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1. 发明授权

US08715727B2 Tablet for pulsed delivery 有权
标题翻译：片剂用于脉冲输送
公开(公告)号：US08715727B2
公开(公告)日：2014-05-06
申请号：US11173929
申请日：2005-07-01
申请人： Bruce Cao , Sandra E. Wassink , Donald J. Treacy, Jr. , Beth A. Burnside , Colin E. Rowlings , John A. Bonck
发明人： Bruce Cao , Sandra E. Wassink , Donald J. Treacy, Jr. , Beth A. Burnside , Colin E. Rowlings , John A. Bonck
IPC分类号： A61K9/22
CPC分类号： A61K9/209 , A61K9/2081 , A61K9/2846 , A61K9/5026 , A61K9/5084 , A61K31/43 , A61K31/545 , A61K31/7048
摘要： A pharmaceutical tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein the delayed release portion comprises an enteric-coated layer and within the enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient, is disclosed.
摘要翻译：一种包含含有活性成分和延迟释放部分的速释部分的药物片剂，其中所述延迟释放部分包含肠溶衣层，并且在所述肠溶衣层内存在至少一种选自肠溶衣，公开了含有活性成分的包衣微粒剂型和含有活性成分的肠溶包衣微片剂型。

2. 发明授权

US6110498A Osmotic drug delivery system 失效
标题翻译：渗透药物输送系统
公开(公告)号：US6110498A
公开(公告)日：2000-08-29
申请号：US954947
申请日：1997-10-22
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
IPC分类号： A61K9/00 , A61K9/22 , A61K9/32 , A61K47/00 , A61K9/24 , A61K9/14 , A61K9/20
CPC分类号： A61K9/0004 , Y10S514/96
摘要： An osmotic drug delivery system, preferably in tablet form, which dispenses a therapeutic agent having limited water solubility in solubilized form. The delivery system comprises a core that is free of swellable polymers and comprises nonswelling solubilizing agents and wicking agents. The solubilized therapeutic agent is delivered through a passageway in the semipermeable coating of the tablet.
摘要翻译：渗透性药物递送系统，优选片剂形式，其分散具有溶解形式的水溶性有限的治疗剂。递送系统包括不含可溶胀聚合物的芯，并且包含非溶胀增溶剂和芯吸剂。溶解的治疗剂通过片剂的半透性涂层中的通道递送。

3. 发明授权

US06514532B2 Soluble form osmotic dose delivery system 有权
公开(公告)号：US06514532B2
公开(公告)日：2003-02-04
申请号：US10035077
申请日：2001-12-28
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
IPC分类号： A61K924
CPC分类号： A61K9/0004 , Y10S514/96
摘要： Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semi-permeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.

4. 发明授权

US06361796B1 Soluble form osmotic dose delivery system 有权
标题翻译：可溶形式渗透剂量递送系统
公开(公告)号：US06361796B1
公开(公告)日：2002-03-26
申请号：US09634224
申请日：2000-08-09
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
IPC分类号： A61K924
CPC分类号： A61K9/0004 , Y10S514/96
摘要： Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semi-permeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; (b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.
摘要翻译：公开了一种渗透性药物递送系统，其包括（a）半透壁，其在药物递送期间保持其完整性，并且具有至少一个通过其的通道; （b）所述壁内的单一的均匀组合物，该组合物基本上由（i）药物活性剂，（ii）至少一种增强药物活性剂的溶解度的非溶胀增溶剂组成; （iii）至少一种非溶胀渗透剂和（iv）分散在整个组合物中的不溶胀芯吸剂，其增强药剂与进入的含水流体的表面积接触。

5. 发明授权

US06284276B1 Soluble form osmotic dose delivery system 有权
标题翻译：可溶形式渗透剂量递送系统
公开(公告)号：US06284276B1
公开(公告)日：2001-09-04
申请号：US09613202
申请日：2000-07-11
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
IPC分类号： A61K924
CPC分类号： A61K9/0004 , Y10S514/96
摘要： Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semipermeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; (b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.
摘要翻译：公开了一种渗透性药物递送系统，其包含（a）半透性壁，其在药物递送期间保持其完整性并且具有至少一个通过其的通道; （b）所述壁内的单一的均匀组合物，该组合物基本上由（i）药物活性剂，（ii）至少一种增强药物活性剂的溶解度的非溶胀增溶剂组成; （iii）至少一种非溶胀渗透剂和（iv）分散在整个组合物中的不溶胀芯吸剂，其增强药剂与进入的含水流体的表面积接触。

6. 发明授权

US08758820B2 Robust pellet 有权
标题翻译：坚固的颗粒
公开(公告)号：US08758820B2
公开(公告)日：2014-06-24
申请号：US10915912
申请日：2004-08-11
申请人： Bruce X. Cao , Beth A. Burnside , Sandra E. Wassink , Matt R. Baker
发明人： Bruce X. Cao , Beth A. Burnside , Sandra E. Wassink , Matt R. Baker
IPC分类号： A61K9/14 , A61K9/50 , A61K31/43 , A61K9/16 , C07D499/00
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K31/43 , C07D499/00
摘要： Compositions and methods for making robust pellets that contain a high percentage, by weight, of active drug agent, and which also contain additional components that enhance the absorption and solubility of the active drug agent within the gastrointestinal tract (GI tract) without diminishing the robust nature of the pellet, are disclosed.
摘要翻译：用于制备含有高百分比（重量）的活性药物的强力颗粒的组合物和方法，并且还含有增加活性药物在胃肠道（胃肠道）内的吸收和溶解性的另外的组分，而不会降低健壮的公开了颗粒的性质。

7. 发明授权

US06814979B2 Osmotic drug delivery system 有权
标题翻译：渗透药物输送系统
公开(公告)号：US06814979B2
公开(公告)日：2004-11-09
申请号：US10324187
申请日：2002-12-20
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
IPC分类号： A61K924
CPC分类号： A61K9/0004 , Y10S514/96
摘要： Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semi-permeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; (b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.

