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1. 发明授权

US07234648B2 Volatile substance-controlling composition 有权
标题翻译：易挥发物质控制组合物
公开(公告)号：US07234648B2
公开(公告)日：2007-06-26
申请号：US10699470
申请日：2003-10-31
申请人： Bruce Ernest Tepper , Ravindra Ranatunga , Victor Nicholas Vega , Ramon Andres Urteaga
发明人： Bruce Ernest Tepper , Ravindra Ranatunga , Victor Nicholas Vega , Ramon Andres Urteaga
IPC分类号： A61L9/014
CPC分类号： A61L9/014 , A61L9/042 , A61L15/46 , A61L2300/20 , A61L2300/602 , Y10T428/258
摘要： The present invention relates to a volatile substance-controlling composition comprising: a) a sorbent have a plurality of surfaces; and b) a fragrance component comprising at least one PRM, wherein said fragrance component is impregnated onto said surfaces of said sorbent and wherein in the presence of one or more volatile substances said fragrance component is released from said sorbent and said volatile substances are adsorbed by said sorbent.
摘要翻译：本发明涉及挥发性物质控制组合物，其包含：a）吸附剂具有多个表面; 和b）包含至少一种PRM的香料组分，其中所述香料组分浸渍在所述吸附剂的所述表面上，并且其中在存在一种或多种挥发性物质的情况下，所述香料组分从所述吸附剂中释放并且所述挥发性物质被所说的吸附剂。

2. 发明授权

US07549598B2 Method of making and applying volatile substance-controlling composition 有权
标题翻译：制备和应用挥发性物质控制组合物的方法
公开(公告)号：US07549598B2
公开(公告)日：2009-06-23
申请号：US11803603
申请日：2007-05-15
申请人： Bruce Ernest Tepper , Ravindra Ranatunga , Victor Nicholas Vega , Ramon Andres Urteaga
发明人： Bruce Ernest Tepper , Ravindra Ranatunga , Victor Nicholas Vega , Ramon Andres Urteaga
IPC分类号： B05D7/22 , A61L9/04
CPC分类号： A61L9/014 , A61L9/042 , A61L15/46 , A61L2300/20 , A61L2300/602 , Y10T428/258
摘要： A method of controlling the spread of volatile substances is provided. The method comprises the steps of: a) impregnating a fragrance component comprising at least one PRM onto a plurality of surfaces of a sorbent to form a volatile substance-controlling composition; and b) disposing the volatile substance-controlling composition into an article wherein the fragrance component is released from the sorbent primarily in the presence of one or more volatile substances when the volatile substances are adsorbed by the sorbent.
摘要翻译：提供了控制挥发性物质扩散的方法。该方法包括以下步骤：a）将包含至少一种PRM的香料组分浸渍在吸附剂的多个表面上以形成挥发性物质控制组合物; 以及b）将挥发性物质控制组合物置于制品中，其中当挥发性物质被吸附剂吸附时，主要在存在一种或多种挥发性物质的情况下将香料组分从吸附剂中释放出来。

3. 发明申请

US20070202604A1 Metabonomic methods to assess health of skin 有权
标题翻译：评估皮肤健康的代谢组学方法
公开(公告)号：US20070202604A1
公开(公告)日：2007-08-30
申请号：US11707670
申请日：2007-02-16
申请人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
发明人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
IPC分类号： G01N33/92
CPC分类号： G01R33/465 , A61B10/0035 , G01N33/6881 , G01N2800/20 , Y10S707/99943
摘要： The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at different times during a treatment are used to diagnose skin conditions or to appraise various skin treatments for efficacy.
摘要翻译：本发明涉及评估皮肤健康的方法。生物标志物用于评估皮肤样品。使用代谢组学方法，采用不同皮肤部位或在治疗期间不同时间取样的样品用于诊断皮肤状况或评估各种皮肤治疗的疗效。

