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1. 发明授权

US08460374B2 Mask configured to maintain nutrient transport without producing visible diffraction patterns 有权
$Mask configured to maintain nutrient transport without producing visible diffraction patterns$
公开(公告)号：US08460374B2
公开(公告)日：2013-06-11
申请号：US11290201
申请日：2005-11-30
申请人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
发明人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
IPC分类号： A61F2/14
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： A mask configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes. The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.

2. 发明授权

US07628810B2 Mask configured to maintain nutrient transport without producing visible diffraction patterns 有权
$Mask configured to maintain nutrient transport without producing visible diffraction patterns$
标题翻译：掩模配置为保持营养物质的运输而不产生可见的衍射图案
公开(公告)号：US07628810B2
公开(公告)日：2009-12-08
申请号：US10854033
申请日：2004-05-26
申请人： Bruce A. Christie , Thomas A. Silvestrini
发明人： Bruce A. Christie , Thomas A. Silvestrini
IPC分类号： A61F2/14 , G02C7/04
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： A mask configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes. The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.
摘要翻译：构造成植入患者角膜以增加患者的焦点深度的掩模包括前表面，后表面和多个孔。前表面被配置为邻近第一角膜层。后表面配置成邻近第二角膜层。多个孔至少部分地在前表面和后表面之间延伸。多个孔的孔构造成基本上消除可见的衍射图。

3. 发明授权

US08079706B2 Method and apparatus for aligning a mask with the visual axis of an eye 失效
标题翻译：将面罩与眼睛视轴对准的方法和装置
公开(公告)号：US08079706B2
公开(公告)日：2011-12-20
申请号：US11418390
申请日：2006-05-03
申请人： Thomas A. Silvestrini , Bruce A. Christie , Kevin F. Hahnen , Carl F. Knopp
发明人： Thomas A. Silvestrini , Bruce A. Christie , Kevin F. Hahnen , Carl F. Knopp
IPC分类号： A61B3/00 , A61F2/14
CPC分类号： A61B3/152 , A61B3/0091
摘要： An apparatus is provided for aligning an implant with a visual axis of an eye of a patient. The apparatus has an instrument with an instrument axis and an aperture through which the patient may look along the instrument axis. The implant includes an aperture having an implant axis that can be positioned substantially collinear with the instrument axis. The implant further includes a substantially opaque annulus extending between the aperture and an outer periphery of the implant. The annulus has a nutrient transport structure for conveying nutrients between anterior and posterior surfaces of the implant.
摘要翻译：提供了一种用于使植入物与患者的眼睛的视轴对准的装置。该装置具有仪器的轴线和孔，患者可以沿着仪器轴线观察。植入物包括具有植入轴线的孔，该植入物轴线可以被定位成与仪器轴线基本共线。所述植入物还包括在所述孔和所述植入物的外周之间延伸的基本上不透明的环。环状物具有用于在植入物的前表面和后表面之间输送营养物质的营养输送结构。

4. 发明申请

US20050033420A1 Mask configured to maintain nutrient transport without producing visible diffraction patterns 有权
$Mask configured to maintain nutrient transport without producing visible diffraction patterns$
标题翻译：掩模配置为保持营养物质的运输而不产生可见的衍射图案
公开(公告)号：US20050033420A1
公开(公告)日：2005-02-10
申请号：US10854033
申请日：2004-05-26
申请人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
发明人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
IPC分类号： A61B20060101 , A61B3/15 , A61F2/14 , A61F2/16 , A61F9/00 , G02C7/04
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： A mask configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes. The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.
摘要翻译：构造成植入患者角膜以增加患者的焦点深度的掩模包括前表面，后表面和多个孔。前表面被配置为邻近第一角膜层。后表面配置成邻近第二角膜层。多个孔至少部分地在前表面和后表面之间延伸。多个孔的孔构造成基本上消除可见的衍射图。

5. 发明授权

US09138142B2 Masked intraocular devices 有权
标题翻译：屏蔽眼内装置
公开(公告)号：US09138142B2
公开(公告)日：2015-09-22
申请号：US11417667
申请日：2006-05-03
申请人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
发明人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
IPC分类号： A61B3/15 , A61F2/16 , A61F2/14 , G02C7/04 , G02C7/16
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： An ophthalmic device that includes a mask configured to be implanted posterior of the cornea. The mask is configured to increase the depth of focus of the patient. The mask includes an aperture configured to transmit along an optical axis substantially all incident light and a substantially opaque portion surrounding at least a portion of the aperture. The ophthalmic device can further include a plurality of light transmission structures configured to allow some light to pass through the substantially opaque portion. The light transmission structures are configured to minimize generation of visible artifacts due to the transmission of light through the light transmission structures.
摘要翻译：一种眼科装置，其包括构造成植入角膜后方的掩模。掩模被配置为增加患者的焦点深度。掩模包括孔，所述孔被配置为沿着光轴传输基本上所有的入射光和围绕孔的至少一部分的基本上不透明的部分。眼科装置还可以包括多个光透射结构，其被配置为允许一些光穿过基本上不透明的部分。光传输结构被配置为最小化由于透过光透射结构的光的透射而导致的可见伪影的产生。

