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1. 发明申请

US20130145485A1 METHODS AND COMPOSITIONS FOR ALTERATION OF A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) GENE 有权
标题翻译：改变CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR（CFTR）GENE的方法和组合物
公开(公告)号：US20130145485A1
公开(公告)日：2013-06-06
申请号：US13558101
申请日：2012-07-25
申请人： Brian R. Davis , Dmitry M. Guschin , Michael C. Holmes , David Paschon , Philip Tam
发明人： Brian R. Davis , Dmitry M. Guschin , Michael C. Holmes , David Paschon , Philip Tam
IPC分类号： C12N5/071
CPC分类号： A61K48/00 , A61K38/00 , A61K48/005 , C07K2319/81 , C12N5/0662 , C12N9/22 , C12N15/85 , C12N15/907 , C12N2015/8536 , C12N2800/30 , C12N2800/80
摘要： Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models.
摘要翻译：使用这些核酸酶改变CFTR基因的核酸酶和方法以及细胞和动物模型的产生。

2. 发明申请

US20130052395A1 COMPOSITE COMPONENT HAVING A MULTILAYER CAP 审中-公开
标题翻译：具有多层盖子的复合组件
公开(公告)号：US20130052395A1
公开(公告)日：2013-02-28
申请号：US13590143
申请日：2012-08-20
申请人： Brian R. Davis , Bryan K. Buhrts , Scott A. Haemmerle , William G. Taylor , Jessica A. Alessandro
发明人： Brian R. Davis , Bryan K. Buhrts , Scott A. Haemmerle , William G. Taylor , Jessica A. Alessandro
IPC分类号： B32B3/04 , B32B27/30 , B32B27/08 , B32B27/32
CPC分类号： B32B27/20 , B32B27/304 , B32B2255/10 , B32B2255/26 , B32B2262/067 , B32B2264/067 , B32B2419/00 , Y10T428/239 , Y10T428/3158 , Y10T428/3188 , Y10T428/3192 , Y10T428/31938
摘要： A component comprised of a substrate and a multilayer cap. In one example, the inner cap layer may be a material that is typically not considered to be suitable for use with the substrate. In another example, the substrate may be provided with at least two different cap layers to gain the benefits of each cap layer.
摘要翻译：由基材和多层盖组成的组分。在一个示例中，内盖层可以是通常不被认为适合与基底一起使用的材料。在另一示例中，衬底可以设置有至少两个不同的盖层，以获得每个盖层的益处。

3. 发明授权

US4288416A Process for manufacturing titanium compounds 失效
标题翻译：钛化合物的制造方法
公开(公告)号：US4288416A
公开(公告)日：1981-09-08
申请号：US151999
申请日：1980-05-30
申请人： Brian R. Davis , Joseph A. Rahm
发明人： Brian R. Davis , Joseph A. Rahm
IPC分类号： C01G23/053 , C22B34/12 , C01G23/00
CPC分类号： C22B34/125 , C01G23/0532 , Y02P10/212
摘要： A process is provided for the manufacture of titanium compounds and particularly titanium dioxide wherein excess titaniferous bearing material is reacted with dilute sulfuric acid having a concentration of between about 25% and about 60% by weight at a temperature below about 140.degree. C. Thereafter, the titanium sulphate may be recovered or processed to provide titanium dioxide hydrate accompanied by recycling the spent acid for reaction with the titaniferous bearing material charged to the process. The titanium hydrate may be calcined to provide titanium dioxide pigment.
摘要翻译：提供了一种用于制造钛化合物，特别是二氧化钛的方法，其中过量的含钛载体材料在低于约140℃的温度下与浓度为约25％至约60％重量的稀硫酸反应。之后，可以回收或加工硫酸钛以提供二氧化钛水合物，伴随着废弃的酸再循环，以与装入该方法的含钛承载材料反应。可以将钛水合物煅烧以提供二氧化钛颜料。

4. 发明授权

US4275040A Process for extracting titanium values from titaniferous bearing material 失效
标题翻译：从含钛材料中提取钛值的方法
公开(公告)号：US4275040A
公开(公告)日：1981-06-23
申请号：US154680
申请日：1980-05-30
申请人： Brian R. Davis
发明人： Brian R. Davis
IPC分类号： B01D11/02 , B01D11/04 , C01G23/00 , C22B34/12
CPC分类号： C22B34/125 , Y10S423/09
摘要： Process of extracting titanium values from titaniferous bearing material by circulating a reaction mixture containing titanium values in an agitation column located within a reaction vessel in a direction countercurrent to the flow of the reaction mixture in the annular space located between the agitation column and the inner reaction vessel wall, said circulation being done in a manner to maintain the titaniferous bearing material in a continuous turbulent suspension flow in the agitation column and discharging the reaction mixture from the reaction vessel and recovering the extracted titanium values.
摘要翻译：通过在位于反应容器内的搅拌塔中循环含有钛值的反应混合物，在与位于搅拌塔和内部反应之间的环形空间中的反应混合物的流动相反的方向上，从含钛载体材料中提取钛值的方法所述循环的方式是将含钛轴承材料保持在搅拌塔中的连续湍流悬浮液中，并将反应混合物从反应容器中排出并回收提取的钛值。

