专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4154850A Certain di-(substituted phenoxy) alkanes and hypolipidaemic use thereof 失效
标题翻译：某些二（取代苯氧基）烷烃及其降血脂药用
公开(公告)号：US4154850A
公开(公告)日：1979-05-15
申请号：US821772
申请日：1977-08-04
申请人： Brian Morgan , Keith H. Baggaley , Richard M. Hindley
发明人： Brian Morgan , Keith H. Baggaley , Richard M. Hindley
IPC分类号： C07C69/92 , A61K31/085 , A61K31/10 , A61K31/125 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/357 , A61K31/36 , A61P3/06 , C07C41/00 , C07C43/205 , C07C43/23 , C07C45/00 , C07C47/277 , C07C47/575 , C07C49/255 , C07C49/84 , C07C51/00 , C07C59/64 , C07C59/68 , C07C65/21 , C07C65/24 , C07C67/00 , C07C69/035 , C07C69/612 , C07C69/708 , C07C69/734 , C07C69/736 , C07C201/00 , C07C205/37 , C07C213/00 , C07C217/84 , C07C231/00 , C07C231/12 , C07C235/34 , C07C235/46 , C07C241/00 , C07C243/32 , C07C243/38 , C07C253/00 , C07C255/37 , C07D317/56 , A61K31/235 , C07C69/76
CPC分类号： C07C321/00 , C07C49/255 , C07C49/84
摘要： A class of di-(substituted phenoxy) alkanes having from 7 to 25 carbon atoms in the alkane moiety have hypolipidaemic activity.
摘要翻译：一类在烷烃部分具有7至25个碳原子的二（取代苯氧基）烷烃具有降脂活性。

2. 发明授权

US4206145A Hypolipidaemic compounds and compositions 失效
标题翻译：降血脂化合物和组合物
公开(公告)号：US4206145A
公开(公告)日：1980-06-03
申请号：US859557
申请日：1977-12-12
申请人： Richard M. Hindley , Keith H. Baggaley
发明人： Richard M. Hindley , Keith H. Baggaley
IPC分类号： C07C87/28
摘要： Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
摘要翻译：其中芳香族苯胺环在氨基官能的对位具有含羧酸，盐或酯，烷基，羟基烷基，氰基或酰基的取代基的某些取代的芳烷基苯胺具有降血脂活性。

3. 发明授权

US4362892A Hypolipidaemic compounds 失效
标题翻译：降血脂化合物
公开(公告)号：US4362892A
公开(公告)日：1982-12-07
申请号：US859379
申请日：1977-12-12
申请人： Richard M. Hindley , Keith H. Baggaley
发明人： Richard M. Hindley , Keith H. Baggaley
IPC分类号： A61K31/135 , A61K20060101 , A61K31/04 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , A61P3/06 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07D317/30 , C07C87/28 , C07C91/00
CPC分类号： A61K31/04 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , C07C1/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07C67/00 , C07D317/30
摘要： Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
摘要翻译：其中芳香族苯胺环在氨基官能的对位具有含羧酸，盐或酯，烷基，羟基烷基，氰基或酰基的取代基的某些取代的芳烷基苯胺具有降血脂活性。

