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1. 发明申请

US20100119577A1 THERAPEUTIC COMPOSITE FOR CARTILAGE DISORDER USING EXTRACELLULAR MATRIX (ECM) SCAFFOLD 审中-公开
标题翻译：使用细胞基质（ECM）SCAFFOLD的治疗病症的治疗复合物
公开(公告)号：US20100119577A1
公开(公告)日：2010-05-13
申请号：US12598523
申请日：2007-05-06
申请人： Byoung-Hyun Min , So Ra Park , Cheng Zhe Jin , Byung Hyune Choi
发明人： Byoung-Hyun Min , So Ra Park , Cheng Zhe Jin , Byung Hyune Choi
IPC分类号： A61F2/00 , C12N11/02 , C12N13/00 , A61K35/12
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L2430/06
摘要： The present invention relates to a method for preparing a cell-derived ECM scaffold to which chondrocytes or stem cells are attached, a method for cartilage regeneration by tissue engineering, which comprises using the cell-derived ECM scaffold, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold as an effective component. More specifically, the present invention relates to a method for cartilage regeneration by tissue engineering, which comprises transplanting ECM scaffold, having chondrocytes or stem cells attached thereto, into cartilage defects, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold, having chondrocytes or stem cells attached thereto, as an effective component. According to the present invention, when the inventive ECM scaffold having chondrocytes or stem cells attached thereto is transplanted into a cartilage defect, mature articular cartilage having the same appearance and characteristics as those of natural cartilage tissue, can be regenerated without side effects such as inflammatory responses.
摘要翻译：本发明涉及一种制备软骨细胞或干细胞连接的细胞衍生的ECM支架的方法，一种通过组织工程软骨再生的方法，其包括使用细胞衍生的ECM支架和用于治疗软骨的治疗组合物其包含ECM支架作为有效成分。更具体地说，本发明涉及通过组织工程软骨再生的方法，其包括将附着有软骨细胞或干细胞的ECM支架移植到软骨缺损中，以及用于治疗软骨病症的治疗组合物，其含有ECM支架，具有附着于其上的软骨细胞或干细胞作为有效成分。根据本发明，当将附着有软骨细胞或干细胞的本发明的ECM支架移植到软骨缺损中时，具有与天然软骨组织相同的外观和特征的成熟关节软骨可以再生而无副作用，例如炎性回应。

2. 发明申请

US20100136645A1 METHOD FOR PREPARING A CELL-DERIVED EXTRACELLULAR MATRIX SCAFFOLD 审中-公开
标题翻译：用于制备细胞衍生的细胞外基质SCAFFOLD的方法
公开(公告)号：US20100136645A1
公开(公告)日：2010-06-03
申请号：US12596008
申请日：2007-04-17
申请人： Byoung-Hyun Min , So Ra Park , Cheng Zhe Jin , Kwideok Park
发明人： Byoung-Hyun Min , So Ra Park , Cheng Zhe Jin , Kwideok Park
IPC分类号： C12N13/00 , C12N5/02
CPC分类号： C12N5/0655 , A61L27/3633 , A61L27/3817 , A61L27/48 , A61L27/56 , C12N2533/54 , C12N2533/90 , C08L67/04
摘要： The present invention relates to a method for fabricating a cell-derived extracellular matrix scaffold, more particularly, to a method for fabricating a cell-derived extracellular matrix scaffold, the method comprising the steps of obtaining a chondrocyte/extracellular matrix (ECM) membrane from chondrocytes derived from animal cartilage, obtaining a pellet-type scaffold-free construct by culturing after centrifuging the obtained chondrocytes/extracellular matrix (ECM) membrane and freeze-drying the obtained pellet-type construct. The cell-derived ECM scaffold according to the invention is a porous scaffold fabricated using cartilage tissue engineered by culturing chondrocytes in an in vitro scaffold-free system, which is not reduced in size during the cultivation and thus useful for cartilage regeneration.
摘要翻译：本发明涉及一种用于制备细胞衍生的细胞外基质支架的方法，更具体地涉及一种制备细胞衍生的细胞外基质支架的方法，所述方法包括以下步骤：从软骨细胞/细胞外基质（ECM）从动物软骨衍生的软骨细胞，通过在离心获得的软骨细胞/细胞外基质（ECM）膜并冷冻干燥获得的颗粒型构建体之后培养获得颗粒型无支架构建体。根据本发明的细胞衍生的ECM支架是使用在体外无支架体系中培养软骨细胞工程化的软骨组织制造的多孔支架，其在培养期间尺寸不减小，因此可用于软骨再生。

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