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1. 发明授权

US07211408B2 Recombitope peptides 失效
标题翻译：重组单抗肽
公开(公告)号：US07211408B2
公开(公告)日：2007-05-01
申请号：US10463113
申请日：2003-06-16
申请人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-Chang Kuo , Malcolm Morville
发明人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-Chang Kuo , Malcolm Morville
IPC分类号： G01N33/00 , C12N15/09 , C07K1/00
CPC分类号： C07K16/18 , A61K38/00 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62 , G01N33/5091 , Y10S530/806 , Y10S530/858 , Y10S530/868
摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.
摘要翻译：本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。本发明的重组匹配肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞衍生自蛋白质抗原的表位。本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

2. 发明授权

US07482008B1 Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor 失效
标题翻译：人类T细胞反应性猫科动物蛋白（TRFP）从室内灰尘中分离出来，并用于其中
公开(公告)号：US07482008B1
公开(公告)日：2009-01-27
申请号：US09662784
申请日：2000-09-15
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
IPC分类号： A61K39/35 , A61K39/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K1/00
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
摘要翻译：从真空袋提取物中分离得到的基本上纯的共价连接的人T细胞反应性猫科蛋白（TRFP），通过亲和纯化从几个家庭用猫收集的房屋灰尘获得; 编码全部或部分TRFP或肽的DNA; 含有这种蛋白质或肽或其部分的组合物; 并且公开了与TRFP或肽反应的抗体。还公开了重组TRFP或肽; 修饰或突变的TRFP肽; 它们用于诊断或治疗目的。

3. 发明授权

US5547669A Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I 失效
标题翻译：包含猫过敏原T细胞表位的重组肽，Fel d I
公开(公告)号：US5547669A
公开(公告)日：1996-08-20
申请号：US807529
申请日：1991-12-13
申请人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville
发明人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville
IPC分类号： A61K38/00 , C07K14/415 , C07K14/47 , C07K16/18 , C12N15/62 , G01N33/50 , C12N15/12 , A61K38/17 , A61K39/35
CPC分类号： C07K16/18 , C07K14/415 , C07K14/47 , C07K14/4705 , C12N15/62 , G01N33/5091 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , Y10S530/806 , Y10S530/858 , Y10S530/868
摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.
摘要翻译：本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。本发明的重组亲和素肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞衍生自蛋白质抗原的表位。本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

4. 发明授权

US6019972A Peptides of human T cell reactive feline protein (TRFP) 失效
标题翻译：人T细胞反应性猫科蛋白（TRFP）的肽
公开(公告)号：US6019972A
公开(公告)日：2000-02-01
申请号：US300928
申请日：1994-09-02
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville , Thomas J. Briner
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville , Thomas J. Briner
IPC分类号： A61K38/00 , A61P37/08 , C07K14/415 , C07K14/47 , C07K14/725 , C07K16/18 , C12N15/62 , G01N33/50 , A61K39/35 , C07K7/00 , C07K7/06 , C07K7/08
CPC分类号： G01N33/5091 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C12N15/62 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
摘要翻译：从真空袋提取物中分离得到的基本上纯的共价连接的人T细胞反应性猫科蛋白（TRFP），该真空袋提取物通过亲和纯化从几个家庭与猫收集的房屋灰分获得; 编码全部或部分TRFP或肽的DNA; 含有这种蛋白质或肽或其部分的组合物; 并且公开了与TRFP或肽反应的抗体。还公开了重组TRFP或肽; 修饰或突变的TRFP肽; 它们用于诊断或治疗目的。

5. 发明授权

US4185117A Method of treatment with glycinamides 失效
标题翻译：用甘氨酰胺治疗的方法
公开(公告)号：US4185117A
公开(公告)日：1980-01-22
申请号：US937880
申请日：1978-08-29
申请人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
发明人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
IPC分类号： A61K31/165 , A61K31/195 , A61K31/22 , A61K31/24
CPC分类号： A61K31/195 , A61K31/165 , A61K31/22 , Y10S514/866 , Y10S514/909
摘要： L- and DL- Phenylglycines of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl and R.sup.1 is NH.sub.2, OH or completes a carboxylic ester group, useful in treating certain cardiovascular diseases, diabetes and obesity.
摘要翻译：式（I）的L-和DL-苯基甘氨酸及其药学上可接受的盐，其中R是氢或甲基，并且R 1是NH 2，OH或完成羧基酯基，可用于治疗某些心血管疾病，糖尿病和肥胖。

