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1. 发明申请

US20100179768A1 Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes 审中-公开
标题翻译：糖尿病监测与控制策略检测方法，系统与计算机仿真环境
公开(公告)号：US20100179768A1
公开(公告)日：2010-07-15
申请号：US12664444
申请日：2008-06-20
申请人： Boris P. Kovatchev , Marc D. Breton , Claudio Cobelli , Chiara Dalla Man
发明人： Boris P. Kovatchev , Marc D. Breton , Claudio Cobelli , Chiara Dalla Man
IPC分类号： G06F19/00 , G01N33/48
摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.
摘要翻译： 1型糖尿病监测方法，开环和闭环治疗策略的电脑测试模拟环境。模拟环境的一些示例性主要组成部分包括但不限于以下内容：1）在三个年龄组中具有1型糖尿病的计算机“受试者”的“群体” 2）CGM传感器误差的模拟器; 3）胰岛素泵和离散胰岛素输送的模拟器; 4）允许输入用户指定的治疗方案的界面; 和5）一套评估测试治疗策略质量的标准化结果测量和图表。这些组分可以单独使用或组合使用，用于糖尿病的开环或闭环控制治疗的临床前评估。

2. 发明申请

US20120245556A1 System, Method and Computer Program Product For Adjustment of Insulin Delivery in Diabetes Using Nominal Open-Loop Profiles 审中-公开
标题翻译：系统，方法和计算机程序产品用于调整使用标称开环配置文件的糖尿病胰岛素输送
公开(公告)号：US20120245556A1
公开(公告)日：2012-09-27
申请号：US13393647
申请日：2010-08-31
申请人： Boris P. Kovatchev , Giuseppe DeNicolao , Lalo Magni , Chiara Dalla Man , Claudio Cobelli
发明人： Boris P. Kovatchev , Giuseppe DeNicolao , Lalo Magni , Chiara Dalla Man , Claudio Cobelli
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/4839 , A61M2230/201 , G06F19/3468 , G16H50/50
摘要： A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject.
摘要翻译：一种用于校正患有糖尿病的受试者的名义治疗策略的方法，系统和计算机程序产品。方法，系统和计算机程序产品可以被配置用于提供输入，由此输入可以包括：用于对象的开环治疗设置，关于对象的血糖状态的数据; 和（可选）有关膳食和/或运动受试者的数据。方法，系统和计算机程序产品可以被配置用于提供输出，由此输出可以包括针对受试者的胰岛素递送给对象的开环治疗设置的调整（校正）。

3. 发明申请

US20120130698A1 System, Method and Computer Simulation Environment For In Silico Trials in Pre-Diabetes and Type 2 Diabetes 审中-公开
标题翻译：系统，方法和计算机模拟环境在糖尿病和2型糖尿病前的皮检中
公开(公告)号：US20120130698A1
公开(公告)日：2012-05-24
申请号：US13380839
申请日：2010-06-25
申请人： Boris P. Kovatchev , Claudio Cobelli , Chiara Dalla Man
发明人： Boris P. Kovatchev , Claudio Cobelli , Chiara Dalla Man
IPC分类号： G06G7/48
CPC分类号： G16H50/50
摘要： An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.
摘要翻译：提供了一种电子系统，其模拟T2DM或前体糖尿病受试者的葡萄糖 - 胰岛素代谢系统，其中所述系统包括模拟T2DM或前驱糖尿病受试者中的动态葡萄糖浓度的子系统，包括模拟内源葡萄糖产生的电子模块（EGP（ t））或膳食葡萄糖出现率（Ra（t >>，或葡萄糖利用率（U（t））或肾脏排泄葡萄糖（B（t））），该子系统模拟所述T2DM中的动态胰岛素浓度或包括模拟胰岛素分泌的电子模块（S（t）），包含虚拟T2DM或前体糖尿病受试者群体的电子数据库，每个虚拟对象具有多个代谢参数;以及处理模块，其计算效果通过输入多个代谢参数值，对虚拟受试者的葡萄糖胰岛素代谢系统的至少一个代谢参数值的变化。

4. 发明授权

US11238990B2 System, method and computer simulation environment for in silico trials in pre-diabetes and type 2 diabetes 有权
公开(公告)号：US11238990B2
公开(公告)日：2022-02-01
申请号：US13380839
申请日：2010-06-25
申请人： Boris P. Kovatchev , Claudio Cobelli , Chiara Dalla Man
发明人： Boris P. Kovatchev , Claudio Cobelli , Chiara Dalla Man
IPC分类号： G16H10/00 , G16H50/50 , G16H50/70 , G06N5/00 , G16H10/60 , A61B5/00 , G16H50/20
摘要： An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.

