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1. 发明申请

US20050074463A1 Therapeutic vaccination method, mutated peptides of hiv reverse transciptase and their use for vaccination and diagnostic purposes 审中-公开
标题翻译：治疗性接种方法，hiv逆转录酶的突变肽及其用于疫苗接种和诊断目的
公开(公告)号：US20050074463A1
公开(公告)日：2005-04-07
申请号：US10489123
申请日：2001-09-14
申请人： Brigitte Autran , Assia Samri , Patrice Debre , Vincent Calvez , Christine Katlama , Gaby Haas
发明人： Brigitte Autran , Assia Samri , Patrice Debre , Vincent Calvez , Christine Katlama , Gaby Haas
IPC分类号： A61K38/00 , A61K39/00 , A61K39/39 , A61K48/00 , A61P31/00 , A61P31/18 , A61P35/00 , C07K7/06 , C07K7/08 , C12N9/12 , C12Q1/02 , A61K39/21
CPC分类号： C12N9/1276 , A61K39/00 , C12N2799/021
摘要： The invention concerns treatment of infectious and tumoral pathologies comprising a anti-infective and/or anti-tumoral chemotherapeutic treatment phase inducing resistance mutations and a therapeutic vaccination phase directed against said resistance mutations and the agents used in said treatment More particularly, the invention concerns peptides of 8 to 80 amino acids of the HIV reverse transcriptase sequence and comprising at least a mutation with respect to said wild sequence of said enzyme, mutation induced in response to treatments by nucleoside and non-nucleoside analogues of the HIV reverse transcriptase. The invention also concerns a pharmaceutical composition or vaccine based on said peptides, for inducing an immune response specific of said mutated sequences and for enhancing or prolonging the efficiency of treatments with nucleoside or non-nucleoside analogues of the HIV reverse transcriptase. The invention further concerns epitopes derived from said peptide sequences to evaluate the specific immune response following the vaccine injection.
摘要翻译：本发明涉及感染性和肿瘤病理学的治疗，其包括诱导抗性突变的抗感染和/或抗肿瘤化学治疗期，以及针对所述抗性突变的治疗性接种期和用于所述治疗的药剂。更具体地，本发明涉及肽所述HIV逆转录酶序列的8至80个氨基酸，并且对于所述酶的所述野生型序列至少包含突变，所述突变响应于HIV逆转录酶的核苷和非核苷类似物的处理而诱导。本发明还涉及基于所述肽的药物组合物或疫苗，用于诱导所述突变序列特异性的免疫应答，并且用于增强或延长用HIV逆转录酶的核苷或非核苷类似物处理的效率。本发明还涉及来自所述肽序列的表位，以评估疫苗注射后的特异性免疫应答。

