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1. 发明授权

US06531321B1 Blood control and system for erythrocyte sedimentation measurement 有权
标题翻译：血液控制和红细胞沉降测定系统
公开(公告)号：US06531321B1
公开(公告)日：2003-03-11
申请号：US09662960
申请日：2000-09-15
申请人： Wayne L. Ryan , Bradford A. Hunsley
发明人： Wayne L. Ryan , Bradford A. Hunsley
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/5094 , Y10T436/10 , Y10T436/101666 , Y10T436/106664
摘要： A control and system for blood testing, including a control having stabilized blood cells that have been introduced into a suspension including an aggregating agent and preferably a surfactant. The control and system is used advantageously for indirect acute protein plasma measurement, including erythrocyte sedimentation rate testing.
摘要翻译：一种用于血液检测的对照和系统，包括具有稳定的血细胞的对照物，该对照物已被引入包含聚集剂和优选表面活性剂的悬浮液中。控制和系统有利地用于间接急性蛋白质血浆测量，包括红细胞沉降速率测试。

2. 发明申请

US20080286748A1 BLOOD COLLECTION TUBE WITH SURFACTANT 有权
标题翻译：血液收集管与表面活性剂
公开(公告)号：US20080286748A1
公开(公告)日：2008-11-20
申请号：US12136374
申请日：2008-06-10
申请人： Bradford A. Hunsley , Wayne L. Ryan
发明人： Bradford A. Hunsley , Wayne L. Ryan
IPC分类号： A01N1/02 , C12M1/00
CPC分类号： G01N15/05 , B01L3/5082 , B01L2200/085 , B01L2300/0858
摘要： Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with a closed end opposite the first end; and applying to a substantial portion of the receptacle a containment barrier. The improvements also pertain to resulting blood collection tubes, additives for blood collection tubes that permit reliable sedimentation test data after 8 hours from the blood draw, and methods of administering health care using the aforenoted tubes, additives or both.
摘要翻译：血液收集和检测的改进。在一个方面，一种制造采血管的改进方法，特别示出用于沉降速率测试，包括提供具有开放的第一端的细长玻璃管，用于接收至少1ml的静脉穿刺血液样品，形成为封闭的在第一端相对端; 并向容器的大部分施加容纳屏障。所述改进还涉及所述采血管，用于采血管的添加剂，其允许从抽血8小时后可靠的沉降测试数据，以及使用前述管，添加剂或两者进行保健的方法。

3. 发明授权

US07390663B2 Process, composition and kit for providing a stable whole blood calibrator/control 有权
标题翻译：用于提供稳定的全血校准器/控制的方法，组成和试剂盒
公开(公告)号：US07390663B2
公开(公告)日：2008-06-24
申请号：US11362362
申请日：2006-02-23
申请人： Wayne L. Ryan , Bradford A. Hunsley
发明人： Wayne L. Ryan , Bradford A. Hunsley
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： C12Q1/54 , G01N33/80 , Y10T436/10 , Y10T436/104998 , Y10T436/106664 , Y10T436/108331 , Y10T436/144444 , Y10T436/25 , Y10T436/2525
摘要： The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a glycolyzed red blood cell component which has been treated with a glycolysis stabilizing effective amount of at least one non-crosslinking aldehyde compound which may be added to fresh plasma along with an amount of glucose to form a simulated whole blood glucose control product, effective for maintaining a particular and essentially stable glucose concentration over a period of time sufficient for accurate measurement and calibration of a glucose measuring instrument.
摘要翻译：本发明涉及用于在葡萄糖监测仪器中使用的稳定的校准器和/或控制，试剂盒和方法。原则上，本发明教导了糖酵解的红细胞成分，其已用糖酵解稳定有效量的至少一种非交联醛化合物处理，该化合物可与一定量的葡萄糖一起加入到新鲜血浆中以形成模拟的全血葡萄糖对照产品，其有效地用于在足以准确测量和校准葡萄糖测量仪器的时间段内维持特定且基本上稳定的葡萄糖浓度。

