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1. 发明申请

US20070244096A1 Fused Bicyclic Nitrogen-Containing Heterocycles 审中-公开
标题翻译：融合双环含氮杂环
公开(公告)号：US20070244096A1
公开(公告)日：2007-10-18
申请号：US11743376
申请日：2007-05-02
申请人： Brian Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin McMinn , Nobuya Ogawa , Steven Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人： Brian Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin McMinn , Nobuya Ogawa , Steven Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号： A61K31/55 , A61K31/542 , A61K31/5383 , C07D497/02 , C07D498/02 , C07D491/02
CPC分类号： C07D491/04
摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译：本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物，药物组合物和方法。特别地，本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。

2. 发明申请

US20080083893A1 Voice-controlled faucet for water conservation 审中-公开
标题翻译：语音控制水龙头节水
公开(公告)号：US20080083893A1
公开(公告)日：2008-04-10
申请号：US11542840
申请日：2006-10-04
申请人： Steven Rubenstein
发明人： Steven Rubenstein
IPC分类号： F16K31/02
CPC分类号： E03C1/057 , G10L15/26
摘要： The invention provides simplified methods and devices for conserving water by controlling water flow from plumbing fixtures using voice or sound commands. One aspect of the invention provides a method for conserving water that includes the step of: providing a faucet or showerhead or the like with voice or sound control of the amount of water flow, which control does not include control of temperature of water exiting the fixture. Another aspect of the invention provides a device for conserving water that includes a voice or sound command-responsive control unit that controls the amount of flow of water from a plumbing fixture such as a faucet or showerhead by actuating a valve that is disposed downstream of the mixing of hot and cold water. Valve states may include only open and closed, i.e., on and off, or may optionally include one or more intermediate flow positions.
摘要翻译：本发明通过使用语音或声音命令控制来自卫生设备的水流来提供用于节约用水的简化方法和装置。本发明的一个方面提供了一种保存水的方法，其包括以下步骤：提供具有水流量的声音或声音控制的水龙头或喷头等，该控制不包括控制离开固定装置的水的温度。本发明的另一方面提供了一种用于节约用水的装置，其包括声音或声音指令响应控制单元，其通过致动安装在水龙头或淋浴头的下游的阀门来控制来自诸如水龙头或淋浴头的卫生设备的水流量混合冷热水。阀状态可以仅包括打开和关闭，即，打开和关闭，或者可以可选地包括一个或多个中间流动位置。

3. 发明申请

US20060167263A1 Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权
标题翻译：乙酰氨基苯甲酸化合物及其用于无意义抑制和治疗疾病
公开(公告)号：US20060167263A1
公开(公告)日：2006-07-27
申请号：US11048657
申请日：2005-01-21
申请人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
发明人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
IPC分类号： C07D209/46 , C07D207/24 , C07C327/38
CPC分类号： C07C235/24 , C07C235/74 , C07C323/60 , C07C327/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/273 , C07D209/48 , C07D213/74 , C07D239/38 , C07D257/04 , C07D271/10 , C07D317/64
摘要： Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译：公开了新型乙酰氨基苯甲酸化合物，使用方法和包含乙酰氨基苯甲酸衍生物的药物组合物。所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。

4. 发明申请

US20070203123A1 Use of acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease 失效
标题翻译：使用乙酰氨基苯甲酸化合物进行无味抑制和治疗疾病
公开(公告)号：US20070203123A1
公开(公告)日：2007-08-30
申请号：US11789625
申请日：2007-04-24
申请人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
发明人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
IPC分类号： A61K31/55 , A61K31/445 , A61K31/24 , A61K31/195 , A61K31/277
CPC分类号： C07C235/24 , C07C235/74 , C07C323/60 , C07C327/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/273 , C07D209/48 , C07D213/74 , C07D239/38 , C07D257/04 , C07D271/10 , C07D317/64
摘要： Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译：公开了新型乙酰氨基苯甲酸化合物，使用方法和包含乙酰氨基苯甲酸衍生物的药物组合物。所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。

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