2. 发明申请

US20140037666A1 COMPOSITIONS FOR PREVENTING AND/OR TREATING AN INFECTION BY AN HIV-1 VIRUS 有权
标题翻译：用于预防和/或治疗HIV-1病毒感染的组合物
公开(公告)号：US20140037666A1
公开(公告)日：2014-02-06
申请号：US14111790
申请日：2012-04-13
申请人： Patrice Debre , Vincent Vieillard
发明人： Patrice Debre , Vincent Vieillard
IPC分类号： C07K7/08 , A61K45/06 , G01N33/569 , A61K39/12
CPC分类号： C07K7/08 , A61K39/00 , A61K39/12 , A61K45/06 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C07K16/1063 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N2740/16122 , C12N2740/16134 , G01N33/56988 , G01N2333/16 , G01N2469/20
摘要： The present invention relates to an immunogenic composition comprising an antigenic peptide of formula (I) below: Nt-S—X1-X2-X3-K—X4-Ct (I) [SEQ ID No 1], wherein—Nt consists of a peptide having from 0 to 50 amino acids in length, —Ct consists of a peptide having from 0 to 50 amino acids in length, —each of X1 to X4 consists of an amino acid residue, wherein: —(i) X1 means the specific amino acid W or (ii) X1 means any amino acid residue excepted W, —(i) X2 means the specific amino acid S or (ii) X2 means any amino acid residue excepted S, —(i) X3 means the specific amino acid N or (ii) X3 means any amino acid residue excepted N, —(i) X4 means the specific amino acid S or (ii) X4 means any amino acid residue excepted S, with the proviso that—three out of the four amino acid residues X1, X2, X3 and X4 mean the specific amino acid defined in their respective meaning (i) above, and—the remaining amino acid residue among X1 to X4 means any amino acid residue excepted the specific amino acid residue defined in its meaning (i), for preventing and/or treating an infection of an individual with an HIV-1 virus.
摘要翻译：本发明涉及包含以下式（I）的抗原肽的免疫原性组合物：Nt-S-X1-X2-X3-K-X4-Ct（I）[SEQ ID No.1]，其中-Nt由具有0至50个氨基酸长度的肽，-Ct由长度为0至50个氨基酸的肽组成，每个X1至X4由氨基酸残基组成，其中：（i）X1表示特异性氨基酸W或（ii）X1表示除W以外的任何氨基酸残基， - （i）X2表示特定氨基酸S或（ii）X2表示除S以外的任何氨基酸残基，（i）X3表示特定氨基酸 N或（ii）X3表示除N以外的任何氨基酸残基， - （i）X4表示特定氨基酸S或（ii）X4表示除S以外的任何氨基酸残基，条件是四个氨基酸中的三个残基X1，X2，X3和X4表示其各自含义（i）中定义的特定氨基酸，X1至X4中的剩余氨基酸残基表示除特定氨基酸之外的任何氨基酸残基 d限定在其含义（i）中，用于预防和/或治疗患有HIV-1病毒的个体的感染。

3. 发明授权

US10174080B2 Compositions for preventing and/or treating an infection by an HIV-1 virus 有权
公开(公告)号：US10174080B2
公开(公告)日：2019-01-08
申请号：US15712195
申请日：2017-09-22
申请人： Patrice Debre , Vincent Vieillard
发明人： Patrice Debre , Vincent Vieillard
IPC分类号： A61K39/00 , C12Q1/68 , C07K14/00 , A61K39/395 , C07H21/04 , C07K7/08 , C07K16/10 , C07K14/005 , A61K39/12 , A61K45/06 , G01N33/569
摘要： The present invention relates to an immunogenic composition comprising an antigenic peptide of formula (I) below: Nt-S-X1-X2-X3-K-X4-Ct (I) [SEQ ID No 1], wherein Nt consists of a peptide having from 0 to 50 amino acids in length, Ct consists of a peptide having from 0 to 50 amino acids in length, each of X1 to X4 consists of an amino acid residue, wherein: (i) X1 means the specific amino acid W or (ii) X1 means any amino acid residue excepted W, (i) X2 means the specific amino acid S or (ii) X2 means any amino acid residue excepted S, (i) X3 means the specific amino acid N or (ii) X3 means any amino acid residue excepted N, (i) X4 means the specific amino acid S or (ii) X4 means any amino acid residue excepted S, with the proviso that three out of the four amino acid residues X1, X2, X3 and X4 mean the specific amino acid defined in their respective meaning (i) above, and the remaining amino acid residue among X1 to X4 means any amino acid residue excepted the specific amino acid residue defined in its meaning (i), for preventing and/or treating an infection of an individual with an HIV-1 virus.

4. 发明授权

US07915221B2 Methods for construction and screening of libraries of chemokine variants 失效
标题翻译：趋化因子变体文库的构建和筛选方法
公开(公告)号：US07915221B2
公开(公告)日：2011-03-29
申请号：US11730521
申请日：2007-04-02
申请人： Guy Gorochov , Oliver Hartley , Karim Dorgham , Patrice Debre , Robin Offord
发明人： Guy Gorochov , Oliver Hartley , Karim Dorgham , Patrice Debre , Robin Offord
IPC分类号： A06K36/00 , C07K14/00 , C40B30/40
CPC分类号： C40B40/02 , A61K38/04 , C07K14/521 , C07K14/523 , C12N15/1037
摘要： The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
摘要翻译：本发明提供了一种用于设计和/或选择激动剂或拮抗剂趋化因子变体的方法，其结合噬菌体展示技术和筛选表达相应天然趋化因子的受体的活细胞。它还提供了具有针对所述受体的激动剂性质的RANTES变体，以及用于预防和/或治疗病毒性疾病的方法，以及用于预防和/或治疗炎性或恶性疾病的线索。

