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    • 4. 发明申请
    • RESORBABLE STRUCTURE FOR TREATING AND HEALING OF TISSUE DEFECTS
    • 组织缺陷治疗和治疗的可持续结构
    • US20060210598A1
    • 2006-09-21
    • US11381037
    • 2006-05-01
    • Douglas EvansJeffrey KellyTodd DeWitt
    • Douglas EvansJeffrey KellyTodd DeWitt
    • A61F13/00
    • A61L31/148A61L27/56A61L27/58A61L31/146
    • Devices and processes (e.g., improved Plasticized Melt Flow processes (PMF) or improved Phase Separation Polymer Concentration (PSPC), etc.) used to make resorbable and non-resorbable structures for treating and/or healing of tissue defects are disclosed. Among the advantages of using these improved processes are the preservation of molecular weight and the broadening of the processing conditions for temperature sensitive polymers and therapies (e.g. polylactide, polyglycolide, polycaprolactone or Cisplatin, etc.). This reduction in processing temperature, pressure and time can help to preserve the molecular weight and/or integrity of the final product or any additive incorporated therein. Additionally, pore size and shape tailoring can increase the osteoconductive nature of the device.
    • 公开了用于制备用于治疗和/或愈合组织缺陷的可再吸收和不可再吸收的结构的装置和方法(例如,改进的增塑熔体流动方法(PMF)或改进的相分离聚合物浓度(PSPC)等)。 使用这些改进方法的优点在于保持分子量和加热温度敏感聚合物和疗法(例如聚丙交酯,聚乙交酯,聚己内酯或顺铂等)的加工条件。 加工温度,压力和时间的这种降低有助于保持最终产品或其中所含的任何添加剂的分子量和/或完整性。 此外,孔径和形状调整可以增加器件的骨传导性质。