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1. 发明授权

US07608638B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US07608638B2
公开(公告)日：2009-10-27
申请号：US11876612
申请日：2007-10-22
申请人： Bob G. Sanders , Kimberly Kline , Daurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Daurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A61K31/355 , C07D311/24 , C07D311/72
CPC分类号： C07D215/46 , C07D215/38 , C07D311/58 , C07D311/66 , C07D311/72 , C07D311/76
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
摘要翻译：本发明提供具有以下结构式的抗增殖化合物，其中X是氧，氮或硫; Y选自氧，氮和硫，其中当Y是氧或氮时，n是1，当Y是硫时，n是0.还提供了诱导细胞凋亡的方法，包括给予包含一个化合物

2. 发明申请

US20080119514A1 TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF 有权
标题翻译： TOCOPHEROLS，TOCOTRIENOLS，其他色素和侧链衍生物及其用途
公开(公告)号：US20080119514A1
公开(公告)日：2008-05-22
申请号：US11876612
申请日：2007-10-22
申请人： Bob G. Sanders , Kimberly Kline , Daurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Daurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A61K31/47 , A61K31/355 , C07D311/76 , A61P31/00 , A61P19/00 , A61P17/00 , A61P35/04 , C07D215/00
CPC分类号： C07D215/46 , C07D215/38 , C07D311/58 , C07D311/66 , C07D311/72 , C07D311/76
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
摘要翻译：本发明提供具有以下结构式的抗增殖化合物，其中X是氧，氮或硫; Y选自氧，氮和硫，其中当Y是氧或氮时，n是1，当Y是硫时，n是0.还提供了诱导细胞凋亡的方法，包括给予包含一个化合物

3. 发明授权

US07312232B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US07312232B2
公开(公告)日：2007-12-25
申请号：US10644418
申请日：2003-08-20
申请人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A61K31/47 , A61K31/355 , C07D311/66 , C07D311/70 , C07D311/72
CPC分类号： C07D215/46 , C07D215/38 , C07D311/58 , C07D311/66 , C07D311/72 , C07D311/76
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.
摘要翻译：本发明提供具有以下结构式的抗增殖化合物，其中X是氧，氮或硫; Y选自氧，氮和硫，其中当Y是氧或氮时，n是1，当Y是硫时，n是0.还提供了诱导细胞凋亡的方法，包括给予包含具有所述结构式的化合物。

4. 发明授权

US06770672B1 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US06770672B1
公开(公告)日：2004-08-03
申请号：US09502592
申请日：2000-02-11
申请人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A61K31355
CPC分类号： C07D311/72 , C07D215/20 , C07D215/38
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
摘要翻译：本发明提供了具有结构式的结构的抗增殖化合物，X是氧，氮或硫; Y选自氧，氮和硫，其中当Y是氧或氮时，n是1，当Y是硫时，n是0.还提供了诱导细胞凋亡的方法，包括给予包含一个化合物

5. 发明授权

US06645998B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US06645998B2
公开(公告)日：2003-11-11
申请号：US10122019
申请日：2002-04-12
申请人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A61K31355
CPC分类号： C07D311/66 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
摘要翻译：本发明提供了具有结构式的结构的抗增殖化合物，X是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸酯，硫酸酯，磷酸酯，醇，醚和腈 ; R 2是氢，甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R 3选自氢，甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R 4为甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R 5为烷基，烯基，炔基，芳基，杂芳基，羧基，酰胺和酯。还提供了诱导细胞凋亡的方法，包括给予包含化合物的组合物。

6. 发明授权

US06417223B1 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof 有权
标题翻译：生育酚，生育三烯酚，其他色胺和侧链衍生物，并使用
公开(公告)号：US06417223B1
公开(公告)日：2002-07-09
申请号：US09404001
申请日：1999-09-23
申请人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
发明人： Bob G. Sanders , Kimberly Kline , Laurence Hurley , Robb Gardner , Marla Menchaca , Weiping Yu , Puthucode N. Ramanan , Shenquan Liu , Karen Israel
IPC分类号： A01N4316
CPC分类号： C07D311/66 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.
摘要翻译：本发明提供了具有结构式的结构的抗增殖化合物，X是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸酯，硫酸酯，磷酸酯，醇，醚和腈; R2是氢，甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R 3选自氢，甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R4是甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖和胺; R5是烷基，烯基，炔基，芳基，杂芳基，羧基，酰胺和酯。还提供了诱导细胞凋亡的方法，包括给予包含化合物的组合物。

