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1. 发明授权

US5610712A Laser diffraction particle sizing method using a monomode optical fiber 失效
$Laser diffraction particle sizing method using a monomode optical fiber$
标题翻译：使用单模光纤的激光衍射颗粒尺寸测定方法
公开(公告)号：US5610712A
公开(公告)日：1997-03-11
申请号：US545424
申请日：1995-10-09
申请人： Brian D. Schmitz , Steven E. Bott , William H. Hart
发明人： Brian D. Schmitz , Steven E. Bott , William H. Hart
IPC分类号： G01B11/08 , G01N15/02 , G01N15/14 , G02B27/46 , G01N21/47
CPC分类号： G01N15/0211 , G02B27/46
摘要： A fiber optic spatial filter assembly for laser diffraction particle sizing apparatus utilizing a laser to generate a monochromatic light beam which is coupled to an optical fiber operating substantially in a monomode and creating a beam of light having a high degree of spatial coherence which is then passed through collimating lenses to interrogate and impinge upon the particles of matter through which the laser diffracted light passes. The light scattered by the particles is focused onto a Fourier plane and thereafter impinges upon a photooptical detector array, positioned coincident with the Fourier plane, for measuring the light intensities of the scattered light by scattering angle, thus enabling the computation of particle size.
摘要翻译：一种用于激光衍射粒子尺寸设备的光纤空间滤光器组件，其利用激光器来产生单色光束，该单色光束耦合到基本上以单模操作的光纤并且产生具有高空间相干性的光束，然后通过该光束然后通过通过准直透镜来询问并撞击激光衍射光通过的物质颗粒。由颗粒散射的光聚焦到傅立叶平面上，然后撞击与傅立叶平面重合的光电检测器阵列，用于通过散射角度测量散射光的光强度，从而能够计算粒径。

2. 发明授权

US4953978A Particle size analysis utilizing polarization intensity differential scattering 失效
标题翻译：利用极化强度差分散射的粒度分析
公开(公告)号：US4953978A
公开(公告)日：1990-09-04
申请号：US319480
申请日：1989-03-03
申请人： Steven E. Bott , W. Howard Hart
发明人： Steven E. Bott , W. Howard Hart
IPC分类号： G01N15/02 , G01N15/14 , G01N21/21 , G01N21/49 , G01N21/51
CPC分类号： G01N15/0211 , G01N2021/4711 , G01N2021/4716 , G01N2021/4792 , G01N21/51
摘要： Two arrangements are disclosed to provide high resolution measurement of sub-micrometer and micrometer particle size distributions. In a first arrangement, scattered light is measured over a wide range of scattering angles. At the same time, light scattered at low scattering angles is measured with high angular resolution. In the second arrangement an improved Polarization Intensity Differential Scattering (PIDS) measurement is made possible by providing an interrogating light beam of selected wavelength including a first component parallel to the scattering plane and a second component perpendicular to the scattering plane. Photodetecting arrangements detect light scattered by the particles at least at two scattering angles.
摘要翻译：公开了两种布置以提供亚微米和微米粒度分布的高分辨率测量。在第一布置中，在宽的散射角范围内测量散射光。同时，以高分辨率测量以低散射角散射的光。在第二种装置中，通过提供包括平行于散射平面的第一分量和垂直于散射平面的第二分量的选定波长的询问光束，可以实现改进的极化强度差分散射（PIDS）测量。光检测装置至少在两个散射角度下检测由颗粒散射的光。

3. 发明授权

US09375349B2 System and method for providing laser shot patterns to the lens of an eye 有权
标题翻译：用于向眼睛的镜片提供激光射击图案的系统和方法
公开(公告)号：US09375349B2
公开(公告)日：2016-06-28
申请号：US12842870
申请日：2010-07-23
申请人： Rudolph W. Frey , Steven E. Bott , Gary P. Gray
发明人： Rudolph W. Frey , Steven E. Bott , Gary P. Gray
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00825 , A61F9/00838 , A61F2009/0087 , A61F2009/00897
摘要： There is provided a system, apparatus and methods for developing laser systems that can create precise predetermined shot patterns for providing areas of varying softness in the lens of an eye. These areas of varying softness may have shapes that correspond to instruments used to remove material from the lens of the eye. There is further provided a multiplicity of spheres pattern, which may provide for bubble formation which in turn lubricates the lens material for removal after sectioning.
摘要翻译：提供了一种用于开发激光系统的系统，装置和方法，其可以创建精确的预定射击模式，以在眼睛的晶状体中提供变化的柔软度的区域。这些变化柔软的区域可以具有与用于从眼睛的镜片中去除材料的仪器相对应的形状。还提供了多种球形图案，其可以提供气泡形成，其又在切片之后润滑透镜材料以便去除。