5. 发明授权

US08372955B2 Purified antibody to the extracellular domain of NKp44L 有权
标题翻译：针对NKp44L细胞外结构域的纯化抗体
公开(公告)号：US08372955B2
公开(公告)日：2013-02-12
申请号：US11927400
申请日：2007-10-29
申请人： Vincent Viellard , Patrice Debre
发明人： Vincent Viellard , Patrice Debre
IPC分类号： A61K39/395 , A61K39/00 , C07K16/08
CPC分类号： C07K16/28 , G01N15/1459 , G01N33/505 , G01N33/56988 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/149
摘要： The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease.
摘要翻译：本发明涉及体外诊断患有属于人类免疫缺陷病毒（HIV）家族的病毒的个体的感染的进展状态的领域以及该感染性疾病的治疗方法。

6. 发明申请

US20090117110A1 Method for the In Vitro Assessment of the Progression Status of an Infection by an HIV Virus in an Individual 有权
标题翻译：个体感染HIV病毒感染进展状况的体外评估方法
公开(公告)号：US20090117110A1
公开(公告)日：2009-05-07
申请号：US11927400
申请日：2007-10-29
申请人： Vincent Vieillard , Patrice Debre
发明人： Vincent Vieillard , Patrice Debre
IPC分类号： A61K39/395 , C07K16/00 , A61P31/18
CPC分类号： C07K16/28 , G01N15/1459 , G01N33/505 , G01N33/56988 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/149
摘要： The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease.
摘要翻译：本发明涉及体外诊断患有属于人类免疫缺陷病毒（HIV）家族的病毒的个体的感染的进展状态的领域以及该感染性疾病的治疗方法。

7. 发明授权

US5246699A Maturation of hemopoietic cells 失效
标题翻译： HEMOPOIETIC细胞的成熟
公开(公告)号：US5246699A
公开(公告)日：1993-09-21
申请号：US781248
申请日：1991-12-30
申请人： Patrice Debre , Mohammad D. Mossalayi
发明人： Patrice Debre , Mohammad D. Mossalayi
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , A61P7/00 , C07K14/735
CPC分类号： C07K14/70535 , A61K38/2006 , A61K38/00 , Y10S435/975
摘要： The invention concerns the use of IgE-binding factor (IgE-bf) for the stimulation of the maturation, i.e. of the differentiation and proliferation, of myeloid precursor cells in context with interleukin-1 (IL-1). The invention further concerns a a pharmaceutical preparation comprising IgE-bf either alone or in combination with IL-1 for the treatment or prevention of diseases by stimulating the maturation of myeloid precursor cells.
摘要翻译： PCT No.PCT / EP91 / 00821 Sec。 371日期1991年12月30日 102（e）1991年12月30日PCT PCT 1991年4月30日PCT。出版物WO91 / 16915 PCT 1991年11月14日，本发明涉及IgE结合因子（IgE-bf）用于刺激髓系前体细胞的成熟（即分化和增殖）在白介素-1（IL-1））。本发明还涉及包含单独或与IL-1组合的IgE-bf的药物制剂，用于通过刺激骨髓前体细胞的成熟来治疗或预防疾病。