7. 发明授权

US08148424B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US08148424B2
公开(公告)日：2012-04-03
申请号：US12771439
申请日：2010-04-30
申请人： Bob G. Sanders , Kimberly Kline , Weiping Yu
发明人： Bob G. Sanders , Kimberly Kline , Weiping Yu
IPC分类号： A01N43/16
CPC分类号： C07D311/66 , C07D215/20 , C07D215/46 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
摘要翻译：本发明提供具有结构式的抗增殖化合物，其中X和Y独立地是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸酯，硫酸酯，磷酸酯，醇，醚或腈; R2和R3是氢或R4; R4是甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖或胺; 并且R 5是烯基; 其中当Y是氮时，所述氮被R 6取代，其中R 6是氢或甲基。还提供了治疗细胞增殖性疾病和诱导细胞凋亡的方法，其中还包括施用该化合物。

8. 发明授权

US07300954B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US07300954B2
公开(公告)日：2007-11-27
申请号：US10695275
申请日：2003-10-28
申请人： Bob G. Sanders , Kimberly Kline , Weiping Yu
发明人： Bob G. Sanders , Kimberly Kline , Weiping Yu
IPC分类号： A01N43/16
CPC分类号： C07D311/66 , C07D215/20 , C07D215/46 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitrites; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
摘要翻译：本发明提供具有结构式的抗增殖化合物，其中X和Y独立地是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸根，硫酸根，酒精，醚或亚硝酸盐; R 2和R 3是氢或R 4; R 4是甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖或胺; R 5是链烯基; 当Y为氮时，所述氮被R 6取代，其中R 6为氢或甲基。还提供了治疗细胞增殖性疾病和诱导细胞凋亡的方法，其中还包括施用该化合物。

9. 发明授权

US08664264B2 Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 有权
标题翻译：生育酚，生育三烯酚，其他色满反应和侧链衍生物及其用途
公开(公告)号：US08664264B2
公开(公告)日：2014-03-04
申请号：US13406893
申请日：2012-02-28
申请人： Bob G. Sanders , Kimberly Kline , Weiping Yu
发明人： Bob G. Sanders , Kimberly Kline , Weiping Yu
IPC分类号： A01N43/16
CPC分类号： C07D311/66 , C07D215/20 , C07D215/46 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
摘要翻译：本发明提供具有结构式的抗增殖化合物，其中X和Y独立地是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸酯，硫酸酯，磷酸酯，醇，醚或腈; R2和R3是氢或R4; R4是甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖或胺; 并且R 5是烯基; 其中当Y是氮时，所述氮被R 6取代，其中R 6是氢或甲基。还提供了治疗细胞增殖性疾病和诱导细胞凋亡的方法，其中还包括施用该化合物。

10. 发明申请

US20100303899A1 TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF 有权
标题翻译： TOCOPHEROLS，TOCOTRIENOLS，其他色素和侧链衍生物及其用途
公开(公告)号：US20100303899A1
公开(公告)日：2010-12-02
申请号：US12771439
申请日：2010-04-30
申请人： BOB G. SANDERS , Kimberly Kline , Weiping Yu
发明人： BOB G. SANDERS , Kimberly Kline , Weiping Yu
IPC分类号： A61K9/127 , A61K31/355 , A61K31/655 , A61P35/02 , A61P35/00 , A61P17/06 , A61P17/00 , A61P19/02 , A61P37/00 , A61P31/18 , C12N5/07
CPC分类号： C07D311/66 , C07D215/20 , C07D215/46 , C07D311/58 , C07D311/72
摘要： The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
摘要翻译：本发明提供具有结构式的抗增殖化合物，其中X和Y独立地是氧，氮或硫; R 1是烷基，烯基，炔基，芳基，杂芳基，羧酸，羧酸酯，羧酰胺，酯，硫代酰胺，硫醇酸，硫醇酯，糖，烷氧基连接的糖，胺，磺酸酯，硫酸酯，磷酸酯，醇，醚或腈; R2和R3是氢或R4; R4是甲基，苄基羧酸，苄基羧酸酯，苄基甲酰胺，苄基酯，糖或胺; 并且R 5是烯基; 其中当Y是氮时，所述氮被R 6取代，其中R 6是氢或甲基。还提供了治疗细胞增殖性疾病和诱导细胞凋亡的方法，其中还包括施用该化合物。

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