probe 失效
标题翻译：用于确定候选探针的特异性的方法和装置
公开(公告)号：US07856322B2
公开(公告)日：2010-12-21
申请号：US11610185
申请日：2006-12-13
申请人： Ki-eun Kim , Ji-young Oh
发明人： Ki-eun Kim , Ji-young Oh
IPC分类号： G06F7/00
CPC分类号： G06F19/22 , G06F19/14 , G06F19/20
摘要： Provided are a method and apparatus for determining specificity of a candidate probe.
摘要翻译：提供了一种用于确定候选探针的特异性的方法和装置。

8. 发明授权

US07641858B2 Apparatus for introducing fluid into microfluidic chip by using centrifugal force, a system including the apparatus, and a method of using the apparatus 有权
标题翻译：用于通过离心力将流体引入微流体芯片的装置，包括该装置的系统以及使用该装置的方法
公开(公告)号：US07641858B2
公开(公告)日：2010-01-05
申请号：US11846794
申请日：2007-08-29
申请人： Young-rok Kim , Jun-hong Min , Kak Namkoong , Kwang-ho Cheong , Chang-eun Yoo , Ki-woong Han , Ki-eun Kim
发明人： Young-rok Kim , Jun-hong Min , Kak Namkoong , Kwang-ho Cheong , Chang-eun Yoo , Ki-woong Han , Ki-eun Kim
IPC分类号： B01L3/14 , B65B3/04
CPC分类号： B01L9/527 , B01L3/5021 , B01L3/5027 , B01L2200/027 , B01L2300/0832 , B01L2400/0409 , C12M23/16
摘要： An apparatus introducing a fluid using a centrifugal force includes an introduction member including a chip receiver and a fluid introduction reservoir, the chip receiver receiving a first part of a microfluidic chip, the first part including an inlet, the fluid introduction reservoir storing a fluid to be introduced to the microfluidic chip, the fluid introduction reservoir having an exit formed to correspond to the inlet of the microfluidic chip received in the chip receiver, and a support member supporting a second part of the microfluidic chip, wherein the microfluidic chip is disposed between the introduction member and the support member, the apparatus is rotatable in a state where the introduction member is closer to a center of rotation than the microfluidic chip, and the fluid is introducible from the fluid introduction reservoir through the inlet into the microfluidic chip due to a centrifugal force generated by rotation.
摘要翻译：使用离心力引入流体的装置包括引入构件，其包括芯片接收器和流体引入储存器，所述芯片接收器接收微流体芯片的第一部分，所述第一部分包括入口，所述流体引入储存器将流体存储到引入到微流体芯片中，流体引入储存器具有形成为对应于接收在芯片接收器中的微流体芯片的入口的出口，以及支撑微流体芯片的第二部分的支撑构件，其中微流体芯片设置在引导构件和支撑构件，该装置可以在导入构件比微流体芯片更靠近旋转中心的状态下旋转，并且流体可以从流体引入储存器通过入口引入到微流体芯片中，这是由于由旋转产生的离心力。

9. 发明申请

US20110306198A1 METHOD OF FABRICATING SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE 审中-公开
标题翻译：制造半导体集成电路器件的方法
公开(公告)号：US20110306198A1
公开(公告)日：2011-12-15
申请号：US13157615
申请日：2011-06-10
申请人： Yong-Kuk Jeong , Dong-Suk Shin , Jong-Hun Kim , Hyun-Kwan Yu , Ki-eun Kim
发明人： Yong-Kuk Jeong , Dong-Suk Shin , Jong-Hun Kim , Hyun-Kwan Yu , Ki-eun Kim
IPC分类号： H01L21/28
CPC分类号： H01L29/7833 , H01L21/823412 , H01L21/823425 , H01L29/6653 , H01L29/6659 , H01L29/7843
摘要： A method of fabricating a semiconductor integrated circuit device includes forming a gate pattern on a semiconductor substrate, the gate pattern having a gate insulation film and a gate electrode. A spacer is formed on sidewalls of the gate pattern. A silicide layer is formed by a silicide process on at least one portion of the semiconductor substrate exposed by the gate pattern and the spacer, the silicide layer being formed using a silicide process. A stress buffer layer is formed on a resultant structure having the silicide layer. A stress film is formed on the stress buffer layer.
摘要翻译：一种制造半导体集成电路器件的方法包括在半导体衬底上形成栅极图案，栅极图案具有栅极绝缘膜和栅电极。在栅极图案的侧壁上形成间隔物。硅化物层通过硅化物工艺在由栅极图案和间隔物暴露的半导体衬底的至少一部分上形成，硅化物层使用硅化物工艺形成。在具有硅化物层的所得结构上形成应力缓冲层。在应力缓冲层上形成应力膜。

10. 发明申请

US20060224328A1 System and method for searching patents using DNA fragment number 审中-公开
标题翻译：使用DNA片段数搜索专利的系统和方法
公开(公告)号：US20060224328A1
公开(公告)日：2006-10-05
申请号：US11264730
申请日：2005-11-01
申请人： Ki-eun Kim
发明人： Ki-eun Kim
IPC分类号： G06F19/00 , G06F17/30
CPC分类号： G06Q50/24 , G06F16/93
摘要： Provided is a system for searching for patent documents by using a DNA fragment number. The system includes a DNA fragment sequence database storing information about DNA fragment sequences; a patent sequence database storing information about patent DNA fragment sequences of patent documents; a patent database storing information about patent documents; an interface receiving a DNA fragment number from a client; a sequence extracting unit extracting a DNA fragment sequence corresponding to the DNA fragment number from the DNA fragment sequence database; a matching sequence search unit searching for patent DNA fragment sequences matching the extracted DNA fragment sequence in the patent sequence database; a patent number extracting unit searching for patent numbers of patent documents including the patent DNA fragment sequences from the patent sequence database; and a patent search unit searching for patent documents from the patent database by inputting the extracted patent numbers.
摘要翻译：提供了通过使用DNA片段号搜索专利文献的系统。该系统包括存储关于DNA片段序列的信息的DNA片段序列数据库; 存储专利文献专利DNA片段序列的信息的专利序列数据库; 存储专利文献信息的专利数据库; 从客户端接收DNA片段号的接口; 序列提取单元，从DNA片段序列数据库中提取与DNA片段数相对应的DNA片段序列; 匹配序列搜索单元，搜索与所述专利序列数据库中提取的DNA片段序列匹配的专利DNA片段序列; 专利号提取单元，从专利序列数据库中搜索专利文献专利号，包括专利DNA片段序列; 以及通过输入所提取的专利号从专利数据库中搜索专利文献的专利检索单元。

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