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1. 发明授权

US5258496A Isolation and purification of lung surfactant protein 失效
标题翻译：肺表面活性蛋白的分离和纯化
公开(公告)号：US5258496A
公开(公告)日：1993-11-02
申请号：US551524
申请日：1990-07-10
申请人： Bradley J. Benson , Douglas Buckley , David Lesikar , Asha Naidu , Kate B. Silverness
发明人： Bradley J. Benson , Douglas Buckley , David Lesikar , Asha Naidu , Kate B. Silverness
IPC分类号： C07K1/16 , C07K1/14 , C07K1/20 , C07K1/36 , C07K14/435 , C07K14/785 , C07K19/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C07K3/12 , C07K3/20 , C07K15/06 , C07K15/16
CPC分类号： C07K14/785 , Y10S530/848
摘要： Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
摘要翻译：提供了分离和纯化重组肺表面活性蛋白的方法。该方法包括多步骤步骤，包括用C1-C4脂族醇萃取和采用C1-C4脂族醇作为洗脱剂的色谱纯化步骤。还提供了使用公开的分离和纯化步骤获得的纯化蛋白质。

2. 发明授权

US5403915A Isolation and purification of lung surfactant protein 失效
标题翻译：肺表面活性蛋白的分离和纯化
公开(公告)号：US5403915A
公开(公告)日：1995-04-04
申请号：US108482
申请日：1993-08-18
申请人： Bradley J. Benson , Douglas Buckley , David Lesikar , Asha Naidu , Kate B. Silverness
发明人： Bradley J. Benson , Douglas Buckley , David Lesikar , Asha Naidu , Kate B. Silverness
IPC分类号： C07K1/16 , C07K1/14 , C07K1/20 , C07K1/36 , C07K14/435 , C07K14/785 , C07K19/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C07K3/20 , C07K15/06
CPC分类号： C07K14/785 , Y10S530/848
摘要： Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C.sub.1 -C.sub.4 aliphatic alcohol and chromatographic purification steps which employ a C.sub.1 -C.sub.4 aliphatic alcohol as eluant. Purified proteins obtained using the disclosed isolation and purification steps are provided as well.
摘要翻译：提供了分离和纯化重组肺表面活性蛋白的方法。该方法包括多步骤步骤，包括用C1-C4脂族醇萃取和采用C1-C4脂族醇作为洗脱剂的色谱纯化步骤。还提供了使用公开的分离和纯化步骤获得的纯化蛋白质。

3. 发明授权

US5876970A Surfactant compositions and methods 失效
标题翻译：表面活性剂组合物和方法
公开(公告)号：US5876970A
公开(公告)日：1999-03-02
申请号：US278189
申请日：1994-07-21
申请人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
发明人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
IPC分类号： A61K35/42 , A61K38/00 , A61K38/17 , C07K1/107 , C07K14/785 , G01N33/68 , C12P21/02 , C07H21/04 , C07K14/47
CPC分类号： C07K14/785 , A61K38/00
摘要： Stable lung surfactant compositions are provided, as well as methods for their preparation, modification, formulation, assay, and therapeutic use.
摘要翻译：提供稳定的肺表面活性剂组合物，以及其制备，修饰，制剂，测定和治疗用途的方法。

4. 发明授权

US4933280A Recombinant DNA sequence encoding Alveolar Surfactant Protein 失效
标题翻译：编码肺泡表面活性蛋白的重组DNA序列
公开(公告)号：US4933280A
公开(公告)日：1990-06-12
申请号：US857715
申请日：1986-04-30
申请人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
发明人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
IPC分类号： C12N15/09 , A61K38/00 , A61P11/00 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/705 , C07K14/785 , C12N1/20 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12N15/85 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C12N15/85 , C07K14/785 , C12P21/02 , A61K38/00
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones for the 10K protein have also been obtained. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译：公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 也获得了10K蛋白的克隆。描述了用于获得重组形式的这些蛋白质的方法和载体。大量这些蛋白质通过重组技术的可用性允许在合适的药物组合物中使用ASP来治疗呼吸缺陷综合征。

5. 发明授权

US5104853A Alveolar surfactant proteins having cys to ser mutations 失效
标题翻译：具有cys至Ser突变的肺泡表面蛋白
公开(公告)号：US5104853A
公开(公告)日：1992-04-14
申请号：US524360
申请日：1990-05-17
申请人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
发明人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
IPC分类号： A61K38/00 , A61P11/00 , C07K14/00 , C07K14/785 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/85 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C12N15/70 , C07K14/785 , C12N15/85 , A61K38/00
摘要： Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques. The peptides of the invention include surfactant proteins having serine replacements for the cysteines.
摘要翻译：各种特异性人SP-18和人SP-5衍生肽具有肺泡表面活性蛋白（ASP）活性。使用合成方法或通过重组技术制备这些肽。本发明的肽包括具有丝氨酸替代半胱氨酸的表面活性蛋白。

6. 发明授权

US4912038A Recombinant DNA sequence encoding alveolar surfactant protein 失效
标题翻译：编码肺泡表面活性蛋白的重组DNA序列
公开(公告)号：US4912038A
公开(公告)日：1990-03-27
申请号：US808843
申请日：1985-12-13
申请人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
发明人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
IPC分类号： A61K38/00 , C07K14/785 , C12N15/12 , C12N15/85 , C12P21/02
CPC分类号： C07K14/785 , C12N15/85 , C12P21/02 , A61K38/00
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones for the 10K protein have also been obtained. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译：公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 也获得了10K蛋白的克隆。描述了用于获得重组形式的这些蛋白质的方法和载体。大量这些蛋白质通过重组技术的可用性允许在合适的药物组合物中使用ASP来治疗呼吸缺陷综合征。