4. 发明授权

US08556425B2 Purkinjie image-based alignment of suction ring in ophthalmic applications 有权
标题翻译： Purkinjie基于图像的吸引环在眼科应用中的对准
公开(公告)号：US08556425B2
公开(公告)日：2013-10-15
申请号：US13017702
申请日：2011-01-31
申请人： Rudolph W. Frey , Steven E. Bott
发明人： Rudolph W. Frey , Steven E. Bott
IPC分类号： A61B3/14 , A61B3/00 , A61B18/18
CPC分类号： A61F9/009 , A61F9/00825 , A61F2009/0087 , A61F2009/00872 , A61F2009/00889
摘要： An alignment device including means for releasably attaching a suction ring and means for applying a pattern of light to an eye of a patient. The alignment device further including means for detecting light reflected from the eye and determining whether the suction ring is aligned relative to the eye based on the detected light.
摘要翻译：一种对准装置，包括用于可释放地附接吸入环的装置和用于向患者的眼睛施加光图案的装置。对准装置还包括用于检测从眼睛反射的光并基于检测到的光来确定吸入环是否相对于眼睛对准的装置。

5. 发明申请

US20120330290A1 SYSTEM AND METHOD FOR MEASURING TILT IN THE CRYSTALLINE LENS FOR LASER PHACO FRAGMENTATION 审中-公开
标题翻译：用于激光激光碎片的晶体镜片中的倾斜测量系统和方法
公开(公告)号：US20120330290A1
公开(公告)日：2012-12-27
申请号：US13427319
申请日：2012-03-22
申请人： Gary P. Gray , Rudolph W. Frey , Steven E. Bott
发明人： Gary P. Gray , Rudolph W. Frey , Steven E. Bott
IPC分类号： A61B18/20 , G06K9/78
CPC分类号： A61B3/145 , A61B3/10 , A61F9/008 , A61F2009/0087 , A61F2009/00872 , A61F2009/00878 , A61F2009/00889 , H04N19/523
摘要： A method of generating three dimensional shapes for a cornea and lens, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of the eye based on the multiple sections of light. For each obtained multiple sectional image, the following processes are performed: a) automatically identifying arcs corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the obtained multiple sectional images; and b) determining an intersection of lines ray traced back from the identified arcs with a known position of a section of space containing the section of light that generated the obtained multiple sectional images, wherein the intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the cornea surfaces and the lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.
摘要翻译：一种用于产生角膜和晶状体的三维形状的方法，所述方法包括以多个部分的光照射眼睛，并且基于所述多个部分的光线获得所述眼睛的多个截面图像。对于每个获得的多个截面图像，执行以下处理：a）通过所获得的多个截面图像的图像分析和曲线拟合来自动识别与眼睛的前角膜和后角膜和眼镜面相对应的弧; 以及b）确定从所识别的弧线回溯的线光线与包含产生所获得的多个截面图像的光的部分的空间部分的已知位置的交点，其中所述交点限定三维弧形曲线。该方法还包括基于将三维弧曲线拟合为三维形状来重建角膜表面和透镜表面的三维形状。

6. 发明申请

US20110190740A1 PLACIDO RING MEASUREMENT OF ASTIGMATISM AXIS AND LASER MARKING OF ASTIGMATISM AXIS 审中-公开
标题翻译：惯性轴的定位环测量和轴向的激光标记
公开(公告)号：US20110190740A1
公开(公告)日：2011-08-04
申请号：US13017499
申请日：2011-01-31
申请人： Rudolph W. Frey , Steven E. Bott
发明人： Rudolph W. Frey , Steven E. Bott
IPC分类号： A61B18/20 , A61B3/107
CPC分类号： A61F9/00825 , A61F9/00827 , A61F2009/0087 , A61F2009/00872 , A61F2009/00889
摘要： A laser treatment system that includes means for measuring an astigmatism axis of a cornea of an eye of a patient and means for applying a laser beam to the eye.
摘要翻译：一种激光治疗系统，其包括用于测量患者眼睛的角膜的散光轴线的装置和将激光束施加到眼睛的装置。

7. 发明申请

US20100022994A1 LIQUID FILLED INDEX MATCHING DEVICE FOR OPHTHALMIC LASER PROCEDURES 有权
标题翻译：液体填充指示器用于光学激光程序
公开(公告)号：US20100022994A1
公开(公告)日：2010-01-28
申请号：US12509021
申请日：2009-07-24
申请人： Rudolph W. Frey , Steven E. Bott , Gerrit N. Porter
发明人： Rudolph W. Frey , Steven E. Bott , Gerrit N. Porter
IPC分类号： A61F9/009
CPC分类号： A61F9/009 , A61F2009/0087 , A61F2009/00889
摘要： There is provided a device for use as an interface between a laser surgery device and the eye of a patient. The device is filled with a liquid that matches the index of refraction of the eye. The device further has a curved lens that follows the curvature of the outer surface of the patient's eye. In this manner the interface device, through which the laser beam must travel, has essentially the same index of refraction as the eye.
摘要翻译：提供了用作激光手术装置和患者眼睛之间的界面的装置。该装置充满与眼睛的折射率匹配的液体。该装置还具有跟随患者眼睛的外表面的曲率的弯曲透镜。以这种方式，激光束必须行进的界面装置具有与眼睛基本上相同的折射率。

