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1. 发明申请

US20130147916A1 MICROSCOPY SYSTEM AND METHOD FOR CREATING THREE DIMENSIONAL IMAGES USING PROBE MOLECULES 有权
标题翻译：使用探针分子创建三维图像的微观系统和方法
公开(公告)号：US20130147916A1
公开(公告)日：2013-06-13
申请号：US13257588
申请日：2010-03-18
申请人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
发明人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G01B11/24 , G02B21/0056 , G02B21/0064 , G02B21/0068 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/22
摘要： A system (100) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage (160). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera (155). Object planes in corresponding recorded regions of interest are recorded in the camera (155). A signal from the regions of interest is combined into a three dimensional image.
摘要翻译：公开并描述了使用探针分子产生三维图像的系统（100）和方法。样品安装在台架（160）上。样品具有多个探针分子。样品用光照射，导致探针分子发光。探针发光可以分成至少四个对应于样品中与物平面对应的四个检测平面的路径。通过照相机（155）检测至少四个检测平面。相关记录的感兴趣区域中的对象平面被记录在相机（155）中。来自感兴趣区域的信号被组合成三维图像。

2. 发明授权

US08994807B2 Microscopy system and method for creating three dimensional images using probe molecules 有权
标题翻译：显微镜系统和使用探针分子创建三维图像的方法
公开(公告)号：US08994807B2
公开(公告)日：2015-03-31
申请号：US13257588
申请日：2010-03-18
申请人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
发明人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
IPC分类号： H04N7/18 , H04N15/00 , H04N13/02 , G02B21/36 , G02B21/00 , G02B21/22 , G02B21/16 , G01B11/24
CPC分类号： G02B21/367 , G01B11/24 , G02B21/0056 , G02B21/0064 , G02B21/0068 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/22
摘要： A system (100) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage (160). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera (155). Object planes in corresponding recorded regions of interest are recorded in the camera (155). A signal from the regions of interest is combined into a three dimensional image.
摘要翻译：公开并描述了使用探针分子产生三维图像的系统（100）和方法。样品安装在台架（160）上。样品具有多个探针分子。样品用光照射，导致探针分子发光。探针发光可以分成至少四个对应于样品中与物平面对应的四个检测平面的路径。通过照相机（155）检测至少四个检测平面。相关记录的感兴趣区域中的对象平面被记录在相机（155）中。来自感兴趣区域的信号被组合成三维图像。

3. 发明申请

US20120287244A1 NON-COHERENT LIGHT MICROSCOPY 审中-公开
标题翻译：非相干光显微镜
公开(公告)号：US20120287244A1
公开(公告)日：2012-11-15
申请号：US13236509
申请日：2011-09-19
申请人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
发明人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
IPC分类号： H04N13/02
CPC分类号： H01J37/26 , G01N21/6458 , G02B21/002 , G02B21/16 , G02B21/361 , G02B27/1006 , H01J37/228 , H01J37/28
摘要： An optical microscope (101) with heightened resolution and capable of providing three dimensional images is disclosed and described. The microscope (101) can include a sample stage (160) for mounting a sample having a plurality of probe molecules. At least one non-coherent light source (127) can be provided. At least one lens (140a, 140b) can be configured to direct a beam of light from the at least one non-coherent light source (127) toward the sample causing the probe molecules to luminesce. A camera (155) can be configured to detect luminescence from the probe molecules. A light beam path modification module (132, 150) can be configured to alter a path length of the probe molecule luminescence to allow camera luminescence detection at a plurality of object planes.
摘要翻译：公开并描述了具有高分辨率并且能够提供三维图像的光学显微镜（101）。显微镜（101）可以包括用于安装具有多个探针分子的样品的样品台（160）。可以提供至少一个非相干光源（127）。至少一个透镜（140a，140b）可被配置成将来自至少一个非相干光源（127）的光束引向样品，使得探针分子发光。相机（155）可被配置为检测来自探针分子的发光。光束路径修改模块（132,150）可以被配置为改变探针分子发光的路径长度以允许在多个物体平面处的照相机发光检测。

