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1. 发明申请

US20120034131A1 APPARATUS, SYSTEM AND METHOD FOR PREVENTING BIOLOGICAL CONTAMINATION TO MATERIALS DURING STORAGE USING PULSED ELECTRICAL ENERGY 审中-公开
标题翻译：装置，系统和方法，用于防止在使用脉冲电能存储期间对材料的生物污染
公开(公告)号：US20120034131A1
公开(公告)日：2012-02-09
申请号：US13259516
申请日：2010-03-24
申请人： Boris Rubinsky , Michael Belkin , Alexander Goldberg , Ariel Sverdlik
发明人： Boris Rubinsky , Michael Belkin , Alexander Goldberg , Ariel Sverdlik
IPC分类号： A61L2/03
CPC分类号： A23L3/32 , A23B4/012 , A23L3/005 , A61L2/035 , A61L12/023
摘要： A container having a main storage space for holding a matter, having an inlet/outlet opening and fitted with a PEF system. The PEF system comprises two or more electrodes disposed within said container and contacting the matter; and electric pulse source connected to the two or more electrodes and adapted to pass pulsed electric energy through the matter. The PEF system being activated to deliver a treatment protocol to the matter.
摘要翻译：具有用于保持物品的主存储空间的容器，具有入口/出口开口并装配有PEF系统。 PEF系统包括设置在所述容器内并接触物体的两个或更多个电极; 并且电脉冲源连接到两个或更多个电极并且适于通过该物质传递脉冲电能。 PEF系统被激活以提供治疗方案。

2. 发明授权

US08603087B2 Methods and systems for treating restenosis using electroporation 有权
标题翻译：使用电穿孔治疗再狭窄的方法和系统
公开(公告)号：US08603087B2
公开(公告)日：2013-12-10
申请号：US11864320
申请日：2007-09-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/00
CPC分类号： A61B18/1492 , A61B2017/22002 , A61B2018/00214 , A61B2018/0022 , A61B2018/00422
摘要： A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.
摘要翻译：提供减少再狭窄的系统。导管装置设置有位于可充气气囊的至少第一和第二单极电极。气囊的大小可在再狭窄部位定位和扩张。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为以足以产生再狭窄部位的电穿孔并且低于对再狭窄部位造成热损伤的量以受控的方式将电场施加到再狭窄部位。

3. 发明申请

US20130196441A1 ELECTROPORATION ELECTRODE CONFIGURATION AND METHODS 审中-公开
标题翻译：电镀电极配置和方法
公开(公告)号：US20130196441A1
公开(公告)日：2013-08-01
申请号：US13700384
申请日：2011-05-31
申请人： Boris Rubinsky , Gregory D. Troszak
发明人： Boris Rubinsky , Gregory D. Troszak
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , A61N1/327
摘要： Provided herein are the concept that “singularity-based configuration” electrodes design and method can produce in an ionic substance local high electric fields with low potential differences between electrodes. The singularity-based configuration described here includes: an anode electrode; a cathode electrode; and an insulator disposed between the anode electrode and the cathode electrode. The singularity-based electrode design concept refers to electrodes in which the anode and cathode are adjacent to each other, placed essentially co-planar and are separated by an insulator. The essentially co-planar anode/insulator/cathode configuration bound one surface of the volume of interest and produce desired electric fields locally, i.e., in the vicinity of the interface between the anode and cathode. In an ideal configuration, the interface dimension between the anode and the cathode tends to zero and becomes a point of singularity.
摘要翻译：这里提供的是“奇异性配置”电极设计和方法可以在离子物质中产生电极之间具有低电位差的局部高电场的概念。这里描述的基于奇点的配置包括：阳极电极; 阴极电极; 以及设置在阳极电极和阴极电极之间的绝缘体。基于奇点的电极设计概念是指电极，其中阳极和阴极彼此相邻，基本上共面并且由绝缘体分开。基本上共平面的阳极/绝缘体/阴极配置结合感兴趣体积的一个表面，并且局部地产生所需的电场，即在阳极和阴极之间的界面附近。在理想的配置中，阳极和阴极之间的界面尺寸趋于零，并成为一个奇点。