7. 发明授权

US06178698B2 Balanced door closing apparatus 有权
标题翻译：平衡门关闭装置
公开(公告)号：US06178698B2
公开(公告)日：2001-01-30
申请号：US09337442
申请日：1999-06-21
申请人： Jeffrey P. Benson , Bradley J. Benson
发明人： Jeffrey P. Benson , Bradley J. Benson
IPC分类号： E05D706
CPC分类号： E05F3/22 , E05D15/30 , E05F3/10 , E05Y2900/00
摘要： An improved door closing apparatus (20) is adapted for use with a door frame (21) that comprises an elongated header (22), a sill (23) and a pair of side jambs (24, 25). A door (26) is adapted to be mounted on the frame for pivotal movement about an axis (y—y). The improved comprises a base (29) adapted to be mounted on the header, a closer mechanism (30) mounted on the base and having a first shaft (31) adapted to be oriented perpendicularly with respect to the axis of elongation of the header. The closer mechanism is operatively arranged to selectively urge the first shaft to rotate relative to the closer mechanism. A second shaft (33) is mounted on the base for pivotal movement relative thereto. The second shaft is substantially aligned with the pivotal excess of the door. First and second arms (34, 35) are mounted on the first and second shafts, respectively, for movement therewith. A link (36) pivotally connects the first and second arms that respective locations eccentric to the axes of the first and second shafts. Hence, a force transmitted by the closing mechanism may be transmitted through the first shaft, the first arm, the link, the second arm and the second shaft to urge the door to pivot in one direction about its axis.
摘要翻译：改进的关门装置（20）适合于与包括细长头部（22），基底（23）和一对侧边条（24,25）的门框（21）一起使用。门（26）适于安装在框架上以围绕轴线（y-y）枢转运动。改进的包括适于安装在集管上的底座（29），安装在基座上的更靠近的机构（30），并且具有适于相对于集管的伸长轴线垂直定向的第一轴（31）。较近的机构可操作地布置成选择性地推动第一轴相对于较近的机构旋转。第二轴（33）安装在基座上以相对于其枢转运动。第二轴基本上与门的枢转过多对齐。第一和第二臂（34,35）分别安装在第一和第二轴上以与其一起运动。连杆（36）将第一和第二臂枢转地连接到相对于第一和第二轴的轴线偏心的相应位置。因此，由闭合机构传递的力可以通过第一轴，第一臂，连杆，第二臂和第二轴传递，以促使门围绕其轴线在一个方向上枢转。

8. 发明授权

US5840527A Recombinant alveolar surfactant protein 失效
标题翻译：重组肺泡表达蛋白
公开(公告)号：US5840527A
公开(公告)日：1998-11-24
申请号：US483939
申请日：1995-06-07
申请人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
发明人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
IPC分类号： A61K38/00 , C07K14/785 , C12N15/70 , C12N15/85 , C12N1/00 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/785 , C12N15/70 , C12N15/85 , A61K38/00 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： Recombinant materials for the production of low molecular weight hydrophobic lung surfactant proteins are disclosed and claimed. The monomeric forms of the proteins from human and canine sources have apparent molecular weights of about 5 kd and form dimers under some conditions. The availability of these recombinant materials permits production of large amounts of these proteins through recombinant techniques and permits the use of these proteins in pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译：公开和要求保护用于生产低分子量疏水性肺表面活性蛋白质的重组材料。来自人和犬源的蛋白质的单体形式具有约5kd的表观分子量，并且在某些条件下形成二聚体。这些重组材料的可用性允许通过重组技术生产大量的这些蛋白质，并允许在药物组合物中使用这些蛋白质来治疗呼吸缺陷综合征。

9. 外观设计

USD371224S Baseball style bicycle helmet 失效
公开(公告)号：USD371224S
公开(公告)日：1996-06-25
申请号：US31468
申请日：1994-11-28
申请人： Richard N. Carlson , Bradley J. Benson
设计人： Richard N. Carlson , Bradley J. Benson

10. 发明授权

US5430020A Recombinant alveolar surfactant protein 失效
标题翻译：重组肺泡表达蛋白
公开(公告)号：US5430020A
公开(公告)日：1995-07-04
申请号：US74290
申请日：1993-06-09
申请人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
发明人： James W. Schilling, Jr. , Robert T. White , Barbara Cordell , Bradley J. Benson
IPC分类号： A61K38/00 , C07K14/785 , C12N15/70 , C12N15/85 , C07K7/00
CPC分类号： C07K14/785 , C12N15/70 , C12N15/85 , A61K38/00 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2830/55 , C12N2830/85
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones encoding variants of the SP-18 and SP-5 forms of human protein are disclosed. Methods and vectors for obtaining these proteins in recombinant form are also described. An improved method for purification of the 32K protein takes advantage of its carbohydrate affinity. Pharmaceutical compositions in the treatment of respiratory deficiency syndrome use the 10K proteins with or without the 32K form. Synthetic peptides based on the human SP-5 protein are provided as well, which peptides show significant ASP activity.
摘要翻译：公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 公开了编码SP-18和SP-5形式的人类蛋白质的变体的克隆。还描述了用于获得重组形式的这些蛋白质的方法和载体。改进的32K蛋白质的纯化方法利用其碳水化合物亲合力。治疗呼吸缺陷综合症的药物组合物使用具有或不具有32K形式的10K蛋白质。还提供了基于人SP-5蛋白的合成肽，该肽显示出显着的ASP活性。

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