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1. 发明授权

US08178553B2 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US08178553B2
公开(公告)日：2012-05-15
申请号：US12690633
申请日：2010-01-20
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
IPC分类号： A61K31/4178 , A61K31/437 , A61K31/4439 , A61P3/00 , A61P29/00 , A61P11/00 , C07D491/048 , C07D471/04 , C07D401/14 , C07D403/06
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

2. 发明授权

US07683088B2 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US07683088B2
公开(公告)日：2010-03-23
申请号：US11653798
申请日：2007-01-16
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/4166 , A61K31/4035 , A61K31/343 , C07D233/02 , C07D209/46 , C07D307/87
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

3. 发明申请

US20070265299A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070265299A1
公开(公告)日：2007-11-15
申请号：US11653798
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/44 , A61K31/4152 , A61K31/4412 , A61K31/4709 , A61K35/00 , A61P11/00 , A61P11/08 , A61P17/06 , A61P3/14 , A61P37/00 , A61P37/08 , A61P9/00 , A61P9/10 , C07D215/06 , C07D233/02 , C07D401/06 , C07D471/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPS, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPS，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

4. 发明申请

US20070197564A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070197564A1
公开(公告)日：2007-08-23
申请号：US11653511
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
IPC分类号： A61K31/52 , C07D471/02 , A61K31/4745 , A61K31/513 , A61K31/519 , C07D473/02 , C07D487/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

5. 发明授权

US07746183B2 Measurement apparatus for improving performance of standard cell library 有权
标题翻译：用于提高标准细胞库性能的测量装置
公开(公告)号：US07746183B2
公开(公告)日：2010-06-29
申请号：US12145334
申请日：2008-06-24
申请人： Seong-Heon Kim , Woo Chol Shin , Kyeong Soon Cho
发明人： Seong-Heon Kim , Woo Chol Shin , Kyeong Soon Cho
IPC分类号： G01R23/00
CPC分类号： G01R31/318594 , H03K3/03
摘要： Disclosed herein is a measurement apparatus for improving performances of standard cells in a standard cell library when verifying performance of the standard cell library through a ring oscillator among various test element groups (TEGs). A built-in circuit is used to measure and verify performance of the standard cell library through a TEG. Therefore, it is possible to effectively improve performances of the standard cells in the standard cell library. Particularly, it is possible to not only remove human errors or internal errors of equipment, but also perform the measurement more readily, rapidly and accurately. Further, it is possible to curtail the use of high-performance equipment or manpower and time required in a measurement process.
摘要翻译：本文公开了一种用于在通过各种测试元件组（TEG）中的环形振荡器验证标准单元库的性能时，提高标准单元库中的标准单元的性能的测量装置。内置电路用于通过TEG测量和验证标准单元库的性能。因此，能够有效地提高标准单元库的标准单元的性能。特别是，不仅可以消除设备的人为错误或内部错误，还可以更加快速，准确地进行测量。此外，可以减少测量过程中所需的高性能设备或人力和时间的使用。

6. 发明申请

US20090002081A1 MEASUREMENT APPARATUS FOR IMPROVING PERFORMANCE OF STANDARD CELL LIBRARY 有权
标题翻译：用于提高标准细胞库性能的测量装置
公开(公告)号：US20090002081A1
公开(公告)日：2009-01-01
申请号：US12145334
申请日：2008-06-24
申请人： Seong-Heon Kim , Woo Chol SHIN , Kyeong Soon CHO
发明人： Seong-Heon Kim , Woo Chol SHIN , Kyeong Soon CHO
IPC分类号： G01R23/04
CPC分类号： G01R31/318594 , H03K3/03
摘要： Disclosed herein is a measurement apparatus for improving performances of standard cells in a standard cell library when verifying performance of the standard cell library through a ring oscillator among various test element groups (TEGs). A built-in circuit is used to measure and verify performance of the standard cell library through a TEG. Therefore, it is possible to effectively improve performances of the standard cells in the standard cell library. Particularly, it is possible to not only remove human errors or internal errors of equipment, but also perform the measurement more readily, rapidly and accurately. Further, it is possible to curtail the use of high-performance equipment or manpower and time required in a measurement process.
摘要翻译：本文公开了一种用于在通过各种测试元件组（TEG）中的环形振荡器验证标准单元库的性能时，提高标准单元库中的标准单元的性能的测量装置。内置电路用于通过TEG测量和验证标准单元库的性能。因此，能够有效地提高标准单元库的标准单元的性能。特别是，不仅可以消除设备的人为错误或内部错误，还可以更加快速，准确地进行测量。此外，可以减少测量过程中所需的高性能设备或人力和时间的使用。