8. 发明授权

US09802983B2 Compositions for preventing and/or treating an infection by an HIV-1 virus 有权
公开(公告)号：US09802983B2
公开(公告)日：2017-10-31
申请号：US14870287
申请日：2015-09-30
申请人： Patrice Debre , Vincent Vieillard
发明人： Patrice Debre , Vincent Vieillard
IPC分类号： A61K39/00 , C12Q1/68 , C07K14/00 , A61K39/395 , C07H21/04 , C07K7/08 , C07K16/10 , C07K14/005 , A61K39/12 , A61K45/06 , G01N33/569
CPC分类号： C07K7/08 , A61K39/00 , A61K39/12 , A61K45/06 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C07K16/1063 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N2740/16122 , C12N2740/16134 , G01N33/56988 , G01N2333/16 , G01N2469/20
摘要： The present invention relates to an immunogenic composition comprising an antigenic peptide of formula (I) below: Nt-S-X1-X2-X3-K-X4-Ct (I) [SEQ ID No 1], wherein —Nt consists of a peptide having from 0 to 50 amino acids in length, —Ct consists of a peptide having from 0 to 50 amino acids in length, —each of X1 to X4 consists of an amino acid residue, wherein: —(i) X1 means the specific amino acid W or (ii) X1 means any amino acid residue excepted W, —(i) X2 means the specific amino acid S or (ii) X2 means any amino acid residue excepted S, —(i) X3 means the specific amino acid N or (ii) X3 means any amino acid residue excepted N, —(i) X4 means the specific amino acid S or (ii) X4 means any amino acid residue excepted S, with the proviso that —three out of the four amino acid residues X1, X2, X3 and X4 mean the specific amino acid defined in their respective meaning (i) above, and —the remaining amino acid residue among X1 to X4 means any amino acid residue excepted the specific amino acid residue defined in its meaning (i), for preventing and/or treating an infection of an individual with an HIV-1 virus.

9. 发明申请

US20140024018A1 METHOD FOR THE PROGNOSIS OF PROGRESSION OF THE HIV DISEASE 审中-公开
标题翻译：预防艾滋病毒进展的方法
公开(公告)号：US20140024018A1
公开(公告)日：2014-01-23
申请号：US14000880
申请日：2012-02-21
申请人： Laurence Meyer , Vincent Viellard , Patrice Debre , Joël Crouzet
发明人： Laurence Meyer , Vincent Viellard , Patrice Debre , Joël Crouzet
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703 , G01N33/56988
摘要： An in vitro method for the prognosis of progression of an HIV-1 infection in a patient infected with an HIV-1 virus, comprising the steps of: a) measuring the level of antibodies directed against the 3S peptide of SEQ ID NO 2 in a sample collected from the said patient, b) comparing the level of anti-3S antibodies measured at step a) with a reference value of anti-3S antibody level that is indicative of the progression of the HIV-1 infection.
摘要翻译：用于预测感染HIV-1病毒的患者中HIV-1感染进展的体外方法，包括以下步骤：a）测量针对SEQ ID NO 2的3S肽的抗体水平从所述患者收集的样品，b）将步骤a）中测量的抗-33抗体的水平与指示HIV-1感染进展的抗-33抗体水平的参考值进行比较。

10. 发明申请

US20090075874A1 Methods for construction and screening of libraries of chemokine variants 失效
标题翻译：趋化因子变体文库的构建和筛选方法
公开(公告)号：US20090075874A1
公开(公告)日：2009-03-19
申请号：US11730521
申请日：2007-04-02
申请人： Guy Gorochov , Oliver Hartley , Karim Dorgham , Patrice Debre , Robin Offord
发明人： Guy Gorochov , Oliver Hartley , Karim Dorgham , Patrice Debre , Robin Offord
IPC分类号： A61K38/16 , C07K14/00 , C40B30/04 , A61P31/18 , A61P29/00
CPC分类号： C40B40/02 , A61K38/04 , C07K14/521 , C07K14/523 , C12N15/1037
摘要： The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
摘要翻译：本发明提供了一种用于设计和/或选择激动剂或拮抗剂趋化因子变体的方法，其结合噬菌体展示技术和筛选表达相应天然趋化因子的受体的活细胞。它还提供了具有针对所述受体的激动剂性质的RANTES变体，以及用于预防和/或治疗病毒性疾病的方法，以及用于预防和/或治疗炎性或恶性疾病的线索。

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