4. 发明授权

US5614414A Liquid lipoprotein control 失效
标题翻译：液体脂蛋白对照
公开(公告)号：US5614414A
公开(公告)日：1997-03-25
申请号：US413477
申请日：1995-03-30
申请人： Wayne L. Ryan , Bradford A. Hunsley
发明人： Wayne L. Ryan , Bradford A. Hunsley
IPC分类号： G01N33/92 , G01N33/96 , G01N31/00
CPC分类号： G01N33/96 , G01N33/92 , G01N2800/044 , Y10T436/104165
摘要： An accurate, stable, liquid lipoprotein control composition is provided. The control composition of the present invention preferably comprises lipoprotein, suffactant and a divalent cation. The control may further comprise a chelating agent. It has been surprisingly found that when suffactant and a divalent cation are added to lipoprotein, it performs like native lipoprotein in human serum, i.e. not aggregated or subject to matrix effects. In addition, the control composition of the present invention is stable for up to about 5 months at room temperature (about 22.degree. C.) and up to about 12 months when refrigerated (about 2.degree. C. to about 10.degree. C.). Methods of making and using the control composition are also provided.
摘要翻译：提供了准确，稳定的液体脂蛋白对照组合物。本发明的对照组合物优选包含脂蛋白，腋下和二价阳离子。对照还可以包含螯合剂。已经令人惊讶地发现，当向脂蛋白加入腋下和二价阳离子时，其在人血清中表现为天然脂蛋白，即不聚集或受基质影响。此外，本发明的对照组合物在室温（约22℃）下可稳定长达约5个月，并且在冷藏（约2℃至约10℃）时至多约12个月）。还提供了制备和使用对照组合物的方法。

5. 发明授权

US07767460B2 Blood collection tube with surfactant 有权
标题翻译：采血管与表面活性剂
公开(公告)号：US07767460B2
公开(公告)日：2010-08-03
申请号：US12136374
申请日：2008-06-10
申请人： Bradford A. Hunsley , Wayne L. Ryan
发明人： Bradford A. Hunsley , Wayne L. Ryan
IPC分类号： G01N33/86 , B01L3/14
CPC分类号： G01N15/05 , B01L3/5082 , B01L2200/085 , B01L2300/0858
摘要： Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with a closed end opposite the first end; and applying to a substantial portion of the receptacle a containment barrier. The improvements also pertain to resulting blood collection tubes, additives for blood collection tubes that permit reliable sedimentation test data after 8 hours from the blood draw, and methods of administering health care using the aforenoted tubes, additives or both.
摘要翻译：血液收集和检测的改进。在一个方面，一种制造采血管的改进方法，特别示出用于沉降速率测试，包括提供具有开放的第一端的细长玻璃管，用于接收至少1ml的静脉穿刺血液样品，形成为封闭的在第一端相对端; 并向容器的大部分施加容纳屏障。所述改进还涉及所述采血管，用于采血管的添加剂，其允许从抽血8小时后可靠的沉降测试数据，以及使用前述管，添加剂或两者进行保健的方法。

6. 发明授权

US07419832B2 Blood collection tube with surfactant 有权
标题翻译：采血管与表面活性剂
公开(公告)号：US07419832B2
公开(公告)日：2008-09-02
申请号：US11369928
申请日：2006-03-07
申请人： Bradford A. Hunsley , Wayne L. Ryan
发明人： Bradford A. Hunsley , Wayne L. Ryan
IPC分类号： G01N33/86
CPC分类号： G01N15/05 , B01L3/5082 , B01L2200/085 , B01L2300/0858
摘要： Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with a closed end opposite the first end; and applying to a substantial portion of the receptacle a containment barrier. The improvements also pertain to resulting blood collection tubes, additives for blood collection tubes that permit reliable sedimentation test data after 8 hours from the blood draw, and methods of administering health care using the aforenoted tubes, additives or both.
摘要翻译：血液收集和检测的改进。在一个方面，一种制造采血管的改进方法，特别示出用于沉降速率测试，包括提供具有开放的第一端的细长玻璃管，用于接收至少1ml的静脉穿刺血液样品，形成为封闭的在第一端相对端; 并向容器的大部分施加容纳屏障。所述改进还涉及所述采血管，用于采血管的添加剂，其允许从抽血8小时后可靠的沉降测试数据，以及使用前述管，添加剂或两者进行保健的方法。