7. 发明申请

US20100169045A1 MEASUREMENT APPARATUS FOR IMPROVING PERFORMANCE OF STANDARD CELL LIBRARY 审中-公开
标题翻译：用于提高标准细胞库性能的测量装置
公开(公告)号：US20100169045A1
公开(公告)日：2010-07-01
申请号：US12643007
申请日：2009-12-21
申请人： Woo-Chol Shin , Seong-Heon Kim , Kyeong-Soon Cho
发明人： Woo-Chol Shin , Seong-Heon Kim , Kyeong-Soon Cho
IPC分类号： G06F17/18
CPC分类号： G01R31/2882 , G01R31/31726 , G01R31/31727
摘要： Disclosed herein is a measurement apparatus for improving performances of standard cells in a standard cell library when verifying performance of the standard cell library through a ring oscillator among various test element groups (TEGs). The measurement apparatus includes a ring oscillator block activated in response to an enable signal externally inputted thereto for outputting measurement result values, a decoder for selectively outputting one or more of the measurement result values from the ring oscillator block, and a statistics assistor for receiving output values from the decoder for a predetermined period and outputting a maximum value, a minimum value and an average value of the received values. The ring oscillator block includes a pulse generator for generating a pulse in response to the enable signal, a pulse stable unit for synchronizing the pulse generated by the pulse generator with a system clock pulse, a clock enable unit for outputting the system clock pulse according to a state of the pulse outputted from the pulse stable unit, a counter operating at any one of a rising edge and falling edge of the system clock pulse outputted from the clock enable unit, and a captured data storage unit responsive to the enable signal for receiving an output of the counter and storing a final count value or outputting it to the decoder.
摘要翻译：本文公开了一种用于在通过各种测试元件组（TEG）中的环形振荡器验证标准单元库的性能时，提高标准单元库中的标准单元的性能的测量装置。测量装置包括响应于外部输入的用于输出测量结果值的使能信号而激活的环形振荡器模块，用于选择性地输出来自环形振荡器模块的测量结果值中的一个或多个的解码器，以及用于接收输出的统计装置值，并输出所接收的值的最大值，最小值和平均值。环形振荡器模块包括用于响应于使能信号产生脉冲的脉冲发生器，用于使由脉冲发生器产生的脉冲与系统时钟脉冲同步的脉冲稳定单元，用于根据系统时钟脉冲输出系统时钟脉冲的时钟使能单元从脉冲稳定单元输出的脉冲的状态，从时钟使能单元输出的系统时钟脉冲的上升沿和下降沿中的任何一个操作的计数器，以及响应于使能信号接收的捕获数据存储单元计数器的输出并存储最终计数值或将其输出到解码器。

8. 发明授权

US07094374B2 Method for manufacturing ceramic balls for water treatment 失效
标题翻译：水处理陶瓷球的制造方法
公开(公告)号：US07094374B2
公开(公告)日：2006-08-22
申请号：US10332682
申请日：2001-07-06
申请人： Jae-Kyung Ko , Seong-Heon Kim , Suck-Joon Kang
发明人： Jae-Kyung Ko , Seong-Heon Kim , Suck-Joon Kang
IPC分类号： B29C67/24 , C02F1/10
CPC分类号： C04B35/14 , C02F1/505 , C04B38/009 , C04B2235/3281 , C04B2235/3291 , C04B2235/3409 , C04B2235/3418
摘要： A method for manufacturing ceramic bails for water treatment capable of exerting microbicidal activity in water and solution is provided. The method includes producing a first composition by dissolving borax (Na2B4O7.10H2O) and copper sulfate (CuSO4.5H2O) in an equivalent ratio of 1:1 to water, and drying the solution to produce a first composition, producing a second composition by adding silica to a first mixture of nitric acid and silver mixed in an equivalent ratio of 1:1 while heating the first mixture, adding more than 3 weight percents of the first composition to 200 weight percents of distilled water based on 100 weight percents of a ceramic ball while heating the distilled water, adding more than 8 weight percents of the second composition to a second mixture of the first composition and the distilled water when a total weight of the second mixture is reduced by a half, and drying the second mixture; and dehydrating the second mixture at a temperature of 400° C. to 500° C.
摘要翻译：提供了一种能够在水和溶液中施加杀菌活性的用于水处理的陶瓷保险丝的方法。该方法包括通过将硼砂（Na 2 N 2 O 3 N 2 O 2 O 2 O）溶解来制备第一组合物，和硫酸铜（CuSO 4·5H 2 O）以1:1的当量比与水反应，并干燥该溶液以制备第一组合物，制备第二组合物通过在加热第一混合物的同时以1:1的当量比混合的硝酸和银的第一混合物中加入二氧化硅，加入大于3重量％的第一组合物至200重量％的蒸馏水，基于100重量％陶瓷球，同时加热蒸馏水，当第二混合物的总重量减少一半时，向第一组合物和蒸馏水的第二混合物中加入多于8重量％的第二组合物，并干燥第二混合物 ; 并将第二混合物在400℃至500℃的温度下脱水。

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