4. 发明申请

US20120226218A1 EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION 有权
标题翻译：使用非热不可逆电极制造的细小基体材料
公开(公告)号：US20120226218A1
公开(公告)日：2012-09-06
申请号：US13391577
申请日：2010-09-02
申请人： Mary Phillips , Elad Maor , Boris Rubinsky , Jacob Lavee
发明人： Mary Phillips , Elad Maor , Boris Rubinsky , Jacob Lavee
IPC分类号： A61M37/00 , A61K35/22 , A61K35/42 , A61K35/38 , A61K35/12 , A61K35/34
CPC分类号： A61K35/34 , A61K35/22 , A61K35/38 , A61K35/42 , A61K35/44 , A61L27/3604 , A61L27/3683 , A61L27/3834 , A61L2430/40
摘要： Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically.
摘要翻译：公开了细胞外基质材料，其通过用脉冲电场对目标区域进行非热不可逆电穿孔（NTIRE）而产生，以在不存在热损伤的情况下杀死细胞。可以去除死细胞材料，并将剩余的非细胞基质材料植入修复部位以进行医疗或化妆品处理。

5. 发明授权

US08162918B2 Gels with predetermined conductivity used in electroporation of tissue 有权
标题翻译：具有预定电导率的凝胶用于组织电穿孔
公开(公告)号：US08162918B2
公开(公告)日：2012-04-24
申请号：US12716967
申请日：2010-03-03
申请人： Antoni Ivorra , Boris Rubinsky
发明人： Antoni Ivorra , Boris Rubinsky
IPC分类号： A61M31/00
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

6. 发明申请

US20120071872A1 Systems for Treating Tissue Sites Using Electroporation 审中-公开
标题翻译：使用电穿孔处理组织部位的系统
公开(公告)号：US20120071872A1
公开(公告)日：2012-03-22
申请号：US13305252
申请日：2011-11-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/00
CPC分类号： A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/143 , A61N1/327
摘要： A system for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site.
摘要翻译：一种用于治疗组织部位的系统。至少第一和第二单极电极被配置为在患者的组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导组织部位中的细胞的电穿孔，以产生组织部位的细胞的坏死，但不足以对其产生热损伤作用大部分组织部位。

7. 发明申请

US20100160850A1 GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE 有权
标题翻译：在组织电导中使用预测的电导率的凝胶
公开(公告)号：US20100160850A1
公开(公告)日：2010-06-24
申请号：US12716967
申请日：2010-03-03
申请人： ANTONI IVORRA , Boris Rubinsky
发明人： ANTONI IVORRA , Boris Rubinsky
IPC分类号： A61N1/30
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

8. 发明申请

US20100097081A1 Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties 有权
标题翻译：用于确定组织水含量特性的体积感应相移检测系统
公开(公告)号：US20100097081A1
公开(公告)日：2010-04-22
申请号：US12616102
申请日：2009-11-10
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01R27/08
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差和第二感应线圈（或天线）位于组织样本的相对侧上。

9. 发明申请

US20060293731A1 Methods and systems for treating tumors using electroporation 审中-公开
标题翻译：使用电穿孔治疗肿瘤的方法和系统
公开(公告)号：US20060293731A1
公开(公告)日：2006-12-28
申请号：US11165961
申请日：2005-06-24
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61F7/00
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00797 , A61B2018/143
摘要： A system is provided for treating tumor tissue sites of a patient. At least first and second mono-polar electrodes are configured to be introduced at or near the tumor tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tumor tissue site, to create necrosis of cells of the tumor tissue site, but insufficient to create a thermal damaging effect to a majority of the tumor tissue site.
摘要翻译：提供了一种用于治疗患者的肿瘤组织部位的系统。至少第一和第二单极电极被配置为在患者的肿瘤组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导肿瘤组织部位的细胞的电穿孔，以产生肿瘤组织部位的细胞坏死，但不足以产生热损伤作用到大多数肿瘤组织部位。

10. 发明申请

US20060293713A1 Methods and systems for treating BPH using electroporation 有权
标题翻译：使用电穿孔治疗BPH的方法和系统
公开(公告)号：US20060293713A1
公开(公告)日：2006-12-28
申请号：US11166974
申请日：2005-06-24
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61N1/18
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476
摘要： A system for treating benign prostate hyperplasia (BPH) of a prostate. At least first and second mono-polar electrodes are configured to be introduced at or near a BPH tissue site of the prostate gland of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the BPH tissue site, to create necrosis of cells of the BPH tissue site, but insufficient to create a thermal damaging effect to a majority of the BPH tissue site.
摘要翻译：一种用于治疗前列腺良性前列腺增生（BPH）的系统。至少第一和第二单极电极被配置为在患者的前列腺的BPH组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导BPH组织部位中的细胞的电穿孔，以产生BPH组织部位的细胞坏死，但不足以产生热损伤作用到大多数BPH组织部位。

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