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1. 发明授权

US08694116B2 Method and apparatus for establishing context among events and optimizing implanted medical device performance 有权
标题翻译：用于在事件之间建立上下文并优化植入的医疗设备性能的方法和装置
公开(公告)号：US08694116B2
公开(公告)日：2014-04-08
申请号：US13447816
申请日：2012-04-16
申请人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
发明人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/37211 , A61N1/37235 , A61N1/37282 , G06F19/00
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.
摘要翻译：一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。便携式电子设备适于用作与植入的设备进行无线通信的接口。在一个实施例中，便携式电子设备与临床程序员接口以供医生使用。

2. 发明申请

US20110015692A1 COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权
标题翻译：可重构心脏器械组合重组控制治疗与抗再感染治疗
公开(公告)号：US20110015692A1
公开(公告)日：2011-01-20
申请号：US12891674
申请日：2010-09-27
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/365
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

3. 发明授权

US08483828B2 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US08483828B2
公开(公告)日：2013-07-09
申请号：US12891674
申请日：2010-09-27
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/365 , A61N1/05
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

4. 发明授权

US07996074B2 System and method for providing closely-followed cardiac therapy management through automated patient care 失效
标题翻译：通过自动病人护理提供紧密的心脏治疗管理的系统和方法
公开(公告)号：US07996074B2
公开(公告)日：2011-08-09
申请号：US11378677
申请日：2006-03-17
申请人： Bruce H. KenKnight , Yatheendhar D. Manicka
发明人： Bruce H. KenKnight , Yatheendhar D. Manicka
IPC分类号： A61B5/04
CPC分类号： A61B5/0031 , A61B5/0006
摘要： A system and method for providing closely-followed cardiac therapy management through automated patient care is presented. A patient under remote care is enrolled in a monitoring program following commencement of a cardiac therapy regimen to be undertaken by the patient. A wearable monitor, including one or more patient physiology sensors and a wireless interface providing enabling bi-directional data exchange, is provided to the patient. Patient physiometry, including quantitative physiological measures, is periodically collected from the wearable monitor over the wireless interface concomitant to performance of the cardiac therapy regimen. The patient physiometry is evaluated to determine a trend indicating an onset, progression, regression, absence of, and status quo of patient health status.
摘要翻译：提出了一种通过自动化病人护理提供紧密相关的心脏治疗管理的系统和方法。远程护理的患者在患者进行的心脏治疗方案开始之后登记在监测程序中。包括一个或多个患者生理学传感器和提供启用双向数据交换的无线接口的可穿戴监视器被提供给患者。包括定量生理测量在内的患者物理测量，通过无线接口从耐磨监视器中定期收集，同时伴随着心脏治疗方案的表现。评估患者物理量以确定指示患者健康状况的发作，进展，回归，不存在和现状的趋势。

5. 发明授权

US07260431B2 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US07260431B2
公开(公告)日：2007-08-21
申请号：US10850341
申请日：2004-05-20
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

6. 发明授权

US08014863B2 Heart attack or ischemia detector 有权
标题翻译：心脏病发作或缺血检测仪
公开(公告)号：US08014863B2
公开(公告)日：2011-09-06
申请号：US11625045
申请日：2007-01-19
申请人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
发明人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
IPC分类号： A61B5/02
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译：一种包括可植入触发事件检测器和可植入缺血检测器的系统。可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

7. 发明授权

US08628471B2 System and method for predicting patient health within a patient management system 失效
标题翻译：用于预测患者管理系统内的患者健康的系统和方法
公开(公告)号：US08628471B2
公开(公告)日：2014-01-14
申请号：US12827985
申请日：2010-06-30
申请人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
发明人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
IPC分类号： A61B5/0452 , A61B5/026 , A61B5/0205 , A61B5/053
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0205 , A61B5/0456 , A61B5/0464 , A61B5/0809 , A61B5/11 , A61B5/14532 , A61B2562/0219
摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译：公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。

8. 发明授权

US08160716B2 Method and apparatus for establishing context among events and optimizing implanted medical device performance 有权
标题翻译：用于在事件之间建立上下文并优化植入的医疗设备性能的方法和装置
公开(公告)号：US08160716B2
公开(公告)日：2012-04-17
申请号：US12891338
申请日：2010-09-27
申请人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
发明人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/37211 , A61N1/37235 , A61N1/37282 , G06F19/00
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.
摘要翻译：一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。便携式电子设备适于用作与植入的设备进行无线通信的接口。在一个实施例中，便携式电子设备与临床程序员接口以供医生使用。

9. 发明授权

US07805193B2 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

10. 发明申请

US20080177194A1 HEART ATTACK DETECTOR 有权
标题翻译：心脏攻击检测器
公开(公告)号：US20080177194A1
公开(公告)日：2008-07-24
申请号：US11625045
申请日：2007-01-19
申请人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
发明人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
IPC分类号： A61B5/04
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译：一种包括可植入触发事件检测器和可植入缺血检测器的系统。可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

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