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    • 5. 发明授权
    • Volume-independent diagnostic test carrier and methods in which it is
used to determine an analyte
    • 体积独立的诊断测试载体及其用于确定分析物的方法
    • US5846837A
    • 1998-12-08
    • US900401
    • 1997-07-21
    • Detlef ThymHelmut Leininger
    • Detlef ThymHelmut Leininger
    • G01N31/22G01N33/52G01N33/66G01N33/49
    • G01N33/521Y10T436/25375
    • The present invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), which is characterized in that the network (4) is hydrophilic but not capillary active on its own and an inert cover (5) made of sample-impermeable material is arranged over the areas (6) of the network that extend beyond the detection layer in such a way that a sample application site (7) remains free on the region of the network (4) covering the detection layer as well as the use of such a test carrier for the determination of analyte in a liquid. In addition the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.
    • 本发明涉及一种包含支撑层(2)的诊断测试载体(1),其上布置有检测层(3),其上包含测定液体样品中的分析物所需的试剂和覆盖检测层(3)的网络(4) ),其大于所述检测层(3)并且附接到所述支撑层(2),其特征在于,所述网络(4)本身是亲水的但不是毛细管活动的,并且惰性盖(5)制成 样品不可渗透材料布置在网络的延伸超过检测层的区域(6)上,使得样品施加部位(7)在覆盖检测层的网络(4)的区域上保持空闲,如 以及使用这种测试载体来测定液体中的分析物。 此外,本发明涉及借助于根据本发明的测试载体来确定液体样品中的分析物的方法。
    • 7. 发明授权
    • Analytical system with means for detecting too small sample volumes
    • 具有检测太小样品量的手段的分析系统
    • US6055060A
    • 2000-04-25
    • US895368
    • 1997-07-16
    • Franz BolduanBernd EisenbarthKarl MiltnerHelmut LeiningerDetlef Thym
    • Franz BolduanBernd EisenbarthKarl MiltnerHelmut LeiningerDetlef Thym
    • G01N31/22G01N21/27G01N21/86G01N33/487G01N33/52G01N35/00G01N35/02G01N35/10G01N21/00
    • G01N21/8483G01N35/00029G01N35/00594G01N35/00603G01N2035/009G01N35/1016
    • Analytical system for evaluating test elements having means of determining whether a sufficient amount of sample liquid was evenly applied to an application zone comprising in a first embodiment of the invention at least two sources of light which illuminate separate or at least not fully overlapping areas of the application zone or the evaluation zone of the test strip, a control unit with which the light sources, of which there at least two, can be independently activated, at least one sensor which detects light reflected by the evaluation zone or transmitted by the evaluation zone and supplies an output signal proportional to the intensity of light as well as an evaluation unit which receives a first output signal from the sensor and converts it into a first measured value when the first of the light sources is activated, receives a second output signal from the sensor and converts it into a second measured value when the second of the light sources, is activated and compares the measured values and determines whether the deviation of the first value measured from the second value measured is sufficiently small. In a second embodiment of an analytical system according to the invention, at least one light source is used to illuminate the sample application zone or the evaluation zone of a test element and at least two sensors detect light reflected or transmitted by the evaluation zone, the output signal of the sensors being converted into measured values by the evaluation unit which determines whether the deviation of the measured values is sufficiently small.
    • 用于评估测试元件的分析系统,其具有确定足够量的样品液体是否均匀地施加到包括本发明的第一实施方案的施用区域中的装置,所述至少两个光源照射所述第一实施例的分离的或至少不完全重叠的区域 应用区域或测试条的评估区域,控制单元,其中至少两个的光源可独立地被激活;至少一个传感器,其检测由评估区域反射或由评估区域传输的光 并且提供与光强成正比的输出信号以及评估单元,该评估单元从第一传感器接收第一输出信号并将其转换为第一测量值,当第一光源被激活时,从第一测量值接收第二输出信号 传感器并将其转换成第二个测量值,当第二个光源被激活并比较我 并确定从测量的第二值测得的第一值的偏差是否足够小。 在根据本发明的分析系统的第二实施例中,使用至少一个光源来照射测试元件的样品施加区域或评估区域,并且至少两个传感器检测由评估区域反射或透射的光, 由评估单元将传感器的输出信号转换为测量值,该评估单元确定测量值的偏差是否足够小。
    • 10. 发明授权
    • Diagnostic test carrier and methods in which it is used to determine an
analyte
    • 诊断测试载体及其用于测定分析物的方法
    • US6025203A
    • 2000-02-15
    • US897608
    • 1997-07-21
    • Peter VetterHelmut Leininger
    • Peter VetterHelmut Leininger
    • G01N31/22G01N33/52G01N33/48
    • G01N33/525Y10T436/25375Y10T436/255
    • The invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine an analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), wherein the network (4) is a plied knitted fabric the threads of which are highly roughened on the side facing the detection layer (3) whereas the threads on the side of the knitted fabric which face away from the detection layer (3) are relatively smooth as well as the use of such a test carrier to determine an analyte in a liquid and the use of such a knitted fabric as a layer spreading liquid in a diagnostic test carrier. Moreover the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.
    • 本发明涉及一种诊断测试载体(1),其包含支撑层(2),其上布置有检测层(3),其上包含确定液体样品中的分析物所需的试剂和覆盖检测层(3)的网络(4) ),其大于所述检测层(3)并且附接到所述支撑层(2),其中所述网络(4)是其面线向所述检测层(3)侧的线被高度粗糙化的合股针织物 ),而针对织物的远离检测层(3)的那侧的线相对平滑,以及使用这种测试载体来确定液体中的分析物以及使用这样的针织物作为 在诊断测试载体中铺展液体的层。 此外,本发明涉及借助于根据本发明的测试载体来确定液体样品中的分析物的方法。