8. 发明授权

US08425936B2 Antibiotic product, use and formulation thereof 有权
标题翻译：抗生素产品，其用途和配方
公开(公告)号：US08425936B2
公开(公告)日：2013-04-23
申请号：US10894787
申请日：2004-07-20
申请人： Beth A. Burnside , Henry H. Flanner , Colin Rowlings
发明人： Beth A. Burnside , Henry H. Flanner , Colin Rowlings
IPC分类号： A61K9/22 , A61K8/52
CPC分类号： A61K9/4808 , A61K9/2077
摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译：抗生素产品由至少三种剂型形成，每种剂型具有不同的释放特征，抗生素产物的C max在小于约十二小时内达到。在一个实施方案中，存在立即释放剂型，以及两种或更多种缓释剂型，其中每种剂型具有不同的释放特征，其中各自在不同时间达到Cmax。

9. 发明申请

US20080132478A1 Modified release amoxicillin products 有权
标题翻译：改性释放阿莫西林产品
公开(公告)号：US20080132478A1
公开(公告)日：2008-06-05
申请号：US11633315
申请日：2006-12-04
申请人： Henry H. Flanner , Sanna Tolle-Sander , Donald Treacy , Beth A. Burnside , Susan P. Clausen
发明人： Henry H. Flanner , Sanna Tolle-Sander , Donald Treacy , Beth A. Burnside , Susan P. Clausen
IPC分类号： A61K31/43 , A61P31/04
CPC分类号： A61K31/43
摘要： An amoxicillin product comprising: at least one modified release component(s), wherein the at least one modified release component(s) comprises at least amoxicillin and a pharmaceutically acceptable carrier; and wherein when administered to a patient or subject in the fed state said amoxicillin product exhibits a pharmacokinetic profile for amoxicillin in the plasma characterized as follows: (1) the ratio of the portion of the AUC as measured from 2 hours post-administration to 5 hours post-administration to the portion of the AUC as measured from administration to 2 hours post-administration is at least 2.0:1; and (2) the ratio of the portion of the AUC as measured from 5 hours post-administration to 12 hours post-administration to the portion of the AUC as measured from administration to 2 hours post-administration is at least 1.1:1.
摘要翻译：一种阿莫西林产品，其包含：至少一种改性释放组分，其中所述至少一种修饰的释放组分至少包含阿莫西林和药学上可接受的载体; 并且其中当在给药状态下给予患者或受试者时，所述阿莫西林产品在血浆中表现出阿姆西林的药代动力学特征，其特征如下：（1）从给药后2小时测量的AUC部分的比例为5 给药后至投药至服药后2小时AUC的部分至少为2.0：1; 和（2）从给药后5小时至给药后12小时测量的AUC部分与从给药至给药后2小时测量的部分AUC的比例为至少1.1:1。

10. 发明申请

US20070154547A1 Gastric release pulse system for drug delivery 有权
标题翻译：用于药物输送的胃释放脉冲系统
公开(公告)号：US20070154547A1
公开(公告)日：2007-07-05
申请号：US11644707
申请日：2006-12-22
申请人： Henry H. Flanner , Donald Treacy , Sanna Tolle-Sander , Scott Ibrahim , Marcus Schestopol , Beth A. Burnside
发明人： Henry H. Flanner , Donald Treacy , Sanna Tolle-Sander , Scott Ibrahim , Marcus Schestopol , Beth A. Burnside
IPC分类号： A61K9/22
CPC分类号： A61K9/0004 , A61K9/0065 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/209 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K9/5084
摘要： Disclosed are pharmaceutical products for providing pulses of at least one pharmaceutically active ingredient from a patient's stomach, or from a subsequent gastrointestinal site proximal thereto, for absorption thereof at a site(s) more distal in the gastrointestinal tract than the patient's stomach, or than the subsequent gastrointestinal site proximal thereto. The product comprises first, second, and third pharmaceutical dosage forms, each of which comprises at least one pharmaceutically active agent and a pharmaceutically acceptable carrier. The product is formulated such that at least two of the first, second, and third pharmaceutical dosage forms further comprise means for providing temporary gastric-retention of the at least two of the first, second, and third pharmaceutical dosage forms within the patient's stomach, or at the subsequent gastrointestinal site proximal thereto.
摘要翻译：公开了用于从患者的胃或其后接近的胃肠部位提供至少一种药物活性成分的脉冲的药物产品，用于在胃肠道比患者的胃更远的部位吸收它们，或比随后的胃肠部位近端。该产品包含第一，第二和第三药物剂型，其各自包含至少一种药物活性剂和药学上可接受的载体。该产品被配制成使得第一，第二和第三药物剂型中的至少两个进一步包括用于在患者的胃内提供至少两种第一，第二和第三药物剂型的临时胃滞留的装置，或在其后的胃肠部位。

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