4. 发明授权

US06989471B2 Absorbent article with phase change material 有权
标题翻译：具相变材料的吸收制品
公开(公告)号：US06989471B2
公开(公告)日：2006-01-24
申请号：US09778375
申请日：2001-02-07
申请人： Mattias Schmidt , Mark James Kline , Bruno Johannes Ehrnsperger , Cornelia Sprengard-Eichel , Bruce Ernest Tepper
发明人： Mattias Schmidt , Mark James Kline , Bruno Johannes Ehrnsperger , Cornelia Sprengard-Eichel , Bruce Ernest Tepper
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61F13/82 , A61F13/475 , A61F13/494 , A61F13/495 , A61F13/5605 , A61F13/84 , F28D20/02 , F28D20/028 , Y10S977/841 , Y10S977/955
摘要： An absorbent article which includes a phase change material capable of adding or removing heat to or from at least a portion of the absorbent article to perform a useful function on the article. The phase change material may be activated by an action of the wearer or caregiver or by environmental conditions between the article and wearer.
摘要翻译：一种吸收制品，其包括相变材料，该相变材料能够向吸收制品的至少一部分添加或除去热量，以对该制品进行有用的功能。相变材料可以通过穿着者或看护者的作用或物品与佩戴者之间的环境条件而被激活。

5. 发明授权

US07761242B2 Metabonomic methods to assess health of skin 有权
标题翻译：评估皮肤健康的代谢组学方法
公开(公告)号：US07761242B2
公开(公告)日：2010-07-20
申请号：US11707670
申请日：2007-02-16
申请人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
发明人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
IPC分类号： G06F7/00
CPC分类号： G01R33/465 , A61B10/0035 , G01N33/6881 , G01N2800/20 , Y10S707/99943
摘要： The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at different times during a treatment are used to diagnose skin conditions or to appraise various skin treatments for efficacy.
摘要翻译：本发明涉及评估皮肤健康的方法。生物标志物用于评估皮肤样品。使用代谢组学方法，采用不同皮肤部位或在治疗期间不同时间取样的样品用于诊断皮肤状况或评估各种皮肤治疗的疗效。

6. 发明申请

US20130344120A1 Mouth Rinse Emulsions 审中-公开
标题翻译：口腔冲洗乳液
公开(公告)号：US20130344120A1
公开(公告)日：2013-12-26
申请号：US13529064
申请日：2012-06-21
申请人： Douglas Craig Scott , Niranjan Ramji , Bruce Ernest Tepper
发明人： Douglas Craig Scott , Niranjan Ramji , Bruce Ernest Tepper
IPC分类号： A61K8/92 , A61K8/06 , C12Q1/18 , A61Q11/00
CPC分类号： A61Q17/005 , A61K8/062 , A61K8/416 , A61Q11/00 , C12Q1/18
摘要： Disclosed are oral care mouth rinse compositions formulated as stable oil-in-water emulsions comprising: (a) at least about 0.025% by weight of a quaternary ammonium antimicrobial agent, (b) at least about 0.05% by weight of an essentially water-insoluble volatile oil, and (c) at least about 50% by weight water, wherein the emulsion comprises oil droplets having an average mean particle size of about 350 nm or less. Examples of quaternary ammonium antimicrobial agent include cetylpyridinium chloride (CPC), tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide.
摘要翻译：公开了配制为稳定的水包油乳液的口腔护理口腔漂洗组合物，其包含：（a）至少约0.025重量％的季铵抗微生物剂，（b）至少约0.05重量％不溶性挥发油，和（c）至少约50重量％的水，其中所述乳液包含平均粒度为约350nm或更小的油滴。季铵抗菌剂的实例包括氯化十六烷基吡啶（CPC），氯化十四烷基吡啶，氯化N-十四烷基-4-乙基吡啶鎓或溴化三苯胺。

7. 发明申请

US20110020857A1 Metabonomic Methods to Assess Health of Skin 审中-公开
标题翻译：评估皮肤健康的代表性方法
公开(公告)号：US20110020857A1
公开(公告)日：2011-01-27
申请号：US12828324
申请日：2010-07-01
申请人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
发明人： Robert Stephen Honkonen , Wendy Qin , Hui Yang , David John Maltbie , Bruce Ernest Tepper
IPC分类号： C12Q1/02
CPC分类号： G01R33/465 , A61B10/0035 , G01N33/6881 , G01N2800/20 , Y10S707/99943
摘要： The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at different times during a treatment are used to diagnose skin conditions or to appraise various skin treatments for efficacy.
摘要翻译：本发明涉及评估皮肤健康的方法。生物标志物用于评估皮肤样品。使用代谢组学方法，采用不同皮肤部位或在治疗期间不同时间取样的样品用于诊断皮肤状况或评估各种皮肤治疗的疗效。

