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1. 发明授权

US09640375B2 Method for crystallizing low mass ions for diagnosing colorectal cancer and method for diagnosing colorectal cancer using same 有权
公开(公告)号：US09640375B2
公开(公告)日：2017-05-02
申请号：US13816560
申请日：2011-08-12
申请人： Byong Chul Yoo , In Hoo Kim , Kyung Hee Kim , Jun Hwa Lee , Kwang Gi Kim , Hee Jin Chang , Dae Yong Kim , Jae Hwan Oh , Byung Chang Kim , Ji Won Park , Sun Young Kim
发明人： Byong Chul Yoo , In Hoo Kim , Kyung Hee Kim , Jun Hwa Lee , Kwang Gi Kim , Hee Jin Chang , Dae Yong Kim , Jae Hwan Oh , Byung Chang Kim , Ji Won Park , Sun Young Kim
IPC分类号： G01N33/48 , H01J49/00 , G01N33/574 , G01N33/68 , G06F19/00 , G06G7/58 , G06F19/24
CPC分类号： H01J49/0036 , G01N33/57419 , G01N33/6848 , G06F19/24 , G06F19/703
摘要： The present invention provides a method for determining low mass ions for diagnosing colorectal cancer by using a MALDI-TOF mass spectrometer to biostatistically analyze low mass ions, which are extracted from a biological sample, and a method for providing information for diagnosing colorectal cancer using same. The present inventions can provide a diagnostic method, which requires low cost and a short time for analysis, can analyze large areas, and which can provide superior and credible discriminations.

2. 发明申请

US20130206977A1 METHOD FOR CRYSTALLIZING LOW MASS IONS FOR DIAGNOSING COLORECTAL CANCER AND METHOD FOR DIAGNOSING COLORECTAL CANCER USING SAME 有权
标题翻译：用于结晶低质量离子用于诊断颜色性癌症的方法和使用其诊断颜色癌症的方法
公开(公告)号：US20130206977A1
公开(公告)日：2013-08-15
申请号：US13816560
申请日：2011-08-12
申请人： Byong Chul Yoo , In Hoo Kim , Kyung Hee Kim , Jun Hwa Lee , Kwang Gi Kim , Hee Jin Chang , Dae Yong Kim , Jae Hwan Oh , Byung Chang Kim , Ji Won PARK , Sun Young Kim
发明人： Byong Chul Yoo , In Hoo Kim , Kyung Hee Kim , Jun Hwa Lee , Kwang Gi Kim , Hee Jin Chang , Dae Yong Kim , Jae Hwan Oh , Byung Chang Kim , Ji Won PARK , Sun Young Kim
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G01N33/57419 , G01N33/6848 , G06F19/24 , G06F19/703
摘要： The present invention provides a method for crystallizing low mass ions for diagnosing colorectal cancer by using a MALDI-TOF mass spectrometer to biostatistically analyze low mass ions, which are extracted from a biological sample, and a method for providing information for diagnosing colorectal cancer using same. The present inventions can provide a diagnostic method, which requires low cost and a short time for analysis, can analyze large areas, and which can provide superior and credible discriminations.
摘要翻译：本发明提供了一种通过使用MALDI-TOF质谱仪来生物统计分析从生物样品提取的低质量离子来结晶用于诊断结肠直肠癌的低质量离子的方法，以及提供用于使用其诊断结肠直肠癌的信息的方法。本发明可以提供诊断方法，其需要低成本和短时间的分析，可以分析大面积，并且可以提供优异和可信的辨别。

3. 发明申请

US20110095179A1 Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS 有权
标题翻译：疾病诊断方法，使用TOF-SIMS的标记筛选方法和标记
公开(公告)号：US20110095179A1
公开(公告)日：2011-04-28
申请号：US12994263
申请日：2008-06-25
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： B01D59/44
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/s) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体而言，本发明提供使用飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量峰（m / s）峰的图案来诊断疾病的方法，标记筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

4. 发明授权

US08283117B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS 有权
标题翻译：疾病诊断方法，标记筛选方法和使用TOF-SIMS的标记
公开(公告)号：US08283117B2
公开(公告)日：2012-10-09
申请号：US12994263
申请日：2008-06-25
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： A61K38/21
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供了使用以飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰的图案，标记物，标记筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

5. 发明授权

US08871438B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS 有权
标题翻译：疾病诊断方法，标记筛选方法和使用TOF-SIMS的标记
公开(公告)号：US08871438B2
公开(公告)日：2014-10-28
申请号：US13570507
申请日：2012-08-09
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供使用飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰图案，标记物筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

6. 发明申请

US20130065266A1 Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS 有权
标题翻译：疾病诊断方法，使用TOF-SIMS的标记筛选方法和标记
公开(公告)号：US20130065266A1
公开(公告)日：2013-03-14
申请号：US13570507
申请日：2012-08-09
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： G01N27/62 , H01J49/40
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供使用飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰图案，标记物筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

7. 发明授权

US10435752B2 Use of ADCY3 for diagnosis and treatment of gastric cancer 有权
公开(公告)号：US10435752B2
公开(公告)日：2019-10-08
申请号：US14411970
申请日：2012-08-20
申请人： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
发明人： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
IPC分类号： C12Q1/6886 , C12Q1/527 , G01N33/574 , C12N15/113
摘要： The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.

8. 发明申请

US20150240313A1 USE OF ADCY3 FOR DIAGNOSIS AND TREATMENT OF GASTRIC CANCER 审中-公开
标题翻译：使用ADCY3进行诊断和治疗胃癌
公开(公告)号：US20150240313A1
公开(公告)日：2015-08-27
申请号：US14411970
申请日：2012-08-20
申请人： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
发明人： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12Q1/527 , C12Q2600/154 , C12Q2600/158 , C12Y406/01001 , G01N33/57446
摘要： The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.
摘要翻译：本发明涉及：用于检测胃癌标志物的组合物，其包含用于测量ADCY3或其蛋白质的mRNA的表达水平或甲基化水平的制剂; 用于诊断胃癌的试剂盒，含有该组合物; 通过用该制剂处理生物样品来确定是否存在与该制剂的互补结合的材料并将其与对照组比较来诊断胃癌的方法; 用于治疗和预防胃癌的组合物，其含有能抑制ADCY3多核苷酸或ADCY3多肽的制剂; 以及通过将组合物给予个体来治疗胃癌的方法。根据本发明，可以使用ADCY3作为诊断胃癌的标志物来诊断具有高诊断灵敏度和特异性的胃癌，因此可以大大有助于降低胃癌的死亡率。

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