6. 发明授权

US06759234B1 Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response 失效
标题翻译：用于对人施用能够下调抗原特异性免疫应答的肽的组合物和方法
公开(公告)号：US06759234B1
公开(公告)日：2004-07-06
申请号：US08300510
申请日：1994-09-02
申请人： Malcolm L. Gefter , Ze′ev Shaked , Malcolm Morville
发明人： Malcolm L. Gefter , Ze′ev Shaked , Malcolm Morville
IPC分类号： A61K3816
CPC分类号： A61K38/16 , A61K39/35 , A61K2039/545
摘要： The present invention provides therapeutic compositions and methods for treating disease conditions in humans associated with an antigen specific immune response by the human to an antigen such as a protein antigen (i.e. allergy and autoimmune diseases). Therapeutic compositions of the invention are reproducible preparations which are suitable for human therapy. Compositions of the invention comprise at least one isolated peptide having a defined sequence of amino acid residues and the composition is capable of down regulating an antigen specific immune response to an offending antigen in a population of humans subject to the antigen specific immune response. Compositions and methods of the invention may be used to treat sensitivity to protein allergens in humans and may also be used to treat autoimmune disease such as rheumatoid arthritis, diabetes, myasthenia gravis, Grave's disease, Good Pasture's syndrome, thyroiditis and multiple sclerosis.
摘要翻译：本发明提供用于治疗人类与人类对抗原（例如过敏和自身免疫性疾病）的抗原特异性免疫应答相关的疾病状况的治疗组合物和方法。本发明的治疗组合物是适用于人类治疗的可重复制剂。本发明的组合物包含具有确定的氨基酸残基序列的至少一种分离的肽，并且该组合物能够下调受抗原特异性免疫应答的人群中的违规抗原的抗原特异性免疫应答。本发明的组合物和方法可用于治疗人类对蛋白质过敏原的敏感性，并且还可用于治疗自身免疫疾病，例如类风湿性关节炎，糖尿病，重症肌无力，格雷夫斯病，良好牧场综合征，甲状腺炎和多发性硬化。

7. 发明授权

US4148920A Therapeutic L- and DL- phenylglycines to treat diseases or disorders of reduced blood flow or oxygen availability 失效
标题翻译：治疗性L-和DL-苯基甘氨酸用于治疗血液流量减少或氧气供应的疾病或障碍
公开(公告)号：US4148920A
公开(公告)日：1979-04-10
申请号：US834768
申请日：1977-09-19
申请人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
发明人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
IPC分类号： A61K31/16 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61P3/04 , A61P3/08 , A61P9/00 , A61P9/08 , A61P9/10 , A61K31/24
CPC分类号： A61K31/165 , A61K31/195 , A61K31/22
摘要： L- and DL- Phenylglycines of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl and R.sup.1 is NH.sub.2, OH or completes a carboxylic ester group, useful in treating certain cardiovascular diseases, diabetes and obesity.
摘要翻译：式（I）的L-和DL-苯基甘氨酸及其药学上可接受的盐，其中R是氢或甲基，并且R 1是NH 2，OH或完成羧基酯基，可用于治疗某些心血管疾病，糖尿病和肥胖。

8. 发明授权

US4239779A Use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease 失效
标题翻译：苯乙醛酸及其衍生物在治疗缺血性心脏病中的应用
公开(公告)号：US4239779A
公开(公告)日：1980-12-16
申请号：US75730
申请日：1979-09-14
申请人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville , Michael G. Page
发明人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville , Michael G. Page
IPC分类号： A61K31/19 , A61K31/22 , A61K31/235
CPC分类号： A61K31/22 , A61K31/19
摘要： The use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease and the hyperglycemia of diabetes.
摘要翻译：苯乙醛酸及其衍生物在治疗缺血性心脏病和糖尿病高血糖症中的应用。

9. 发明授权

US4219566A Phenylglyoxylic acids and derivatives thereof 失效
标题翻译：苯乙醛酸及其衍生物
公开(公告)号：US4219566A
公开(公告)日：1980-08-26
申请号：US915904
申请日：1978-06-16
申请人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville , Michael G. Page
发明人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville , Michael G. Page
IPC分类号： A61K31/185 , A61K31/19 , A61K31/215 , A61K31/22 , A61P3/08 , A61P9/00 , C07C59/84 , C07C59/88 , C07C59/90 , A61K31/235
CPC分类号： A61K31/22 , A61K31/19 , C07C59/84 , C07C59/88 , C07C59/90 , Y10S514/866
摘要： The use of phenylglyoxylic acids and derivatives thereof in the treatment of ischemic heart disease and the hyperglycemia of diabetes.
摘要翻译：苯乙醛酸及其衍生物在治疗缺血性心脏病和糖尿病高血糖症中的应用。

10. 发明授权

US4186210A Method of treatment with glycinamides 失效
公开(公告)号：US4186210A
公开(公告)日：1980-01-29
申请号：US938019
申请日：1978-08-30
申请人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
发明人： Ian T. Barnish , Peter E. Cross , John C. Danilewicz , Malcolm Morville
IPC分类号： A61K31/165 , A61K31/195 , A61K31/22 , A61K31/24
CPC分类号： A61K31/22 , A61K31/165 , A61K31/195
摘要： L- and DL- Phenylglycines of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl and R.sup.1 is NH.sub.2, OH or completes a carboxylic ester group, useful in treating certain cardiovascular diseases, diabetes and obesity.

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