8. 发明授权

US06791004B2 Absorbent article with thermal cell actuator 失效
标题翻译：具有热电池致动器的吸收制品
公开(公告)号：US06791004B2
公开(公告)日：2004-09-14
申请号：US09778371
申请日：2001-02-07
申请人： Cornelia Sprengard-Eichel , Mark James Kline , Bruno Johannes Ehrnsperger , Tracey Elaine Beckman , Constance Lee Fisher , Mattias Schmidt , Donald Carroll Roe , Bruce Ernest Tepper
发明人： Cornelia Sprengard-Eichel , Mark James Kline , Bruno Johannes Ehrnsperger , Tracey Elaine Beckman , Constance Lee Fisher , Mattias Schmidt , Donald Carroll Roe , Bruce Ernest Tepper
IPC分类号： A61F1315
CPC分类号： A61F13/82 , A61F13/475 , A61F13/494 , A61F13/495 , A61F13/5605 , A61F13/84 , F28D20/02 , F28D20/028 , Y10S977/841 , Y10S977/955
摘要： An absorbent article which includes a thermal cell actuator capable of adding or removing heat to or from at least a portion of the absorbent article to perform a useful function on the article. The thermal cell actuator may be activated by an action of the wearer or caregiver or by environmental conditions between the article and wearer.
摘要翻译：一种吸收制品，其包括能够向吸收制品的至少一部分添加或去除热量以对该制品执行有用功能的热电池致动器。热电池致动器可以通过穿着者或看护者的动作或者物品与佩戴者之间的环境条件来激活。

9. 发明授权

US06756032B1 Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge 失效
标题翻译：增强和/或延长主要挑战对具有次要挑战的响应系统的影响的方法
公开(公告)号：US06756032B1
公开(公告)日：2004-06-29
申请号：US09614669
申请日：2000-07-12
申请人： Bruce Ernest Tepper , Susan Baldwin , Scott Edward Osborne , Mauricio Odio
发明人： Bruce Ernest Tepper , Susan Baldwin , Scott Edward Osborne , Mauricio Odio
IPC分类号： A61B1000
CPC分类号： A61K49/0006 , Y10S530/859
摘要： The present invention relates to a method comprising subjecting a test site of a responsive system to a primary challenge; subjecting the same test site to a secondary challenge, wherein the secondary challenge is designed to enhance and/or prolong a response of the responsive system to the primary challenge, without confounding the response nor altering the mechanism by which the primary challenge elicits a response from the responsive system; and assessing the response subsequent to the secondary challenge. The methods claimed herein also preferably comprise the additional step(s) of subjecting test site(s) to one or more pre-challenge intervention(s) and/or post-challenge intervention(s) and/or concurrent-challenge intervention(s). The methods of the present invention are also useful in a study design, also claimed herein, wherein the study comprises the steps of the method outlined above in addition to comprising the steps of creating one or more controls selected from the group consisting of negative controls, primary controls, secondary controls, positive controls, and mixtures thereof. The use of the novel methods described herein often significantly shorten the duration of and/or number of subjects needed for studies aimed at understanding the etiology of a disease and/or the ability of a intervention or challenge to prevent, cure, heal, and/or reduce and/or induce damage or injury to a responsive system.
摘要翻译：本发明涉及一种方法，包括使响应系统的测试部位进行初步挑战; 对相同的测试场所进行二次挑战，其中次要挑战被设计为增强和/或延长响应系统对主要挑战的响应，而不会混淆响应，也不改变主要挑战引起响应的机制响应系统; 并评估二次挑战之后的反应。本文要求保护的方法还优选地包括使试验部位进行一次或多次攻击前干预和/或攻击后干预和/或并发挑战干预的附加步骤（s））。本发明的方法还可用于本文还要求保护的研究设计中，其中所述研究包括上述方法的步骤，此外还包括以下步骤：产生选自以下的一种或多种对照：阴性对照，初级对照，二级对照，阳性对照及其混合物。使用本文所述的新颖方法通常显着地缩短旨在了解疾病病因的研究所需的受试者的持续时间和/或数量和/或干预或挑战的能力以预防，治愈，愈合和/ 或减少和/或引起对响应系统的损害或伤害。

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