4. 发明授权

US5391565A Oxazolidine dione derivatives 失效
标题翻译：恶唑烷二酮衍生物
公开(公告)号：US5391565A
公开(公告)日：1995-02-21
申请号：US978706
申请日：1993-02-03
申请人： Richard M. Hindley
发明人： Richard M. Hindley
IPC分类号： A61K31/42 , A61K31/421 , A61K31/425 , A61K31/44 , A61K31/496 , A61K31/505 , A61P3/06 , A61P3/08 , A61P9/00 , C07D263/44 , C07D263/58 , C07D413/12 , C07D417/12
CPC分类号： C07D263/44 , C07D263/58 , C07D413/10
摘要： Compounds of the formula: ##STR1## or tautomeric forms and a pharmaceutically acceptable salt, and pharmaceutically acceptable solvates thereof, wherein:A.sup.1 is a substituted or unsubstituted oxazole substituted by up to 4 substituents selected from the group consisting of C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, phenyl, and halogen or any two substituents on adjacent carbon atoms, together with the carbon atoms to which they are attached, form a benzene ring, and wherein the carbon atoms of the benzene ring represented by the said two substituents are unsubstituted or substituted with up to three groups selected from halogen, C.sub.1-6 -alkyl, phenyl, C.sub.1-6 -alkoxy, halo-C.sub.1-6 -alkyl, hydroxy, amino, nitro, carboxy, C.sub.1-6 -alkoxycarbonyl, C.sub.1-6 -alkoxycarbonyl-C.sub.1-6 -alkyl, C.sub.1-6 -alkylcarbonyloxy, and C.sub.1-5 -alkylcarbonyl;R.sup.l is a hydrogen atom, a C.sub.1-6 -alkyl group, a C.sub.1-6 -alkylcarbonyloxy group, a phenyl-C.sub.1-6 -alkyl group, wherein the phenyl moiety may be substituted or unsubstituted, or a substituted or unsubstituted phenyl group, wherein the said phenyl groups may be substituted with up to three groups selected from halogen, C.sub.1-6 -alkyl, phenyl, C.sub.1-6 -alkoxy, halo-C.sub.1-6 -alkyl, hydroxy, amino, nitro, carboxy, C.sub.1-6 -alkoxycarbonyl, C.sub.1-6 -alkoxycarbonyl-C.sub.1-6 -alkyl, C.sub.1-6 -alkylcarbonyloxy, and C.sub.1-6 -alkylcarbonyl;A.sup.2 is a benzene ring having in total up to five substituents wherein three optional substituents are selected from halogen, C.sub.1-6 -alkyl, phenyl, C.sub.1-6 -alkoxy, halo-C.sub.1-6 -alkyl, hydroxy, amino, nitro, carboxy, C.sub.1-6 -alkoxycarbonyl. C.sub.1-6 -alkoxycarbonyl-C.sub.1-6 -alkyl, C.sub.1-6 -alkylcarbonyloxy, and C.sub.1-6 -alkylcarbonyl; and n is an integer from 2 to 6, are disclosed as hypoglycemics, hypolipidemics and antihypertensives.
摘要翻译： PCT No.PCT / GB91 / 01337 Sec。 371日期：1993年2月3日 102（e）日期1993年2月3日PCT 1991年8月5日PCT PCT。出版物WO92 / 02520 日期：1992年2月20日，下列化合物：或互变异构形式及其药学上可接受的盐及其药学上可接受的溶剂化物，其中：A1是被至多4个取代基取代的取代或未取代的恶唑， C 1-6 - 烷基，C 1-6 - 烷氧基，苯基和卤素或相邻碳原子上的任何两个取代基与它们所连接的碳原子一起形成苯环，并且其中苯的碳原子由所述两个取代基表示的环是未取代的或被至多三个选自卤素，C 1-6 - 烷基，苯基，C 1-6 - 烷氧基，卤代-C 1-6 - 烷基，羟基，氨基，硝基，羧基， C 1-6 - 烷氧基羰基，C 1-6 - 烷氧基羰基-C 1-6 - 烷基，C 1-6 - 烷基羰基氧基和C 1-5 - 烷基羰基; R1是氢原子，C1-6烷基，C1-6烷基羰基氧基，苯基-C1-6烷基，其中苯基部分可以是取代或未取代的，或取代或未取代的苯基，其中所述苯基可以被最多三个选自卤素，C 1-6 - 烷基，苯基，C 1-6 - 烷氧基，卤代-C 1-6 - 烷基，羟基，氨基，硝基，羧基，C 1-6 - 烷氧基羰基-C 1-6 - 烷基，C 1-6 - 烷基羰基氧基和C 1-6 - 烷基羰基; A2是总共具有五个取代基的苯环，其中三个任选的取代基选自卤素，C 1-6 - 烷基，苯基，C 1-6 - 烷氧基，卤代-C 1-6 - 烷基，羟基，氨基，硝基，羧基，C 1-6 - 烷氧基羰基。 C 1-6 - 烷氧基羰基-C 1-6 - 烷基，C 1-6 - 烷基羰基氧基和C 1-6 - 烷基羰基; 并且n是2至6的整数，被公开为低血糖症，降血脂药和抗高血压药。