5. 发明授权

US10546659B2 Method, system and computer simulation environment for testing of monitoring and control strategies in diabetes 有权
公开(公告)号：US10546659B2
公开(公告)日：2020-01-28
申请号：US12664444
申请日：2008-06-20
申请人： Boris P. Kovatchev , Marc D. Breton , Claudio Cobelli , Chiara Dalla Man
发明人： Boris P. Kovatchev , Marc D. Breton , Claudio Cobelli , Chiara Dalla Man
IPC分类号： G16H50/50 , G16H20/17
摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.

6. 发明授权

US09827371B2 Method for controlling the delivery of insulin and the related system 有权
公开(公告)号：US09827371B2
公开(公告)日：2017-11-28
申请号：US14389936
申请日：2012-03-23
申请人： Paola Soru , Lalo Magni , Chiara Toffanin , Giuseppe De Nicolao , Chiara Dalla Man , Claudio Cobelli
发明人： Paola Soru , Lalo Magni , Chiara Toffanin , Giuseppe De Nicolao , Chiara Dalla Man , Claudio Cobelli
IPC分类号： A61B5/145 , A61M5/172 , A61M5/142 , G06F19/00
CPC分类号： A61M5/1723 , A61M5/14276 , A61M2005/14208 , A61M2205/04 , G06F19/00 , G06F19/3456 , G06F19/3468 , G16H50/20
摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

7. 发明申请

US20150174322A1 METHOD FOR CONTROLLING THE DELIVERY OF INSULIN AND THE RELATED SYSTEM 有权
标题翻译：用于控制胰岛素分泌和相关系统的方法
公开(公告)号：US20150174322A1
公开(公告)日：2015-06-25
申请号：US14389936
申请日：2012-03-23
申请人： Paola Soru , Lalo Magni , Chiara Toffanin , Giuseppe De Nicolao , Chiara Dalla Man , Claudio Cobelli
发明人： Paola Soru , Lalo Magni , Chiara Toffanin , Giuseppe De Nicolao , Chiara Dalla Man , Claudio Cobelli
IPC分类号： A61M5/172 , G06F19/00 , A61M5/142
CPC分类号： A61M5/1723 , A61M5/14276 , A61M2005/14208 , A61M2205/04 , G06F19/00 , G06F19/3456 , G06F19/3468 , G16H50/20
摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.
摘要翻译：方法（400）基于代表患者（P）将消费的膳食的至少一部分（m（k + i））的数据（d）来控制糖尿病患者（P）中胰岛素的递送。该方法基于代表膳食的至少一部分（m（k + i））的数据（d），从代表患者（P）的常规治疗或开环规则的块（R）），参考胰岛素值（u0）。该方法还基于表示在患者（P）中检测到的血糖水平的输入数据（ŷ），参考血糖水平和反馈数据（yCGM）之间的差异的数据。控制模块（301; 401）基于各种代表性数据提供要传送给患者（P）的胰岛素（i）的值。

8. 发明申请

US20100262117A1 PREDICTIVE CONTROL BASED SYSTEM AND METHOD FOR CONTROL OF INSULIN DELIVERY IN DIABETES USING GLUCOSE SENSING 审中-公开
标题翻译：基于预测控制的系统和使用葡萄糖感测控制糖尿病胰岛素的方法
公开(公告)号：US20100262117A1
公开(公告)日：2010-10-14
申请号：US12740275
申请日：2008-10-31
申请人： Lalo Magni , Giuseppe De Nicolao , Davide Martino Raimondo , Claudio Cobelli , Chiara Dalla Man
发明人： Lalo Magni , Giuseppe De Nicolao , Davide Martino Raimondo , Claudio Cobelli , Chiara Dalla Man
IPC分类号： A61M37/00
CPC分类号： G06F19/3468 , A61B5/14532 , A61B5/4839 , A61B5/7275 , A61M5/1723 , A61M2005/14208 , A61M2230/201 , G16H50/50
摘要： A system and method for providing optimal insulin injections to a subject, using a controller, a continuous glucose monitor, and an insulin delivery unit is disclosed. The controller possesses a discrete-time, linear model predictive control law, means for sending information to the insulin delivery unit, and means for receiving information from the CGM. The control law implemented is derived from a discrete-time model of glucose insulin dynamics and an aggressiveness parameter. The result is that using only glucose measurements obtained from sensor readings and, prior values of external insulin infusion and meal and exercise announcement the optimal insulin injection necessary to safely regulate blood glucose can be calculated.
摘要翻译：公开了一种使用控制器，连续葡萄糖监测器和胰岛素递送单元向受试者提供最佳胰岛素注射的系统和方法。控制器具有离散时间线性模型预测控制规则，用于向胰岛素递送单元发送信息的装置，以及用于从CGM接收信息的装置。实施的控制规律来自葡萄糖胰岛素动力学的离散时间模型和侵略性参数。结果是，仅使用从传感器读数获得的葡萄糖测量值，以及外部胰岛素输注和膳食和运动通知的先前值可以计算安全调节血糖所需的最佳胰岛素注射。

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