7. 发明授权

US5770451A Liquid lipoprotein control 失效
标题翻译：液体脂蛋白对照
公开(公告)号：US5770451A
公开(公告)日：1998-06-23
申请号：US823364
申请日：1997-03-24
申请人： Wayne L. Ryan , Bradford A. Hunsley
发明人： Wayne L. Ryan , Bradford A. Hunsley
IPC分类号： G01N33/92 , G01N33/96 , G01N31/00
CPC分类号： G01N33/92 , G01N33/96 , G01N2800/044 , Y10T436/10 , Y10T436/104165
摘要： An accurate, stable, liquid lipoprotein control composition is provided. The control composition of the present invention preferably contains lipoprotein, surfactant and a divalent cation. The control may further contain an anti-oxidant agent and a chelating agent. The control composition of the present invention is stable for up to about 12 months at room temperature and up to about 24 months when refrigerated. Methods of making and using the control composition are also provided.
摘要翻译：提供了准确，稳定的液体脂蛋白对照组合物。本发明的对照组合物优选含有脂蛋白，表面活性剂和二价阳离子。对照还可以含有抗氧化剂和螯合剂。本发明的对照组合物在室温下稳定长达约12个月，在冷藏时稳定至约24个月。还提供了制备和使用对照组合物的方法。

8. 发明授权

US07608457B2 Blood collection and testing improvements 有权
标题翻译：血液收集和检测改进
公开(公告)号：US07608457B2
公开(公告)日：2009-10-27
申请号：US11077397
申请日：2005-03-10
申请人： Bradford A. Hunsley
发明人： Bradford A. Hunsley
IPC分类号： G01N33/86
CPC分类号： B01L3/5082 , B01L2200/085 , B01L2300/0854 , B01L2300/16
摘要： Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with a closed end opposite the first end; and applying to a substantial portion of the receptacle a containment barrier.
摘要翻译：血液收集和检测的改进。在一个方面，一种制造采血管的改进方法，特别示出用于沉降速率测试，包括提供具有开放的第一端的细长玻璃管，用于接收至少1ml的静脉穿刺血液样品，形成为封闭的在第一端相对端; 并向容器的大部分施加容纳屏障。

9. 发明申请

US20100086962A1 HEMATOLOGY CONTROLS AND METHODS 审中-公开
标题翻译：血液学控制与方法
公开(公告)号：US20100086962A1
公开(公告)日：2010-04-08
申请号：US12573332
申请日：2009-10-05
申请人： Bradford A. Hunsley , Lei Chen
发明人： Bradford A. Hunsley , Lei Chen
IPC分类号： C12Q1/02
CPC分类号： G01N33/96 , G01N33/5094 , G01N2496/05
摘要： An integrated hematology control and methods for making the same, including a first cellular component derived from a plurality of processed animal red blood cells other than human blood cells and a second cellular component derived from a plurality of processed animal red blood cells other than human blood cells and a plurality of human blood cells, wherein the control simulates erythroblasts and white blood cells of a human blood sample on an automated blood analyzer.
摘要翻译：一种综合血液学控制及其制备方法，包括衍生自除人血细胞以外的多种加工动物红细胞的第一细胞成分和源自除人血液以外的多种加工动物红细胞的第二细胞成分细胞和多个人血细胞，其中所述对照模拟自动血液分析仪上的人血液样品的成红细胞和白细胞。

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