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1. 发明授权

US07982024B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US07982024B2
公开(公告)日：2011-07-19
申请号：US12756417
申请日：2010-04-08
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
IPC分类号： C07H21/04 , C12N15/00 , C12N5/07 , C12N5/16 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

2. 发明授权

US08642037B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US08642037B2
公开(公告)日：2014-02-04
申请号：US13169474
申请日：2011-06-27
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

3. 发明授权

US07037498B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US07037498B2
公开(公告)日：2006-05-02
申请号：US10038591
申请日：2002-01-04
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

4. 发明申请

US20120005767A1 ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR 有权
标题翻译：抗胰岛素样生长因子I受体
公开(公告)号：US20120005767A1
公开(公告)日：2012-01-05
申请号：US13169474
申请日：2011-06-27
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
IPC分类号： A01K67/027 , A61K39/395 , C07H21/00 , A61P35/00 , A61K49/00 , G01N33/566 , C12P21/08 , C12P21/00 , C12N5/10 , C12N1/21 , C12N1/15 , C12N5/16 , C07K16/28 , C12N15/63
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

5. 发明授权

US07815907B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US07815907B2
公开(公告)日：2010-10-19
申请号：US11144248
申请日：2005-06-02
申请人： Bruce D Cohen , Jean Beebe , Penelope E Miller , James D Moyer , Jose R Corvalan , Michael Gallo
发明人： Bruce D Cohen , Jean Beebe , Penelope E Miller , James D Moyer , Jose R Corvalan , Michael Gallo
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

6. 发明申请

US20100255538A1 ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR 有权
标题翻译：抗胰岛素样生长因子I受体
公开(公告)号：US20100255538A1
公开(公告)日：2010-10-07
申请号：US12756417
申请日：2010-04-08
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose R. Corvalan , Michael Gallo
IPC分类号： C12P21/08 , C07H21/04 , C12N15/63 , C12N5/07
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

7. 发明授权

US07700742B2 Antibodies to insulin-like growth factor I receptor 有权
公开(公告)号：US07700742B2
公开(公告)日：2010-04-20
申请号：US11144222
申请日：2005-06-02
申请人： Bruce D Cohen , Jean Beebe , Penelope E Miller , James D Moyer , Jose R Corvalan , Michael Gallo
发明人： Bruce D Cohen , Jean Beebe , Penelope E Miller , James D Moyer , Jose R Corvalan , Michael Gallo
IPC分类号： C12P21/08
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.

8. 发明申请

US20050281812A1 Antibodies to insulin-like growth factor I receptor 有权
公开(公告)号：US20050281812A1
公开(公告)日：2005-12-22
申请号：US11144222
申请日：2005-06-02
申请人： Bruce Cohen , Jean Beebe , Penelope Miller , James Moyer , Jose Corvalan , Michael Gallo
发明人： Bruce Cohen , Jean Beebe , Penelope Miller , James Moyer , Jose Corvalan , Michael Gallo
IPC分类号： A01K67/027 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.

9. 发明申请

US20130236931A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS 审中-公开
标题翻译：免疫球蛋白和其他蛋白质的序列多样性生成
公开(公告)号：US20130236931A1
公开(公告)日：2013-09-12
申请号：US13765484
申请日：2013-02-12
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K16/00 , C07K2317/56 , C12N15/102 , C12N15/113 , C12N2310/14
摘要： An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s).
摘要翻译：描述了用于产生序列的体外系统，因此蛋白质的结构多样性。可以使用适当选择的编码所选蛋白质或蛋白质区域的重组信号序列（RSS）的核酸分子来构建该系统。所选择的蛋白可以是例如免疫球蛋白（Ig）V，D，J和/或C区，非免疫球蛋白（非Ig）蛋白的区域，或Ig区和非Ig的组合地区。组装这些适当选择的组分并将其引入合适的可重组的宿主细胞中允许RSS序列之间的重组，并将序列和结构多样性引入到蛋白质中。

10. 发明申请

US20050100546A1 Human monoclonal antibodies to epidermal growth factor receptor 审中-公开
标题翻译：人表皮生长因子受体单克隆抗体
公开(公告)号：US20050100546A1
公开(公告)日：2005-05-12
申请号：US11021795
申请日：2004-12-22
申请人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
发明人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
IPC分类号： A61K38/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.
摘要翻译：根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。提供了含有重链和轻链免疫球蛋白分子的Nuclotide序列编码和氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

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