5. 发明授权

US4248839A Chlorination of impure magnesium chloride melt 失效
标题翻译：氯化不纯的氯化镁熔体
公开(公告)号：US4248839A
公开(公告)日：1981-02-03
申请号：US61587
申请日：1979-07-30
申请人： Robert D. Toomey , Brian R. Davis , Ramaswami Neelameggham , R. Keith Darlington
发明人： Robert D. Toomey , Brian R. Davis , Ramaswami Neelameggham , R. Keith Darlington
IPC分类号： C01F5/32
CPC分类号： C01F5/32
摘要： Magnesium oxide is chlorinated in molten impure magnesium chlorine with chlorine gas by adding ferrous chloride to magnesium chloride brine, drying the brine, adding a mixture of calcined petroleum coke and charcoal to the dried brine, melting the product and chlorinating the formed melt. Ferrous chloride is added in amounts sufficient to provide from about 1.0% to 2.2% by weight of iron in the dried product. A highly reactive carbon source is added in amounts of from about 0.8 to 2.3% by weight and a carbon source that is less reactive than the highly reactive carbon source is added in amounts ranging from about 0.8 to 2.3% by weight of dried brine. Iron levels in the magnesium chloride melt may be adjusted upwardly by addition of a mixture of iron oxide and charcoal.A melt cell characterized by side entry electrodes disposed at angles from 40.degree. to 50.degree., an arched roof configuration, and an improved electrode refractory and ceramic sleeve construction is used to chlorinate the magnesium.
摘要翻译：通过向氯化镁盐水中加入氯化亚铁，干燥盐水，将煅烧石油焦炭和木炭的混合物加入到干燥的盐水中，使产物熔化并对形成的熔体进行氯化，将氧化镁在熔融的不纯的氯化镁中用氯气氯化。加入氯化亚铁的量足以在干燥产物中提供约1.0重量％至2.2重量％的铁。高反应性碳源的添加量为约0.8-2.3重量％，反应性低于高反应性碳源的碳源的加入量为干燥盐水的约0.8-2.3重量％。可以通过加入氧化铁和木炭的混合物向上调节氯化镁熔体中的铁含量。一种熔融池，其特征在于以40°至50°的角度设置的侧入口电极，拱形屋顶结构以及改进的电极耐火材料和陶瓷套筒构造用于对镁进行氯化。

6. 发明授权

US06751757B2 Disk drive data protection using clusters containing error detection sectors 失效
公开(公告)号：US06751757B2
公开(公告)日：2004-06-15
申请号：US09732244
申请日：2000-12-07
申请人： Richard J. Biskup , Brian R. Davis , James A. McDonald , Robert W. Horst
发明人： Richard J. Biskup , Brian R. Davis , James A. McDonald , Robert W. Horst
IPC分类号： G06F1108
CPC分类号： G11B27/105 , G11B20/1816 , G11B2020/10916 , G11B2220/20 , G11B2220/415
摘要： The present invention is related to methods and apparatus that can enhance the reliability of a hard drive by providing a built-in error check in the drive. Conventional hard drives can erroneously seek to an incorrect location on a platter of the hard drive. The erroneous seek corrupts the data stream and is difficult to detect and correct. Embodiments of the present invention can detect a logical block address assigned to a portion of the platter of the hard drive and thereby detect when an erroneous seek has occurred. Upon detection of an error, one embodiment of the present invention can further take corrective action to read from the correct portion of the platter.

7. 发明授权

US4288418A Process for manufacturing titanium dioxide 失效
标题翻译：制造二氧化钛的方法
公开(公告)号：US4288418A
公开(公告)日：1981-09-08
申请号：US202039
申请日：1980-10-29
申请人： Brian R. Davis , Joseph A. Rahm
发明人： Brian R. Davis , Joseph A. Rahm
IPC分类号： C01G23/053 , C22B34/12
CPC分类号： C22B34/125 , C01G23/0532 , Y02P10/212
摘要： A process is provided for the manufacture of titanium dioxide pigment wherein excess ilmenite ore is reacted with dilute sulfuric acid having a concentration of between about 25% and about 60% by weight and in preferably at least two stages wherein the first stage is maintained at a temperature up to about 140.degree. C. and the second stage is conducted at a lower temperature (than the first stage) which is below about 100.degree. C. to provide a salt solution of titanium and iron. Thereafter, the titanium is hydrolyzed to provide titanium dioxide hydrate accompanied by recycling the spent acid from the hydrolysis for reaction with the ilmenite ore charged to the process. The titanium hydrate is calcined to provide titanium dioxide pigment.
摘要翻译：提供了一种用于制造二氧化钛颜料的方法，其中过量的钛铁矿矿石与浓硫酸的浓度在约25％至约60％之间，优选至少两级的稀硫酸反应，其中第一级保持在温度高达约140℃，第二阶段在低于约100℃的较低温度（低于第一阶段）进行，以提供钛和铁的盐溶液。此后，钛被水解以提供二氧化钛水合物，伴随着从水解中回收废酸与用于与该方法反应的钛铁矿的反应。将钛水合物煅烧以提供二氧化钛颜料。

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