8. 发明授权

US5698411A Method for determining activity of enzymes in metabolically active whole cells 失效
标题翻译：测定代谢活性全细胞中酶活性的方法
公开(公告)号：US5698411A
公开(公告)日：1997-12-16
申请号：US444051
申请日：1995-05-18
申请人： Frank J. Lucas , Gerald E. Jaffe , Steven E. Bott , James H. Carter
发明人： Frank J. Lucas , Gerald E. Jaffe , Steven E. Bott , James H. Carter
IPC分类号： C12Q1/26 , C12Q1/34 , C12Q1/37 , G01N33/574 , G01N33/58 , C12Q1/02 , C12Q1/00
CPC分类号： G01N33/574 , C12Q1/26 , C12Q1/34 , C12Q1/37 , G01N33/582 , G01N2333/95 , G01N2333/96413 , G01N2333/96466 , G01N2333/96469 , G01N2800/52
摘要： A method for assaying the activity of an enzyme inside a metabolically active whole cell is disclosed. The assay compound includes a leaving group and an indicator group. The leaving group is selected from the group comprising amino acids, peptides, saccharides, sulfates, phosphates, esters, phosphate esters, nucleotides, polynucleotides, nucleic acids, pyrimidines, purines, nucleosides, lipids and mixtures thereof. The indicator group is selected from compounds which have a first state when joined to the leaving group, and a second state when the leaving group is cleaved from the indicator group by the enzyme. Preferably, the indicator compounds are rhodamine 110, rhodol, and fluorescein and analogs of these compounds. A method of synthesizing the compound is also disclosed.
摘要翻译：公开了一种用于测定代谢活性全细胞内酶的活性的方法。测定化合物包括离去基团和指示剂组。离去基团选自包括氨基酸，肽，糖，硫酸盐，磷酸盐，酯，磷酸酯，核苷酸，多核苷酸，核酸，嘧啶，嘌呤，核苷，脂质及其混合物的组。指示基团选自与离去基团连接时具有第一状态的化合物，当离去基团被酶从指示剂基团切割时的第二种状态。优选地，指示剂化合物是这些化合物的罗丹明110，rhodol和荧光素以及类似物。还公开了合成该化合物的方法。

9. 发明授权

US10772499B2 System and method for measuring tilt 有权
公开(公告)号：US10772499B2
公开(公告)日：2020-09-15
申请号：US14728760
申请日：2015-06-02
申请人： Gary P. Gray , Rudolph W. Frey , Steven E. Bott
发明人： Gary P. Gray , Rudolph W. Frey , Steven E. Bott
IPC分类号： A61F9/08 , A61B3/107 , A61F9/008
摘要： A method of generating three dimensional shapes for a cornea and lens of an eye, the method including illuminating an eye with multiple sections of light and obtaining multiple sectional images of said eye based on said multiple sections of light. For each one of the obtained multiple sectional images, the following processes are performed: a) automatically identifying arcs, in two-dimensional space, corresponding to anterior and posterior corneal and lens surfaces of the eye by image analysis and curve fitting of the one of the obtained multiple sectional images; and b) determining an intersection of lines ray traced back from the identified arcs in two-dimensional space with a known position of a section of space containing the section of light that generated the one of the obtained multiple sectional images, wherein the determined intersection defines a three-dimensional arc curve. The method further including reconstructing three-dimensional shapes of the anterior and posterior cornea surfaces and the anterior and posterior lens surfaces based on fitting the three-dimensional arc curve to a three-dimensional shape.

10. 发明授权

US10684449B2 System and method for laser generated corneal and crystalline lens incisions using a variable F/# optical system with aspheric contact interface to the cornea or rotating and adaptive optics 有权
公开(公告)号：US10684449B2
公开(公告)日：2020-06-16
申请号：US13435103
申请日：2012-03-30
申请人： George C. Curatu , Rudolph W. Frey , John McWhirter , Steven E. Bott
发明人： George C. Curatu , Rudolph W. Frey , John McWhirter , Steven E. Bott
IPC分类号： G02B13/00 , G02B27/00 , G02B15/177 , A61F9/008 , G02B26/10 , A61F9/009
摘要： A laser system including a laser source that generates a laser beam and an optical switch that receives the laser beam and sends the laser beam to either a fast path or a slow path, wherein the F/# of the fast path is lower than the F/# of the slow path. The laser system includes an afocal optical system in the slow path and receives the laser beam from the optical switch and an x-y scanner that receives either a laser beam from the slow path or a laser beam from the fast path. The laser system including a scan lens system that performs a z-scan for the scanning laser beam only in the case wherein the scanning laser beam is generated from the laser beam in the fast path. The laser system including an aspheric patient interface device that receives a laser beam from the scan lens system.

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