4. 发明申请

US20120193520A1 BEAM SPLITTER MODULE 失效
标题翻译：光束分离器模块
公开(公告)号：US20120193520A1
公开(公告)日：2012-08-02
申请号：US13363030
申请日：2012-01-31
申请人： Joerg Bewersdorf , Brian Thomas Bennett
发明人： Joerg Bewersdorf , Brian Thomas Bennett
IPC分类号： G01J1/04 , G01J3/51
CPC分类号： G02B27/145 , G02B19/0028 , G02B19/0057 , G02B19/0066 , G02B27/1006 , G02B27/14 , G02B27/141 , G02B27/144
摘要： A primary beam splitter (310) of an optical apparatus (300) can be used to split an incident light beam (305) into a primary plurality of light beams and to direct a first beam of the primary plurality of light beams in a first direction and a second beam of the primary plurality of light beams in a second direction orthogonal to the first direction. Secondary beam splitters (315a,b) positioned in beam paths of the first and second beams can be used to split the first and second beams of the primary plurality of light beams into a secondary plurality of light beams (320a,b) and to split the second beam of the primary plurality of light beams into a tertiary plurality of light beams (325a,b). A primary plurality of beam reflectors (335a,b/340a,b/345a,b) can be positioned and used to redirect the secondary and tertiary plurality of light beams toward a common detector (355).
摘要翻译：可以使用光学设备（300）的主分束器（310）将入射光束（305）分裂成主要的多个光束并且将第一个多个光束的第一光束沿第一方向以及在与第一方向正交的第二方向上的主多个光束的第二光束。定位在第一和第二光束的光束路径中的次级光束分离器（315a，b）可用于将主要多个光束的第一和第二光束分成次级多个光束（320a，b）并分裂所述主多个光束的第二光束成为第三多个光束（325a，b）。可以将主要的多个光束反射器（335a，b / 340a，b / 345a，b）定位并用于将次级和第三级光束朝着公共检测器（355）重定向。

5. 发明授权

US08704150B2 Beam splitter module having a secondary beam splitter for providing orthogonal light beams and parallel light beams 失效
标题翻译：分束器模块具有用于提供正交光束和平行光束的次级分束器
公开(公告)号：US08704150B2
公开(公告)日：2014-04-22
申请号：US13363030
申请日：2012-01-31
申请人： Joerg Bewersdorf , Brian Thomas Bennett
发明人： Joerg Bewersdorf , Brian Thomas Bennett
IPC分类号： H01J3/14
CPC分类号： G02B27/145 , G02B19/0028 , G02B19/0057 , G02B19/0066 , G02B27/1006 , G02B27/14 , G02B27/141 , G02B27/144
摘要： A primary beam splitter (310) of an optical apparatus (300) can be used to split an incident light beam (305) into a primary plurality of light beams and to direct a first beam therefrom in a first direction and a second beam therefrom in a second direction orthogonal to the first direction. Secondary beam splitters (315a,b) positioned in beam paths of the first and second beams can be used to split the first and second beams of the primary plurality of light beams into a secondary plurality of light beams (320a,b) and to split the same into a tertiary plurality of light beams (325a,b). A primary plurality of beam reflectors (335a,b/340a,b/345a,b) can be positioned and used to redirect the secondary and tertiary plurality of light beams toward a common detector (355).
摘要翻译：可以使用光学设备（300）的主分束器（310）将入射光束（305）分裂成主要的多个光束并且将第一光束从第一方向引导，并且将第二光束从第二光束与第一方向正交的第二方向。定位在第一和第二光束的光束路径中的次级光束分离器（315a，b）可用于将主要多个光束的第一和第二光束分成次级多个光束（320a，b）并分裂相同的第三多个光束（325a，b）。可以将主要的多个光束反射器（335a，b / 340a，b / 345a，b）定位并用于将次级和第三级光束朝向公共检测器（355）重定向。

6. 发明申请

US20120195488A1 Methods and Compositions Related to Cellular Assays 审中-公开
标题翻译：与细胞分析相关的方法和组合
公开(公告)号：US20120195488A1
公开(公告)日：2012-08-02
申请号：US13375075
申请日：2010-05-28
申请人： Brian Thomas Bennett , Joerg Bewersdorf
发明人： Brian Thomas Bennett , Joerg Bewersdorf
IPC分类号： C12Q1/68 , G01N33/566 , G06K9/00 , C12Q1/02
CPC分类号： G01N33/5008
摘要： The present invention relates generally to the fields of molecular biology and cancer. More specifically, the invention concerns methods and compositions useful for diagnosing and assessing a subject's response to therapy.
摘要翻译：本发明一般涉及分子生物学和癌症领域。更具体地，本发明涉及可用于诊断和评估受试者对治疗反应的方法和组合物。

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