5. 发明授权

US5063240A Novel compounds 失效
公开(公告)号：US5063240A
公开(公告)日：1991-11-05
申请号：US521157
申请日：1990-05-07
申请人： Richard M. Hindley
发明人： Richard M. Hindley
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61P3/06 , A61P3/08 , A61P9/12 , C07D277/34
CPC分类号： C07D277/34
摘要： A compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof, characterized in that:R.sup.1 represents hydrogen, alkyl, aralkyl or aryl and R.sup.2 represents hydrogen or R.sup.1 and R.sup.2 together represent a bond;R.sup.3 represents hydrogen and R.sup.4 represents hydrogen, akyl, aralkyl or aryl or R.sup.3 and R.sup.4 together represent a bond;X represents a bond, >C.dbd.O, >CHOH, O, S or NR wherein R is an alkyl group;n represents an integer 1, 2 or 3;m represents an integer 1, 2 or 3 andA.sup.1 and A.sup.2 each independently represent a benzene ring having a total up to 5 substituents comprising up to 3 optional substituents; a process for preparing such a compound, a pharmaceutical composition comprising such a compound and the use of such compounds and compositions in medicine.

6. 发明授权

US5478851A Dioxothiazolidine compounds 失效
标题翻译：二恶唑烷化合物
公开(公告)号：US5478851A
公开(公告)日：1995-12-26
申请号：US50175
申请日：1993-04-30
申请人： Barrie C. C. Cantello , David Haigh , Richard M. Hindley
发明人： Barrie C. C. Cantello , David Haigh , Richard M. Hindley
IPC分类号： A61K31/425 , A61K31/426 , A61K31/44 , A61P3/06 , A61P3/08 , A61P3/10 , C07D277/20 , C07D277/34 , C07D417/12
CPC分类号： C07D417/12 , C07D277/34
摘要： It has now been discovered that certain novel amide substituted thiazolidinedione derivatives show improved blood-glucose lowering activity and are therefore of potential use in the treatment and/or prophylaxis of hyperglycaemia and are of particular use in the treatment of Type II diabetes.
摘要翻译： PCT No.PCT / GB91 / 01833 Sec。 371日期：1993年04月30日 102（e）日期1993年4月30日PCT 1991年10月18日PCT公布。出版物WO92 / 07850 日期：1992年5月14日。现在已经发现，某些新的酰胺取代的噻唑烷二酮衍生物显示改善的血糖降低活性，因此在治疗和/或预防高血糖中具有潜在的用途，并且特别用于治疗类型 II型糖尿病

7. 发明授权

US5194443A Compounds 失效
标题翻译：化合物
公开(公告)号：US5194443A
公开(公告)日：1993-03-16
申请号：US645092
申请日：1991-01-24
申请人： Richard M. Hindley
发明人： Richard M. Hindley
IPC分类号： C07D277/20 , C07D277/42 , C07D277/82 , C07D417/12
CPC分类号： C07D277/20 , C07D277/42 , C07D277/82 , C07D417/12
摘要： Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein:A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group;R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group;R.sup.2 and R.sup.3 each represent hydrogen, or R.sup.2 and R.sup.3 together represent a bond;A.sup.2 represents a benzene ring having in total up to five substituents; andn represents an integer in the range of from 2 to 6; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.
摘要翻译：式（I）的化合物：其中：A1表示取代或未取代的芳族杂环基;或其药学上可接受的盐， R1表示氢原子，烷基，酰基，芳烷基，其中芳基部分可以是取代或未取代的，或取代或未取代的芳基; R2和R3各自表示氢，或R2和R3一起表示键; A2代表总共有五个取代基的苯环; n表示2〜6的整数，含有这些化合物的药物组合物以及这些化合物和组合物在医药中的用途。

