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1. 发明申请

US20060063766A1 Use of aryl- and heteroaryl-substituted tetrahydroisoquinolines to block reuptake of norepinephrine, dopamine, and serotonin 审中-公开
标题翻译：使用芳基和杂芳基取代的四氢异喹啉来阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US20060063766A1
公开(公告)日：2006-03-23
申请号：US11183102
申请日：2005-07-15
申请人： Bruce Molino , Shuang Liu , Barry Berkowitz , Marlene Cohen , Peter Guzzo , James Beck
发明人： Bruce Molino , Shuang Liu , Barry Berkowitz , Marlene Cohen , Peter Guzzo , James Beck
IPC分类号： A61K31/53 , A61K31/517 , A61K31/502 , A61K31/4743 , A61K31/4741 , A61K31/4709
CPC分类号： C07D417/04 , A61K31/4709 , A61K31/4741 , A61K31/4743 , A61K31/502 , A61K31/517 , A61K31/53 , C07D217/00 , C07D217/04 , C07D217/08 , C07D217/12 , C07D217/14 , C07D217/16 , C07D217/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
摘要翻译：本发明的化合物由式（I）中所示的化学结构表示：

2. 发明申请

US20060111396A1 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin 审中-公开
公开(公告)号：US20060111396A1
公开(公告)日：2006-05-25
申请号：US11284266
申请日：2005-11-21
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to a method of treating disorders by administering a compound of the formulae IA-IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1-R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein.

3. 发明申请

US20060111395A1 Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin 审中-公开
标题翻译：芳基和杂芳基取代的四氢异喹啉及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US20060111395A1
公开(公告)日：2006-05-25
申请号：US11284264
申请日：2005-11-21
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to a method of treating disorders by administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein R1—R8 are as described herein, R4 being aryl or heteroaryl.
摘要翻译：本发明涉及通过向需要这种治疗的患者施用治疗有效量的式（I）化合物来治疗疾病的方法：其中R 1 -R 8， / SUP>如本文所述，R 4是芳基或杂芳基。

4. 发明申请

US20060111393A1 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin 审中-公开
标题翻译： 4-苯基取代的四氢异喹啉及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US20060111393A1
公开(公告)日：2006-05-25
申请号：US10994688
申请日：2004-11-22
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to a method of treating disorders by administering a compound of the formulae IA-IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1-R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein.
摘要翻译：本发明涉及通过给予式IA-IF的化合物来治疗疾病的方法。这些化合物是以下结构的四氢异喹啉：式IA，IB，IC，ID，IE和IF各自化合物的R 1〜R 8如上所述这里。

5. 发明申请

US20060111386A1 Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof 审中-公开
公开(公告)号：US20060111386A1
公开(公告)日：2006-05-25
申请号：US11284330
申请日：2005-11-21
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745
摘要： The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

6. 发明申请

US20060111394A1 Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin 审中-公开
公开(公告)号：US20060111394A1
公开(公告)日：2006-05-25
申请号：US10994956
申请日：2004-11-22
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to a method of treating disorders by administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl.

7. 发明申请

US20060111385A1 Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof 审中-公开
标题翻译：新型4-苯基取代的四氢异喹啉及其治疗用途
公开(公告)号：US20060111385A1
公开(公告)日：2006-05-25
申请号：US10994706
申请日：2004-11-22
申请人： Bruce Molino , Barry Berkowitz , Marlene Cohen
发明人： Bruce Molino , Barry Berkowitz , Marlene Cohen
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745
摘要： The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
摘要翻译：本发明涉及一种治疗包括认知障碍，广泛性焦虑症，急性应激障碍，社交恐惧症，简单恐怖症，月经前焦虑症，社会焦虑症，重度抑郁症，进食障碍，肥胖症，神经性厌食症，癫痫症，神经性贪食症，暴饮暴食症，药物滥用障碍，化学依赖性，尼古丁成瘾，可卡因成瘾，酒精成瘾，安非他明成瘾，Lesch-Nyhan综合征，神经变性疾病，晚黄体期综合征，发作性睡眠，精神症状愤怒，排斥反应，运动障碍，锥体外综合征，Tic障碍，不宁腿综合征，迟发性运动障碍，睡眠相关饮食障碍，夜间饮食综合征，压力性尿失禁，偏头痛，神经性疼痛，糖尿病性神经病，纤维肌痛综合征，慢性疲劳综合征，性功能障碍，早泄和男性阳。该方法包括向需要这种治疗的患者施用治疗有效量的所公开的化合物。这样的化合物是如本文所述的具有式IA，IB，IIA，IIB，IIIA或IIIC的4-苯基取代的四氢异喹啉。

