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1. 发明授权

US11076916B2 Thermal accelerant compositions and methods of use 有权
公开(公告)号：US11076916B2
公开(公告)日：2021-08-03
申请号：US16708416
申请日：2019-12-09
申请人： Rhode Island Hospital , Brown University
发明人： William Keun Chan Park , Damian E. Dupuy
IPC分类号： A61K45/06 , A61B18/18 , A61B18/14 , A61B18/00
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermia tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

2. 发明申请

US20150224212A1 FERRITIN-BASED TUMOR TARGETING AGENT, AND IMAGING AND TREATMENT METHODS 审中-公开
标题翻译：基于FERRITIN的肿瘤靶向剂，成像和治疗方法
公开(公告)号：US20150224212A1
公开(公告)日：2015-08-13
申请号：US14626071
申请日：2015-02-19
申请人： Brown University , Rhode Island Hospital
发明人： William Keun Chan Park , David R. Mills , Edward G. Walsh
IPC分类号： A61K49/18 , G01N33/574
CPC分类号： A61K49/1875 , C07K16/2896 , G01N33/57492 , G01N33/57496 , G01N2333/47
摘要： An MRI contrast material includes tumor-targeting metal-loaded ferritin nanoparticles constructed with genetically modified ferritin coupled to a target-specific agent. Ferritin derived from Archaeoglobus flulgidus (AfFtn-AA) forms hollow nanocages surrounding paramagnetic or superparamagnetic metal core, storing a significantly greater quantity of iron (approximately 7,000 Fe ions per ferritin cage) or other paramagnetic or superparamagnetic metal than natural ferritins, and is conjugated via a short linker with a monoclonal antibody against a cell surface antigen overexpressed by a cancer, to selectively and efficiently attach to tumor cells to enhance MRI contrast. Significant T2 contrast with diminished T1 effect was observed owing to the heterogeneous nanoconjugate distribution when bound to cells. In a treatment method, after imaging, an external stimulus heats the cell-bound agent to release the metal and selectively destroy the targeted cells. The enhanced imaging and release of toxic metal ions provides simultaneous early detection and treatment.
摘要翻译： MRI造影材料包括用与靶特异性试剂偶联的遗传修饰的铁蛋白构建的肿瘤靶向金属负载的铁蛋白纳米颗粒。衍生自弓形虫（AfFtn-AA）的铁蛋白形成围绕顺磁性或超顺磁性金属核心的中空纳米笼，与天然铁蛋白相比，存储显着更多量的铁（每个铁蛋白笼约7,000个Fe离子）或其他顺磁性或超顺磁性金属，具有针对由癌细胞过度表达的细胞表面抗原的单克隆抗体的短接头，选择性且有效地附着于肿瘤细胞以增强MRI对比度。当与细胞结合时，由于异质纳米缀合物分布，观察到T1效应降低的显着T2对比。在处理方法中，在成像之后，外部刺激加热细胞结合剂以释放金属并选择性地破坏靶细胞。有毒金属离子的增强成像和释放提供同时的早期检测和处理。

3. 发明授权

US12016624B2 Thermal accelerant compositions and methods of use 有权
公开(公告)号：US12016624B2
公开(公告)日：2024-06-25
申请号：US17371683
申请日：2021-07-09
申请人： Rhode Island Hospital , Brown University
发明人： William Keun Chan Park , Damian E. Dupuy
IPC分类号： A61B18/18 , A61B18/14 , A61K45/06 , A61B18/00
CPC分类号： A61B18/1815 , A61B18/14 , A61K45/06 , A61B2018/00095 , A61B2018/00577 , A61B2018/00595 , A61B2018/00982
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

4. 发明授权

US11497554B2 Heat substrate and/or image enhancement compositions and enhanced tissue ablation methods 有权
公开(公告)号：US11497554B2
公开(公告)日：2022-11-15
申请号：US15831615
申请日：2017-12-05
申请人： Brown University , Rhode Island Hospital
发明人： Damian E. Dupuy , William Keun Chan Park , Edward G. Walsh
IPC分类号： A61B18/18 , A61B5/055 , A61K41/00 , A61K49/18 , A61K49/04 , A61K33/14 , A61K33/18 , A61K33/26 , A61B5/00 , A61N5/02 , A61N5/04 , A61N5/10 , A61K38/17 , A61K9/00
摘要： Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal ablation treatment, and may be percutaneously delivered and imaged by x-ray CT during placement of the microwave treatment antenna, allowing more precise positioning and more complete ablation of a tumor site. One method of treating a target tissue uses image-guided delivery of a heat substrate with a reverse-phase change polymer, and may apply energy to fix a mass of the material in the tissue. The fixed polymer may increase hyperthermia, form a thermal boundary, or blockade a vessel or passage so as to reduce or prevent undesired conductive cooling by contiguous tissue, or may deliver a localized treatment drug at the site, upon heating or as it degrades over time.