8. 发明授权

US4593023A 6-oxomorpholines 失效
标题翻译： 6-氧代吗啉
公开(公告)号：US4593023A
公开(公告)日：1986-06-03
申请号：US735357
申请日：1985-05-17
申请人： Richard M. Hindley
发明人： Richard M. Hindley
IPC分类号： A61K31/535 , A61K31/5375 , A61P1/00 , A61P3/00 , A61P3/08 , C07C67/00 , C07C227/00 , C07C229/14 , C07C229/16 , C07D265/32
CPC分类号： C07D265/32
摘要： A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, thereof, in which R.sup.1 is hydrogen, halogen, or trifluoromethyl,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen or methyl.R.sup.4 is --O(CH.sub.2).sub.a CO.sub.2 H, --O(CH.sub.2).sub.b M, --CO.sub.2 H or an esteror amide derivative thereof in whicha is an integer from 1 to 6,b is an integer from 2 to 7, andM is hydroxy, C.sub.1-6 alkoxy or ##STR2## in which R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or ##STR3## together form a five or six membered ring, and n is 1 or 2; a process for preparing such a compound and its use in medicine and agriculture.
摘要翻译：式（I）化合物：其中R 1是氢，卤素或三氟甲基，R 2是氢或卤素，R 3是氢或甲基。 R 4是-O（CH 2）a CO 2 H，-O（CH 2）b M，-CO 2 H或其中a为1至6的整数的酯或酰胺衍生物，b为2至7的整数，M为羟基，C 1-6烷氧基或者其中R 5和R 6各自为氢或C 1-6烷基或“IMAGE”一起形成五或六元环，且n为1或2; 这种化合物的制备方法及其在医药和农业中的应用。

9. 发明授权

US5075300A Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US5075300A
公开(公告)日：1991-12-24
申请号：US398490
申请日：1989-08-25
申请人： Richard M. Hindley , David Haigh , Peter T. Duff
发明人： Richard M. Hindley , David Haigh , Peter T. Duff
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/496 , A61K31/505 , A61P3/06 , A61P3/08 , A61P9/00 , C07D263/58 , C07D277/34 , C07D417/12
CPC分类号： C07D417/12
摘要： A compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharamaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein:A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group;A.sup.2 represents a benzene ring having in total up to five substituents;X represents O, S or NR.sup.1 l wherein R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group;Y represents O or S providing that Y does not represent O when X represents NR.sup.1 ;R.sup.2 and R.sup.3 each represent hydrogen, or R.sup.2 and R.sup.3 together represent a bond; andn represents an integer in the range of from 2 to 6; a process for preparing such a compound; a pharmaceutical composition comprising such a compound; and the use of such a compound and a composition in medicine.

10. 发明授权

US5002953A Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US5002953A
公开(公告)日：1991-03-26
申请号：US457272
申请日：1989-12-27
申请人： Richard M. Hindley
发明人： Richard M. Hindley
IPC分类号： C07D277/34 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/496 , A61K31/505 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/12 , C07D213/74 , C07D239/42 , C07D263/48 , C07D263/58 , C07D277/20 , C07D277/42 , C07D277/82 , C07D417/12
CPC分类号： C07D277/20 , C07D277/22 , C07D277/42 , C07D277/82 , C07D417/12
摘要： Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein:A.sup.1 represents a substituted or unsubstituted aromatic heterocyclyl group;R.sup.1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group;R.sup.2 and R.sup.3 each represent hydrogen, or R.sup.2 and R.sup.3 together represent a bond;A.sup.2 represents a benzene ring having in total up to five substituents; andn represents an integer in the range of from 2 to 6; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式