6. 发明授权

US08864824B2 Method and apparatus for aligning a mask with the visual axis of an eye 有权
标题翻译：将面罩与眼睛视轴对准的方法和装置
公开(公告)号：US08864824B2
公开(公告)日：2014-10-21
申请号：US11417875
申请日：2006-05-03
申请人： Thomas A. Silvestrini , Bruce A. Christie , Kevin F. Hahnen
发明人： Thomas A. Silvestrini , Bruce A. Christie , Kevin F. Hahnen
IPC分类号： A61F2/14
CPC分类号： A61B3/152 , A61B3/0091
摘要： A method is provided for increasing the depth of focus of an eye of a patient. A visual axis of the eye is aligned with an instrument axis of an ophthalmic instrument. The ophthalmic instrument has an aperture through which the patient may look along the instrument axis. A first reference target is imaged on the instrument axis at a first distance with respect to the eye. A second reference target is imaged on the instrument axis with the ophthalmic instrument at a second distance with respect to the eye. The second distance is greater than the first distance. Movement is provided such that the patient's eye is in a position where the images of the first and second reference targets appear to the patient's eye to be aligned. A mask comprising a pin-hole aperture having a mask axis is aligned with the instrument axis such that the mask axis and the instrument axis are substantially collinear. The mask is applied to the eye of the patient while the alignment of the mask axis and the instrument axis is maintained. Maintaining alignment of the mask axis and the instrument axis may be facilitated by capturing an image of the eye.
摘要翻译：提供了一种用于增加患者眼睛的焦点深度的方法。眼睛的视轴与眼科仪器的仪器轴线对准。眼科器具具有孔，患者可沿着该孔观察仪器轴线。第一参考目标在仪器轴上相对于眼睛以第一距离成像。第二参考目标在仪器轴上与眼科仪器相对于眼睛相距第二距离成像。第二距离大于第一距离。提供运动，使得患者的眼睛处于第一和第二参考对象的图像对患者眼睛看起来对齐的位置。包括具有掩模轴的针孔的掩模与仪器轴线对准，使得掩模轴线和仪器轴线基本上共线。当保持掩模轴和仪器轴的对准时，将掩模施加到患者的眼睛。通过捕捉眼睛的图像可以方便地保持掩模轴和仪器轴的对准。

7. 发明授权

US08858624B2 Method for increasing the depth of focus of a patient 有权
标题翻译：增加患者焦点深度的方法
公开(公告)号：US08858624B2
公开(公告)日：2014-10-14
申请号：US11417497
申请日：2006-05-03
申请人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
发明人： Bruce A. Christie , Thomas A. Silvestrini , Kevin F. Hahnen
IPC分类号： A61F2/14 , G02C7/16 , G02C7/04 , A61B3/15 , A61F2/16
CPC分类号： A61F2/15 , A61B3/152 , A61F2/14 , A61F2/147 , A61F9/007 , A61F2002/1699 , A61F2250/0023 , A61F2250/0067 , A61F2250/0098 , G02C7/04 , G02C7/165
摘要： A mask configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes. The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.
摘要翻译：构造成植入患者角膜以增加患者的焦点深度的掩模包括前表面，后表面和多个孔。前表面被配置为邻近第一角膜层。后表面配置成邻近第二角膜层。多个孔至少部分地在前表面和后表面之间延伸。多个孔的孔构造成基本上消除可见的衍射图。

8. 发明授权

US08529492B2 Drug delivery devices and methods 有权
公开(公告)号：US08529492B2
公开(公告)日：2013-09-10
申请号：US12973853
申请日：2010-12-20
申请人： Luke Clauson , Thomas A. Silvestrini , Tsontcho Ianchulev , Steven John
发明人： Luke Clauson , Thomas A. Silvestrini , Tsontcho Ianchulev , Steven John
IPC分类号： A61M5/00 , A61M37/00 , A61M31/00 , A61F2/14 , A61F11/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61K9/0024 , A61K9/0048 , A61K31/00 , A61K47/30 , A61M27/002 , A61M2210/0606 , Y02A50/491
摘要： This disclosure relates generally to methods and devices for use in treating eye conditions with implantable drug delivery devices. One method includes introducing an implant into the suprachoroidal space, wherein the interior volume of the implant is plugged with a drug-release material comprising at least one active agent that elutes through at least one opening in the implant, wherein the drug-release material degrades from the interior volume of the implant over a period time.

9. 发明授权

US08444589B2 Ocular implant with fluid outflow pathways having microporous membranes 有权
标题翻译：具有微孔膜的流体流出路径的眼植入物
公开(公告)号：US08444589B2
公开(公告)日：2013-05-21
申请号：US13157221
申请日：2011-06-09
申请人： Thomas A. Silvestrini
发明人： Thomas A. Silvestrini
IPC分类号： A61B19/00
CPC分类号： A61F9/00781
摘要： Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can include reversibly deformable portions that have a plurality of openings layered, covered or otherwise spanned by an elastomeric film or membrane having micropores. The micropores allow for fluid flow out of the implant while inhibit cellular infiltration and blockage of the openings.
摘要翻译：公开了用于治疗诸如青光眼的眼睛疾病的装置，方法和系统。这里描述的植入物增强了通过眼睛的正常流出系统的水流量，而极少到没有并发症。植入物可包括可逆变形部分，其具有由具有微孔的弹性体膜或膜层叠，覆盖或以其它方式跨越的多个开口。微孔允许流体从植入物流出，同时抑制细胞浸润和堵塞开口。

10. 发明授权

US08262726B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
标题翻译：具有刚度品质的眼植入物，植入方法和系统
公开(公告)号：US08262726B2
公开(公告)日：2012-09-11
申请号：US12898630
申请日：2010-10-05
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

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