8. 发明申请

US20150299302A1 Adult Stem Cells/Progenitor Cells and Stem Cell Proteins for Treatment of Eye Injuries and Diseases 审中-公开
标题翻译：成人干细胞/祖细胞和干细胞蛋白用于治疗眼睛损伤和疾病
公开(公告)号：US20150299302A1
公开(公告)日：2015-10-22
申请号：US14717503
申请日：2015-05-20
申请人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz
发明人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz
IPC分类号： C07K16/18
CPC分类号： A61K35/28 , A61K9/0048 , A61K9/0051 , A61K38/1709 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2035/124 , C07K16/18 , C07K2317/76 , C12N5/0663 , C12N2501/25 , C12N2501/48
摘要： The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invention includes administration of TSG-6, STC-1, or a combination thereof to the ocular as a treatment for an ocular disease, disorder or condition in a mammal.
摘要翻译：本发明包括用于治疗哺乳动物眼部疾病，病症或状况的方法和组合物。本发明包括具有抗炎，抗细胞凋亡，免疫调节和抗肿瘤发生特性的间充质基质细胞群。本发明包括将TSG-6，STC-1或其组合施用于眼睛，作为哺乳动物眼部疾病，病症或状况的治疗。

9. 发明申请

US20140308295A1 Adult Stem Cells/Progenitor Cells and Stem Cell Proteins for Treatment of Eye Injuries and Diseases 有权
标题翻译：成人干细胞/祖细胞和干细胞蛋白用于治疗眼睛损伤和疾病
公开(公告)号：US20140308295A1
公开(公告)日：2014-10-16
申请号：US14250807
申请日：2014-04-11
申请人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz
发明人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz
IPC分类号： C07K16/18
CPC分类号： A61K35/28 , A61K9/0048 , A61K9/0051 , A61K38/1709 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2035/124 , C07K16/18 , C07K2317/76 , C12N5/0663 , C12N2501/25 , C12N2501/48
摘要： The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invention includes administration of TSG-6, STC-1, or a combination thereof to the ocular as a treatment for an ocular disease, disorder or condition in a mammal.
摘要翻译：本发明包括用于治疗哺乳动物眼部疾病，病症或状况的方法和组合物。本发明包括具有抗炎，抗细胞凋亡，免疫调节和抗肿瘤发生特性的间充质基质细胞群。本发明包括将TSG-6，STC-1或其组合施用于眼睛，作为哺乳动物眼部疾病，病症或状况的治疗。

10. 发明授权

US10105396B2 Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases 有权
公开(公告)号：US10105396B2
公开(公告)日：2018-10-23
申请号：US15632633
申请日：2017-06-26
申请人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz , Gavin W. Roddy , Robert Rosa
发明人： Darwin J. Prockop , Joo Youn Oh , Barry Berkowitz , Gavin W. Roddy , Robert Rosa
IPC分类号： A61K38/17 , A61K35/28 , A61K39/00 , A61K39/395 , A61K9/00 , C12N5/0775 , C07K16/18 , A61K45/06 , A61K35/12
摘要： The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invention includes administration of TSG-6, STC-1, or a combination thereof to the ocular as a treatment for an ocular disease, disorder or condition in a mammal.

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