5. 发明申请

US20210330382A1 THERMAL ACCELERANT COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20210330382A1
公开(公告)日：2021-10-28
申请号：US17371683
申请日：2021-07-09
申请人： Rhode Island Hospital , Brown University
发明人： William Keun Chan Park , Damian E. Dupuy
IPC分类号： A61B18/18 , A61K45/06 , A61B18/14 , A61B18/00
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

6. 发明申请

US20230070990A1 Heat Substrate and/or Image Enhancement Compositions and Enhanced Tissue Ablation Methods 有权
公开(公告)号：US20230070990A1
公开(公告)日：2023-03-09
申请号：US17985767
申请日：2022-11-11
申请人： Brown University , Rhode Island Hospital
发明人： Damian E. Dupuy , William Keun Chan Park , Edward G. Walsh
IPC分类号： A61B18/18 , A61B5/055 , A61K41/00 , A61K49/18 , A61N5/02 , A61K49/04 , A61N5/04 , A61N5/10 , A61K38/17 , A61K33/14 , A61K33/18 , A61K9/00 , A61K33/26
摘要： Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal ablation treatment, and may be percutaneously delivered and imaged by x-ray CT during placement of the microwave treatment antenna, allowing more precise positioning and more complete ablation of a tumor site. One method of treating a target tissue uses image-guided delivery of a heat substrate with a reverse-phase change polymer, and may apply energy to fix a mass of the material in the tissue. The fixed polymer may increase hyperthermia, form a thermal boundary, or blockade a vessel or passage so as to reduce or prevent undesired conductive cooling by contiguous tissue, or may deliver a localized treatment drug at the site, upon heating or as it degrades over time.

7. 发明授权

US10722289B2 Thermal accelerant compositions and methods of use 有权
公开(公告)号：US10722289B2
公开(公告)日：2020-07-28
申请号：US15389809
申请日：2016-12-23
申请人： RHODE ISLAND HOSPITAL , BROWN UNIVERSITY
发明人： William Keun Chan Park , Damian E. Dupuy , Edward G. Walsh
IPC分类号： A61B18/14 , A61B18/18 , A61B18/00
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a low-viscosity but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

8. 发明申请

US20180153617A1 Heat Substrate and/or Image Enhancement Compositions and Enhanced Tissue Ablation Methods 审中-公开
公开(公告)号：US20180153617A1
公开(公告)日：2018-06-07
申请号：US15831615
申请日：2017-12-05
申请人： Brown University , Rhode Island Hospital
发明人： Damian E. Dupuy , William Keun Chan Park , Edward G. Walsh
IPC分类号： A61B18/18 , A61K41/00 , A61N5/02 , A61K33/26 , A61K49/18
CPC分类号： A61B18/1815 , A61B5/0035 , A61B5/055 , A61B2018/1869 , A61K9/0004 , A61K9/0024 , A61K33/14 , A61K33/18 , A61K33/26 , A61K38/1709 , A61K41/0052 , A61K49/04 , A61K49/0404 , A61K49/1818 , A61N5/025 , A61N5/045 , A61N5/10
摘要： Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal ablation treatment, and may be percutaneously delivered and imaged by x-ray CT during placement of the microwave treatment antenna, allowing more precise positioning and more complete ablation of a tumor site. One method of treating a target tissue uses image-guided delivery of a heat substrate with a reverse-phase change polymer, and may apply energy to fix a mass of the material in the tissue. The fixed polymer may increase hyperthermia, form a thermal boundary, or blockade a vessel or passage so as to reduce or prevent undesired conductive cooling by contiguous tissue, or may deliver a localized treatment drug at the site, upon heating or as it degrades over time.

9. 发明申请

US20170182165A1 THERMAL ACCELERANT COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：US20170182165A1
公开(公告)日：2017-06-29
申请号：US15389809
申请日：2016-12-23
申请人： RHODE ISLAND HOSPITAL , BROWN UNIVERSITY
发明人： William Keun Chan Park , Damian E. Dupuy , Edward G. Walsh
IPC分类号： A61K41/00 , A61B18/14 , A61B18/18
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a low-viscosity but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

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