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1. 发明授权

US07507580B2 Ztnfr14, a tumor necrosis factor receptor 失效
标题翻译： Ztnfr14，一种肿瘤坏死因子受体
公开(公告)号：US07507580B2
公开(公告)日：2009-03-24
申请号：US10967527
申请日：2004-10-18
申请人： Brian A. Fox , James L. Holloway , Paul O. Sheppard , Stacey R. Dillon
发明人： Brian A. Fox , James L. Holloway , Paul O. Sheppard , Stacey R. Dillon
IPC分类号： C07K14/705 , C12N5/10 , C12N15/11
CPC分类号： C07K14/7151 , A61K38/00
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译：公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。多肽可用于检测配体，以及激动剂和拮抗剂。多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。

2. 发明授权

US07833520B2 Method of using interferon-like protein ZCYTO21(IL-29) to treat hepatitis B 有权
标题翻译：使用干扰素样蛋白ZCYTO21（IL-29）治疗乙型肝炎的方法
公开(公告)号：US07833520B2
公开(公告)日：2010-11-16
申请号：US12628078
申请日：2009-11-30
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
IPC分类号： A61K38/20 , A61K38/21 , A61K38/00 , C07K14/00
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

3. 发明申请

US20090326204A1 INTERFERON-LIKE PROTEIN ZCYTO21 审中-公开
标题翻译：类似蛋白质的ZCYTO21
公开(公告)号：US20090326204A1
公开(公告)日：2009-12-31
申请号：US12341273
申请日：2008-12-22
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

4. 发明授权

US07445773B2 Cytokine protein family 有权
公开(公告)号：US07445773B2
公开(公告)日：2008-11-04
申请号：US11539078
申请日：2006-10-05
申请人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
发明人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
IPC分类号： A61K38/21 , A61K38/00 , A61K38/19 , C07K14/00 , C07H21/04
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

5. 发明授权

US06914135B2 Kunitz domain polypeptide zkun10 有权
标题翻译： Kunitz结构域多肽zkun10
公开(公告)号：US06914135B2
公开(公告)日：2005-07-05
申请号：US10315432
申请日：2002-12-09
申请人： Paul O. Sheppard , Brian A. Fox
发明人： Paul O. Sheppard , Brian A. Fox
IPC分类号： A61K38/00 , C07K14/81 , C07H21/02 , C12Q1/34
CPC分类号： C07K14/8114 , A61K38/00
摘要： Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:4, and the sequence of the Kunitz domain is shown in residues 57 through 107 of SEQ ID NO:2. The polypeptide also includes an N-terminal collagen domain in which a von Willebrand domain resides, and is shown in SEQ ID NO: 5. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and as inhibitors of protease degradation of plasma proteins.
摘要翻译：公开了包含Kunitz结构域的蛋白酶抑制剂。 Kunitz结构域包含如SEQ ID NO：4所示的氨基酸残基的基序，Kunitz结构域的序列显示于SEQ ID NO：2的残基57至107中。多肽还包括其中von Willebrand结构域所在的N-末端胶原结构域，并且显示于SEQ ID NO：5中。还公开了制备蛋白酶抑制剂的方法，以及在该方法中有用的表达载体和培养细胞。蛋白酶抑制剂可以用作细胞培养基的组分，蛋白质纯化，以及作为血浆蛋白质蛋白酶降解的抑制剂。

6. 发明申请

US20120142612A1 CYTOKINE PROTEIN FAMILY 有权
标题翻译：细胞因子蛋白家族
公开(公告)号：US20120142612A1
公开(公告)日：2012-06-07
申请号：US13353524
申请日：2012-01-19
申请人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
发明人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
IPC分类号： A61K38/19 , A61P9/00 , A61P3/10 , A61P31/12 , A61P35/00
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译：本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。该蛋白家族的受体是II类细胞因子受体。本发明包括减少病毒感染和增加单核细胞计数的方法。本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。

7. 发明申请

US20110195916A1 CYTOKINE PROTEIN FAMILY 有权
标题翻译：细胞因子蛋白家族
公开(公告)号：US20110195916A1
公开(公告)日：2011-08-11
申请号：US13028101
申请日：2011-02-15
申请人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
发明人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
IPC分类号： A61K38/16 , A61P43/00
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译：本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。该蛋白家族的受体是II类细胞因子受体。本发明包括减少病毒感染和增加单核细胞计数的方法。本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。

8. 发明申请

US20110054148A1 ANTIBODIES TO INTERFERON-LIKE PROTEIN ZCYTO21(IL-29) 有权
标题翻译：干扰素类抗生素ZCYTO21（IL-29）
公开(公告)号：US20110054148A1
公开(公告)日：2011-03-03
申请号：US12895139
申请日：2010-09-30
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Halderman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Halderman , Francis J. Grant
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

9. 发明授权

US07655222B2 Method of using interferon-like protein ZCYTO20 (IL-28A) or ZCYTO22 (IL-28B) to treat hepatitis C 有权
标题翻译：使用干扰素样蛋白ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗丙型肝炎的方法
公开(公告)号：US07655222B2
公开(公告)日：2010-02-02
申请号：US11868170
申请日：2007-10-05
申请人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
发明人： Paul O. Sheppard , Brian A. Fox , Kevin M. Klucher , David W. Taft , Wayne Kindsvogel
IPC分类号： A61K38/20 , A61K38/00 , A61K38/21 , C07K14/00
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译：本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。该蛋白家族的受体是II类细胞因子受体。本发明包括减少病毒感染和增加单核细胞计数的方法。本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。

10. 发明授权

US07485700B2 Interferon-like protein ZCYTO21 有权
标题翻译：干扰素样蛋白ZCYTO21
公开(公告)号：US07485700B2
公开(公告)日：2009-02-03
申请号：US11548056
申请日：2006-10-10
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
IPC分类号： C07K14/52 , C07K14/00 , C12N15/00 , C12P21/00 , A61K38/21 , C07H21/04
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

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